^STUDY !CHEMICAL_NAME=C.I. Acid red 14 !STUDY_CONCLUSION=Positive !DEPOSITOR_STUDY_NUMBER=142045_SCE !STRESSOR_TYPE=CHEMICAL !INSTITUTION=NTP !STUDY_TITLE=Cytogenetic study of C.I. Acid red 14 in rodent Sister Chromatid Exchange Test !STUDY_DESIGN=Parallel !SUBJECT_TYPE=LAB_ANIMAL !OLD_NTP_STUDY_TYPE=ROD_SCE !NTP_STUDY_TYPE=Genetic Toxicology - Rodent Cytogenetics !TIME_TYPE=Study !STUDY_VARIABLES=COMPOUND|DOSE|DOSE_UNIT|DOSE_DURATION|DOSE_DURATION_UNIT|TRIAL_RESULT|ASSAY_TRIAL|TREND_TEST_PVALUE|TREATMENT_GROUP_TYPE ^GROUP #GROUP_NAME #COMPARATOR_NAME #IS_CONTROL_GROUP #SUPER_GROUP_NAME #TREATMENT_GROUP_TYPE #DEPOSITOR_NAME #ASSAY_TRIAL #COMPOUND #SAMPLE_TIME #SEX #SPECIES_COMMON_NAME #ORGAN_NAME #STRAIN #DOSE #DOSE_UNIT #DOSE_DURATION #DOSE_DURATION_UNIT #DOSE_FREQUENCY #TRIAL_RESULT #TREND_TEST_PVALUE #START_DATE #CONTROL_SUBSTANCE_NAME $GROUP_NAME $COMPARATOR_NAME $IS_CONTROL_GROUP $SUPER_GROUP_NAME $TREATMENT_GROUP_TYPE $DEPOSITOR_NAME $ASSAY_TRIAL $COMPOUND $SAMPLE_TIME $SEX $SPECIES_COMMON_NAME $ORGAN_NAME $STRAIN $DOSE $DOSE_UNIT $DOSE_DURATION $DOSE_DURATION_UNIT $DOSE_FREQUENCY $TRIAL_RESULT $TREND_TEST_PVALUE $START_DATE $CONTROL_SUBSTANCE_NAME 1 1 1 42 Male Mouse Bone Marrow B6C3F1 42 hour 1/study Positive 1987-12-09 0.0_mg/kg_1_1 T 1 Vehicle Control 1 Corn Oil 0.0 mg/kg Corn Oil 450.0_mg/kg_1_2 0.0_mg/kg_1_1 1 Test Chemical 2 C.I. Acid red 14 450.0 mg/kg 900.0_mg/kg_1_3 0.0_mg/kg_1_1 1 Test Chemical 3 C.I. Acid red 14 900.0 mg/kg 1800.0_mg/kg_1_4 0.0_mg/kg_1_1 1 Test Chemical 4 C.I. Acid red 14 1800.0 mg/kg 2.5_mg/kg_1_5 0.0_mg/kg_1_1 T 1 Positive Control 5 Dimethylbenzanthracene 2.5 mg/kg Dimethylbenzanthracene 2 2 2 23 Male Mouse Bone Marrow B6C3F1 23 hour 1/study Positive 1988-01-27 0.0_mg/kg_2_1 T 2 Vehicle Control 1 Corn Oil 0.0 mg/kg Corn Oil 450.0_mg/kg_2_2 0.0_mg/kg_2_1 2 Test Chemical 2 C.I. Acid red 14 450.0 mg/kg 900.0_mg/kg_2_3 0.0_mg/kg_2_1 2 Test Chemical 3 C.I. Acid red 14 900.0 mg/kg 1800.0_mg/kg_2_4 0.0_mg/kg_2_1 2 Test Chemical 4 C.I. Acid red 14 1800.0 mg/kg 2.5_mg/kg_2_5 0.0_mg/kg_2_1 T 2 Positive Control 5 Dimethylbenzanthracene 2.5 mg/kg Dimethylbenzanthracene ^SUBJECT #PARTICIPANT_DISPLAY_NAME #GROUP_NAME #DEPOSITOR_NAME #ANIMAL_STATUS $PARTICIPANT_DISPLAY_NAME $GROUP_NAME $DEPOSITOR_NAME $ANIMAL_STATUS 0.0_mg/kg_1_1_7069 0.0_mg/kg_1_1 7069 Normal 0.0_mg/kg_1_1_7073 0.0_mg/kg_1_1 7073 Normal 0.0_mg/kg_1_1_7082 0.0_mg/kg_1_1 7082 Normal 0.0_mg/kg_1_1_7111 0.0_mg/kg_1_1 7111 Normal 450.0_mg/kg_1_2_7095 450.0_mg/kg_1_2 7095 Normal 450.0_mg/kg_1_2_7097 450.0_mg/kg_1_2 7097 Normal 450.0_mg/kg_1_2_7100 450.0_mg/kg_1_2 7100 Normal 450.0_mg/kg_1_2_7103 450.0_mg/kg_1_2 7103 Normal 900.0_mg/kg_1_3_7096 900.0_mg/kg_1_3 7096 Normal 900.0_mg/kg_1_3_7099 900.0_mg/kg_1_3 7099 Normal 900.0_mg/kg_1_3_7101 900.0_mg/kg_1_3 7101 Normal 900.0_mg/kg_1_3_7109 900.0_mg/kg_1_3 7109 Normal 1800.0_mg/kg_1_4_7104 1800.0_mg/kg_1_4 7104 Normal 1800.0_mg/kg_1_4_7105 1800.0_mg/kg_1_4 7105 Normal 1800.0_mg/kg_1_4_7107 1800.0_mg/kg_1_4 7107 Normal 1800.0_mg/kg_1_4_7110 1800.0_mg/kg_1_4 7110 Normal 2.5_mg/kg_1_5_7056 2.5_mg/kg_1_5 7056 Normal 2.5_mg/kg_1_5_7067 2.5_mg/kg_1_5 7067 Normal 2.5_mg/kg_1_5_7092 2.5_mg/kg_1_5 7092 Normal 2.5_mg/kg_1_5_7102 2.5_mg/kg_1_5 7102 Normal 0.0_mg/kg_2_1_7446 0.0_mg/kg_2_1 7446 Normal 0.0_mg/kg_2_1_7464 0.0_mg/kg_2_1 7464 Normal 0.0_mg/kg_2_1_7496 0.0_mg/kg_2_1 7496 Normal 0.0_mg/kg_2_1_7500 0.0_mg/kg_2_1 7500 Normal 450.0_mg/kg_2_2_7447 450.0_mg/kg_2_2 7447 Normal 450.0_mg/kg_2_2_7452 450.0_mg/kg_2_2 7452 Normal 450.0_mg/kg_2_2_7453 450.0_mg/kg_2_2 7453 Normal 450.0_mg/kg_2_2_7460 450.0_mg/kg_2_2 7460 Normal 900.0_mg/kg_2_3_7450 900.0_mg/kg_2_3 7450 Normal 900.0_mg/kg_2_3_7451 900.0_mg/kg_2_3 7451 Normal 900.0_mg/kg_2_3_7455 900.0_mg/kg_2_3 7455 Normal 900.0_mg/kg_2_3_7463 900.0_mg/kg_2_3 7463 Normal 1800.0_mg/kg_2_4_7444 1800.0_mg/kg_2_4 7444 Normal 1800.0_mg/kg_2_4_7449 1800.0_mg/kg_2_4 7449 Normal 1800.0_mg/kg_2_4_7458 1800.0_mg/kg_2_4 7458 Normal 1800.0_mg/kg_2_4_7461 1800.0_mg/kg_2_4 7461 Normal 2.5_mg/kg_2_5_7448 2.5_mg/kg_2_5 7448 Normal 2.5_mg/kg_2_5_7473 2.5_mg/kg_2_5 7473 Normal 2.5_mg/kg_2_5_7485 2.5_mg/kg_2_5 7485 Normal 2.5_mg/kg_2_5_7511 2.5_mg/kg_2_5 7511 Normal ^STRESSOR_PROTOCOL=CHEM_STRESSOR_PROTOCOL #PROTOCOL_DISPLAY_NAME #PROTOCOL_DESC #STRESSOR_NAME #ROUTE_ADMIN #DOSE_PER_ADMIN #DOSE_PER_ADMIN_UNIT #DOSE_FREQUENCY #DOSE_FREQUENCY_UNIT #VEHICLE_NAME #IS_POSITIVE_CONTROL #IS_VEHICLE_CONTROL #IS_LABEL $PROTOCOL_DISPLAY_NAME $PROTOCOL_DESC $STRESSOR_NAME $ROUTE_ADMIN $DOSE_PER_ADMIN $DOSE_PER_ADMIN_UNIT $DOSE_FREQUENCY $DOSE_FREQUENCY_UNIT $VEHICLE_NAME $IS_POSITIVE_CONTROL $IS_VEHICLE_CONTROL $IS_LABEL C.I. Acid red 14_450.0_mg/kg C.I. Acid red 14 Intraperitoneal Injection 450.0 mg/kg 1 per study Corn Oil C.I. Acid red 14_900.0_mg/kg C.I. Acid red 14 Intraperitoneal Injection 900.0 mg/kg 1 per study Corn Oil C.I. Acid red 14_1800.0_mg/kg C.I. Acid red 14 Intraperitoneal Injection 1800.0 mg/kg 1 per study Corn Oil Corn Oil_0.0_mg/kg No Stressor Intraperitoneal Injection 0.0 mg/kg 1 per study Corn Oil T Dimethylbenzanthracene_2.5_mg/kg Dimethylbenzanthracene Intraperitoneal Injection 2.5 mg/kg 1 per study Corn Oil T BrdUrd tablet implant BrdUrd subcutaneously implanted 1 per study T colchicine injection colchicine IP injection 1 per study T ^DISPOSITION=EUTHANASIA_PROTOCOL #PROTOCOL_DISPLAY_NAME $PROTOCOL_DISPLAY_NAME Common euthanasia protocol ^PREPARATION=LAB_ANIMAL_PREPARATION_PROTOCOL #PROTOCOL_DISPLAY_NAME #PROTOCOL_DESC #IS_TERMINAL #ORGAN #SPECIMEN_TYPE $PROTOCOL_DISPLAY_NAME $PROTOCOL_DESC $IS_TERMINAL $ORGAN $SPECIMEN_TYPE Femur marrow cell slide preparation One or both femurs were removed and the marrow was flushed out with phosphate-buffered saline (pH 7.0). The cells were treated with a hypotonic salt solution, fixed, and dropped onto chilled slides. After a 24 hour drying period, the slides were stained using fluorescence-plus-Giemsa and scored. T Bone marrow Cell ^TIMELINE #TIME_IN_STUDY #TIME_IN_STUDY_UNIT #GROUP_NAME #PROTOCOL_DISPLAY_NAME $TIME_IN_STUDY $TIME_IN_STUDY_UNIT $GROUP_NAME $PROTOCOL_DISPLAY_NAME 0 hour 0.0_mg/kg_1_1 Corn Oil_0.0_mg/kg 18 hour 0.0_mg/kg_1_1 BrdUrd tablet implant 40 hour 0.0_mg/kg_1_1 colchicine injection 42 hour 0.0_mg/kg_1_1 Common euthanasia protocol 0 hour 450.0_mg/kg_1_2 C.I. Acid red 14_450.0_mg/kg 18 hour 450.0_mg/kg_1_2 BrdUrd tablet implant 40 hour 450.0_mg/kg_1_2 colchicine injection 42 hour 450.0_mg/kg_1_2 Common euthanasia protocol 0 hour 900.0_mg/kg_1_3 C.I. Acid red 14_900.0_mg/kg 18 hour 900.0_mg/kg_1_3 BrdUrd tablet implant 40 hour 900.0_mg/kg_1_3 colchicine injection 42 hour 900.0_mg/kg_1_3 Common euthanasia protocol 0 hour 1800.0_mg/kg_1_4 C.I. Acid red 14_1800.0_mg/kg 18 hour 1800.0_mg/kg_1_4 BrdUrd tablet implant 40 hour 1800.0_mg/kg_1_4 colchicine injection 42 hour 1800.0_mg/kg_1_4 Common euthanasia protocol 0 hour 2.5_mg/kg_1_5 Dimethylbenzanthracene_2.5_mg/kg 18 hour 2.5_mg/kg_1_5 BrdUrd tablet implant 40 hour 2.5_mg/kg_1_5 colchicine injection 42 hour 2.5_mg/kg_1_5 Common euthanasia protocol 0 hour 0.0_mg/kg_2_1 Corn Oil_0.0_mg/kg -1 hour 0.0_mg/kg_2_1 BrdUrd tablet implant 21 hour 0.0_mg/kg_2_1 colchicine injection 23 hour 0.0_mg/kg_2_1 Common euthanasia protocol 0 hour 450.0_mg/kg_2_2 C.I. Acid red 14_450.0_mg/kg -1 hour 450.0_mg/kg_2_2 BrdUrd tablet implant 21 hour 450.0_mg/kg_2_2 colchicine injection 23 hour 450.0_mg/kg_2_2 Common euthanasia protocol 0 hour 900.0_mg/kg_2_3 C.I. Acid red 14_900.0_mg/kg -1 hour 900.0_mg/kg_2_3 BrdUrd tablet implant 21 hour 900.0_mg/kg_2_3 colchicine injection 23 hour 900.0_mg/kg_2_3 Common euthanasia protocol 0 hour 1800.0_mg/kg_2_4 C.I. Acid red 14_1800.0_mg/kg -1 hour 1800.0_mg/kg_2_4 BrdUrd tablet implant 21 hour 1800.0_mg/kg_2_4 colchicine injection 23 hour 1800.0_mg/kg_2_4 Common euthanasia protocol 0 hour 2.5_mg/kg_2_5 Dimethylbenzanthracene_2.5_mg/kg -1 hour 2.5_mg/kg_2_5 BrdUrd tablet implant 21 hour 2.5_mg/kg_2_5 colchicine injection 23 hour 2.5_mg/kg_2_5 Common euthanasia protocol ^ASSAY=GENETOX #PARTICIPANT_DISPLAY_NAME #STUDY_TIME #STUDY_TIME_UNIT #PROTOCOL_NAME #ANIMALS_EXAMINED #SCE_PER_CELL_MEAN[MEAN] #SCE_CELLS_EXAMINED #SCE_PER_CELL_MEAN #SCE_PER_CELL_MEAN[SEM] #SCE_PER_CELL_MEAN[PAIRWISE_PVALUE] #SCE_PER_CELL_MEAN[TREND_PVALUE] $PARTICIPANT_DISPLAY_NAME $STUDY_TIME $STUDY_TIME_UNIT $PROTOCOL_NAME $ANIMALS_EXAMINED $SCE_PER_CELL_MEAN[MEAN] $SCE_CELLS_EXAMINED $SCE_PER_CELL_MEAN $SCE_PER_CELL_MEAN[SEM] $SCE_PER_CELL_MEAN[PAIRWISE_PVALUE] $SCE_PER_CELL_MEAN[TREND_PVALUE] 0.0_mg/kg_1_1 42 hours Femur marrow cell slide preparation 4 7.14 0.138 0.0000 0.0_mg/kg_1_1_7069 42 hours Femur marrow cell slide preparation 25 7.19 0.546 0.0_mg/kg_1_1_7073 42 hours Femur marrow cell slide preparation 25 7.19 0.737 0.0_mg/kg_1_1_7082 42 hours Femur marrow cell slide preparation 25 6.77 0.387 0.0_mg/kg_1_1_7111 42 hours Femur marrow cell slide preparation 25 7.43 0.618 450.0_mg/kg_1_2 42 hours Femur marrow cell slide preparation 4 6.53 0.880 0.2684 450.0_mg/kg_1_2_7095 42 hours Femur marrow cell slide preparation 25 4.97 0.544 450.0_mg/kg_1_2_7097 42 hours Femur marrow cell slide preparation 25 8.86 0.740 450.0_mg/kg_1_2_7100 42 hours Femur marrow cell slide preparation 25 6.89 0.636 450.0_mg/kg_1_2_7103 42 hours Femur marrow cell slide preparation 25 5.40 0.503 900.0_mg/kg_1_3 42 hours Femur marrow cell slide preparation 4 8.41 0.774 0.1020 900.0_mg/kg_1_3_7096 42 hours Femur marrow cell slide preparation 25 8.88 0.948 900.0_mg/kg_1_3_7099 42 hours Femur marrow cell slide preparation 25 6.38 0.677 900.0_mg/kg_1_3_7101 42 hours Femur marrow cell slide preparation 25 10.08 1.161 900.0_mg/kg_1_3_7109 42 hours Femur marrow cell slide preparation 25 8.24 0.619 1800.0_mg/kg_1_4 42 hours Femur marrow cell slide preparation 4 11.31 2.275 0.0824 1800.0_mg/kg_1_4_7104 42 hours Femur marrow cell slide preparation 25 7.98 0.666 1800.0_mg/kg_1_4_7105 42 hours Femur marrow cell slide preparation 25 6.80 0.693 1800.0_mg/kg_1_4_7107 42 hours Femur marrow cell slide preparation 25 15.04 0.978 1800.0_mg/kg_1_4_7110 42 hours Femur marrow cell slide preparation 25 15.41 1.290 2.5_mg/kg_1_5 42 hours Femur marrow cell slide preparation 4 13.97 0.535 0.0003 2.5_mg/kg_1_5_7056 42 hours Femur marrow cell slide preparation 25 14.76 0.995 2.5_mg/kg_1_5_7067 42 hours Femur marrow cell slide preparation 25 12.38 0.976 2.5_mg/kg_1_5_7092 42 hours Femur marrow cell slide preparation 25 14.40 0.815 2.5_mg/kg_1_5_7102 42 hours Femur marrow cell slide preparation 25 14.30 0.897 0.0_mg/kg_2_1 23 hours Femur marrow cell slide preparation 4 4.87 0.160 0.0000 0.0_mg/kg_2_1_7446 23 hours Femur marrow cell slide preparation 25 4.67 0.378 0.0_mg/kg_2_1_7464 23 hours Femur marrow cell slide preparation 25 4.82 0.482 0.0_mg/kg_2_1_7496 23 hours Femur marrow cell slide preparation 25 5.34 0.508 0.0_mg/kg_2_1_7500 23 hours Femur marrow cell slide preparation 25 4.67 0.417 450.0_mg/kg_2_2 23 hours Femur marrow cell slide preparation 4 7.78 0.930 0.0251 450.0_mg/kg_2_2_7447 23 hours Femur marrow cell slide preparation 25 6.72 0.526 450.0_mg/kg_2_2_7452 23 hours Femur marrow cell slide preparation 25 10.47 1.316 450.0_mg/kg_2_2_7453 23 hours Femur marrow cell slide preparation 25 7.53 0.712 450.0_mg/kg_2_2_7460 23 hours Femur marrow cell slide preparation 25 6.39 0.724 900.0_mg/kg_2_3 23 hours Femur marrow cell slide preparation 4 6.69 0.610 0.0269 900.0_mg/kg_2_3_7450 23 hours Femur marrow cell slide preparation 25 6.41 0.539 900.0_mg/kg_2_3_7451 23 hours Femur marrow cell slide preparation 25 7.89 1.119 900.0_mg/kg_2_3_7455 23 hours Femur marrow cell slide preparation 25 7.38 0.827 900.0_mg/kg_2_3_7463 23 hours Femur marrow cell slide preparation 26 5.12 0.414 1800.0_mg/kg_2_4 23 hours Femur marrow cell slide preparation 4 9.45 1.119 0.0124 1800.0_mg/kg_2_4_7444 23 hours Femur marrow cell slide preparation 25 7.18 0.531 1800.0_mg/kg_2_4_7449 23 hours Femur marrow cell slide preparation 25 10.31 1.557 1800.0_mg/kg_2_4_7458 23 hours Femur marrow cell slide preparation 25 12.20 0.970 1800.0_mg/kg_2_4_7461 23 hours Femur marrow cell slide preparation 25 8.20 1.223 2.5_mg/kg_2_5 23 hours Femur marrow cell slide preparation 4 9.03 0.784 0.0057 2.5_mg/kg_2_5_7448 23 hours Femur marrow cell slide preparation 25 9.43 0.812 2.5_mg/kg_2_5_7473 23 hours Femur marrow cell slide preparation 25 11.04 0.615 2.5_mg/kg_2_5_7485 23 hours Femur marrow cell slide preparation 25 8.25 0.580 2.5_mg/kg_2_5_7511 23 hours Femur marrow cell slide preparation 25 7.42 0.663