^STUDY !CHEMICAL_NAME=4,4'-Oxydianiline !STUDY_CONCLUSION=Positive !DEPOSITOR_STUDY_NUMBER=888699 !STRESSOR_TYPE=Chemical !INSTITUTION=NTP !STUDY_TITLE=Effects of 4,4'-Oxydianiline in Mouse Lymphoma Study 888699 !STUDY_DESIGN=Parallel !SUBJECT_TYPE=IN_VITRO !NTP_STUDY_TYPE=Genetic Toxicology - Mammalian Cell Mutagenicity !TIME_TYPE=Study !STUDY_VARIABLES=MICROSOMAL_ACTIVATION_USED|DOSE|TRIAL_RESULT|ASSAY_TRIAL|TREATMENT_GROUP_TYPE ^GROUP #GROUP_NAME #COMPARATOR_NAME #IS_CONTROL_GROUP #TREATMENT_GROUP_TYPE #DEPOSITOR_NAME #SUPER_GROUP_NAME #ASSAY_TRIAL #MICROSOMAL_ACTIVATION_USED #DOSE #DOSE_UNIT #TRIAL_RESULT #CONTROL_SUBSTANCE_NAME #DOUBLING_TIME_UNIT #DOUBLING_TIME #IS_ADHERENT $GROUP_NAME $COMPARATOR_NAME $IS_CONTROL_GROUP $TREATMENT_GROUP_TYPE $DEPOSITOR_NAME $SUPER_GROUP_NAME $ASSAY_TRIAL $MICROSOMAL_ACTIVATION_USED $DOSE $DOSE_UNIT $TRIAL_RESULT $CONTROL_SUBSTANCE_NAME $DOUBLING_TIME_UNIT $DOUBLING_TIME $IS_ADHERENT 1_Nonactivation 1 Nonactivation Positive 0.0_ug/mL_1_Nonactivation_1_Dimethyl Sulfoxide T Vehicle Control 1 1_Nonactivation 0.0 ug/mL Dimethyl Sulfoxide hour 10 F 15.625_ug/mL_1_Nonactivation_2_4,4'-Oxydianiline 0.0_ug/mL_1_Nonactivation_1_Dimethyl Sulfoxide Test Chemical 2 1_Nonactivation 15.625 ug/mL hour 10 F 31.25_ug/mL_1_Nonactivation_3_4,4'-Oxydianiline 0.0_ug/mL_1_Nonactivation_1_Dimethyl Sulfoxide Test Chemical 3 1_Nonactivation 31.25 ug/mL hour 10 F 62.5_ug/mL_1_Nonactivation_4_4,4'-Oxydianiline 0.0_ug/mL_1_Nonactivation_1_Dimethyl Sulfoxide Test Chemical 4 1_Nonactivation 62.5 ug/mL hour 10 F 125.0_ug/mL_1_Nonactivation_5_4,4'-Oxydianiline 0.0_ug/mL_1_Nonactivation_1_Dimethyl Sulfoxide Test Chemical 5 1_Nonactivation 125.0 ug/mL hour 10 F 250.0_ug/mL_1_Nonactivation_6_4,4'-Oxydianiline 0.0_ug/mL_1_Nonactivation_1_Dimethyl Sulfoxide Test Chemical 6 1_Nonactivation 250.0 ug/mL hour 10 F 500.0_ug/mL_1_Nonactivation_7_4,4'-Oxydianiline 0.0_ug/mL_1_Nonactivation_1_Dimethyl Sulfoxide Test Chemical 7 1_Nonactivation 500.0 ug/mL hour 10 F 15.0_ug/mL_1_Nonactivation_8_Methyl Methane Sulfonate 0.0_ug/mL_1_Nonactivation_1_Dimethyl Sulfoxide T Positive Control 8 1_Nonactivation 15.0 ug/mL Methyl Methane Sulfonate hour 10 F 250.0_ug/mL_1_Nonactivation_9_Ethyl Methane Sulfonate 0.0_ug/mL_1_Nonactivation_1_Dimethyl Sulfoxide T Positive Control 9 1_Nonactivation 250.0 ug/mL Ethyl Methane Sulfonate hour 10 F 2_Nonactivation 2 Nonactivation Positive 0.0_ug/mL_2_Nonactivation_1_Dimethyl Sulfoxide T Vehicle Control 1 2_Nonactivation 0.0 ug/mL Dimethyl Sulfoxide hour 10 F 50.0_ug/mL_2_Nonactivation_2_4,4'-Oxydianiline 0.0_ug/mL_2_Nonactivation_1_Dimethyl Sulfoxide Test Chemical 2 2_Nonactivation 50.0 ug/mL hour 10 F 100.0_ug/mL_2_Nonactivation_3_4,4'-Oxydianiline 0.0_ug/mL_2_Nonactivation_1_Dimethyl Sulfoxide Test Chemical 3 2_Nonactivation 100.0 ug/mL hour 10 F 150.0_ug/mL_2_Nonactivation_4_4,4'-Oxydianiline 0.0_ug/mL_2_Nonactivation_1_Dimethyl Sulfoxide Test Chemical 4 2_Nonactivation 150.0 ug/mL hour 10 F 200.0_ug/mL_2_Nonactivation_5_4,4'-Oxydianiline 0.0_ug/mL_2_Nonactivation_1_Dimethyl Sulfoxide Test Chemical 5 2_Nonactivation 200.0 ug/mL hour 10 F 250.0_ug/mL_2_Nonactivation_6_4,4'-Oxydianiline 0.0_ug/mL_2_Nonactivation_1_Dimethyl Sulfoxide Test Chemical 6 2_Nonactivation 250.0 ug/mL hour 10 F 300.0_ug/mL_2_Nonactivation_7_4,4'-Oxydianiline 0.0_ug/mL_2_Nonactivation_1_Dimethyl Sulfoxide Test Chemical 7 2_Nonactivation 300.0 ug/mL hour 10 F 15.0_ug/mL_2_Nonactivation_8_Methyl Methane Sulfonate 0.0_ug/mL_2_Nonactivation_1_Dimethyl Sulfoxide T Positive Control 8 2_Nonactivation 15.0 ug/mL Methyl Methane Sulfonate hour 10 F 250.0_ug/mL_2_Nonactivation_9_Ethyl Methane Sulfonate 0.0_ug/mL_2_Nonactivation_1_Dimethyl Sulfoxide T Positive Control 9 2_Nonactivation 250.0 ug/mL Ethyl Methane Sulfonate hour 10 F ^SUBJECT #PARTICIPANT_DISPLAY_NAME #GROUP_NAME #DEATH_STATUS $PARTICIPANT_DISPLAY_NAME $GROUP_NAME $DEATH_STATUS 0.0_ug/mL_1_Nonactivation_1_Dimethyl Sulfoxide_1 0.0_ug/mL_1_Nonactivation_1_Dimethyl Sulfoxide 0.0_ug/mL_1_Nonactivation_1_Dimethyl Sulfoxide_2 0.0_ug/mL_1_Nonactivation_1_Dimethyl Sulfoxide 0.0_ug/mL_1_Nonactivation_1_Dimethyl Sulfoxide_3 0.0_ug/mL_1_Nonactivation_1_Dimethyl Sulfoxide 0.0_ug/mL_1_Nonactivation_1_Dimethyl Sulfoxide_4 0.0_ug/mL_1_Nonactivation_1_Dimethyl Sulfoxide 15.625_ug/mL_1_Nonactivation_2_4,4'-Oxydianiline_1 15.625_ug/mL_1_Nonactivation_2_4,4'-Oxydianiline 15.625_ug/mL_1_Nonactivation_2_4,4'-Oxydianiline_2 15.625_ug/mL_1_Nonactivation_2_4,4'-Oxydianiline 31.25_ug/mL_1_Nonactivation_3_4,4'-Oxydianiline_1 31.25_ug/mL_1_Nonactivation_3_4,4'-Oxydianiline 31.25_ug/mL_1_Nonactivation_3_4,4'-Oxydianiline_2 31.25_ug/mL_1_Nonactivation_3_4,4'-Oxydianiline 62.5_ug/mL_1_Nonactivation_4_4,4'-Oxydianiline_1 62.5_ug/mL_1_Nonactivation_4_4,4'-Oxydianiline 62.5_ug/mL_1_Nonactivation_4_4,4'-Oxydianiline_2 62.5_ug/mL_1_Nonactivation_4_4,4'-Oxydianiline 125.0_ug/mL_1_Nonactivation_5_4,4'-Oxydianiline_1 125.0_ug/mL_1_Nonactivation_5_4,4'-Oxydianiline 125.0_ug/mL_1_Nonactivation_5_4,4'-Oxydianiline_2 125.0_ug/mL_1_Nonactivation_5_4,4'-Oxydianiline 250.0_ug/mL_1_Nonactivation_6_4,4'-Oxydianiline_1 250.0_ug/mL_1_Nonactivation_6_4,4'-Oxydianiline 250.0_ug/mL_1_Nonactivation_6_4,4'-Oxydianiline_2 250.0_ug/mL_1_Nonactivation_6_4,4'-Oxydianiline 500.0_ug/mL_1_Nonactivation_7_4,4'-Oxydianiline_1 500.0_ug/mL_1_Nonactivation_7_4,4'-Oxydianiline Lethal 500.0_ug/mL_1_Nonactivation_7_4,4'-Oxydianiline_2 500.0_ug/mL_1_Nonactivation_7_4,4'-Oxydianiline Lethal 15.0_ug/mL_1_Nonactivation_8_Methyl Methane Sulfonate_1 15.0_ug/mL_1_Nonactivation_8_Methyl Methane Sulfonate 15.0_ug/mL_1_Nonactivation_8_Methyl Methane Sulfonate_2 15.0_ug/mL_1_Nonactivation_8_Methyl Methane Sulfonate 250.0_ug/mL_1_Nonactivation_9_Ethyl Methane Sulfonate_1 250.0_ug/mL_1_Nonactivation_9_Ethyl Methane Sulfonate 250.0_ug/mL_1_Nonactivation_9_Ethyl Methane Sulfonate_2 250.0_ug/mL_1_Nonactivation_9_Ethyl Methane Sulfonate 0.0_ug/mL_2_Nonactivation_1_Dimethyl Sulfoxide_1 0.0_ug/mL_2_Nonactivation_1_Dimethyl Sulfoxide 0.0_ug/mL_2_Nonactivation_1_Dimethyl Sulfoxide_2 0.0_ug/mL_2_Nonactivation_1_Dimethyl Sulfoxide 0.0_ug/mL_2_Nonactivation_1_Dimethyl Sulfoxide_3 0.0_ug/mL_2_Nonactivation_1_Dimethyl Sulfoxide 0.0_ug/mL_2_Nonactivation_1_Dimethyl Sulfoxide_4 0.0_ug/mL_2_Nonactivation_1_Dimethyl Sulfoxide 50.0_ug/mL_2_Nonactivation_2_4,4'-Oxydianiline_1 50.0_ug/mL_2_Nonactivation_2_4,4'-Oxydianiline 50.0_ug/mL_2_Nonactivation_2_4,4'-Oxydianiline_2 50.0_ug/mL_2_Nonactivation_2_4,4'-Oxydianiline 100.0_ug/mL_2_Nonactivation_3_4,4'-Oxydianiline_1 100.0_ug/mL_2_Nonactivation_3_4,4'-Oxydianiline 100.0_ug/mL_2_Nonactivation_3_4,4'-Oxydianiline_2 100.0_ug/mL_2_Nonactivation_3_4,4'-Oxydianiline 150.0_ug/mL_2_Nonactivation_4_4,4'-Oxydianiline_1 150.0_ug/mL_2_Nonactivation_4_4,4'-Oxydianiline 150.0_ug/mL_2_Nonactivation_4_4,4'-Oxydianiline_2 150.0_ug/mL_2_Nonactivation_4_4,4'-Oxydianiline 200.0_ug/mL_2_Nonactivation_5_4,4'-Oxydianiline_1 200.0_ug/mL_2_Nonactivation_5_4,4'-Oxydianiline 200.0_ug/mL_2_Nonactivation_5_4,4'-Oxydianiline_2 200.0_ug/mL_2_Nonactivation_5_4,4'-Oxydianiline 250.0_ug/mL_2_Nonactivation_6_4,4'-Oxydianiline_1 250.0_ug/mL_2_Nonactivation_6_4,4'-Oxydianiline Lethal 250.0_ug/mL_2_Nonactivation_6_4,4'-Oxydianiline_2 250.0_ug/mL_2_Nonactivation_6_4,4'-Oxydianiline Lethal 300.0_ug/mL_2_Nonactivation_7_4,4'-Oxydianiline_1 300.0_ug/mL_2_Nonactivation_7_4,4'-Oxydianiline Lethal 300.0_ug/mL_2_Nonactivation_7_4,4'-Oxydianiline_2 300.0_ug/mL_2_Nonactivation_7_4,4'-Oxydianiline Lethal 15.0_ug/mL_2_Nonactivation_8_Methyl Methane Sulfonate_1 15.0_ug/mL_2_Nonactivation_8_Methyl Methane Sulfonate 15.0_ug/mL_2_Nonactivation_8_Methyl Methane Sulfonate_2 15.0_ug/mL_2_Nonactivation_8_Methyl Methane Sulfonate 250.0_ug/mL_2_Nonactivation_9_Ethyl Methane Sulfonate_1 250.0_ug/mL_2_Nonactivation_9_Ethyl Methane Sulfonate 250.0_ug/mL_2_Nonactivation_9_Ethyl Methane Sulfonate_2 250.0_ug/mL_2_Nonactivation_9_Ethyl Methane Sulfonate ^STRESSOR_PROTOCOL=CHEM_STRESSOR_PROTOCOL #PROTOCOL_DISPLAY_NAME #STRESSOR_NAME #DOSE #DOSE_UNIT #VEHICLE_NAME #IS_POSITIVE_CONTROL #IS_NEGATIVE_CONTROL #IS_VEHICLE_CONTROL #ROUTE $PROTOCOL_DISPLAY_NAME $STRESSOR_NAME $DOSE $DOSE_UNIT $VEHICLE_NAME $IS_POSITIVE_CONTROL $IS_NEGATIVE_CONTROL $IS_VEHICLE_CONTROL $ROUTE 4,4'-Oxydianiline_300.0_ug/mL 4,4'-Oxydianiline 300.0 ug/mL Dimethyl Sulfoxide Culture medium 4,4'-Oxydianiline_125.0_ug/mL 4,4'-Oxydianiline 125.0 ug/mL Dimethyl Sulfoxide Culture medium 4,4'-Oxydianiline_15.625_ug/mL 4,4'-Oxydianiline 15.625 ug/mL Dimethyl Sulfoxide Culture medium 4,4'-Oxydianiline_31.25_ug/mL 4,4'-Oxydianiline 31.25 ug/mL Dimethyl Sulfoxide Culture medium 4,4'-Oxydianiline_200.0_ug/mL 4,4'-Oxydianiline 200.0 ug/mL Dimethyl Sulfoxide Culture medium Ethyl Methane Sulfonate_250.0_ug/mL Ethyl Methane Sulfonate 250.0 ug/mL Dimethyl Sulfoxide T Culture medium 4,4'-Oxydianiline_250.0_ug/mL 4,4'-Oxydianiline 250.0 ug/mL Dimethyl Sulfoxide Culture medium 4,4'-Oxydianiline_150.0_ug/mL 4,4'-Oxydianiline 150.0 ug/mL Dimethyl Sulfoxide Culture medium 4,4'-Oxydianiline_500.0_ug/mL 4,4'-Oxydianiline 500.0 ug/mL Dimethyl Sulfoxide Culture medium Dimethyl Sulfoxide_0.0_ug/mL No Stressor 0.0 ug/mL Dimethyl Sulfoxide T Culture medium Methyl Methane Sulfonate_15.0_ug/mL Methyl Methane Sulfonate 15.0 ug/mL Dimethyl Sulfoxide T Culture medium 4,4'-Oxydianiline_62.5_ug/mL 4,4'-Oxydianiline 62.5 ug/mL Dimethyl Sulfoxide Culture medium 4,4'-Oxydianiline_50.0_ug/mL 4,4'-Oxydianiline 50.0 ug/mL Dimethyl Sulfoxide Culture medium 4,4'-Oxydianiline_100.0_ug/mL 4,4'-Oxydianiline 100.0 ug/mL Dimethyl Sulfoxide Culture medium ^CARE=CULTURE_PROTOCOL #PROTOCOL_DISPLAY_NAME #PROTOCOL_DESC #MEDIUM #SUPPLEMENTS #SERUM_PERCENTAGE #SERUM_TYPE #ACTIVATION #SPECIES #GAS_PHASE_PERCENT_CO2 #CULTURE_TEMPERATURE_MAX #CULTURE_TEMPERATURE_UNIT #IS_STOP #SEEDING_DENSITY #SEEDING_DENSITY_UNIT $PROTOCOL_DISPLAY_NAME $PROTOCOL_DESC $MEDIUM $SUPPLEMENTS $SERUM_PERCENTAGE $SERUM_TYPE $ACTIVATION $SPECIES $GAS_PHASE_PERCENT_CO2 $CULTURE_TEMPERATURE_MAX $CULTURE_TEMPERATURE_UNIT $IS_STOP $SEEDING_DENSITY $SEEDING_DENSITY_UNIT Culture_treatment Treated cultures contained 6 x 10 6 cells in 10 mL of medium. This volume included the S9 fraction in those experiments performed with metabolic activation. Incubation with the test chemical continued for 4 hours. Stock cultures were grown in F10p medium containing THMG (3 ug/ml thymidine, 5 ug/ml hypoxanthine, 0.1 ug/ml methotrexate and 7.5 ug/ml glycine) for 24 hours then moved to medium with THG for 1 to 3 days prior to use. Periodically frozen cells were used to start new cultures. Fischer's medium 2 mM l-glutamine, 110 ug/mL sodium pyruvate, 0.05% luronic F68, antibiotics 10 Heat-inactivated horse serum 5 37 degree C 500000 cells/ml Culture_expression After exposure to test article for 4 hours the medium plus chemical was removed and the cells resuspended in 20 mL of fresh medium. Fischer's medium 2 mM l-glutamine, 110 ug/mL sodium pyruvate, 0.05% luronic F68, antibiotics 10 Heat-inactivated horse serum 5 37 degree C T Culture_plating After the 48-hour expression period, 3 x 10^6 cells were plated in medium and soft agar supplemented with trifluorothymidine (TFT) for selection of TFT-resistant cells (TK-/-) and in nonselective medium and soft agar to determine cloning efficiency. Plates were incubated at 37 C. in 5% CO2 for 10 to 12 days. Fischer's medium 2 mM l-glutamine, 110 ug/mL sodium pyruvate, 0.05% luronic F68, antibiotics, 0.35% Noble agar 20 Heat-inactivated horse serum 5 37 degree C 3000000 cells/plate Culture_activation If a clearly positive response was not obtained, the test was repeated using freshly prepared S9 from the livers of either Aroclor 1254-induced or non-induced male Fischer 344 rats. 5 Heat-inactivated horse serum S9 Rat 5 37 degree C ^PREPARATION=CULTURE_PREPARATION_PROTOCOL #PROTOCOL_DISPLAY_NAME #PROTOCOL_DESC #IS_TERMINAL $PROTOCOL_DISPLAY_NAME $PROTOCOL_DESC $IS_TERMINAL Read plate At the end of incubation, colonies were counted with an automated counter. T ^TIMELINE #TIME_IN_STUDY #TIME_IN_STUDY_UNIT #GROUP_NAME #PROTOCOL_DISPLAY_NAME $TIME_IN_STUDY $TIME_IN_STUDY_UNIT $GROUP_NAME $PROTOCOL_DISPLAY_NAME 0 hour 0.0_ug/mL_1_Nonactivation_1_Dimethyl Sulfoxide Culture_treatment 4 hour 0.0_ug/mL_1_Nonactivation_1_Dimethyl Sulfoxide Culture_expression 2 day 0.0_ug/mL_1_Nonactivation_1_Dimethyl Sulfoxide Culture_plating 10 day 0.0_ug/mL_1_Nonactivation_1_Dimethyl Sulfoxide Read plate 0 hour 15.625_ug/mL_1_Nonactivation_2_4,4'-Oxydianiline Culture_treatment 4 hour 15.625_ug/mL_1_Nonactivation_2_4,4'-Oxydianiline Culture_expression 2 day 15.625_ug/mL_1_Nonactivation_2_4,4'-Oxydianiline Culture_plating 10 day 15.625_ug/mL_1_Nonactivation_2_4,4'-Oxydianiline Read plate 0 hour 31.25_ug/mL_1_Nonactivation_3_4,4'-Oxydianiline Culture_treatment 4 hour 31.25_ug/mL_1_Nonactivation_3_4,4'-Oxydianiline Culture_expression 2 day 31.25_ug/mL_1_Nonactivation_3_4,4'-Oxydianiline Culture_plating 10 day 31.25_ug/mL_1_Nonactivation_3_4,4'-Oxydianiline Read plate 0 hour 62.5_ug/mL_1_Nonactivation_4_4,4'-Oxydianiline Culture_treatment 4 hour 62.5_ug/mL_1_Nonactivation_4_4,4'-Oxydianiline Culture_expression 2 day 62.5_ug/mL_1_Nonactivation_4_4,4'-Oxydianiline Culture_plating 10 day 62.5_ug/mL_1_Nonactivation_4_4,4'-Oxydianiline Read plate 0 hour 125.0_ug/mL_1_Nonactivation_5_4,4'-Oxydianiline Culture_treatment 4 hour 125.0_ug/mL_1_Nonactivation_5_4,4'-Oxydianiline Culture_expression 2 day 125.0_ug/mL_1_Nonactivation_5_4,4'-Oxydianiline Culture_plating 10 day 125.0_ug/mL_1_Nonactivation_5_4,4'-Oxydianiline Read plate 0 hour 250.0_ug/mL_1_Nonactivation_6_4,4'-Oxydianiline Culture_treatment 4 hour 250.0_ug/mL_1_Nonactivation_6_4,4'-Oxydianiline Culture_expression 2 day 250.0_ug/mL_1_Nonactivation_6_4,4'-Oxydianiline Culture_plating 10 day 250.0_ug/mL_1_Nonactivation_6_4,4'-Oxydianiline Read plate 0 hour 500.0_ug/mL_1_Nonactivation_7_4,4'-Oxydianiline Culture_treatment 4 hour 500.0_ug/mL_1_Nonactivation_7_4,4'-Oxydianiline Culture_expression 2 day 500.0_ug/mL_1_Nonactivation_7_4,4'-Oxydianiline Culture_plating 10 day 500.0_ug/mL_1_Nonactivation_7_4,4'-Oxydianiline Read plate 0 hour 15.0_ug/mL_1_Nonactivation_8_Methyl Methane Sulfonate Culture_treatment 4 hour 15.0_ug/mL_1_Nonactivation_8_Methyl Methane Sulfonate Culture_expression 2 day 15.0_ug/mL_1_Nonactivation_8_Methyl Methane Sulfonate Culture_plating 10 day 15.0_ug/mL_1_Nonactivation_8_Methyl Methane Sulfonate Read plate 0 hour 250.0_ug/mL_1_Nonactivation_9_Ethyl Methane Sulfonate Culture_treatment 4 hour 250.0_ug/mL_1_Nonactivation_9_Ethyl Methane Sulfonate Culture_expression 2 day 250.0_ug/mL_1_Nonactivation_9_Ethyl Methane Sulfonate Culture_plating 10 day 250.0_ug/mL_1_Nonactivation_9_Ethyl Methane Sulfonate Read plate 0 hour 0.0_ug/mL_2_Nonactivation_1_Dimethyl Sulfoxide Culture_treatment 4 hour 0.0_ug/mL_2_Nonactivation_1_Dimethyl Sulfoxide Culture_expression 2 day 0.0_ug/mL_2_Nonactivation_1_Dimethyl Sulfoxide Culture_plating 10 day 0.0_ug/mL_2_Nonactivation_1_Dimethyl Sulfoxide Read plate 0 hour 50.0_ug/mL_2_Nonactivation_2_4,4'-Oxydianiline Culture_treatment 4 hour 50.0_ug/mL_2_Nonactivation_2_4,4'-Oxydianiline Culture_expression 2 day 50.0_ug/mL_2_Nonactivation_2_4,4'-Oxydianiline Culture_plating 10 day 50.0_ug/mL_2_Nonactivation_2_4,4'-Oxydianiline Read plate 0 hour 100.0_ug/mL_2_Nonactivation_3_4,4'-Oxydianiline Culture_treatment 4 hour 100.0_ug/mL_2_Nonactivation_3_4,4'-Oxydianiline Culture_expression 2 day 100.0_ug/mL_2_Nonactivation_3_4,4'-Oxydianiline Culture_plating 10 day 100.0_ug/mL_2_Nonactivation_3_4,4'-Oxydianiline Read plate 0 hour 150.0_ug/mL_2_Nonactivation_4_4,4'-Oxydianiline Culture_treatment 4 hour 150.0_ug/mL_2_Nonactivation_4_4,4'-Oxydianiline Culture_expression 2 day 150.0_ug/mL_2_Nonactivation_4_4,4'-Oxydianiline Culture_plating 10 day 150.0_ug/mL_2_Nonactivation_4_4,4'-Oxydianiline Read plate 0 hour 200.0_ug/mL_2_Nonactivation_5_4,4'-Oxydianiline Culture_treatment 4 hour 200.0_ug/mL_2_Nonactivation_5_4,4'-Oxydianiline Culture_expression 2 day 200.0_ug/mL_2_Nonactivation_5_4,4'-Oxydianiline Culture_plating 10 day 200.0_ug/mL_2_Nonactivation_5_4,4'-Oxydianiline Read plate 0 hour 250.0_ug/mL_2_Nonactivation_6_4,4'-Oxydianiline Culture_treatment 4 hour 250.0_ug/mL_2_Nonactivation_6_4,4'-Oxydianiline Culture_expression 2 day 250.0_ug/mL_2_Nonactivation_6_4,4'-Oxydianiline Culture_plating 10 day 250.0_ug/mL_2_Nonactivation_6_4,4'-Oxydianiline Read plate 0 hour 300.0_ug/mL_2_Nonactivation_7_4,4'-Oxydianiline Culture_treatment 4 hour 300.0_ug/mL_2_Nonactivation_7_4,4'-Oxydianiline Culture_expression 2 day 300.0_ug/mL_2_Nonactivation_7_4,4'-Oxydianiline Culture_plating 10 day 300.0_ug/mL_2_Nonactivation_7_4,4'-Oxydianiline Read plate 0 hour 15.0_ug/mL_2_Nonactivation_8_Methyl Methane Sulfonate Culture_treatment 4 hour 15.0_ug/mL_2_Nonactivation_8_Methyl Methane Sulfonate Culture_expression 2 day 15.0_ug/mL_2_Nonactivation_8_Methyl Methane Sulfonate Culture_plating 10 day 15.0_ug/mL_2_Nonactivation_8_Methyl Methane Sulfonate Read plate 0 hour 250.0_ug/mL_2_Nonactivation_9_Ethyl Methane Sulfonate Culture_treatment 4 hour 250.0_ug/mL_2_Nonactivation_9_Ethyl Methane Sulfonate Culture_expression 2 day 250.0_ug/mL_2_Nonactivation_9_Ethyl Methane Sulfonate Culture_plating 10 day 250.0_ug/mL_2_Nonactivation_9_Ethyl Methane Sulfonate Read plate 0 hour 100.0_ug/mL_2_Nonactivation_3_4,4'-Oxydianiline 4,4'-Oxydianiline_100.0_ug/mL 0 hour 250.0_ug/mL_2_Nonactivation_9_Ethyl Methane Sulfonate Ethyl Methane Sulfonate_250.0_ug/mL 0 hour 15.625_ug/mL_1_Nonactivation_2_4,4'-Oxydianiline 4,4'-Oxydianiline_15.625_ug/mL 0 hour 15.0_ug/mL_1_Nonactivation_8_Methyl Methane Sulfonate Methyl Methane Sulfonate_15.0_ug/mL 0 hour 200.0_ug/mL_2_Nonactivation_5_4,4'-Oxydianiline 4,4'-Oxydianiline_200.0_ug/mL 0 hour 62.5_ug/mL_1_Nonactivation_4_4,4'-Oxydianiline 4,4'-Oxydianiline_62.5_ug/mL 0 hour 150.0_ug/mL_2_Nonactivation_4_4,4'-Oxydianiline 4,4'-Oxydianiline_150.0_ug/mL 0 hour 250.0_ug/mL_2_Nonactivation_6_4,4'-Oxydianiline 4,4'-Oxydianiline_250.0_ug/mL 0 hour 50.0_ug/mL_2_Nonactivation_2_4,4'-Oxydianiline 4,4'-Oxydianiline_50.0_ug/mL 0 hour 250.0_ug/mL_1_Nonactivation_9_Ethyl Methane Sulfonate Ethyl Methane Sulfonate_250.0_ug/mL 0 hour 0.0_ug/mL_1_Nonactivation_1_Dimethyl Sulfoxide Dimethyl Sulfoxide_0.0_ug/mL 0 hour 300.0_ug/mL_2_Nonactivation_7_4,4'-Oxydianiline 4,4'-Oxydianiline_300.0_ug/mL 0 hour 31.25_ug/mL_1_Nonactivation_3_4,4'-Oxydianiline 4,4'-Oxydianiline_31.25_ug/mL 0 hour 0.0_ug/mL_2_Nonactivation_1_Dimethyl Sulfoxide Dimethyl Sulfoxide_0.0_ug/mL 0 hour 15.0_ug/mL_2_Nonactivation_8_Methyl Methane Sulfonate Methyl Methane Sulfonate_15.0_ug/mL 0 hour 250.0_ug/mL_1_Nonactivation_6_4,4'-Oxydianiline 4,4'-Oxydianiline_250.0_ug/mL 0 hour 500.0_ug/mL_1_Nonactivation_7_4,4'-Oxydianiline 4,4'-Oxydianiline_500.0_ug/mL 0 hour 125.0_ug/mL_1_Nonactivation_5_4,4'-Oxydianiline 4,4'-Oxydianiline_125.0_ug/mL ^ASSAY=GENETOX #PARTICIPANT_DISPLAY_NAME #STUDY_TIME #STUDY_TIME_UNIT #PROTOCOL_NAME #LY_CLONING_EFFICIENCY #LY_CLONING_EFFICIENCY[COMMENTS] #LY_RELATIVE_TOTAL_GROWTH #LY_MUTANT_COLONIES #LY_MUTANT_FREQUENCY #LY_AVERAGE_MUTANT_FREQUENCY #LY_AVERAGE_MUTANT_FREQUENCY[COMMENTS] $PARTICIPANT_DISPLAY_NAME $STUDY_TIME $STUDY_TIME_UNIT $PROTOCOL_NAME $LY_CLONING_EFFICIENCY $LY_CLONING_EFFICIENCY[COMMENTS] $LY_RELATIVE_TOTAL_GROWTH $LY_MUTANT_COLONIES $LY_MUTANT_FREQUENCY $LY_AVERAGE_MUTANT_FREQUENCY $LY_AVERAGE_MUTANT_FREQUENCY[COMMENTS] 0.0_ug/mL_1_Nonactivation_1_Dimethyl Sulfoxide 10 day Read plate 34 0.0_ug/mL_1_Nonactivation_1_Dimethyl Sulfoxide_1 10 day Read plate 84 104 92 37 0.0_ug/mL_1_Nonactivation_1_Dimethyl Sulfoxide_2 10 day Read plate 86 98 92 36 0.0_ug/mL_1_Nonactivation_1_Dimethyl Sulfoxide_3 10 day Read plate 91 100 85 31 0.0_ug/mL_1_Nonactivation_1_Dimethyl Sulfoxide_4 10 day Read plate 78 98 77 33 15.625_ug/mL_1_Nonactivation_2_4,4'-Oxydianiline 10 day Read plate 35 15.625_ug/mL_1_Nonactivation_2_4,4'-Oxydianiline_1 10 day Read plate 75 82 82 36 15.625_ug/mL_1_Nonactivation_2_4,4'-Oxydianiline_2 10 day Read plate 94 98 97 34 31.25_ug/mL_1_Nonactivation_3_4,4'-Oxydianiline 10 day Read plate 31 31.25_ug/mL_1_Nonactivation_3_4,4'-Oxydianiline_1 10 day Read plate 75 93 46 20 31.25_ug/mL_1_Nonactivation_3_4,4'-Oxydianiline_2 10 day Read plate 75 93 93 42 62.5_ug/mL_1_Nonactivation_4_4,4'-Oxydianiline 10 day Read plate 55 SIGNIFICANT_RESPONSE 62.5_ug/mL_1_Nonactivation_4_4,4'-Oxydianiline_1 10 day Read plate 89 60 156 58 62.5_ug/mL_1_Nonactivation_4_4,4'-Oxydianiline_2 10 day Read plate 83 65 131 53 125.0_ug/mL_1_Nonactivation_5_4,4'-Oxydianiline 10 day Read plate 100 SIGNIFICANT_RESPONSE 125.0_ug/mL_1_Nonactivation_5_4,4'-Oxydianiline_1 10 day Read plate 68 28 184 90 125.0_ug/mL_1_Nonactivation_5_4,4'-Oxydianiline_2 10 day Read plate 73 25 240 109 250.0_ug/mL_1_Nonactivation_6_4,4'-Oxydianiline 10 day Read plate 105 SIGNIFICANT_RESPONSE 250.0_ug/mL_1_Nonactivation_6_4,4'-Oxydianiline_1 10 day Read plate 27 2 122 152 250.0_ug/mL_1_Nonactivation_6_4,4'-Oxydianiline_2 10 day Read plate 93 7 164 59 500.0_ug/mL_1_Nonactivation_7_4,4'-Oxydianiline 10 day Read plate 15.0_ug/mL_1_Nonactivation_8_Methyl Methane Sulfonate 10 day Read plate 156 SIGNIFICANT_RESPONSE 15.0_ug/mL_1_Nonactivation_8_Methyl Methane Sulfonate_1 10 day Read plate 32 23 138 143 15.0_ug/mL_1_Nonactivation_8_Methyl Methane Sulfonate_2 10 day Read plate 28 19 139 168 250.0_ug/mL_1_Nonactivation_9_Ethyl Methane Sulfonate 10 day Read plate 336 SIGNIFICANT_RESPONSE 250.0_ug/mL_1_Nonactivation_9_Ethyl Methane Sulfonate_1 10 day Read plate 73 70 477 219 250.0_ug/mL_1_Nonactivation_9_Ethyl Methane Sulfonate_2 10 day Read plate 28 27 379 454 0.0_ug/mL_2_Nonactivation_1_Dimethyl Sulfoxide 10 day Read plate 32 0.0_ug/mL_2_Nonactivation_1_Dimethyl Sulfoxide_1 10 day Read plate 112 111 106 32 0.0_ug/mL_2_Nonactivation_1_Dimethyl Sulfoxide_2 10 day Read plate 93 101 101 36 0.0_ug/mL_2_Nonactivation_1_Dimethyl Sulfoxide_3 10 day Read plate 95 100 74 26 0.0_ug/mL_2_Nonactivation_1_Dimethyl Sulfoxide_4 10 day Read plate 94 88 94 33 50.0_ug/mL_2_Nonactivation_2_4,4'-Oxydianiline 10 day Read plate 59 SIGNIFICANT_RESPONSE 50.0_ug/mL_2_Nonactivation_2_4,4'-Oxydianiline_1 10 day Read plate 80 102 157 66 50.0_ug/mL_2_Nonactivation_2_4,4'-Oxydianiline_2 10 day Read plate 87 76 137 53 100.0_ug/mL_2_Nonactivation_3_4,4'-Oxydianiline 10 day Read plate 179 SIGNIFICANT_RESPONSE 100.0_ug/mL_2_Nonactivation_3_4,4'-Oxydianiline_1 10 day Read plate 72 40 382 178 100.0_ug/mL_2_Nonactivation_3_4,4'-Oxydianiline_2 10 day Read plate 73 39 393 181 150.0_ug/mL_2_Nonactivation_4_4,4'-Oxydianiline 10 day Read plate 413 SIGNIFICANT_RESPONSE 150.0_ug/mL_2_Nonactivation_4_4,4'-Oxydianiline_1 10 day Read plate 35 7 406 390 150.0_ug/mL_2_Nonactivation_4_4,4'-Oxydianiline_2 10 day Read plate 32 4 411 435 200.0_ug/mL_2_Nonactivation_5_4,4'-Oxydianiline 10 day Read plate 200.0_ug/mL_2_Nonactivation_5_4,4'-Oxydianiline_1 10 day Read plate 9 REJECTED_VALUE_DUE_TO_QUALITY_CONTROL_CRITERIA 1 119 467 200.0_ug/mL_2_Nonactivation_5_4,4'-Oxydianiline_2 10 day Read plate 8 REJECTED_VALUE_DUE_TO_QUALITY_CONTROL_CRITERIA 1 135 551 250.0_ug/mL_2_Nonactivation_6_4,4'-Oxydianiline 10 day Read plate 300.0_ug/mL_2_Nonactivation_7_4,4'-Oxydianiline 10 day Read plate 15.0_ug/mL_2_Nonactivation_8_Methyl Methane Sulfonate 10 day Read plate 154 SIGNIFICANT_RESPONSE 15.0_ug/mL_2_Nonactivation_8_Methyl Methane Sulfonate_1 10 day Read plate 41 27 216 178 15.0_ug/mL_2_Nonactivation_8_Methyl Methane Sulfonate_2 10 day Read plate 51 26 200 130 250.0_ug/mL_2_Nonactivation_9_Ethyl Methane Sulfonate 10 day Read plate 235 SIGNIFICANT_RESPONSE 250.0_ug/mL_2_Nonactivation_9_Ethyl Methane Sulfonate_1 10 day Read plate 70 77 427 203 250.0_ug/mL_2_Nonactivation_9_Ethyl Methane Sulfonate_2 10 day Read plate 51 56 405 266