^STUDY !CHEMICAL_NAME=Phenazopyridine hydrochloride !STUDY_CONCLUSION=Positive !DEPOSITOR_STUDY_NUMBER=051415 !STRESSOR_TYPE=Chemical !INSTITUTION=NTP !STUDY_TITLE=Effects of Phenazopyridine hydrochloride in Mouse Lymphoma Study 051415 !STUDY_DESIGN=Parallel !SUBJECT_TYPE=IN_VITRO !NTP_STUDY_TYPE=Genetic Toxicology - Mammalian Cell Mutagenicity !TIME_TYPE=Study !STUDY_VARIABLES=MICROSOMAL_ACTIVATION_USED|DOSE|TRIAL_RESULT|ASSAY_TRIAL|TREATMENT_GROUP_TYPE ^GROUP #GROUP_NAME #COMPARATOR_NAME #IS_CONTROL_GROUP #TREATMENT_GROUP_TYPE #DEPOSITOR_NAME #SUPER_GROUP_NAME #ASSAY_TRIAL #MICROSOMAL_ACTIVATION_USED #DOSE #DOSE_UNIT #TRIAL_RESULT #CONTROL_SUBSTANCE_NAME #DOUBLING_TIME_UNIT #DOUBLING_TIME #IS_ADHERENT $GROUP_NAME $COMPARATOR_NAME $IS_CONTROL_GROUP $TREATMENT_GROUP_TYPE $DEPOSITOR_NAME $SUPER_GROUP_NAME $ASSAY_TRIAL $MICROSOMAL_ACTIVATION_USED $DOSE $DOSE_UNIT $TRIAL_RESULT $CONTROL_SUBSTANCE_NAME $DOUBLING_TIME_UNIT $DOUBLING_TIME $IS_ADHERENT 1_Nonactivation 1 Nonactivation Negative 0.0_ug/mL_1_Nonactivation_1_Dimethyl Sulfoxide T Vehicle Control 1 1_Nonactivation 0.0 ug/mL Dimethyl Sulfoxide hour 10 F 45.0_ug/mL_1_Nonactivation_2_Phenazopyridine hydrochloride 0.0_ug/mL_1_Nonactivation_1_Dimethyl Sulfoxide Test Chemical 2 1_Nonactivation 45.0 ug/mL hour 10 F 60.0_ug/mL_1_Nonactivation_3_Phenazopyridine hydrochloride 0.0_ug/mL_1_Nonactivation_1_Dimethyl Sulfoxide Test Chemical 3 1_Nonactivation 60.0 ug/mL hour 10 F 75.0_ug/mL_1_Nonactivation_4_Phenazopyridine hydrochloride 0.0_ug/mL_1_Nonactivation_1_Dimethyl Sulfoxide Test Chemical 4 1_Nonactivation 75.0 ug/mL hour 10 F 90.0_ug/mL_1_Nonactivation_5_Phenazopyridine hydrochloride 0.0_ug/mL_1_Nonactivation_1_Dimethyl Sulfoxide Test Chemical 5 1_Nonactivation 90.0 ug/mL hour 10 F 105.0_ug/mL_1_Nonactivation_6_Phenazopyridine hydrochloride 0.0_ug/mL_1_Nonactivation_1_Dimethyl Sulfoxide Test Chemical 6 1_Nonactivation 105.0 ug/mL hour 10 F 15.0_ug/mL_1_Nonactivation_7_Methyl Methane Sulfonate 0.0_ug/mL_1_Nonactivation_1_Dimethyl Sulfoxide T Positive Control 7 1_Nonactivation 15.0 ug/mL Methyl Methane Sulfonate hour 10 F 2_Nonactivation 2 Nonactivation Equivocal 0.0_ug/mL_2_Nonactivation_1_Dimethyl Sulfoxide T Vehicle Control 1 2_Nonactivation 0.0 ug/mL Dimethyl Sulfoxide hour 10 F 20.0_ug/mL_2_Nonactivation_2_Phenazopyridine hydrochloride 0.0_ug/mL_2_Nonactivation_1_Dimethyl Sulfoxide Test Chemical 2 2_Nonactivation 20.0 ug/mL hour 10 F 40.0_ug/mL_2_Nonactivation_3_Phenazopyridine hydrochloride 0.0_ug/mL_2_Nonactivation_1_Dimethyl Sulfoxide Test Chemical 3 2_Nonactivation 40.0 ug/mL hour 10 F 60.0_ug/mL_2_Nonactivation_4_Phenazopyridine hydrochloride 0.0_ug/mL_2_Nonactivation_1_Dimethyl Sulfoxide Test Chemical 4 2_Nonactivation 60.0 ug/mL hour 10 F 80.0_ug/mL_2_Nonactivation_5_Phenazopyridine hydrochloride 0.0_ug/mL_2_Nonactivation_1_Dimethyl Sulfoxide Test Chemical 5 2_Nonactivation 80.0 ug/mL hour 10 F 100.0_ug/mL_2_Nonactivation_6_Phenazopyridine hydrochloride 0.0_ug/mL_2_Nonactivation_1_Dimethyl Sulfoxide Test Chemical 6 2_Nonactivation 100.0 ug/mL hour 10 F 120.0_ug/mL_2_Nonactivation_7_Phenazopyridine hydrochloride 0.0_ug/mL_2_Nonactivation_1_Dimethyl Sulfoxide Test Chemical 7 2_Nonactivation 120.0 ug/mL hour 10 F 15.0_ug/mL_2_Nonactivation_8_Methyl Methane Sulfonate 0.0_ug/mL_2_Nonactivation_1_Dimethyl Sulfoxide T Positive Control 8 2_Nonactivation 15.0 ug/mL Methyl Methane Sulfonate hour 10 F 1_Induced S9 1 Induced S9 Rejected 0.0_ug/mL_1_Induced S9_1_Dimethyl Sulfoxide T Vehicle Control 1 1_Induced S9 0.0 ug/mL Dimethyl Sulfoxide hour 10 F 35.0_ug/mL_1_Induced S9_2_Phenazopyridine hydrochloride 0.0_ug/mL_1_Induced S9_1_Dimethyl Sulfoxide Test Chemical 2 1_Induced S9 35.0 ug/mL hour 10 F 50.0_ug/mL_1_Induced S9_3_Phenazopyridine hydrochloride 0.0_ug/mL_1_Induced S9_1_Dimethyl Sulfoxide Test Chemical 3 1_Induced S9 50.0 ug/mL hour 10 F 65.0_ug/mL_1_Induced S9_4_Phenazopyridine hydrochloride 0.0_ug/mL_1_Induced S9_1_Dimethyl Sulfoxide Test Chemical 4 1_Induced S9 65.0 ug/mL hour 10 F 80.0_ug/mL_1_Induced S9_5_Phenazopyridine hydrochloride 0.0_ug/mL_1_Induced S9_1_Dimethyl Sulfoxide Test Chemical 5 1_Induced S9 80.0 ug/mL hour 10 F 95.0_ug/mL_1_Induced S9_6_Phenazopyridine hydrochloride 0.0_ug/mL_1_Induced S9_1_Dimethyl Sulfoxide Test Chemical 6 1_Induced S9 95.0 ug/mL hour 10 F 110.0_ug/mL_1_Induced S9_7_Phenazopyridine hydrochloride 0.0_ug/mL_1_Induced S9_1_Dimethyl Sulfoxide Test Chemical 7 1_Induced S9 110.0 ug/mL hour 10 F 2.5_ug/mL_1_Induced S9_8_3-Methylcholanthrene 0.0_ug/mL_1_Induced S9_1_Dimethyl Sulfoxide T Positive Control 8 1_Induced S9 2.5 ug/mL 3-Methylcholanthrene hour 10 F 2_Induced S9 2 Induced S9 Positive 0.0_ug/mL_2_Induced S9_1_Dimethyl Sulfoxide T Vehicle Control 1 2_Induced S9 0.0 ug/mL Dimethyl Sulfoxide hour 10 F 60.0_ug/mL_2_Induced S9_2_Phenazopyridine hydrochloride 0.0_ug/mL_2_Induced S9_1_Dimethyl Sulfoxide Test Chemical 2 2_Induced S9 60.0 ug/mL hour 10 F 70.0_ug/mL_2_Induced S9_3_Phenazopyridine hydrochloride 0.0_ug/mL_2_Induced S9_1_Dimethyl Sulfoxide Test Chemical 3 2_Induced S9 70.0 ug/mL hour 10 F 80.0_ug/mL_2_Induced S9_4_Phenazopyridine hydrochloride 0.0_ug/mL_2_Induced S9_1_Dimethyl Sulfoxide Test Chemical 4 2_Induced S9 80.0 ug/mL hour 10 F 90.0_ug/mL_2_Induced S9_5_Phenazopyridine hydrochloride 0.0_ug/mL_2_Induced S9_1_Dimethyl Sulfoxide Test Chemical 5 2_Induced S9 90.0 ug/mL hour 10 F 2.5_ug/mL_2_Induced S9_6_3-Methylcholanthrene 0.0_ug/mL_2_Induced S9_1_Dimethyl Sulfoxide T Positive Control 6 2_Induced S9 2.5 ug/mL 3-Methylcholanthrene hour 10 F 3_Induced S9 3 Induced S9 Positive 0.0_ug/mL_3_Induced S9_1_Dimethyl Sulfoxide T Vehicle Control 1 3_Induced S9 0.0 ug/mL Dimethyl Sulfoxide hour 10 F 20.0_ug/mL_3_Induced S9_2_Phenazopyridine hydrochloride 0.0_ug/mL_3_Induced S9_1_Dimethyl Sulfoxide Test Chemical 2 3_Induced S9 20.0 ug/mL hour 10 F 35.0_ug/mL_3_Induced S9_3_Phenazopyridine hydrochloride 0.0_ug/mL_3_Induced S9_1_Dimethyl Sulfoxide Test Chemical 3 3_Induced S9 35.0 ug/mL hour 10 F 50.0_ug/mL_3_Induced S9_4_Phenazopyridine hydrochloride 0.0_ug/mL_3_Induced S9_1_Dimethyl Sulfoxide Test Chemical 4 3_Induced S9 50.0 ug/mL hour 10 F 65.0_ug/mL_3_Induced S9_5_Phenazopyridine hydrochloride 0.0_ug/mL_3_Induced S9_1_Dimethyl Sulfoxide Test Chemical 5 3_Induced S9 65.0 ug/mL hour 10 F 80.0_ug/mL_3_Induced S9_6_Phenazopyridine hydrochloride 0.0_ug/mL_3_Induced S9_1_Dimethyl Sulfoxide Test Chemical 6 3_Induced S9 80.0 ug/mL hour 10 F 95.0_ug/mL_3_Induced S9_7_Phenazopyridine hydrochloride 0.0_ug/mL_3_Induced S9_1_Dimethyl Sulfoxide Test Chemical 7 3_Induced S9 95.0 ug/mL hour 10 F 110.0_ug/mL_3_Induced S9_8_Phenazopyridine hydrochloride 0.0_ug/mL_3_Induced S9_1_Dimethyl Sulfoxide Test Chemical 8 3_Induced S9 110.0 ug/mL hour 10 F 2.5_ug/mL_3_Induced S9_9_3-Methylcholanthrene 0.0_ug/mL_3_Induced S9_1_Dimethyl Sulfoxide T Positive Control 9 3_Induced S9 2.5 ug/mL 3-Methylcholanthrene hour 10 F ^SUBJECT #PARTICIPANT_DISPLAY_NAME #GROUP_NAME #DEATH_STATUS $PARTICIPANT_DISPLAY_NAME $GROUP_NAME $DEATH_STATUS 0.0_ug/mL_1_Nonactivation_1_Dimethyl Sulfoxide_1 0.0_ug/mL_1_Nonactivation_1_Dimethyl Sulfoxide 0.0_ug/mL_1_Nonactivation_1_Dimethyl Sulfoxide_2 0.0_ug/mL_1_Nonactivation_1_Dimethyl Sulfoxide 0.0_ug/mL_1_Nonactivation_1_Dimethyl Sulfoxide_3 0.0_ug/mL_1_Nonactivation_1_Dimethyl Sulfoxide 0.0_ug/mL_1_Nonactivation_1_Dimethyl Sulfoxide_4 0.0_ug/mL_1_Nonactivation_1_Dimethyl Sulfoxide 45.0_ug/mL_1_Nonactivation_2_Phenazopyridine hydrochloride_1 45.0_ug/mL_1_Nonactivation_2_Phenazopyridine hydrochloride 45.0_ug/mL_1_Nonactivation_2_Phenazopyridine hydrochloride_2 45.0_ug/mL_1_Nonactivation_2_Phenazopyridine hydrochloride 60.0_ug/mL_1_Nonactivation_3_Phenazopyridine hydrochloride_1 60.0_ug/mL_1_Nonactivation_3_Phenazopyridine hydrochloride 60.0_ug/mL_1_Nonactivation_3_Phenazopyridine hydrochloride_2 60.0_ug/mL_1_Nonactivation_3_Phenazopyridine hydrochloride 75.0_ug/mL_1_Nonactivation_4_Phenazopyridine hydrochloride_1 75.0_ug/mL_1_Nonactivation_4_Phenazopyridine hydrochloride 75.0_ug/mL_1_Nonactivation_4_Phenazopyridine hydrochloride_2 75.0_ug/mL_1_Nonactivation_4_Phenazopyridine hydrochloride 90.0_ug/mL_1_Nonactivation_5_Phenazopyridine hydrochloride_1 90.0_ug/mL_1_Nonactivation_5_Phenazopyridine hydrochloride 90.0_ug/mL_1_Nonactivation_5_Phenazopyridine hydrochloride_2 90.0_ug/mL_1_Nonactivation_5_Phenazopyridine hydrochloride 105.0_ug/mL_1_Nonactivation_6_Phenazopyridine hydrochloride_1 105.0_ug/mL_1_Nonactivation_6_Phenazopyridine hydrochloride 105.0_ug/mL_1_Nonactivation_6_Phenazopyridine hydrochloride_2 105.0_ug/mL_1_Nonactivation_6_Phenazopyridine hydrochloride 15.0_ug/mL_1_Nonactivation_7_Methyl Methane Sulfonate_1 15.0_ug/mL_1_Nonactivation_7_Methyl Methane Sulfonate 15.0_ug/mL_1_Nonactivation_7_Methyl Methane Sulfonate_2 15.0_ug/mL_1_Nonactivation_7_Methyl Methane Sulfonate 0.0_ug/mL_2_Nonactivation_1_Dimethyl Sulfoxide_1 0.0_ug/mL_2_Nonactivation_1_Dimethyl Sulfoxide 0.0_ug/mL_2_Nonactivation_1_Dimethyl Sulfoxide_2 0.0_ug/mL_2_Nonactivation_1_Dimethyl Sulfoxide 0.0_ug/mL_2_Nonactivation_1_Dimethyl Sulfoxide_3 0.0_ug/mL_2_Nonactivation_1_Dimethyl Sulfoxide 0.0_ug/mL_2_Nonactivation_1_Dimethyl Sulfoxide_4 0.0_ug/mL_2_Nonactivation_1_Dimethyl Sulfoxide 20.0_ug/mL_2_Nonactivation_2_Phenazopyridine hydrochloride_1 20.0_ug/mL_2_Nonactivation_2_Phenazopyridine hydrochloride 20.0_ug/mL_2_Nonactivation_2_Phenazopyridine hydrochloride_2 20.0_ug/mL_2_Nonactivation_2_Phenazopyridine hydrochloride 40.0_ug/mL_2_Nonactivation_3_Phenazopyridine hydrochloride_1 40.0_ug/mL_2_Nonactivation_3_Phenazopyridine hydrochloride 40.0_ug/mL_2_Nonactivation_3_Phenazopyridine hydrochloride_2 40.0_ug/mL_2_Nonactivation_3_Phenazopyridine hydrochloride 60.0_ug/mL_2_Nonactivation_4_Phenazopyridine hydrochloride_1 60.0_ug/mL_2_Nonactivation_4_Phenazopyridine hydrochloride 60.0_ug/mL_2_Nonactivation_4_Phenazopyridine hydrochloride_2 60.0_ug/mL_2_Nonactivation_4_Phenazopyridine hydrochloride 80.0_ug/mL_2_Nonactivation_5_Phenazopyridine hydrochloride_1 80.0_ug/mL_2_Nonactivation_5_Phenazopyridine hydrochloride 100.0_ug/mL_2_Nonactivation_6_Phenazopyridine hydrochloride_1 100.0_ug/mL_2_Nonactivation_6_Phenazopyridine hydrochloride 100.0_ug/mL_2_Nonactivation_6_Phenazopyridine hydrochloride_2 100.0_ug/mL_2_Nonactivation_6_Phenazopyridine hydrochloride 120.0_ug/mL_2_Nonactivation_7_Phenazopyridine hydrochloride_1 120.0_ug/mL_2_Nonactivation_7_Phenazopyridine hydrochloride Lethal 120.0_ug/mL_2_Nonactivation_7_Phenazopyridine hydrochloride_2 120.0_ug/mL_2_Nonactivation_7_Phenazopyridine hydrochloride Lethal 15.0_ug/mL_2_Nonactivation_8_Methyl Methane Sulfonate_1 15.0_ug/mL_2_Nonactivation_8_Methyl Methane Sulfonate 15.0_ug/mL_2_Nonactivation_8_Methyl Methane Sulfonate_2 15.0_ug/mL_2_Nonactivation_8_Methyl Methane Sulfonate 0.0_ug/mL_1_Induced S9_1_Dimethyl Sulfoxide_1 0.0_ug/mL_1_Induced S9_1_Dimethyl Sulfoxide 0.0_ug/mL_1_Induced S9_1_Dimethyl Sulfoxide_2 0.0_ug/mL_1_Induced S9_1_Dimethyl Sulfoxide 0.0_ug/mL_1_Induced S9_1_Dimethyl Sulfoxide_3 0.0_ug/mL_1_Induced S9_1_Dimethyl Sulfoxide 0.0_ug/mL_1_Induced S9_1_Dimethyl Sulfoxide_4 0.0_ug/mL_1_Induced S9_1_Dimethyl Sulfoxide 35.0_ug/mL_1_Induced S9_2_Phenazopyridine hydrochloride_1 35.0_ug/mL_1_Induced S9_2_Phenazopyridine hydrochloride 35.0_ug/mL_1_Induced S9_2_Phenazopyridine hydrochloride_2 35.0_ug/mL_1_Induced S9_2_Phenazopyridine hydrochloride 50.0_ug/mL_1_Induced S9_3_Phenazopyridine hydrochloride_1 50.0_ug/mL_1_Induced S9_3_Phenazopyridine hydrochloride 50.0_ug/mL_1_Induced S9_3_Phenazopyridine hydrochloride_2 50.0_ug/mL_1_Induced S9_3_Phenazopyridine hydrochloride 65.0_ug/mL_1_Induced S9_4_Phenazopyridine hydrochloride_1 65.0_ug/mL_1_Induced S9_4_Phenazopyridine hydrochloride 65.0_ug/mL_1_Induced S9_4_Phenazopyridine hydrochloride_2 65.0_ug/mL_1_Induced S9_4_Phenazopyridine hydrochloride 80.0_ug/mL_1_Induced S9_5_Phenazopyridine hydrochloride_1 80.0_ug/mL_1_Induced S9_5_Phenazopyridine hydrochloride 80.0_ug/mL_1_Induced S9_5_Phenazopyridine hydrochloride_2 80.0_ug/mL_1_Induced S9_5_Phenazopyridine hydrochloride 95.0_ug/mL_1_Induced S9_6_Phenazopyridine hydrochloride_1 95.0_ug/mL_1_Induced S9_6_Phenazopyridine hydrochloride 95.0_ug/mL_1_Induced S9_6_Phenazopyridine hydrochloride_2 95.0_ug/mL_1_Induced S9_6_Phenazopyridine hydrochloride 110.0_ug/mL_1_Induced S9_7_Phenazopyridine hydrochloride_1 110.0_ug/mL_1_Induced S9_7_Phenazopyridine hydrochloride Lethal 110.0_ug/mL_1_Induced S9_7_Phenazopyridine hydrochloride_2 110.0_ug/mL_1_Induced S9_7_Phenazopyridine hydrochloride Lethal 2.5_ug/mL_1_Induced S9_8_3-Methylcholanthrene_1 2.5_ug/mL_1_Induced S9_8_3-Methylcholanthrene 2.5_ug/mL_1_Induced S9_8_3-Methylcholanthrene_2 2.5_ug/mL_1_Induced S9_8_3-Methylcholanthrene 0.0_ug/mL_2_Induced S9_1_Dimethyl Sulfoxide_1 0.0_ug/mL_2_Induced S9_1_Dimethyl Sulfoxide 0.0_ug/mL_2_Induced S9_1_Dimethyl Sulfoxide_2 0.0_ug/mL_2_Induced S9_1_Dimethyl Sulfoxide 0.0_ug/mL_2_Induced S9_1_Dimethyl Sulfoxide_3 0.0_ug/mL_2_Induced S9_1_Dimethyl Sulfoxide 0.0_ug/mL_2_Induced S9_1_Dimethyl Sulfoxide_4 0.0_ug/mL_2_Induced S9_1_Dimethyl Sulfoxide 60.0_ug/mL_2_Induced S9_2_Phenazopyridine hydrochloride_1 60.0_ug/mL_2_Induced S9_2_Phenazopyridine hydrochloride 60.0_ug/mL_2_Induced S9_2_Phenazopyridine hydrochloride_2 60.0_ug/mL_2_Induced S9_2_Phenazopyridine hydrochloride 70.0_ug/mL_2_Induced S9_3_Phenazopyridine hydrochloride_1 70.0_ug/mL_2_Induced S9_3_Phenazopyridine hydrochloride 70.0_ug/mL_2_Induced S9_3_Phenazopyridine hydrochloride_2 70.0_ug/mL_2_Induced S9_3_Phenazopyridine hydrochloride 80.0_ug/mL_2_Induced S9_4_Phenazopyridine hydrochloride_1 80.0_ug/mL_2_Induced S9_4_Phenazopyridine hydrochloride 80.0_ug/mL_2_Induced S9_4_Phenazopyridine hydrochloride_2 80.0_ug/mL_2_Induced S9_4_Phenazopyridine hydrochloride 90.0_ug/mL_2_Induced S9_5_Phenazopyridine hydrochloride_1 90.0_ug/mL_2_Induced S9_5_Phenazopyridine hydrochloride Lethal 90.0_ug/mL_2_Induced S9_5_Phenazopyridine hydrochloride_2 90.0_ug/mL_2_Induced S9_5_Phenazopyridine hydrochloride Lethal 2.5_ug/mL_2_Induced S9_6_3-Methylcholanthrene_1 2.5_ug/mL_2_Induced S9_6_3-Methylcholanthrene 2.5_ug/mL_2_Induced S9_6_3-Methylcholanthrene_2 2.5_ug/mL_2_Induced S9_6_3-Methylcholanthrene 0.0_ug/mL_3_Induced S9_1_Dimethyl Sulfoxide_1 0.0_ug/mL_3_Induced S9_1_Dimethyl Sulfoxide 0.0_ug/mL_3_Induced S9_1_Dimethyl Sulfoxide_2 0.0_ug/mL_3_Induced S9_1_Dimethyl Sulfoxide 0.0_ug/mL_3_Induced S9_1_Dimethyl Sulfoxide_3 0.0_ug/mL_3_Induced S9_1_Dimethyl Sulfoxide 0.0_ug/mL_3_Induced S9_1_Dimethyl Sulfoxide_4 0.0_ug/mL_3_Induced S9_1_Dimethyl Sulfoxide 20.0_ug/mL_3_Induced S9_2_Phenazopyridine hydrochloride_1 20.0_ug/mL_3_Induced S9_2_Phenazopyridine hydrochloride 20.0_ug/mL_3_Induced S9_2_Phenazopyridine hydrochloride_2 20.0_ug/mL_3_Induced S9_2_Phenazopyridine hydrochloride 35.0_ug/mL_3_Induced S9_3_Phenazopyridine hydrochloride_1 35.0_ug/mL_3_Induced S9_3_Phenazopyridine hydrochloride 35.0_ug/mL_3_Induced S9_3_Phenazopyridine hydrochloride_2 35.0_ug/mL_3_Induced S9_3_Phenazopyridine hydrochloride 50.0_ug/mL_3_Induced S9_4_Phenazopyridine hydrochloride_1 50.0_ug/mL_3_Induced S9_4_Phenazopyridine hydrochloride 50.0_ug/mL_3_Induced S9_4_Phenazopyridine hydrochloride_2 50.0_ug/mL_3_Induced S9_4_Phenazopyridine hydrochloride 65.0_ug/mL_3_Induced S9_5_Phenazopyridine hydrochloride_1 65.0_ug/mL_3_Induced S9_5_Phenazopyridine hydrochloride 65.0_ug/mL_3_Induced S9_5_Phenazopyridine hydrochloride_2 65.0_ug/mL_3_Induced S9_5_Phenazopyridine hydrochloride 80.0_ug/mL_3_Induced S9_6_Phenazopyridine hydrochloride_1 80.0_ug/mL_3_Induced S9_6_Phenazopyridine hydrochloride 80.0_ug/mL_3_Induced S9_6_Phenazopyridine hydrochloride_2 80.0_ug/mL_3_Induced S9_6_Phenazopyridine hydrochloride 95.0_ug/mL_3_Induced S9_7_Phenazopyridine hydrochloride_1 95.0_ug/mL_3_Induced S9_7_Phenazopyridine hydrochloride Lethal 110.0_ug/mL_3_Induced S9_8_Phenazopyridine hydrochloride_1 110.0_ug/mL_3_Induced S9_8_Phenazopyridine hydrochloride Lethal 110.0_ug/mL_3_Induced S9_8_Phenazopyridine hydrochloride_2 110.0_ug/mL_3_Induced S9_8_Phenazopyridine hydrochloride Lethal 2.5_ug/mL_3_Induced S9_9_3-Methylcholanthrene_1 2.5_ug/mL_3_Induced S9_9_3-Methylcholanthrene 2.5_ug/mL_3_Induced S9_9_3-Methylcholanthrene_2 2.5_ug/mL_3_Induced S9_9_3-Methylcholanthrene ^STRESSOR_PROTOCOL=CHEM_STRESSOR_PROTOCOL #PROTOCOL_DISPLAY_NAME #STRESSOR_NAME #DOSE #DOSE_UNIT #VEHICLE_NAME #IS_POSITIVE_CONTROL #IS_NEGATIVE_CONTROL #IS_VEHICLE_CONTROL #ROUTE $PROTOCOL_DISPLAY_NAME $STRESSOR_NAME $DOSE $DOSE_UNIT $VEHICLE_NAME $IS_POSITIVE_CONTROL $IS_NEGATIVE_CONTROL $IS_VEHICLE_CONTROL $ROUTE Phenazopyridine hydrochloride_90.0_ug/mL Phenazopyridine hydrochloride 90.0 ug/mL Dimethyl Sulfoxide Culture medium Phenazopyridine hydrochloride_65.0_ug/mL Phenazopyridine hydrochloride 65.0 ug/mL Dimethyl Sulfoxide Culture medium Phenazopyridine hydrochloride_110.0_ug/mL Phenazopyridine hydrochloride 110.0 ug/mL Dimethyl Sulfoxide Culture medium Phenazopyridine hydrochloride_50.0_ug/mL Phenazopyridine hydrochloride 50.0 ug/mL Dimethyl Sulfoxide Culture medium Phenazopyridine hydrochloride_80.0_ug/mL Phenazopyridine hydrochloride 80.0 ug/mL Dimethyl Sulfoxide Culture medium Phenazopyridine hydrochloride_120.0_ug/mL Phenazopyridine hydrochloride 120.0 ug/mL Dimethyl Sulfoxide Culture medium Dimethyl Sulfoxide_0.0_ug/mL No Stressor 0.0 ug/mL Dimethyl Sulfoxide T Culture medium Phenazopyridine hydrochloride_95.0_ug/mL Phenazopyridine hydrochloride 95.0 ug/mL Dimethyl Sulfoxide Culture medium 3-Methylcholanthrene_2.5_ug/mL 3-Methylcholanthrene 2.5 ug/mL Dimethyl Sulfoxide T Culture medium Phenazopyridine hydrochloride_100.0_ug/mL Phenazopyridine hydrochloride 100.0 ug/mL Dimethyl Sulfoxide Culture medium Phenazopyridine hydrochloride_60.0_ug/mL Phenazopyridine hydrochloride 60.0 ug/mL Dimethyl Sulfoxide Culture medium Phenazopyridine hydrochloride_75.0_ug/mL Phenazopyridine hydrochloride 75.0 ug/mL Dimethyl Sulfoxide Culture medium Phenazopyridine hydrochloride_70.0_ug/mL Phenazopyridine hydrochloride 70.0 ug/mL Dimethyl Sulfoxide Culture medium Methyl Methane Sulfonate_15.0_ug/mL Methyl Methane Sulfonate 15.0 ug/mL Dimethyl Sulfoxide T Culture medium Phenazopyridine hydrochloride_45.0_ug/mL Phenazopyridine hydrochloride 45.0 ug/mL Dimethyl Sulfoxide Culture medium Phenazopyridine hydrochloride_40.0_ug/mL Phenazopyridine hydrochloride 40.0 ug/mL Dimethyl Sulfoxide Culture medium Phenazopyridine hydrochloride_20.0_ug/mL Phenazopyridine hydrochloride 20.0 ug/mL Dimethyl Sulfoxide Culture medium Phenazopyridine hydrochloride_105.0_ug/mL Phenazopyridine hydrochloride 105.0 ug/mL Dimethyl Sulfoxide Culture medium Phenazopyridine hydrochloride_35.0_ug/mL Phenazopyridine hydrochloride 35.0 ug/mL Dimethyl Sulfoxide Culture medium ^CARE=CULTURE_PROTOCOL #PROTOCOL_DISPLAY_NAME #PROTOCOL_DESC #MEDIUM #SUPPLEMENTS #SERUM_PERCENTAGE #SERUM_TYPE #ACTIVATION #SPECIES #GAS_PHASE_PERCENT_CO2 #CULTURE_TEMPERATURE_MAX #CULTURE_TEMPERATURE_UNIT #IS_STOP #SEEDING_DENSITY #SEEDING_DENSITY_UNIT $PROTOCOL_DISPLAY_NAME $PROTOCOL_DESC $MEDIUM $SUPPLEMENTS $SERUM_PERCENTAGE $SERUM_TYPE $ACTIVATION $SPECIES $GAS_PHASE_PERCENT_CO2 $CULTURE_TEMPERATURE_MAX $CULTURE_TEMPERATURE_UNIT $IS_STOP $SEEDING_DENSITY $SEEDING_DENSITY_UNIT Culture_treatment Treated cultures contained 6 x 10 6 cells in 10 mL of medium. This volume included the S9 fraction in those experiments performed with metabolic activation. Incubation with the test chemical continued for 4 hours. Stock cultures were grown in F10p medium containing THMG (3 ug/ml thymidine, 5 ug/ml hypoxanthine, 0.1 ug/ml methotrexate and 7.5 ug/ml glycine) for 24 hours then moved to medium with THG for 1 to 3 days prior to use. Periodically frozen cells were used to start new cultures. Fischer's medium 2 mM l-glutamine, 110 ug/mL sodium pyruvate, 0.05% luronic F68, antibiotics 10 Heat-inactivated horse serum 5 37 degree C 500000 cells/ml Culture_expression After exposure to test article for 4 hours the medium plus chemical was removed and the cells resuspended in 20 mL of fresh medium. Fischer's medium 2 mM l-glutamine, 110 ug/mL sodium pyruvate, 0.05% luronic F68, antibiotics 10 Heat-inactivated horse serum 5 37 degree C T Culture_plating After the 48-hour expression period, 3 x 10^6 cells were plated in medium and soft agar supplemented with trifluorothymidine (TFT) for selection of TFT-resistant cells (TK-/-) and in nonselective medium and soft agar to determine cloning efficiency. Plates were incubated at 37 C. in 5% CO2 for 10 to 12 days. Fischer's medium 2 mM l-glutamine, 110 ug/mL sodium pyruvate, 0.05% luronic F68, antibiotics, 0.35% Noble agar 20 Heat-inactivated horse serum 5 37 degree C 3000000 cells/plate Culture_activation If a clearly positive response was not obtained, the test was repeated using freshly prepared S9 from the livers of either Aroclor 1254-induced or non-induced male Fischer 344 rats. 5 Heat-inactivated horse serum S9 Rat 5 37 degree C ^PREPARATION=CULTURE_PREPARATION_PROTOCOL #PROTOCOL_DISPLAY_NAME #PROTOCOL_DESC #IS_TERMINAL $PROTOCOL_DISPLAY_NAME $PROTOCOL_DESC $IS_TERMINAL Read plate At the end of incubation, colonies were counted with an automated counter. T ^TIMELINE #TIME_IN_STUDY #TIME_IN_STUDY_UNIT #GROUP_NAME #PROTOCOL_DISPLAY_NAME $TIME_IN_STUDY $TIME_IN_STUDY_UNIT $GROUP_NAME $PROTOCOL_DISPLAY_NAME 0 hour 0.0_ug/mL_1_Nonactivation_1_Dimethyl Sulfoxide Culture_treatment 4 hour 0.0_ug/mL_1_Nonactivation_1_Dimethyl Sulfoxide Culture_expression 2 day 0.0_ug/mL_1_Nonactivation_1_Dimethyl Sulfoxide Culture_plating 10 day 0.0_ug/mL_1_Nonactivation_1_Dimethyl Sulfoxide Read plate 0 hour 45.0_ug/mL_1_Nonactivation_2_Phenazopyridine hydrochloride Culture_treatment 4 hour 45.0_ug/mL_1_Nonactivation_2_Phenazopyridine hydrochloride Culture_expression 2 day 45.0_ug/mL_1_Nonactivation_2_Phenazopyridine hydrochloride Culture_plating 10 day 45.0_ug/mL_1_Nonactivation_2_Phenazopyridine hydrochloride Read plate 0 hour 60.0_ug/mL_1_Nonactivation_3_Phenazopyridine hydrochloride Culture_treatment 4 hour 60.0_ug/mL_1_Nonactivation_3_Phenazopyridine hydrochloride Culture_expression 2 day 60.0_ug/mL_1_Nonactivation_3_Phenazopyridine hydrochloride Culture_plating 10 day 60.0_ug/mL_1_Nonactivation_3_Phenazopyridine hydrochloride Read plate 0 hour 75.0_ug/mL_1_Nonactivation_4_Phenazopyridine hydrochloride Culture_treatment 4 hour 75.0_ug/mL_1_Nonactivation_4_Phenazopyridine hydrochloride Culture_expression 2 day 75.0_ug/mL_1_Nonactivation_4_Phenazopyridine hydrochloride Culture_plating 10 day 75.0_ug/mL_1_Nonactivation_4_Phenazopyridine hydrochloride Read plate 0 hour 90.0_ug/mL_1_Nonactivation_5_Phenazopyridine hydrochloride Culture_treatment 4 hour 90.0_ug/mL_1_Nonactivation_5_Phenazopyridine hydrochloride Culture_expression 2 day 90.0_ug/mL_1_Nonactivation_5_Phenazopyridine hydrochloride Culture_plating 10 day 90.0_ug/mL_1_Nonactivation_5_Phenazopyridine hydrochloride Read plate 0 hour 105.0_ug/mL_1_Nonactivation_6_Phenazopyridine hydrochloride Culture_treatment 4 hour 105.0_ug/mL_1_Nonactivation_6_Phenazopyridine hydrochloride Culture_expression 2 day 105.0_ug/mL_1_Nonactivation_6_Phenazopyridine hydrochloride Culture_plating 10 day 105.0_ug/mL_1_Nonactivation_6_Phenazopyridine hydrochloride Read plate 0 hour 15.0_ug/mL_1_Nonactivation_7_Methyl Methane Sulfonate Culture_treatment 4 hour 15.0_ug/mL_1_Nonactivation_7_Methyl Methane Sulfonate Culture_expression 2 day 15.0_ug/mL_1_Nonactivation_7_Methyl Methane Sulfonate Culture_plating 10 day 15.0_ug/mL_1_Nonactivation_7_Methyl Methane Sulfonate Read plate 0 hour 0.0_ug/mL_2_Nonactivation_1_Dimethyl Sulfoxide Culture_treatment 4 hour 0.0_ug/mL_2_Nonactivation_1_Dimethyl Sulfoxide Culture_expression 2 day 0.0_ug/mL_2_Nonactivation_1_Dimethyl Sulfoxide Culture_plating 10 day 0.0_ug/mL_2_Nonactivation_1_Dimethyl Sulfoxide Read plate 0 hour 20.0_ug/mL_2_Nonactivation_2_Phenazopyridine hydrochloride Culture_treatment 4 hour 20.0_ug/mL_2_Nonactivation_2_Phenazopyridine hydrochloride Culture_expression 2 day 20.0_ug/mL_2_Nonactivation_2_Phenazopyridine hydrochloride Culture_plating 10 day 20.0_ug/mL_2_Nonactivation_2_Phenazopyridine hydrochloride Read plate 0 hour 40.0_ug/mL_2_Nonactivation_3_Phenazopyridine hydrochloride Culture_treatment 4 hour 40.0_ug/mL_2_Nonactivation_3_Phenazopyridine hydrochloride Culture_expression 2 day 40.0_ug/mL_2_Nonactivation_3_Phenazopyridine hydrochloride Culture_plating 10 day 40.0_ug/mL_2_Nonactivation_3_Phenazopyridine hydrochloride Read plate 0 hour 60.0_ug/mL_2_Nonactivation_4_Phenazopyridine hydrochloride Culture_treatment 4 hour 60.0_ug/mL_2_Nonactivation_4_Phenazopyridine hydrochloride Culture_expression 2 day 60.0_ug/mL_2_Nonactivation_4_Phenazopyridine hydrochloride Culture_plating 10 day 60.0_ug/mL_2_Nonactivation_4_Phenazopyridine hydrochloride Read plate 0 hour 80.0_ug/mL_2_Nonactivation_5_Phenazopyridine hydrochloride Culture_treatment 4 hour 80.0_ug/mL_2_Nonactivation_5_Phenazopyridine hydrochloride Culture_expression 2 day 80.0_ug/mL_2_Nonactivation_5_Phenazopyridine hydrochloride Culture_plating 10 day 80.0_ug/mL_2_Nonactivation_5_Phenazopyridine hydrochloride Read plate 0 hour 100.0_ug/mL_2_Nonactivation_6_Phenazopyridine hydrochloride Culture_treatment 4 hour 100.0_ug/mL_2_Nonactivation_6_Phenazopyridine hydrochloride Culture_expression 2 day 100.0_ug/mL_2_Nonactivation_6_Phenazopyridine hydrochloride Culture_plating 10 day 100.0_ug/mL_2_Nonactivation_6_Phenazopyridine hydrochloride Read plate 0 hour 120.0_ug/mL_2_Nonactivation_7_Phenazopyridine hydrochloride Culture_treatment 4 hour 120.0_ug/mL_2_Nonactivation_7_Phenazopyridine hydrochloride Culture_expression 2 day 120.0_ug/mL_2_Nonactivation_7_Phenazopyridine hydrochloride Culture_plating 10 day 120.0_ug/mL_2_Nonactivation_7_Phenazopyridine hydrochloride Read plate 0 hour 15.0_ug/mL_2_Nonactivation_8_Methyl Methane Sulfonate Culture_treatment 4 hour 15.0_ug/mL_2_Nonactivation_8_Methyl Methane Sulfonate Culture_expression 2 day 15.0_ug/mL_2_Nonactivation_8_Methyl Methane Sulfonate Culture_plating 10 day 15.0_ug/mL_2_Nonactivation_8_Methyl Methane Sulfonate Read plate 0 hour 0.0_ug/mL_1_Induced S9_1_Dimethyl Sulfoxide Culture_activation 4 hour 0.0_ug/mL_1_Induced S9_1_Dimethyl Sulfoxide Culture_expression 2 day 0.0_ug/mL_1_Induced S9_1_Dimethyl Sulfoxide Culture_plating 10 day 0.0_ug/mL_1_Induced S9_1_Dimethyl Sulfoxide Read plate 0 hour 35.0_ug/mL_1_Induced S9_2_Phenazopyridine hydrochloride Culture_activation 4 hour 35.0_ug/mL_1_Induced S9_2_Phenazopyridine hydrochloride Culture_expression 2 day 35.0_ug/mL_1_Induced S9_2_Phenazopyridine hydrochloride Culture_plating 10 day 35.0_ug/mL_1_Induced S9_2_Phenazopyridine hydrochloride Read plate 0 hour 50.0_ug/mL_1_Induced S9_3_Phenazopyridine hydrochloride Culture_activation 4 hour 50.0_ug/mL_1_Induced S9_3_Phenazopyridine hydrochloride Culture_expression 2 day 50.0_ug/mL_1_Induced S9_3_Phenazopyridine hydrochloride Culture_plating 10 day 50.0_ug/mL_1_Induced S9_3_Phenazopyridine hydrochloride Read plate 0 hour 65.0_ug/mL_1_Induced S9_4_Phenazopyridine hydrochloride Culture_activation 4 hour 65.0_ug/mL_1_Induced S9_4_Phenazopyridine hydrochloride Culture_expression 2 day 65.0_ug/mL_1_Induced S9_4_Phenazopyridine hydrochloride Culture_plating 10 day 65.0_ug/mL_1_Induced S9_4_Phenazopyridine hydrochloride Read plate 0 hour 80.0_ug/mL_1_Induced S9_5_Phenazopyridine hydrochloride Culture_activation 4 hour 80.0_ug/mL_1_Induced S9_5_Phenazopyridine hydrochloride Culture_expression 2 day 80.0_ug/mL_1_Induced S9_5_Phenazopyridine hydrochloride Culture_plating 10 day 80.0_ug/mL_1_Induced S9_5_Phenazopyridine hydrochloride Read plate 0 hour 95.0_ug/mL_1_Induced S9_6_Phenazopyridine hydrochloride Culture_activation 4 hour 95.0_ug/mL_1_Induced S9_6_Phenazopyridine hydrochloride Culture_expression 2 day 95.0_ug/mL_1_Induced S9_6_Phenazopyridine hydrochloride Culture_plating 10 day 95.0_ug/mL_1_Induced S9_6_Phenazopyridine hydrochloride Read plate 0 hour 110.0_ug/mL_1_Induced S9_7_Phenazopyridine hydrochloride Culture_activation 4 hour 110.0_ug/mL_1_Induced S9_7_Phenazopyridine hydrochloride Culture_expression 2 day 110.0_ug/mL_1_Induced S9_7_Phenazopyridine hydrochloride Culture_plating 10 day 110.0_ug/mL_1_Induced S9_7_Phenazopyridine hydrochloride Read plate 0 hour 2.5_ug/mL_1_Induced S9_8_3-Methylcholanthrene Culture_activation 4 hour 2.5_ug/mL_1_Induced S9_8_3-Methylcholanthrene Culture_expression 2 day 2.5_ug/mL_1_Induced S9_8_3-Methylcholanthrene Culture_plating 10 day 2.5_ug/mL_1_Induced S9_8_3-Methylcholanthrene Read plate 0 hour 0.0_ug/mL_2_Induced S9_1_Dimethyl Sulfoxide Culture_activation 4 hour 0.0_ug/mL_2_Induced S9_1_Dimethyl Sulfoxide Culture_expression 2 day 0.0_ug/mL_2_Induced S9_1_Dimethyl Sulfoxide Culture_plating 10 day 0.0_ug/mL_2_Induced S9_1_Dimethyl Sulfoxide Read plate 0 hour 60.0_ug/mL_2_Induced S9_2_Phenazopyridine hydrochloride Culture_activation 4 hour 60.0_ug/mL_2_Induced S9_2_Phenazopyridine hydrochloride Culture_expression 2 day 60.0_ug/mL_2_Induced S9_2_Phenazopyridine hydrochloride Culture_plating 10 day 60.0_ug/mL_2_Induced S9_2_Phenazopyridine hydrochloride Read plate 0 hour 70.0_ug/mL_2_Induced S9_3_Phenazopyridine hydrochloride Culture_activation 4 hour 70.0_ug/mL_2_Induced S9_3_Phenazopyridine hydrochloride Culture_expression 2 day 70.0_ug/mL_2_Induced S9_3_Phenazopyridine hydrochloride Culture_plating 10 day 70.0_ug/mL_2_Induced S9_3_Phenazopyridine hydrochloride Read plate 0 hour 80.0_ug/mL_2_Induced S9_4_Phenazopyridine hydrochloride Culture_activation 4 hour 80.0_ug/mL_2_Induced S9_4_Phenazopyridine hydrochloride Culture_expression 2 day 80.0_ug/mL_2_Induced S9_4_Phenazopyridine hydrochloride Culture_plating 10 day 80.0_ug/mL_2_Induced S9_4_Phenazopyridine hydrochloride Read plate 0 hour 90.0_ug/mL_2_Induced S9_5_Phenazopyridine hydrochloride Culture_activation 4 hour 90.0_ug/mL_2_Induced S9_5_Phenazopyridine hydrochloride Culture_expression 2 day 90.0_ug/mL_2_Induced S9_5_Phenazopyridine hydrochloride Culture_plating 10 day 90.0_ug/mL_2_Induced S9_5_Phenazopyridine hydrochloride Read plate 0 hour 2.5_ug/mL_2_Induced S9_6_3-Methylcholanthrene Culture_activation 4 hour 2.5_ug/mL_2_Induced S9_6_3-Methylcholanthrene Culture_expression 2 day 2.5_ug/mL_2_Induced S9_6_3-Methylcholanthrene Culture_plating 10 day 2.5_ug/mL_2_Induced S9_6_3-Methylcholanthrene Read plate 0 hour 0.0_ug/mL_3_Induced S9_1_Dimethyl Sulfoxide Culture_activation 4 hour 0.0_ug/mL_3_Induced S9_1_Dimethyl Sulfoxide Culture_expression 2 day 0.0_ug/mL_3_Induced S9_1_Dimethyl Sulfoxide Culture_plating 10 day 0.0_ug/mL_3_Induced S9_1_Dimethyl Sulfoxide Read plate 0 hour 20.0_ug/mL_3_Induced S9_2_Phenazopyridine hydrochloride Culture_activation 4 hour 20.0_ug/mL_3_Induced S9_2_Phenazopyridine hydrochloride Culture_expression 2 day 20.0_ug/mL_3_Induced S9_2_Phenazopyridine hydrochloride Culture_plating 10 day 20.0_ug/mL_3_Induced S9_2_Phenazopyridine hydrochloride Read plate 0 hour 35.0_ug/mL_3_Induced S9_3_Phenazopyridine hydrochloride Culture_activation 4 hour 35.0_ug/mL_3_Induced S9_3_Phenazopyridine hydrochloride Culture_expression 2 day 35.0_ug/mL_3_Induced S9_3_Phenazopyridine hydrochloride Culture_plating 10 day 35.0_ug/mL_3_Induced S9_3_Phenazopyridine hydrochloride Read plate 0 hour 50.0_ug/mL_3_Induced S9_4_Phenazopyridine hydrochloride Culture_activation 4 hour 50.0_ug/mL_3_Induced S9_4_Phenazopyridine hydrochloride Culture_expression 2 day 50.0_ug/mL_3_Induced S9_4_Phenazopyridine hydrochloride Culture_plating 10 day 50.0_ug/mL_3_Induced S9_4_Phenazopyridine hydrochloride Read plate 0 hour 65.0_ug/mL_3_Induced S9_5_Phenazopyridine hydrochloride Culture_activation 4 hour 65.0_ug/mL_3_Induced S9_5_Phenazopyridine hydrochloride Culture_expression 2 day 65.0_ug/mL_3_Induced S9_5_Phenazopyridine hydrochloride Culture_plating 10 day 65.0_ug/mL_3_Induced S9_5_Phenazopyridine hydrochloride Read plate 0 hour 80.0_ug/mL_3_Induced S9_6_Phenazopyridine hydrochloride Culture_activation 4 hour 80.0_ug/mL_3_Induced S9_6_Phenazopyridine hydrochloride Culture_expression 2 day 80.0_ug/mL_3_Induced S9_6_Phenazopyridine hydrochloride Culture_plating 10 day 80.0_ug/mL_3_Induced S9_6_Phenazopyridine hydrochloride Read plate 0 hour 95.0_ug/mL_3_Induced S9_7_Phenazopyridine hydrochloride Culture_activation 4 hour 95.0_ug/mL_3_Induced S9_7_Phenazopyridine hydrochloride Culture_expression 2 day 95.0_ug/mL_3_Induced S9_7_Phenazopyridine hydrochloride Culture_plating 10 day 95.0_ug/mL_3_Induced S9_7_Phenazopyridine hydrochloride Read plate 0 hour 110.0_ug/mL_3_Induced S9_8_Phenazopyridine hydrochloride Culture_activation 4 hour 110.0_ug/mL_3_Induced S9_8_Phenazopyridine hydrochloride Culture_expression 2 day 110.0_ug/mL_3_Induced S9_8_Phenazopyridine hydrochloride Culture_plating 10 day 110.0_ug/mL_3_Induced S9_8_Phenazopyridine hydrochloride Read plate 0 hour 2.5_ug/mL_3_Induced S9_9_3-Methylcholanthrene Culture_activation 4 hour 2.5_ug/mL_3_Induced S9_9_3-Methylcholanthrene Culture_expression 2 day 2.5_ug/mL_3_Induced S9_9_3-Methylcholanthrene Culture_plating 10 day 2.5_ug/mL_3_Induced S9_9_3-Methylcholanthrene Read plate 0 hour 50.0_ug/mL_1_Induced S9_3_Phenazopyridine hydrochloride Phenazopyridine hydrochloride_50.0_ug/mL 0 hour 35.0_ug/mL_3_Induced S9_3_Phenazopyridine hydrochloride Phenazopyridine hydrochloride_35.0_ug/mL 0 hour 110.0_ug/mL_1_Induced S9_7_Phenazopyridine hydrochloride Phenazopyridine hydrochloride_110.0_ug/mL 0 hour 65.0_ug/mL_3_Induced S9_5_Phenazopyridine hydrochloride Phenazopyridine hydrochloride_65.0_ug/mL 0 hour 40.0_ug/mL_2_Nonactivation_3_Phenazopyridine hydrochloride Phenazopyridine hydrochloride_40.0_ug/mL 0 hour 20.0_ug/mL_2_Nonactivation_2_Phenazopyridine hydrochloride Phenazopyridine hydrochloride_20.0_ug/mL 0 hour 50.0_ug/mL_3_Induced S9_4_Phenazopyridine hydrochloride Phenazopyridine hydrochloride_50.0_ug/mL 0 hour 60.0_ug/mL_1_Nonactivation_3_Phenazopyridine hydrochloride Phenazopyridine hydrochloride_60.0_ug/mL 0 hour 20.0_ug/mL_3_Induced S9_2_Phenazopyridine hydrochloride Phenazopyridine hydrochloride_20.0_ug/mL 0 hour 60.0_ug/mL_2_Induced S9_2_Phenazopyridine hydrochloride Phenazopyridine hydrochloride_60.0_ug/mL 0 hour 80.0_ug/mL_2_Nonactivation_5_Phenazopyridine hydrochloride Phenazopyridine hydrochloride_80.0_ug/mL 0 hour 95.0_ug/mL_3_Induced S9_7_Phenazopyridine hydrochloride Phenazopyridine hydrochloride_95.0_ug/mL 0 hour 0.0_ug/mL_2_Nonactivation_1_Dimethyl Sulfoxide Dimethyl Sulfoxide_0.0_ug/mL 0 hour 0.0_ug/mL_2_Induced S9_1_Dimethyl Sulfoxide Dimethyl Sulfoxide_0.0_ug/mL 0 hour 15.0_ug/mL_2_Nonactivation_8_Methyl Methane Sulfonate Methyl Methane Sulfonate_15.0_ug/mL 0 hour 110.0_ug/mL_3_Induced S9_8_Phenazopyridine hydrochloride Phenazopyridine hydrochloride_110.0_ug/mL 0 hour 65.0_ug/mL_1_Induced S9_4_Phenazopyridine hydrochloride Phenazopyridine hydrochloride_65.0_ug/mL 0 hour 2.5_ug/mL_2_Induced S9_6_3-Methylcholanthrene 3-Methylcholanthrene_2.5_ug/mL 0 hour 0.0_ug/mL_1_Induced S9_1_Dimethyl Sulfoxide Dimethyl Sulfoxide_0.0_ug/mL 0 hour 120.0_ug/mL_2_Nonactivation_7_Phenazopyridine hydrochloride Phenazopyridine hydrochloride_120.0_ug/mL 0 hour 2.5_ug/mL_1_Induced S9_8_3-Methylcholanthrene 3-Methylcholanthrene_2.5_ug/mL 0 hour 95.0_ug/mL_1_Induced S9_6_Phenazopyridine hydrochloride Phenazopyridine hydrochloride_95.0_ug/mL 0 hour 0.0_ug/mL_3_Induced S9_1_Dimethyl Sulfoxide Dimethyl Sulfoxide_0.0_ug/mL 0 hour 35.0_ug/mL_1_Induced S9_2_Phenazopyridine hydrochloride Phenazopyridine hydrochloride_35.0_ug/mL 0 hour 105.0_ug/mL_1_Nonactivation_6_Phenazopyridine hydrochloride Phenazopyridine hydrochloride_105.0_ug/mL 0 hour 60.0_ug/mL_2_Nonactivation_4_Phenazopyridine hydrochloride Phenazopyridine hydrochloride_60.0_ug/mL 0 hour 15.0_ug/mL_1_Nonactivation_7_Methyl Methane Sulfonate Methyl Methane Sulfonate_15.0_ug/mL 0 hour 100.0_ug/mL_2_Nonactivation_6_Phenazopyridine hydrochloride Phenazopyridine hydrochloride_100.0_ug/mL 0 hour 70.0_ug/mL_2_Induced S9_3_Phenazopyridine hydrochloride Phenazopyridine hydrochloride_70.0_ug/mL 0 hour 0.0_ug/mL_1_Nonactivation_1_Dimethyl Sulfoxide Dimethyl Sulfoxide_0.0_ug/mL 0 hour 80.0_ug/mL_2_Induced S9_4_Phenazopyridine hydrochloride Phenazopyridine hydrochloride_80.0_ug/mL 0 hour 80.0_ug/mL_3_Induced S9_6_Phenazopyridine hydrochloride Phenazopyridine hydrochloride_80.0_ug/mL 0 hour 80.0_ug/mL_1_Induced S9_5_Phenazopyridine hydrochloride Phenazopyridine hydrochloride_80.0_ug/mL 0 hour 2.5_ug/mL_3_Induced S9_9_3-Methylcholanthrene 3-Methylcholanthrene_2.5_ug/mL 0 hour 75.0_ug/mL_1_Nonactivation_4_Phenazopyridine hydrochloride Phenazopyridine hydrochloride_75.0_ug/mL 0 hour 45.0_ug/mL_1_Nonactivation_2_Phenazopyridine hydrochloride Phenazopyridine hydrochloride_45.0_ug/mL 0 hour 90.0_ug/mL_2_Induced S9_5_Phenazopyridine hydrochloride Phenazopyridine hydrochloride_90.0_ug/mL 0 hour 90.0_ug/mL_1_Nonactivation_5_Phenazopyridine hydrochloride Phenazopyridine hydrochloride_90.0_ug/mL ^ASSAY=GENETOX #PARTICIPANT_DISPLAY_NAME #STUDY_TIME #STUDY_TIME_UNIT #PROTOCOL_NAME #LY_CLONING_EFFICIENCY #LY_CLONING_EFFICIENCY[COMMENTS] #LY_RELATIVE_TOTAL_GROWTH #LY_MUTANT_COLONIES #LY_MUTANT_FREQUENCY #LY_AVERAGE_MUTANT_FREQUENCY #LY_AVERAGE_MUTANT_FREQUENCY[COMMENTS] $PARTICIPANT_DISPLAY_NAME $STUDY_TIME $STUDY_TIME_UNIT $PROTOCOL_NAME $LY_CLONING_EFFICIENCY $LY_CLONING_EFFICIENCY[COMMENTS] $LY_RELATIVE_TOTAL_GROWTH $LY_MUTANT_COLONIES $LY_MUTANT_FREQUENCY $LY_AVERAGE_MUTANT_FREQUENCY $LY_AVERAGE_MUTANT_FREQUENCY[COMMENTS] 0.0_ug/mL_1_Nonactivation_1_Dimethyl Sulfoxide 10 day Read plate 23 0.0_ug/mL_1_Nonactivation_1_Dimethyl Sulfoxide_1 10 day Read plate 97 101 81 28 0.0_ug/mL_1_Nonactivation_1_Dimethyl Sulfoxide_2 10 day Read plate 86 105 61 24 0.0_ug/mL_1_Nonactivation_1_Dimethyl Sulfoxide_3 10 day Read plate 124 REJECTED_VALUE_DUE_TO_QUALITY_CONTROL_CRITERIA 98 86 23 0.0_ug/mL_1_Nonactivation_1_Dimethyl Sulfoxide_4 10 day Read plate 118 94 63 18 45.0_ug/mL_1_Nonactivation_2_Phenazopyridine hydrochloride 10 day Read plate 19 45.0_ug/mL_1_Nonactivation_2_Phenazopyridine hydrochloride_1 10 day Read plate 97 87 71 24 45.0_ug/mL_1_Nonactivation_2_Phenazopyridine hydrochloride_2 10 day Read plate 103 89 43 14 60.0_ug/mL_1_Nonactivation_3_Phenazopyridine hydrochloride 10 day Read plate 26 60.0_ug/mL_1_Nonactivation_3_Phenazopyridine hydrochloride_1 10 day Read plate 81 75 30 12 60.0_ug/mL_1_Nonactivation_3_Phenazopyridine hydrochloride_2 10 day Read plate 74 80 87 39 75.0_ug/mL_1_Nonactivation_4_Phenazopyridine hydrochloride 10 day Read plate 16 75.0_ug/mL_1_Nonactivation_4_Phenazopyridine hydrochloride_1 10 day Read plate 101 68 57 19 75.0_ug/mL_1_Nonactivation_4_Phenazopyridine hydrochloride_2 10 day Read plate 119 71 44 12 90.0_ug/mL_1_Nonactivation_5_Phenazopyridine hydrochloride 10 day Read plate 27 90.0_ug/mL_1_Nonactivation_5_Phenazopyridine hydrochloride_1 10 day Read plate 79 46 64 27 90.0_ug/mL_1_Nonactivation_5_Phenazopyridine hydrochloride_2 10 day Read plate 95 67 80 28 105.0_ug/mL_1_Nonactivation_6_Phenazopyridine hydrochloride 10 day Read plate 21 105.0_ug/mL_1_Nonactivation_6_Phenazopyridine hydrochloride_1 10 day Read plate 95 19 36 13 105.0_ug/mL_1_Nonactivation_6_Phenazopyridine hydrochloride_2 10 day Read plate 74 12 66 30 15.0_ug/mL_1_Nonactivation_7_Methyl Methane Sulfonate 10 day Read plate 136 SIGNIFICANT_RESPONSE 15.0_ug/mL_1_Nonactivation_7_Methyl Methane Sulfonate_1 10 day Read plate 61 51 193 106 15.0_ug/mL_1_Nonactivation_7_Methyl Methane Sulfonate_2 10 day Read plate 58 36 290 167 0.0_ug/mL_2_Nonactivation_1_Dimethyl Sulfoxide 10 day Read plate 55 0.0_ug/mL_2_Nonactivation_1_Dimethyl Sulfoxide_1 10 day Read plate 87 117 142 55 0.0_ug/mL_2_Nonactivation_1_Dimethyl Sulfoxide_2 10 day Read plate 82 REDUCED_SAMPLE_SIZE_BECAUSE_OF_THE_LOSS_OF_ONE_CULTURE_DISH_DUE_TO_CONTAMINATION 92 128 52 0.0_ug/mL_2_Nonactivation_1_Dimethyl Sulfoxide_3 10 day Read plate 96 REDUCED_SAMPLE_SIZE_BECAUSE_OF_THE_LOSS_OF_ONE_CULTURE_DISH_DUE_TO_CONTAMINATION 96 157.5 55 0.0_ug/mL_2_Nonactivation_1_Dimethyl Sulfoxide_4 10 day Read plate 75 96 134 59 20.0_ug/mL_2_Nonactivation_2_Phenazopyridine hydrochloride 10 day Read plate 82 20.0_ug/mL_2_Nonactivation_2_Phenazopyridine hydrochloride_1 10 day Read plate 54 REDUCED_SAMPLE_SIZE_BECAUSE_OF_THE_LOSS_OF_ONE_CULTURE_DISH_DUE_TO_CONTAMINATION 48 127.5 78 20.0_ug/mL_2_Nonactivation_2_Phenazopyridine hydrochloride_2 10 day Read plate 56 REDUCED_SAMPLE_SIZE_BECAUSE_OF_THE_LOSS_OF_ONE_CULTURE_DISH_DUE_TO_CONTAMINATION 50 145.5 86 40.0_ug/mL_2_Nonactivation_3_Phenazopyridine hydrochloride 10 day Read plate 88 SIGNIFICANT_RESPONSE 40.0_ug/mL_2_Nonactivation_3_Phenazopyridine hydrochloride_1 10 day Read plate 68 46 163 80 40.0_ug/mL_2_Nonactivation_3_Phenazopyridine hydrochloride_2 10 day Read plate 51 REDUCED_SAMPLE_SIZE_BECAUSE_OF_THE_LOSS_OF_ONE_CULTURE_DISH_DUE_TO_CONTAMINATION 45 145.5 96 60.0_ug/mL_2_Nonactivation_4_Phenazopyridine hydrochloride 10 day Read plate 77 60.0_ug/mL_2_Nonactivation_4_Phenazopyridine hydrochloride_1 10 day Read plate 68 51 154 76 60.0_ug/mL_2_Nonactivation_4_Phenazopyridine hydrochloride_2 10 day Read plate 62 49 143 77 80.0_ug/mL_2_Nonactivation_5_Phenazopyridine hydrochloride 10 day Read plate 80.0_ug/mL_2_Nonactivation_5_Phenazopyridine hydrochloride_1 10 day Read plate 77 48 176 76 100.0_ug/mL_2_Nonactivation_6_Phenazopyridine hydrochloride 10 day Read plate 90 SIGNIFICANT_RESPONSE 100.0_ug/mL_2_Nonactivation_6_Phenazopyridine hydrochloride_1 10 day Read plate 95 23 239 84 100.0_ug/mL_2_Nonactivation_6_Phenazopyridine hydrochloride_2 10 day Read plate 78 REDUCED_SAMPLE_SIZE_BECAUSE_OF_THE_LOSS_OF_ONE_CULTURE_DISH_DUE_TO_CONTAMINATION 15 225 96 120.0_ug/mL_2_Nonactivation_7_Phenazopyridine hydrochloride 10 day Read plate 15.0_ug/mL_2_Nonactivation_8_Methyl Methane Sulfonate 10 day Read plate 444 SIGNIFICANT_RESPONSE 15.0_ug/mL_2_Nonactivation_8_Methyl Methane Sulfonate_1 10 day Read plate 38 REDUCED_SAMPLE_SIZE_BECAUSE_OF_THE_LOSS_OF_ONE_CULTURE_DISH_DUE_TO_CONTAMINATION 21 565.5 496 15.0_ug/mL_2_Nonactivation_8_Methyl Methane Sulfonate_2 10 day Read plate 43 26 503 391 0.0_ug/mL_1_Induced S9_1_Dimethyl Sulfoxide 10 day Read plate 119 0.0_ug/mL_1_Induced S9_1_Dimethyl Sulfoxide_1 10 day Read plate 57 REDUCED_SAMPLE_SIZE_BECAUSE_OF_THE_LOSS_OF_ONE_CULTURE_DISH_DUE_TO_CONTAMINATION 99 212 123 0.0_ug/mL_1_Induced S9_1_Dimethyl Sulfoxide_2 10 day Read plate 33 REJECTED_VALUE_DUE_TO_QUALITY_CONTROL_CRITERIA 71 194 195 0.0_ug/mL_1_Induced S9_1_Dimethyl Sulfoxide_3 10 day Read plate 29 REJECTED_VALUE_DUE_TO_QUALITY_CONTROL_CRITERIA 52 208 236 0.0_ug/mL_1_Induced S9_1_Dimethyl Sulfoxide_4 10 day Read plate 59 101 202 114 35.0_ug/mL_1_Induced S9_2_Phenazopyridine hydrochloride 10 day Read plate 273 SIGNIFICANT_RESPONSE 35.0_ug/mL_1_Induced S9_2_Phenazopyridine hydrochloride_1 10 day Read plate 42 36 360 288 35.0_ug/mL_1_Induced S9_2_Phenazopyridine hydrochloride_2 10 day Read plate 56 REDUCED_SAMPLE_SIZE_BECAUSE_OF_THE_LOSS_OF_ONE_CULTURE_DISH_DUE_TO_CONTAMINATION 37 436 258 50.0_ug/mL_1_Induced S9_3_Phenazopyridine hydrochloride 10 day Read plate 231 SIGNIFICANT_RESPONSE 50.0_ug/mL_1_Induced S9_3_Phenazopyridine hydrochloride_1 10 day Read plate 66 33 452 228 50.0_ug/mL_1_Induced S9_3_Phenazopyridine hydrochloride_2 10 day Read plate 58 30 403 234 65.0_ug/mL_1_Induced S9_4_Phenazopyridine hydrochloride 10 day Read plate 220 SIGNIFICANT_RESPONSE 65.0_ug/mL_1_Induced S9_4_Phenazopyridine hydrochloride_1 10 day Read plate 47 30 297 213 65.0_ug/mL_1_Induced S9_4_Phenazopyridine hydrochloride_2 10 day Read plate 48 33 323 227 80.0_ug/mL_1_Induced S9_5_Phenazopyridine hydrochloride 10 day Read plate 240 SIGNIFICANT_RESPONSE 80.0_ug/mL_1_Induced S9_5_Phenazopyridine hydrochloride_1 10 day Read plate 33 19 266 271 80.0_ug/mL_1_Induced S9_5_Phenazopyridine hydrochloride_2 10 day Read plate 48 20 303 209 95.0_ug/mL_1_Induced S9_6_Phenazopyridine hydrochloride 10 day Read plate 269 SIGNIFICANT_RESPONSE 95.0_ug/mL_1_Induced S9_6_Phenazopyridine hydrochloride_1 10 day Read plate 41 14 332 268 95.0_ug/mL_1_Induced S9_6_Phenazopyridine hydrochloride_2 10 day Read plate 42 15 343 271 110.0_ug/mL_1_Induced S9_7_Phenazopyridine hydrochloride 10 day Read plate 2.5_ug/mL_1_Induced S9_8_3-Methylcholanthrene 10 day Read plate 516 SIGNIFICANT_RESPONSE 2.5_ug/mL_1_Induced S9_8_3-Methylcholanthrene_1 10 day Read plate 50 53 733 490 2.5_ug/mL_1_Induced S9_8_3-Methylcholanthrene_2 10 day Read plate 49 66 795 543 0.0_ug/mL_2_Induced S9_1_Dimethyl Sulfoxide 10 day Read plate 32 0.0_ug/mL_2_Induced S9_1_Dimethyl Sulfoxide_1 10 day Read plate 99 89 98 33 0.0_ug/mL_2_Induced S9_1_Dimethyl Sulfoxide_2 10 day Read plate 97 107 79 27 0.0_ug/mL_2_Induced S9_1_Dimethyl Sulfoxide_3 10 day Read plate 104 105 93 30 0.0_ug/mL_2_Induced S9_1_Dimethyl Sulfoxide_4 10 day Read plate 107 99 115 36 60.0_ug/mL_2_Induced S9_2_Phenazopyridine hydrochloride 10 day Read plate 132 SIGNIFICANT_RESPONSE 60.0_ug/mL_2_Induced S9_2_Phenazopyridine hydrochloride_1 10 day Read plate 96 11 335 116 60.0_ug/mL_2_Induced S9_2_Phenazopyridine hydrochloride_2 10 day Read plate 70 9 310 147 70.0_ug/mL_2_Induced S9_3_Phenazopyridine hydrochloride 10 day Read plate 110 SIGNIFICANT_RESPONSE 70.0_ug/mL_2_Induced S9_3_Phenazopyridine hydrochloride_1 10 day Read plate 78 8 241 104 70.0_ug/mL_2_Induced S9_3_Phenazopyridine hydrochloride_2 10 day Read plate 55 8 193 117 80.0_ug/mL_2_Induced S9_4_Phenazopyridine hydrochloride 10 day Read plate 113 SIGNIFICANT_RESPONSE 80.0_ug/mL_2_Induced S9_4_Phenazopyridine hydrochloride_1 10 day Read plate 72 8 198 92 80.0_ug/mL_2_Induced S9_4_Phenazopyridine hydrochloride_2 10 day Read plate 57 8 229 134 90.0_ug/mL_2_Induced S9_5_Phenazopyridine hydrochloride 10 day Read plate 2.5_ug/mL_2_Induced S9_6_3-Methylcholanthrene 10 day Read plate 282 SIGNIFICANT_RESPONSE 2.5_ug/mL_2_Induced S9_6_3-Methylcholanthrene_1 10 day Read plate 69 53 542 261 2.5_ug/mL_2_Induced S9_6_3-Methylcholanthrene_2 10 day Read plate 65 REDUCED_SAMPLE_SIZE_BECAUSE_OF_THE_LOSS_OF_ONE_CULTURE_DISH_DUE_TO_CONTAMINATION 53 594 303 0.0_ug/mL_3_Induced S9_1_Dimethyl Sulfoxide 10 day Read plate 33 0.0_ug/mL_3_Induced S9_1_Dimethyl Sulfoxide_1 10 day Read plate 83 97 96 39 0.0_ug/mL_3_Induced S9_1_Dimethyl Sulfoxide_2 10 day Read plate 90 100 74 27 0.0_ug/mL_3_Induced S9_1_Dimethyl Sulfoxide_3 10 day Read plate 86 100 82 32 0.0_ug/mL_3_Induced S9_1_Dimethyl Sulfoxide_4 10 day Read plate 86 103 86 33 20.0_ug/mL_3_Induced S9_2_Phenazopyridine hydrochloride 10 day Read plate 74 SIGNIFICANT_RESPONSE 20.0_ug/mL_3_Induced S9_2_Phenazopyridine hydrochloride_1 10 day Read plate 87 23 189 72 20.0_ug/mL_3_Induced S9_2_Phenazopyridine hydrochloride_2 10 day Read plate 104 44 237 76 35.0_ug/mL_3_Induced S9_3_Phenazopyridine hydrochloride 10 day Read plate 75 SIGNIFICANT_RESPONSE 35.0_ug/mL_3_Induced S9_3_Phenazopyridine hydrochloride_1 10 day Read plate 80 21 181 75 35.0_ug/mL_3_Induced S9_3_Phenazopyridine hydrochloride_2 10 day Read plate 78 21 174 74 50.0_ug/mL_3_Induced S9_4_Phenazopyridine hydrochloride 10 day Read plate 91 SIGNIFICANT_RESPONSE 50.0_ug/mL_3_Induced S9_4_Phenazopyridine hydrochloride_1 10 day Read plate 68 18 186 92 50.0_ug/mL_3_Induced S9_4_Phenazopyridine hydrochloride_2 10 day Read plate 90 12 243 90 65.0_ug/mL_3_Induced S9_5_Phenazopyridine hydrochloride 10 day Read plate 84 SIGNIFICANT_RESPONSE 65.0_ug/mL_3_Induced S9_5_Phenazopyridine hydrochloride_1 10 day Read plate 91 12 253 93 65.0_ug/mL_3_Induced S9_5_Phenazopyridine hydrochloride_2 10 day Read plate 71 13 160 75 80.0_ug/mL_3_Induced S9_6_Phenazopyridine hydrochloride 10 day Read plate 95 SIGNIFICANT_RESPONSE 80.0_ug/mL_3_Induced S9_6_Phenazopyridine hydrochloride_1 10 day Read plate 72 10 228 106 80.0_ug/mL_3_Induced S9_6_Phenazopyridine hydrochloride_2 10 day Read plate 75 8 189 85 95.0_ug/mL_3_Induced S9_7_Phenazopyridine hydrochloride 10 day Read plate 110.0_ug/mL_3_Induced S9_8_Phenazopyridine hydrochloride 10 day Read plate 2.5_ug/mL_3_Induced S9_9_3-Methylcholanthrene 10 day Read plate 326 SIGNIFICANT_RESPONSE 2.5_ug/mL_3_Induced S9_9_3-Methylcholanthrene_1 10 day Read plate 52 32 524 336 2.5_ug/mL_3_Induced S9_9_3-Methylcholanthrene_2 10 day Read plate 62 29 588 317