^STUDY !CHEMICAL_NAME=Dimethylvinyl chloride (DMVC) !STUDY_CONCLUSION=Positive !DEPOSITOR_STUDY_NUMBER=154330_SCE !STRESSOR_TYPE=CHEMICAL !INSTITUTION=NTP !STUDY_TITLE=Cytogenetic study of Dimethylvinyl chloride (DMVC) in Chinese Hamster Ovary Cell Sister Chromatid Exchange Test !STUDY_DESIGN=Parallel !SUBJECT_TYPE=IN_VITRO !OLD_NTP_STUDY_TYPE=CHO_SCE !NTP_STUDY_TYPE=Genetic Toxicology - Mammalian Cell Cytogenetics !TIME_TYPE=Study !STUDY_VARIABLES=COMPOUND|MICROSOMAL_ACTIVATION_USED|DOSE|DOSE_UNIT|TRIAL_RESULT|TREATMENT_GROUP_TYPE|START_DATE ^GROUP #GROUP_NAME #COMPARATOR_NAME #IS_CONTROL_GROUP #SUPER_GROUP_NAME #TREATMENT_GROUP_TYPE #DEPOSITOR_NAME #ASSAY_TRIAL #COMPOUND #SPECIES_COMMON_NAME #CELL_LINE #STRAIN #MICROSOMAL_ACTIVATION_USED #MICROSOMAL_ACTIVATION_SPECIES #DOSE #DOSE_UNIT #TRIAL_RESULT #START_DATE #CONTROL_SUBSTANCE_NAME $GROUP_NAME $COMPARATOR_NAME $IS_CONTROL_GROUP $SUPER_GROUP_NAME $TREATMENT_GROUP_TYPE $DEPOSITOR_NAME $ASSAY_TRIAL $COMPOUND $SPECIES_COMMON_NAME $CELL_LINE $STRAIN $MICROSOMAL_ACTIVATION_USED $MICROSOMAL_ACTIVATION_SPECIES $DOSE $DOSE_UNIT $TRIAL_RESULT $START_DATE $CONTROL_SUBSTANCE_NAME 1 1 Hamster Chinese Hamster Ovary CHO-W-B1 No Activation N_A Positive 1983-07-19 1_1_Negative (Not Specified) T 1 Vehicle Control 1 Negative (Not Specified) Hamster Chinese Hamster Ovary CHO-W-B1 0 Negative (Not Specified) 1_2_Dimethyl Sulfoxide T 1 Vehicle Control 2 Dimethyl Sulfoxide Hamster Chinese Hamster Ovary CHO-W-B1 0 Dimethyl Sulfoxide 1_3_25.0_ug/mL_Dimethylvinyl chloride (DMVC) 1_2_Dimethyl Sulfoxide 1 Test Chemical 3 Dimethylvinyl chloride (DMVC) Hamster Chinese Hamster Ovary CHO-W-B1 25.0 ug/mL 1_4_50.0_ug/mL_Dimethylvinyl chloride (DMVC) 1_2_Dimethyl Sulfoxide 1 Test Chemical 4 Dimethylvinyl chloride (DMVC) Hamster Chinese Hamster Ovary CHO-W-B1 50.0 ug/mL 1_5_160.0_ug/mL_Dimethylvinyl chloride (DMVC) 1_2_Dimethyl Sulfoxide 1 Test Chemical 5 Dimethylvinyl chloride (DMVC) Hamster Chinese Hamster Ovary CHO-W-B1 160.0 ug/mL 1_6_300.0_ug/mL_Dimethylvinyl chloride (DMVC) 1_2_Dimethyl Sulfoxide 1 Test Chemical 6 Dimethylvinyl chloride (DMVC) Hamster Chinese Hamster Ovary CHO-W-B1 300.0 ug/mL 1_7_400.0_ug/mL_Dimethylvinyl chloride (DMVC) 1_2_Dimethyl Sulfoxide 1 Test Chemical 7 Dimethylvinyl chloride (DMVC) Hamster Chinese Hamster Ovary CHO-W-B1 400.0 ug/mL 1_8_0.05_ug/mL_Mitomycin-C 1_2_Dimethyl Sulfoxide T 1 Positive Control 8 Mitomycin-C Hamster Chinese Hamster Ovary CHO-W-B1 0.05 ug/mL Mitomycin-C 1_9_0.1_ug/mL_Mitomycin-C 1_2_Dimethyl Sulfoxide T 1 Positive Control 9 Mitomycin-C Hamster Chinese Hamster Ovary CHO-W-B1 0.1 ug/mL Mitomycin-C 2 2 Hamster Chinese Hamster Ovary CHO-W-B1 No Activation N_A Positive 1983-08-13 2_1_Negative (Not Specified) T 2 Vehicle Control 1 Negative (Not Specified) Hamster Chinese Hamster Ovary CHO-W-B1 0 Negative (Not Specified) 2_2_Dimethyl Sulfoxide T 2 Vehicle Control 2 Dimethyl Sulfoxide Hamster Chinese Hamster Ovary CHO-W-B1 0 Dimethyl Sulfoxide 2_3_100.0_ug/mL_Dimethylvinyl chloride (DMVC) 2_2_Dimethyl Sulfoxide 2 Test Chemical 3 Dimethylvinyl chloride (DMVC) Hamster Chinese Hamster Ovary CHO-W-B1 100.0 ug/mL 2_4_250.0_ug/mL_Dimethylvinyl chloride (DMVC) 2_2_Dimethyl Sulfoxide 2 Test Chemical 4 Dimethylvinyl chloride (DMVC) Hamster Chinese Hamster Ovary CHO-W-B1 250.0 ug/mL 2_5_500.0_ug/mL_Dimethylvinyl chloride (DMVC) 2_2_Dimethyl Sulfoxide 2 Test Chemical 5 Dimethylvinyl chloride (DMVC) Hamster Chinese Hamster Ovary CHO-W-B1 500.0 ug/mL 2_6_750.0_ug/mL_Dimethylvinyl chloride (DMVC) 2_2_Dimethyl Sulfoxide 2 Test Chemical 6 Dimethylvinyl chloride (DMVC) Hamster Chinese Hamster Ovary CHO-W-B1 750.0 ug/mL 2_7_0.05_ug/mL_Mitomycin-C 2_2_Dimethyl Sulfoxide T 2 Positive Control 7 Mitomycin-C Hamster Chinese Hamster Ovary CHO-W-B1 0.05 ug/mL Mitomycin-C 1_S9 1_S9 Hamster Chinese Hamster Ovary CHO-W-B1 Induced Rat Liver S9 RAT Positive 1983-06-14 1_S9_1_Negative (Not Specified) T 1_S9 Vehicle Control 1 Negative (Not Specified) Hamster Chinese Hamster Ovary CHO-W-B1 0 Negative (Not Specified) 1_S9_2_Dimethyl Sulfoxide T 1_S9 Vehicle Control 2 Dimethyl Sulfoxide Hamster Chinese Hamster Ovary CHO-W-B1 0 Dimethyl Sulfoxide 1_S9_3_50.0_ug/mL_Dimethylvinyl chloride (DMVC) 1_S9_2_Dimethyl Sulfoxide 1_S9 Test Chemical 3 Dimethylvinyl chloride (DMVC) Hamster Chinese Hamster Ovary CHO-W-B1 50.0 ug/mL 1_S9_4_160.0_ug/mL_Dimethylvinyl chloride (DMVC) 1_S9_2_Dimethyl Sulfoxide 1_S9 Test Chemical 4 Dimethylvinyl chloride (DMVC) Hamster Chinese Hamster Ovary CHO-W-B1 160.0 ug/mL 1_S9_5_500.0_ug/mL_Dimethylvinyl chloride (DMVC) 1_S9_2_Dimethyl Sulfoxide 1_S9 Test Chemical 5 Dimethylvinyl chloride (DMVC) Hamster Chinese Hamster Ovary CHO-W-B1 500.0 ug/mL 1_S9_6_1600.0_ug/mL_Dimethylvinyl chloride (DMVC) 1_S9_2_Dimethyl Sulfoxide 1_S9 Test Chemical 6 Dimethylvinyl chloride (DMVC) Hamster Chinese Hamster Ovary CHO-W-B1 1600.0 ug/mL 1_S9_7_5000.0_ug/mL_Dimethylvinyl chloride (DMVC) 1_S9_2_Dimethyl Sulfoxide 1_S9 Test Chemical 7 Dimethylvinyl chloride (DMVC) Hamster Chinese Hamster Ovary CHO-W-B1 5000.0 ug/mL 1_S9_8_1.5_ug/mL_Cyclophosphamide 1_S9_2_Dimethyl Sulfoxide T 1_S9 Positive Control 8 Cyclophosphamide Hamster Chinese Hamster Ovary CHO-W-B1 1.5 ug/mL Cyclophosphamide 2_S9 2_S9 Hamster Chinese Hamster Ovary CHO-W-B1 Induced Rat Liver S9 RAT Weakly Positive 1983-08-13 2_S9_1_Negative (Not Specified) T 2_S9 Vehicle Control 1 Negative (Not Specified) Hamster Chinese Hamster Ovary CHO-W-B1 0 Negative (Not Specified) 2_S9_2_Dimethyl Sulfoxide T 2_S9 Vehicle Control 2 Dimethyl Sulfoxide Hamster Chinese Hamster Ovary CHO-W-B1 0 Dimethyl Sulfoxide 2_S9_3_250.0_ug/mL_Dimethylvinyl chloride (DMVC) 2_S9_2_Dimethyl Sulfoxide 2_S9 Test Chemical 3 Dimethylvinyl chloride (DMVC) Hamster Chinese Hamster Ovary CHO-W-B1 250.0 ug/mL 2_S9_4_500.0_ug/mL_Dimethylvinyl chloride (DMVC) 2_S9_2_Dimethyl Sulfoxide 2_S9 Test Chemical 4 Dimethylvinyl chloride (DMVC) Hamster Chinese Hamster Ovary CHO-W-B1 500.0 ug/mL 2_S9_5_750.0_ug/mL_Dimethylvinyl chloride (DMVC) 2_S9_2_Dimethyl Sulfoxide 2_S9 Test Chemical 5 Dimethylvinyl chloride (DMVC) Hamster Chinese Hamster Ovary CHO-W-B1 750.0 ug/mL 2_S9_6_1600.0_ug/mL_Dimethylvinyl chloride (DMVC) 2_S9_2_Dimethyl Sulfoxide 2_S9 Test Chemical 6 Dimethylvinyl chloride (DMVC) Hamster Chinese Hamster Ovary CHO-W-B1 1600.0 ug/mL 2_S9_7_5000.0_ug/mL_Dimethylvinyl chloride (DMVC) 2_S9_2_Dimethyl Sulfoxide 2_S9 Test Chemical 7 Dimethylvinyl chloride (DMVC) Hamster Chinese Hamster Ovary CHO-W-B1 5000.0 ug/mL 2_S9_8_1.5_ug/mL_Cyclophosphamide 2_S9_2_Dimethyl Sulfoxide T 2_S9 Positive Control 8 Cyclophosphamide Hamster Chinese Hamster Ovary CHO-W-B1 1.5 ug/mL Cyclophosphamide 2_S9_9_2.0_ug/mL_Cyclophosphamide 2_S9_2_Dimethyl Sulfoxide T 2_S9 Positive Control 9 Cyclophosphamide Hamster Chinese Hamster Ovary CHO-W-B1 2.0 ug/mL Cyclophosphamide ^STRESSOR_PROTOCOL=CHEM_STRESSOR_PROTOCOL #PROTOCOL_DISPLAY_NAME #PROTOCOL_DESC #STRESSOR_NAME #DOSE_PER_ADMIN #DOSE_PER_ADMIN_UNIT #VEHICLE_NAME #VEHICLE_CONCENTRATION #VEHICLE_CONC_UNIT #IS_POSITIVE_CONTROL #IS_NEGATIVE_CONTROL #IS_VEHICLE_CONTROL #AGENT_SUPPLIER #AGENT_SUPPLIER_LOCATION $PROTOCOL_DISPLAY_NAME $PROTOCOL_DESC $STRESSOR_NAME $DOSE_PER_ADMIN $DOSE_PER_ADMIN_UNIT $VEHICLE_NAME $VEHICLE_CONCENTRATION $VEHICLE_CONC_UNIT $IS_POSITIVE_CONTROL $IS_NEGATIVE_CONTROL $IS_VEHICLE_CONTROL $AGENT_SUPPLIER $AGENT_SUPPLIER_LOCATION Cyclophosphamide_1.5_ug/mL Cyclophosphamide 1.5 ug/mL DMSO 10 ug/ml T Radian Corporation Austin, TX DMSO No stressor 0 DMSO 10 ug/ml T Dimethylvinyl chloride (DMVC)_25.0_ug/mL Dimethylvinyl chloride (DMVC) 25.0 ug/mL DMSO 10 ug/ml Radian Corporation Austin, TX Mitomycin-C_0.1_ug/mL Mitomycin-C 0.1 ug/mL DMSO 10 ug/ml T Radian Corporation Austin, TX Dimethylvinyl chloride (DMVC)_5000.0_ug/mL Dimethylvinyl chloride (DMVC) 5000.0 ug/mL DMSO 10 ug/ml Radian Corporation Austin, TX Dimethylvinyl chloride (DMVC)_400.0_ug/mL Dimethylvinyl chloride (DMVC) 400.0 ug/mL DMSO 10 ug/ml Radian Corporation Austin, TX Dimethylvinyl chloride (DMVC)_50.0_ug/mL Dimethylvinyl chloride (DMVC) 50.0 ug/mL DMSO 10 ug/ml Radian Corporation Austin, TX Dimethylvinyl chloride (DMVC)_250.0_ug/mL Dimethylvinyl chloride (DMVC) 250.0 ug/mL DMSO 10 ug/ml Radian Corporation Austin, TX Dimethylvinyl chloride (DMVC)_1600.0_ug/mL Dimethylvinyl chloride (DMVC) 1600.0 ug/mL DMSO 10 ug/ml Radian Corporation Austin, TX Dimethylvinyl chloride (DMVC)_750.0_ug/mL Dimethylvinyl chloride (DMVC) 750.0 ug/mL DMSO 10 ug/ml Radian Corporation Austin, TX Mitomycin-C_0.05_ug/mL Mitomycin-C 0.05 ug/mL DMSO 10 ug/ml T Radian Corporation Austin, TX Dimethylvinyl chloride (DMVC)_100.0_ug/mL Dimethylvinyl chloride (DMVC) 100.0 ug/mL DMSO 10 ug/ml Radian Corporation Austin, TX Dimethylvinyl chloride (DMVC)_300.0_ug/mL Dimethylvinyl chloride (DMVC) 300.0 ug/mL DMSO 10 ug/ml Radian Corporation Austin, TX Dimethylvinyl chloride (DMVC)_500.0_ug/mL Dimethylvinyl chloride (DMVC) 500.0 ug/mL DMSO 10 ug/ml Radian Corporation Austin, TX Dimethylvinyl chloride (DMVC)_160.0_ug/mL Dimethylvinyl chloride (DMVC) 160.0 ug/mL DMSO 10 ug/ml Radian Corporation Austin, TX Cyclophosphamide_2.0_ug/mL Cyclophosphamide 2.0 ug/mL DMSO 10 ug/ml T Radian Corporation Austin, TX ^CARE=CULTURE_PROTOCOL #PROTOCOL_DISPLAY_NAME #PROTOCOL_DESC #LIGHT #MEDIUM #SUPPLEMENTS #SERUM_PERCENTAGE #SERUM_TYPE #ACTIVATION #SPECIES #GAS_PHASE_PERCENT_CO2 #CULTURE_TEMPERATURE_MAX #CULTURE_TEMPERATURE_UNIT #IS_STOP $PROTOCOL_DISPLAY_NAME $PROTOCOL_DESC $LIGHT $MEDIUM $SUPPLEMENTS $SERUM_PERCENTAGE $SERUM_TYPE $ACTIVATION $SPECIES $GAS_PHASE_PERCENT_CO2 $CULTURE_TEMPERATURE_MAX $CULTURE_TEMPERATURE_UNIT $IS_STOP SCE_CULTURE Assay without metabolic activation. One day after plating, medium replaced with medium containing with test or control chemicals. After 2 hr BrdUrd was added to 10 uM. Cells were cultured for about 24 hr, medium replaced with fresh medium containing 10 pM BrdUrd and colcemid (final concentration 0.1 pg/ml) was added, and incubation continued for 2 to 3 hr. The total incubation time with test chemical was thus about 26 hr, and total time with BrdUrd was also about 26 hr, beginning about 2 hr after addition of test chemical. Gold light McCoy's 5A medium 2 mM glutamine, LBI used 100 units/ ml penicillin and 100 ug/ml streptomycin, CU did not 10 Fetal calf 5 37 degree C F SCE_CULTURE_S9 Assay with metabolic activation. One day after plating, medium was replaced with S9 mix in medium without fetal calf serum. After 2 hr cells were washed at least twice with buffered saline, and culture medium containing 10% FCS and 10 uM BrdUrd was added. Cells were incubated for 26 hr, with colcemid (0.1 pg/ml) present for the final 2 to 3 hr. Gold light McCoy's 5A medium 2 mM glutamine, LBI used 100 units/ ml penicillin and 100 ug/ml streptomycin, CU did not 10 Fetal calf Aroclor 1254-induced male Sprague-Dawley rat, thawed and mixed with NADPH generating system (final 2.4 mg/ml NADP (Sodium salt), 4.5 mg/ml isocitric acid (trisodium salt), S9 15 ul/ml) Rat 5 37 degree C F ADD_BRDU Gold light BrdU to 10 uM 5 37 degree C F ADD_COLCEMID Gold light Colcemid to 0.1 ug/ml 5 37 degree C F CULTURE_IN_FRESH_MEDIUM Gold light McCoy's 5A medium 2 mM glutamine, LBI used 100 units/ ml penicillin and 100 ug/ml streptomycin, CU did not 10 Fetal calf 5 37 degree C T ^PREPARATION=CULTURE_PREPARATION_PROTOCOL #PROTOCOL_DISPLAY_NAME #PROTOCOL_DESC $PROTOCOL_DISPLAY_NAME $PROTOCOL_DESC MITOTIC_SHAKE_OFF Cell harvest and fixation. Two to three hours after addition of colcemid, cells were collected by mitotic shake-off and treated for up to 3 min at room temperature with hypotonic KCI (75 mM). Cells were then washed twice with fixative (3: 1, methano1:glacial acetic acid, v/v), dropped onto slides, and air-dried. ^TIMELINE #TIME_IN_STUDY #TIME_IN_STUDY_UNIT #GROUP_NAME #PROTOCOL_DISPLAY_NAME $TIME_IN_STUDY $TIME_IN_STUDY_UNIT $GROUP_NAME $PROTOCOL_DISPLAY_NAME 0 hour 1_1_Negative (Not Specified) SCE_CULTURE 2 hour 1_1_Negative (Not Specified) ADD_BRDU 27.0 hour 1_1_Negative (Not Specified) ADD_COLCEMID 29.0 hour 1_1_Negative (Not Specified) MITOTIC_SHAKE_OFF 0 hour 1_2_Dimethyl Sulfoxide SCE_CULTURE 2 hour 1_2_Dimethyl Sulfoxide ADD_BRDU 27.0 hour 1_2_Dimethyl Sulfoxide ADD_COLCEMID 29.0 hour 1_2_Dimethyl Sulfoxide MITOTIC_SHAKE_OFF 0 hour 1_3_25.0_ug/mL_Dimethylvinyl chloride (DMVC) SCE_CULTURE 2 hour 1_3_25.0_ug/mL_Dimethylvinyl chloride (DMVC) ADD_BRDU 27.0 hour 1_3_25.0_ug/mL_Dimethylvinyl chloride (DMVC) ADD_COLCEMID 29.0 hour 1_3_25.0_ug/mL_Dimethylvinyl chloride (DMVC) MITOTIC_SHAKE_OFF 0 hour 1_4_50.0_ug/mL_Dimethylvinyl chloride (DMVC) SCE_CULTURE 2 hour 1_4_50.0_ug/mL_Dimethylvinyl chloride (DMVC) ADD_BRDU 27.0 hour 1_4_50.0_ug/mL_Dimethylvinyl chloride (DMVC) ADD_COLCEMID 29.0 hour 1_4_50.0_ug/mL_Dimethylvinyl chloride (DMVC) MITOTIC_SHAKE_OFF 0 hour 1_5_160.0_ug/mL_Dimethylvinyl chloride (DMVC) SCE_CULTURE 2 hour 1_5_160.0_ug/mL_Dimethylvinyl chloride (DMVC) ADD_BRDU 27.0 hour 1_5_160.0_ug/mL_Dimethylvinyl chloride (DMVC) ADD_COLCEMID 29.0 hour 1_5_160.0_ug/mL_Dimethylvinyl chloride (DMVC) MITOTIC_SHAKE_OFF 0 hour 1_6_300.0_ug/mL_Dimethylvinyl chloride (DMVC) SCE_CULTURE 2 hour 1_6_300.0_ug/mL_Dimethylvinyl chloride (DMVC) ADD_BRDU 27.0 hour 1_6_300.0_ug/mL_Dimethylvinyl chloride (DMVC) ADD_COLCEMID 29.0 hour 1_6_300.0_ug/mL_Dimethylvinyl chloride (DMVC) MITOTIC_SHAKE_OFF 0 hour 1_7_400.0_ug/mL_Dimethylvinyl chloride (DMVC) SCE_CULTURE 2 hour 1_7_400.0_ug/mL_Dimethylvinyl chloride (DMVC) ADD_BRDU 27.0 hour 1_7_400.0_ug/mL_Dimethylvinyl chloride (DMVC) ADD_COLCEMID 29.0 hour 1_7_400.0_ug/mL_Dimethylvinyl chloride (DMVC) MITOTIC_SHAKE_OFF 0 hour 1_8_0.05_ug/mL_Mitomycin-C SCE_CULTURE 2 hour 1_8_0.05_ug/mL_Mitomycin-C ADD_BRDU 27.0 hour 1_8_0.05_ug/mL_Mitomycin-C ADD_COLCEMID 29.0 hour 1_8_0.05_ug/mL_Mitomycin-C MITOTIC_SHAKE_OFF 0 hour 1_9_0.1_ug/mL_Mitomycin-C SCE_CULTURE 2 hour 1_9_0.1_ug/mL_Mitomycin-C ADD_BRDU 27.0 hour 1_9_0.1_ug/mL_Mitomycin-C ADD_COLCEMID 29.0 hour 1_9_0.1_ug/mL_Mitomycin-C MITOTIC_SHAKE_OFF 0 hour 2_1_Negative (Not Specified) SCE_CULTURE 2 hour 2_1_Negative (Not Specified) ADD_BRDU 26.0 hour 2_1_Negative (Not Specified) ADD_COLCEMID 28.0 hour 2_1_Negative (Not Specified) MITOTIC_SHAKE_OFF 0 hour 2_2_Dimethyl Sulfoxide SCE_CULTURE 2 hour 2_2_Dimethyl Sulfoxide ADD_BRDU 26.0 hour 2_2_Dimethyl Sulfoxide ADD_COLCEMID 28.0 hour 2_2_Dimethyl Sulfoxide MITOTIC_SHAKE_OFF 0 hour 2_3_100.0_ug/mL_Dimethylvinyl chloride (DMVC) SCE_CULTURE 2 hour 2_3_100.0_ug/mL_Dimethylvinyl chloride (DMVC) ADD_BRDU 26.0 hour 2_3_100.0_ug/mL_Dimethylvinyl chloride (DMVC) ADD_COLCEMID 28.0 hour 2_3_100.0_ug/mL_Dimethylvinyl chloride (DMVC) MITOTIC_SHAKE_OFF 0 hour 2_4_250.0_ug/mL_Dimethylvinyl chloride (DMVC) SCE_CULTURE 2 hour 2_4_250.0_ug/mL_Dimethylvinyl chloride (DMVC) ADD_BRDU 26.0 hour 2_4_250.0_ug/mL_Dimethylvinyl chloride (DMVC) ADD_COLCEMID 28.0 hour 2_4_250.0_ug/mL_Dimethylvinyl chloride (DMVC) MITOTIC_SHAKE_OFF 0 hour 2_5_500.0_ug/mL_Dimethylvinyl chloride (DMVC) SCE_CULTURE 2 hour 2_5_500.0_ug/mL_Dimethylvinyl chloride (DMVC) ADD_BRDU 26.0 hour 2_5_500.0_ug/mL_Dimethylvinyl chloride (DMVC) ADD_COLCEMID 28.0 hour 2_5_500.0_ug/mL_Dimethylvinyl chloride (DMVC) MITOTIC_SHAKE_OFF 0 hour 2_6_750.0_ug/mL_Dimethylvinyl chloride (DMVC) SCE_CULTURE 2 hour 2_6_750.0_ug/mL_Dimethylvinyl chloride (DMVC) ADD_BRDU 26.0 hour 2_6_750.0_ug/mL_Dimethylvinyl chloride (DMVC) ADD_COLCEMID 28.0 hour 2_6_750.0_ug/mL_Dimethylvinyl chloride (DMVC) MITOTIC_SHAKE_OFF 0 hour 2_7_0.05_ug/mL_Mitomycin-C SCE_CULTURE 2 hour 2_7_0.05_ug/mL_Mitomycin-C ADD_BRDU 26.0 hour 2_7_0.05_ug/mL_Mitomycin-C ADD_COLCEMID 28.0 hour 2_7_0.05_ug/mL_Mitomycin-C MITOTIC_SHAKE_OFF 0 hour 1_S9_1_Negative (Not Specified) SCE_CULTURE_S9 2 hour 1_S9_1_Negative (Not Specified) CULTURE_IN_FRESH_MEDIUM 2 hour 1_S9_1_Negative (Not Specified) ADD_BRDU 27.0 hour 1_S9_1_Negative (Not Specified) ADD_COLCEMID 29.0 hour 1_S9_1_Negative (Not Specified) MITOTIC_SHAKE_OFF 0 hour 1_S9_2_Dimethyl Sulfoxide SCE_CULTURE_S9 2 hour 1_S9_2_Dimethyl Sulfoxide CULTURE_IN_FRESH_MEDIUM 2 hour 1_S9_2_Dimethyl Sulfoxide ADD_BRDU 27.0 hour 1_S9_2_Dimethyl Sulfoxide ADD_COLCEMID 29.0 hour 1_S9_2_Dimethyl Sulfoxide MITOTIC_SHAKE_OFF 0 hour 1_S9_3_50.0_ug/mL_Dimethylvinyl chloride (DMVC) SCE_CULTURE_S9 2 hour 1_S9_3_50.0_ug/mL_Dimethylvinyl chloride (DMVC) CULTURE_IN_FRESH_MEDIUM 2 hour 1_S9_3_50.0_ug/mL_Dimethylvinyl chloride (DMVC) ADD_BRDU 27.0 hour 1_S9_3_50.0_ug/mL_Dimethylvinyl chloride (DMVC) ADD_COLCEMID 29.0 hour 1_S9_3_50.0_ug/mL_Dimethylvinyl chloride (DMVC) MITOTIC_SHAKE_OFF 0 hour 1_S9_4_160.0_ug/mL_Dimethylvinyl chloride (DMVC) SCE_CULTURE_S9 2 hour 1_S9_4_160.0_ug/mL_Dimethylvinyl chloride (DMVC) CULTURE_IN_FRESH_MEDIUM 2 hour 1_S9_4_160.0_ug/mL_Dimethylvinyl chloride (DMVC) ADD_BRDU 27.0 hour 1_S9_4_160.0_ug/mL_Dimethylvinyl chloride (DMVC) ADD_COLCEMID 29.0 hour 1_S9_4_160.0_ug/mL_Dimethylvinyl chloride (DMVC) MITOTIC_SHAKE_OFF 0 hour 1_S9_5_500.0_ug/mL_Dimethylvinyl chloride (DMVC) SCE_CULTURE_S9 2 hour 1_S9_5_500.0_ug/mL_Dimethylvinyl chloride (DMVC) CULTURE_IN_FRESH_MEDIUM 2 hour 1_S9_5_500.0_ug/mL_Dimethylvinyl chloride (DMVC) ADD_BRDU 27.0 hour 1_S9_5_500.0_ug/mL_Dimethylvinyl chloride (DMVC) ADD_COLCEMID 29.0 hour 1_S9_5_500.0_ug/mL_Dimethylvinyl chloride (DMVC) MITOTIC_SHAKE_OFF 0 hour 1_S9_6_1600.0_ug/mL_Dimethylvinyl chloride (DMVC) SCE_CULTURE_S9 2 hour 1_S9_6_1600.0_ug/mL_Dimethylvinyl chloride (DMVC) CULTURE_IN_FRESH_MEDIUM 2 hour 1_S9_6_1600.0_ug/mL_Dimethylvinyl chloride (DMVC) ADD_BRDU 27.0 hour 1_S9_6_1600.0_ug/mL_Dimethylvinyl chloride (DMVC) ADD_COLCEMID 29.0 hour 1_S9_6_1600.0_ug/mL_Dimethylvinyl chloride (DMVC) MITOTIC_SHAKE_OFF 0 hour 1_S9_7_5000.0_ug/mL_Dimethylvinyl chloride (DMVC) SCE_CULTURE_S9 2 hour 1_S9_7_5000.0_ug/mL_Dimethylvinyl chloride (DMVC) CULTURE_IN_FRESH_MEDIUM 2 hour 1_S9_7_5000.0_ug/mL_Dimethylvinyl chloride (DMVC) ADD_BRDU 0.0 hour 1_S9_7_5000.0_ug/mL_Dimethylvinyl chloride (DMVC) ADD_COLCEMID 2.0 hour 1_S9_7_5000.0_ug/mL_Dimethylvinyl chloride (DMVC) MITOTIC_SHAKE_OFF 0 hour 1_S9_8_1.5_ug/mL_Cyclophosphamide SCE_CULTURE_S9 2 hour 1_S9_8_1.5_ug/mL_Cyclophosphamide CULTURE_IN_FRESH_MEDIUM 2 hour 1_S9_8_1.5_ug/mL_Cyclophosphamide ADD_BRDU 27.0 hour 1_S9_8_1.5_ug/mL_Cyclophosphamide ADD_COLCEMID 29.0 hour 1_S9_8_1.5_ug/mL_Cyclophosphamide MITOTIC_SHAKE_OFF 0 hour 2_S9_1_Negative (Not Specified) SCE_CULTURE_S9 2 hour 2_S9_1_Negative (Not Specified) CULTURE_IN_FRESH_MEDIUM 2 hour 2_S9_1_Negative (Not Specified) ADD_BRDU 26.0 hour 2_S9_1_Negative (Not Specified) ADD_COLCEMID 28.0 hour 2_S9_1_Negative (Not Specified) MITOTIC_SHAKE_OFF 0 hour 2_S9_2_Dimethyl Sulfoxide SCE_CULTURE_S9 2 hour 2_S9_2_Dimethyl Sulfoxide CULTURE_IN_FRESH_MEDIUM 2 hour 2_S9_2_Dimethyl Sulfoxide ADD_BRDU 26.0 hour 2_S9_2_Dimethyl Sulfoxide ADD_COLCEMID 28.0 hour 2_S9_2_Dimethyl Sulfoxide MITOTIC_SHAKE_OFF 0 hour 2_S9_3_250.0_ug/mL_Dimethylvinyl chloride (DMVC) SCE_CULTURE_S9 2 hour 2_S9_3_250.0_ug/mL_Dimethylvinyl chloride (DMVC) CULTURE_IN_FRESH_MEDIUM 2 hour 2_S9_3_250.0_ug/mL_Dimethylvinyl chloride (DMVC) ADD_BRDU 26.0 hour 2_S9_3_250.0_ug/mL_Dimethylvinyl chloride (DMVC) ADD_COLCEMID 28.0 hour 2_S9_3_250.0_ug/mL_Dimethylvinyl chloride (DMVC) MITOTIC_SHAKE_OFF 0 hour 2_S9_4_500.0_ug/mL_Dimethylvinyl chloride (DMVC) SCE_CULTURE_S9 2 hour 2_S9_4_500.0_ug/mL_Dimethylvinyl chloride (DMVC) CULTURE_IN_FRESH_MEDIUM 2 hour 2_S9_4_500.0_ug/mL_Dimethylvinyl chloride (DMVC) ADD_BRDU 26.0 hour 2_S9_4_500.0_ug/mL_Dimethylvinyl chloride (DMVC) ADD_COLCEMID 28.0 hour 2_S9_4_500.0_ug/mL_Dimethylvinyl chloride (DMVC) MITOTIC_SHAKE_OFF 0 hour 2_S9_5_750.0_ug/mL_Dimethylvinyl chloride (DMVC) SCE_CULTURE_S9 2 hour 2_S9_5_750.0_ug/mL_Dimethylvinyl chloride (DMVC) CULTURE_IN_FRESH_MEDIUM 2 hour 2_S9_5_750.0_ug/mL_Dimethylvinyl chloride (DMVC) ADD_BRDU 26.0 hour 2_S9_5_750.0_ug/mL_Dimethylvinyl chloride (DMVC) ADD_COLCEMID 28.0 hour 2_S9_5_750.0_ug/mL_Dimethylvinyl chloride (DMVC) MITOTIC_SHAKE_OFF 0 hour 2_S9_6_1600.0_ug/mL_Dimethylvinyl chloride (DMVC) SCE_CULTURE_S9 2 hour 2_S9_6_1600.0_ug/mL_Dimethylvinyl chloride (DMVC) CULTURE_IN_FRESH_MEDIUM 2 hour 2_S9_6_1600.0_ug/mL_Dimethylvinyl chloride (DMVC) ADD_BRDU 26.0 hour 2_S9_6_1600.0_ug/mL_Dimethylvinyl chloride (DMVC) ADD_COLCEMID 28.0 hour 2_S9_6_1600.0_ug/mL_Dimethylvinyl chloride (DMVC) MITOTIC_SHAKE_OFF 0 hour 2_S9_7_5000.0_ug/mL_Dimethylvinyl chloride (DMVC) SCE_CULTURE_S9 2 hour 2_S9_7_5000.0_ug/mL_Dimethylvinyl chloride (DMVC) CULTURE_IN_FRESH_MEDIUM 2 hour 2_S9_7_5000.0_ug/mL_Dimethylvinyl chloride (DMVC) ADD_BRDU 0.0 hour 2_S9_7_5000.0_ug/mL_Dimethylvinyl chloride (DMVC) ADD_COLCEMID 2.0 hour 2_S9_7_5000.0_ug/mL_Dimethylvinyl chloride (DMVC) MITOTIC_SHAKE_OFF 0 hour 2_S9_8_1.5_ug/mL_Cyclophosphamide SCE_CULTURE_S9 2 hour 2_S9_8_1.5_ug/mL_Cyclophosphamide CULTURE_IN_FRESH_MEDIUM 2 hour 2_S9_8_1.5_ug/mL_Cyclophosphamide ADD_BRDU 26.0 hour 2_S9_8_1.5_ug/mL_Cyclophosphamide ADD_COLCEMID 28.0 hour 2_S9_8_1.5_ug/mL_Cyclophosphamide MITOTIC_SHAKE_OFF 0 hour 2_S9_9_2.0_ug/mL_Cyclophosphamide SCE_CULTURE_S9 2 hour 2_S9_9_2.0_ug/mL_Cyclophosphamide CULTURE_IN_FRESH_MEDIUM 2 hour 2_S9_9_2.0_ug/mL_Cyclophosphamide ADD_BRDU 26.0 hour 2_S9_9_2.0_ug/mL_Cyclophosphamide ADD_COLCEMID 28.0 hour 2_S9_9_2.0_ug/mL_Cyclophosphamide MITOTIC_SHAKE_OFF 0 hour 2_S9_9_2.0_ug/mL_Cyclophosphamide Cyclophosphamide_2.0_ug/mL 0 hour 2_3_100.0_ug/mL_Dimethylvinyl chloride (DMVC) Dimethylvinyl chloride (DMVC)_100.0_ug/mL 0 hour 2_6_750.0_ug/mL_Dimethylvinyl chloride (DMVC) Dimethylvinyl chloride (DMVC)_750.0_ug/mL 0 hour 1_S9_3_50.0_ug/mL_Dimethylvinyl chloride (DMVC) Dimethylvinyl chloride (DMVC)_50.0_ug/mL 0 hour 2_S9_2_Dimethyl Sulfoxide DMSO 0 hour 1_S9_5_500.0_ug/mL_Dimethylvinyl chloride (DMVC) Dimethylvinyl chloride (DMVC)_500.0_ug/mL 0 hour 2_4_250.0_ug/mL_Dimethylvinyl chloride (DMVC) Dimethylvinyl chloride (DMVC)_250.0_ug/mL 0 hour 1_5_160.0_ug/mL_Dimethylvinyl chloride (DMVC) Dimethylvinyl chloride (DMVC)_160.0_ug/mL 0 hour 1_S9_2_Dimethyl Sulfoxide DMSO 0 hour 2_S9_6_1600.0_ug/mL_Dimethylvinyl chloride (DMVC) Dimethylvinyl chloride (DMVC)_1600.0_ug/mL 0 hour 1_S9_4_160.0_ug/mL_Dimethylvinyl chloride (DMVC) Dimethylvinyl chloride (DMVC)_160.0_ug/mL 0 hour 1_S9_1_Negative (Not Specified) DMSO 0 hour 2_5_500.0_ug/mL_Dimethylvinyl chloride (DMVC) Dimethylvinyl chloride (DMVC)_500.0_ug/mL 0 hour 1_6_300.0_ug/mL_Dimethylvinyl chloride (DMVC) Dimethylvinyl chloride (DMVC)_300.0_ug/mL 0 hour 2_S9_5_750.0_ug/mL_Dimethylvinyl chloride (DMVC) Dimethylvinyl chloride (DMVC)_750.0_ug/mL 0 hour 2_7_0.05_ug/mL_Mitomycin-C Mitomycin-C_0.05_ug/mL 0 hour 1_9_0.1_ug/mL_Mitomycin-C Mitomycin-C_0.1_ug/mL 0 hour 1_2_Dimethyl Sulfoxide DMSO 0 hour 1_S9_7_5000.0_ug/mL_Dimethylvinyl chloride (DMVC) Dimethylvinyl chloride (DMVC)_5000.0_ug/mL 0 hour 2_S9_3_250.0_ug/mL_Dimethylvinyl chloride (DMVC) Dimethylvinyl chloride (DMVC)_250.0_ug/mL 0 hour 1_S9_6_1600.0_ug/mL_Dimethylvinyl chloride (DMVC) Dimethylvinyl chloride (DMVC)_1600.0_ug/mL 0 hour 1_S9_8_1.5_ug/mL_Cyclophosphamide Cyclophosphamide_1.5_ug/mL 0 hour 2_S9_7_5000.0_ug/mL_Dimethylvinyl chloride (DMVC) Dimethylvinyl chloride (DMVC)_5000.0_ug/mL 0 hour 1_4_50.0_ug/mL_Dimethylvinyl chloride (DMVC) Dimethylvinyl chloride (DMVC)_50.0_ug/mL 0 hour 1_3_25.0_ug/mL_Dimethylvinyl chloride (DMVC) Dimethylvinyl chloride (DMVC)_25.0_ug/mL 0 hour 1_1_Negative (Not Specified) DMSO 0 hour 2_S9_4_500.0_ug/mL_Dimethylvinyl chloride (DMVC) Dimethylvinyl chloride (DMVC)_500.0_ug/mL 0 hour 2_2_Dimethyl Sulfoxide DMSO 0 hour 2_S9_1_Negative (Not Specified) DMSO 0 hour 2_S9_8_1.5_ug/mL_Cyclophosphamide Cyclophosphamide_1.5_ug/mL 0 hour 2_1_Negative (Not Specified) DMSO 0 hour 1_7_400.0_ug/mL_Dimethylvinyl chloride (DMVC) Dimethylvinyl chloride (DMVC)_400.0_ug/mL 0 hour 1_8_0.05_ug/mL_Mitomycin-C Mitomycin-C_0.05_ug/mL ^ASSAY=GENETOX #PARTICIPANT_DISPLAY_NAME #STUDY_TIME #STUDY_TIME_UNIT #PROTOCOL_NAME #SCE_CELLS_EXAMINED #SCE_CHROMOSOMES_EXAMINED #SCE_TOTAL #SCE_PER_CHROMOSOME #SCE_PER_CELL #SCE_PERCENTAGE_INCREASE_OVER_SOLVENT_CONTROL $PARTICIPANT_DISPLAY_NAME $STUDY_TIME $STUDY_TIME_UNIT $PROTOCOL_NAME $SCE_CELLS_EXAMINED $SCE_CHROMOSOMES_EXAMINED $SCE_TOTAL $SCE_PER_CHROMOSOME $SCE_PER_CELL $SCE_PERCENTAGE_INCREASE_OVER_SOLVENT_CONTROL 1_1_Negative (Not Specified) 29.0 hour MITOTIC_SHAKE_OFF 50 1040 340 0.327 6.80 -12.344 1_2_Dimethyl Sulfoxide 29.0 hour MITOTIC_SHAKE_OFF 50 1043 389 0.373 7.78 0.000 1_3_25.0_ug/mL_Dimethylvinyl chloride (DMVC) 29.0 hour MITOTIC_SHAKE_OFF 50 1047 445 0.425 8.90 13.959 1_4_50.0_ug/mL_Dimethylvinyl chloride (DMVC) 29.0 hour MITOTIC_SHAKE_OFF 50 1047 458 0.437 9.16 17.288 1_5_160.0_ug/mL_Dimethylvinyl chloride (DMVC) 29.0 hour MITOTIC_SHAKE_OFF 50 1044 536 0.513 10.72 37.657 1_6_300.0_ug/mL_Dimethylvinyl chloride (DMVC) 29.0 hour MITOTIC_SHAKE_OFF 50 1046 614 0.587 12.28 57.388 1_7_400.0_ug/mL_Dimethylvinyl chloride (DMVC) 29.0 hour MITOTIC_SHAKE_OFF 50 1047 611 0.584 12.22 56.469 1_8_0.05_ug/mL_Mitomycin-C 29.0 hour MITOTIC_SHAKE_OFF 50 1039 1188 1.143 23.76 206.574 1_9_0.1_ug/mL_Mitomycin-C 29.0 hour MITOTIC_SHAKE_OFF 50 1041 1583 1.521 31.66 307.723 2_1_Negative (Not Specified) 28.0 hour MITOTIC_SHAKE_OFF 50 1040 314 0.302 6.28 -10.894 2_2_Dimethyl Sulfoxide 28.0 hour MITOTIC_SHAKE_OFF 50 1030 349 0.339 6.98 0.000 2_3_100.0_ug/mL_Dimethylvinyl chloride (DMVC) 28.0 hour MITOTIC_SHAKE_OFF 50 1044 480 0.460 9.60 35.691 2_4_250.0_ug/mL_Dimethylvinyl chloride (DMVC) 28.0 hour MITOTIC_SHAKE_OFF 50 1043 570 0.547 11.40 61.288 2_5_500.0_ug/mL_Dimethylvinyl chloride (DMVC) 28.0 hour MITOTIC_SHAKE_OFF 50 1042 710 0.681 14.20 101.096 2_6_750.0_ug/mL_Dimethylvinyl chloride (DMVC) 28.0 hour MITOTIC_SHAKE_OFF 0 0 0 0.000 0.00 2_7_0.05_ug/mL_Mitomycin-C 28.0 hour MITOTIC_SHAKE_OFF 50 1032 1005 0.974 20.10 187.408 1_S9_1_Negative (Not Specified) 29.0 hour MITOTIC_SHAKE_OFF 50 1029 383 0.372 7.66 2.828 1_S9_2_Dimethyl Sulfoxide 29.0 hour MITOTIC_SHAKE_OFF 50 1036 375 0.362 7.50 0.000 1_S9_3_50.0_ug/mL_Dimethylvinyl chloride (DMVC) 29.0 hour MITOTIC_SHAKE_OFF 50 1037 355 0.342 7.10 -5.425 1_S9_4_160.0_ug/mL_Dimethylvinyl chloride (DMVC) 29.0 hour MITOTIC_SHAKE_OFF 50 1033 449 0.435 8.98 20.081 1_S9_5_500.0_ug/mL_Dimethylvinyl chloride (DMVC) 29.0 hour MITOTIC_SHAKE_OFF 50 1032 442 0.428 8.84 18.324 1_S9_6_1600.0_ug/mL_Dimethylvinyl chloride (DMVC) 29.0 hour MITOTIC_SHAKE_OFF 50 1022 687 0.672 13.74 85.710 1_S9_7_5000.0_ug/mL_Dimethylvinyl chloride (DMVC) 2.0 hour MITOTIC_SHAKE_OFF 0 0 0 0.000 0.00 1_S9_8_1.5_ug/mL_Cyclophosphamide 29.0 hour MITOTIC_SHAKE_OFF 50 1035 1100 1.063 22.00 193.617 2_S9_1_Negative (Not Specified) 28.0 hour MITOTIC_SHAKE_OFF 50 1043 420 0.403 8.40 -4.511 2_S9_2_Dimethyl Sulfoxide 28.0 hour MITOTIC_SHAKE_OFF 50 1041 439 0.422 8.78 0.000 2_S9_3_250.0_ug/mL_Dimethylvinyl chloride (DMVC) 28.0 hour MITOTIC_SHAKE_OFF 50 1048 407 0.388 8.14 -7.909 2_S9_4_500.0_ug/mL_Dimethylvinyl chloride (DMVC) 28.0 hour MITOTIC_SHAKE_OFF 50 1043 467 0.448 9.34 6.174 2_S9_5_750.0_ug/mL_Dimethylvinyl chloride (DMVC) 28.0 hour MITOTIC_SHAKE_OFF 50 1052 594 0.565 11.88 33.893 2_S9_6_1600.0_ug/mL_Dimethylvinyl chloride (DMVC) 28.0 hour MITOTIC_SHAKE_OFF 0 0 0 0.000 0.00 2_S9_7_5000.0_ug/mL_Dimethylvinyl chloride (DMVC) 2.0 hour MITOTIC_SHAKE_OFF 0 0 0 0.000 0.00 2_S9_8_1.5_ug/mL_Cyclophosphamide 28.0 hour MITOTIC_SHAKE_OFF 50 1048 1533 1.463 30.66 246.870 2_S9_9_2.0_ug/mL_Cyclophosphamide 28.0 hour MITOTIC_SHAKE_OFF 50 1049 1868 1.781 37.36 322.267 ^DATA_TRANSFORMATION=DT_ASSAY_LISTING #DT_ASSAY_NAME #ASSAY_NAME $DT_ASSAY_NAME $ASSAY_NAME SCE SCE_CELLS_EXAMINED SCE SCE_CHROMOSOMES_EXAMINED SCE SCE_TOTAL ^DATA_TRANSFORMATION=DT_SUBJECT_GROUP_LISTING #DT_SUBJECT_GROUP_NAME #GROUP_NAME $DT_SUBJECT_GROUP_NAME $GROUP_NAME 1 1_1_Negative (Not Specified) 1 1_2_Dimethyl Sulfoxide 1 1_3_25.0_ug/mL_Dimethylvinyl chloride (DMVC) 1 1_4_50.0_ug/mL_Dimethylvinyl chloride (DMVC) 1 1_5_160.0_ug/mL_Dimethylvinyl chloride (DMVC) 1 1_6_300.0_ug/mL_Dimethylvinyl chloride (DMVC) 1 1_7_400.0_ug/mL_Dimethylvinyl chloride (DMVC) 1 1_8_0.05_ug/mL_Mitomycin-C 1 1_9_0.1_ug/mL_Mitomycin-C 2 2_1_Negative (Not Specified) 2 2_2_Dimethyl Sulfoxide 2 2_3_100.0_ug/mL_Dimethylvinyl chloride (DMVC) 2 2_4_250.0_ug/mL_Dimethylvinyl chloride (DMVC) 2 2_5_500.0_ug/mL_Dimethylvinyl chloride (DMVC) 2 2_6_750.0_ug/mL_Dimethylvinyl chloride (DMVC) 2 2_7_0.05_ug/mL_Mitomycin-C 1_S9 1_S9_1_Negative (Not Specified) 1_S9 1_S9_2_Dimethyl Sulfoxide 1_S9 1_S9_3_50.0_ug/mL_Dimethylvinyl chloride (DMVC) 1_S9 1_S9_4_160.0_ug/mL_Dimethylvinyl chloride (DMVC) 1_S9 1_S9_5_500.0_ug/mL_Dimethylvinyl chloride (DMVC) 1_S9 1_S9_6_1600.0_ug/mL_Dimethylvinyl chloride (DMVC) 1_S9 1_S9_7_5000.0_ug/mL_Dimethylvinyl chloride (DMVC) 1_S9 1_S9_8_1.5_ug/mL_Cyclophosphamide 2_S9 2_S9_1_Negative (Not Specified) 2_S9 2_S9_2_Dimethyl Sulfoxide 2_S9 2_S9_3_250.0_ug/mL_Dimethylvinyl chloride (DMVC) 2_S9 2_S9_4_500.0_ug/mL_Dimethylvinyl chloride (DMVC) 2_S9 2_S9_5_750.0_ug/mL_Dimethylvinyl chloride (DMVC) 2_S9 2_S9_6_1600.0_ug/mL_Dimethylvinyl chloride (DMVC) 2_S9 2_S9_7_5000.0_ug/mL_Dimethylvinyl chloride (DMVC) 2_S9 2_S9_8_1.5_ug/mL_Cyclophosphamide 2_S9 2_S9_9_2.0_ug/mL_Cyclophosphamide ^DATA_TRANSFORMATION=TREND_ANALYSIS #DT_SUBJECT_GROUP_NAME #DT_ASSAY_NAME #TRIAL_TREND #TRIAL_TREND_P #TRIAL_RESULT $DT_SUBJECT_GROUP_NAME $DT_ASSAY_NAME $TRIAL_TREND $TRIAL_TREND_P $TRIAL_RESULT 1 SCE 9.060 0.000 Positive 2 SCE 11.197 0.000 Positive 1_S9 SCE 10.703 0.000 Positive 2_S9 SCE 4.776 0.000 Weakly Positive