^STUDY !CHEMICAL_NAME=Phenol !STUDY_CONCLUSION=Negative (Nonstandard Protocol) !DEPOSITOR_STUDY_NUMBER=170681_SCE !STRESSOR_TYPE=CHEMICAL !INSTITUTION=NTP !STUDY_TITLE=Cytogenetic study of Phenol in rodent Sister Chromatid Exchange Test !STUDY_DESIGN=Parallel !SUBJECT_TYPE=LAB_ANIMAL !OLD_NTP_STUDY_TYPE=ROD_SCE !NTP_STUDY_TYPE=Genetic Toxicology - Rodent Cytogenetics !TIME_TYPE=Study !STUDY_VARIABLES=COMPOUND|DOSE|DOSE_UNIT|DOSE_DURATION|DOSE_DURATION_UNIT|TRIAL_RESULT|ASSAY_TRIAL|TREND_TEST_PVALUE|TREATMENT_GROUP_TYPE ^GROUP #GROUP_NAME #COMPARATOR_NAME #IS_CONTROL_GROUP #SUPER_GROUP_NAME #TREATMENT_GROUP_TYPE #DEPOSITOR_NAME #ASSAY_TRIAL #COMPOUND #SAMPLE_TIME #SEX #SPECIES_COMMON_NAME #ORGAN_NAME #STRAIN #DOSE #DOSE_UNIT #DOSE_DURATION #DOSE_DURATION_UNIT #DOSE_FREQUENCY #TRIAL_RESULT #TREND_TEST_PVALUE #START_DATE #CONTROL_SUBSTANCE_NAME $GROUP_NAME $COMPARATOR_NAME $IS_CONTROL_GROUP $SUPER_GROUP_NAME $TREATMENT_GROUP_TYPE $DEPOSITOR_NAME $ASSAY_TRIAL $COMPOUND $SAMPLE_TIME $SEX $SPECIES_COMMON_NAME $ORGAN_NAME $STRAIN $DOSE $DOSE_UNIT $DOSE_DURATION $DOSE_DURATION_UNIT $DOSE_FREQUENCY $TRIAL_RESULT $TREND_TEST_PVALUE $START_DATE $CONTROL_SUBSTANCE_NAME 1 1 1 23 Male Mouse Bone Marrow B6C3F1 23 hour 1/study Negative 1986-02-13 0.0_mg/kg_1_1 T 1 Vehicle Control 1 Phosphate Buffered Saline 0.0 mg/kg Phosphate Buffered Saline 75.0_mg/kg_1_2 0.0_mg/kg_1_1 1 Test Chemical 2 Phenol 75.0 mg/kg 150.0_mg/kg_1_3 0.0_mg/kg_1_1 1 Test Chemical 3 Phenol 150.0 mg/kg 300.0_mg/kg_1_4 0.0_mg/kg_1_1 1 Test Chemical 4 Phenol 300.0 mg/kg 0.5_mg/kg_1_5 0.0_mg/kg_1_1 T 1 Positive Control 5 Mitomycin-C 0.5 mg/kg Mitomycin-C 2 2 2 23 Male Mouse Bone Marrow B6C3F1 23 hour 1/study Negative 1986-09-04 0.0_mg/kg_2_1 T 2 Vehicle Control 1 Phosphate Buffered Saline 0.0 mg/kg Phosphate Buffered Saline 75.0_mg/kg_2_2 0.0_mg/kg_2_1 2 Test Chemical 2 Phenol 75.0 mg/kg 150.0_mg/kg_2_3 0.0_mg/kg_2_1 2 Test Chemical 3 Phenol 150.0 mg/kg 300.0_mg/kg_2_4 0.0_mg/kg_2_1 2 Test Chemical 4 Phenol 300.0 mg/kg 0.5_mg/kg_2_5 0.0_mg/kg_2_1 T 2 Positive Control 5 Mitomycin-C 0.5 mg/kg Mitomycin-C ^SUBJECT #PARTICIPANT_DISPLAY_NAME #GROUP_NAME #DEPOSITOR_NAME #ANIMAL_STATUS $PARTICIPANT_DISPLAY_NAME $GROUP_NAME $DEPOSITOR_NAME $ANIMAL_STATUS 0.0_mg/kg_1_1_3351 0.0_mg/kg_1_1 3351 Normal 0.0_mg/kg_1_1_3353 0.0_mg/kg_1_1 3353 Normal 0.0_mg/kg_1_1_3354 0.0_mg/kg_1_1 3354 Normal 0.0_mg/kg_1_1_3355 0.0_mg/kg_1_1 3355 Normal 75.0_mg/kg_1_2_3321 75.0_mg/kg_1_2 3321 Normal 75.0_mg/kg_1_2_3322 75.0_mg/kg_1_2 3322 Normal 75.0_mg/kg_1_2_3323 75.0_mg/kg_1_2 3323 Normal 75.0_mg/kg_1_2_3324 75.0_mg/kg_1_2 3324 Normal 150.0_mg/kg_1_3_3326 150.0_mg/kg_1_3 3326 Normal 150.0_mg/kg_1_3_3327 150.0_mg/kg_1_3 3327 Normal 150.0_mg/kg_1_3_3328 150.0_mg/kg_1_3 3328 Normal 150.0_mg/kg_1_3_3329 150.0_mg/kg_1_3 3329 Normal 300.0_mg/kg_1_4_3331 300.0_mg/kg_1_4 3331 Normal 300.0_mg/kg_1_4_3332 300.0_mg/kg_1_4 3332 Normal 300.0_mg/kg_1_4_3333 300.0_mg/kg_1_4 3333 Normal 300.0_mg/kg_1_4_3334 300.0_mg/kg_1_4 3334 Normal 0.5_mg/kg_1_5_3356 0.5_mg/kg_1_5 3356 Normal 0.5_mg/kg_1_5_3357 0.5_mg/kg_1_5 3357 Normal 0.5_mg/kg_1_5_3358 0.5_mg/kg_1_5 3358 Normal 0.5_mg/kg_1_5_3359 0.5_mg/kg_1_5 3359 Normal 0.0_mg/kg_2_1_4176 0.0_mg/kg_2_1 4176 Normal 0.0_mg/kg_2_1_4177 0.0_mg/kg_2_1 4177 Normal 0.0_mg/kg_2_1_4178 0.0_mg/kg_2_1 4178 Normal 0.0_mg/kg_2_1_4179 0.0_mg/kg_2_1 4179 Normal 75.0_mg/kg_2_2_4166 75.0_mg/kg_2_2 4166 Normal 75.0_mg/kg_2_2_4167 75.0_mg/kg_2_2 4167 Normal 75.0_mg/kg_2_2_4168 75.0_mg/kg_2_2 4168 Normal 75.0_mg/kg_2_2_4169 75.0_mg/kg_2_2 4169 Normal 150.0_mg/kg_2_3_4161 150.0_mg/kg_2_3 4161 Normal 150.0_mg/kg_2_3_4162 150.0_mg/kg_2_3 4162 Normal 150.0_mg/kg_2_3_4163 150.0_mg/kg_2_3 4163 Normal 150.0_mg/kg_2_3_4164 150.0_mg/kg_2_3 4164 Normal 300.0_mg/kg_2_4_4156 300.0_mg/kg_2_4 4156 Normal 300.0_mg/kg_2_4_4157 300.0_mg/kg_2_4 4157 Normal 300.0_mg/kg_2_4_4158 300.0_mg/kg_2_4 4158 Normal 300.0_mg/kg_2_4_4159 300.0_mg/kg_2_4 4159 Normal 0.5_mg/kg_2_5_4171 0.5_mg/kg_2_5 4171 Normal 0.5_mg/kg_2_5_4172 0.5_mg/kg_2_5 4172 Normal 0.5_mg/kg_2_5_4173 0.5_mg/kg_2_5 4173 Normal 0.5_mg/kg_2_5_4174 0.5_mg/kg_2_5 4174 Normal ^STRESSOR_PROTOCOL=CHEM_STRESSOR_PROTOCOL #PROTOCOL_DISPLAY_NAME #PROTOCOL_DESC #STRESSOR_NAME #ROUTE_ADMIN #DOSE_PER_ADMIN #DOSE_PER_ADMIN_UNIT #DOSE_FREQUENCY #DOSE_FREQUENCY_UNIT #VEHICLE_NAME #IS_POSITIVE_CONTROL #IS_VEHICLE_CONTROL #IS_LABEL $PROTOCOL_DISPLAY_NAME $PROTOCOL_DESC $STRESSOR_NAME $ROUTE_ADMIN $DOSE_PER_ADMIN $DOSE_PER_ADMIN_UNIT $DOSE_FREQUENCY $DOSE_FREQUENCY_UNIT $VEHICLE_NAME $IS_POSITIVE_CONTROL $IS_VEHICLE_CONTROL $IS_LABEL Mitomycin-C_0.5_mg/kg Mitomycin-C Intraperitoneal Injection 0.5 mg/kg 1 per study Phosphate Buffered Saline T Phenol_75.0_mg/kg Phenol Intraperitoneal Injection 75.0 mg/kg 1 per study Phosphate Buffered Saline Phenol_300.0_mg/kg Phenol Intraperitoneal Injection 300.0 mg/kg 1 per study Phosphate Buffered Saline Phenol_150.0_mg/kg Phenol Intraperitoneal Injection 150.0 mg/kg 1 per study Phosphate Buffered Saline Phosphate Buffered Saline_0.0_mg/kg No Stressor Intraperitoneal Injection 0.0 mg/kg 1 per study Phosphate Buffered Saline T BrdUrd tablet implant BrdUrd subcutaneously implanted 1 per study T colchicine injection colchicine IP injection 1 per study T ^DISPOSITION=EUTHANASIA_PROTOCOL #PROTOCOL_DISPLAY_NAME $PROTOCOL_DISPLAY_NAME Common euthanasia protocol ^PREPARATION=LAB_ANIMAL_PREPARATION_PROTOCOL #PROTOCOL_DISPLAY_NAME #PROTOCOL_DESC #IS_TERMINAL #ORGAN #SPECIMEN_TYPE $PROTOCOL_DISPLAY_NAME $PROTOCOL_DESC $IS_TERMINAL $ORGAN $SPECIMEN_TYPE Femur marrow cell slide preparation One or both femurs were removed and the marrow was flushed out with phosphate-buffered saline (pH 7.0). The cells were treated with a hypotonic salt solution, fixed, and dropped onto chilled slides. After a 24 hour drying period, the slides were stained using fluorescence-plus-Giemsa and scored. T Bone marrow Cell ^TIMELINE #TIME_IN_STUDY #TIME_IN_STUDY_UNIT #GROUP_NAME #PROTOCOL_DISPLAY_NAME $TIME_IN_STUDY $TIME_IN_STUDY_UNIT $GROUP_NAME $PROTOCOL_DISPLAY_NAME 0 hour 0.0_mg/kg_1_1 Phosphate Buffered Saline_0.0_mg/kg -1 hour 0.0_mg/kg_1_1 BrdUrd tablet implant 21 hour 0.0_mg/kg_1_1 colchicine injection 23 hour 0.0_mg/kg_1_1 Common euthanasia protocol 0 hour 75.0_mg/kg_1_2 Phenol_75.0_mg/kg -1 hour 75.0_mg/kg_1_2 BrdUrd tablet implant 21 hour 75.0_mg/kg_1_2 colchicine injection 23 hour 75.0_mg/kg_1_2 Common euthanasia protocol 0 hour 150.0_mg/kg_1_3 Phenol_150.0_mg/kg -1 hour 150.0_mg/kg_1_3 BrdUrd tablet implant 21 hour 150.0_mg/kg_1_3 colchicine injection 23 hour 150.0_mg/kg_1_3 Common euthanasia protocol 0 hour 300.0_mg/kg_1_4 Phenol_300.0_mg/kg -1 hour 300.0_mg/kg_1_4 BrdUrd tablet implant 21 hour 300.0_mg/kg_1_4 colchicine injection 23 hour 300.0_mg/kg_1_4 Common euthanasia protocol 0 hour 0.5_mg/kg_1_5 Mitomycin-C_0.5_mg/kg -1 hour 0.5_mg/kg_1_5 BrdUrd tablet implant 21 hour 0.5_mg/kg_1_5 colchicine injection 23 hour 0.5_mg/kg_1_5 Common euthanasia protocol 0 hour 0.0_mg/kg_2_1 Phosphate Buffered Saline_0.0_mg/kg -1 hour 0.0_mg/kg_2_1 BrdUrd tablet implant 21 hour 0.0_mg/kg_2_1 colchicine injection 23 hour 0.0_mg/kg_2_1 Common euthanasia protocol 0 hour 75.0_mg/kg_2_2 Phenol_75.0_mg/kg -1 hour 75.0_mg/kg_2_2 BrdUrd tablet implant 21 hour 75.0_mg/kg_2_2 colchicine injection 23 hour 75.0_mg/kg_2_2 Common euthanasia protocol 0 hour 150.0_mg/kg_2_3 Phenol_150.0_mg/kg -1 hour 150.0_mg/kg_2_3 BrdUrd tablet implant 21 hour 150.0_mg/kg_2_3 colchicine injection 23 hour 150.0_mg/kg_2_3 Common euthanasia protocol 0 hour 300.0_mg/kg_2_4 Phenol_300.0_mg/kg -1 hour 300.0_mg/kg_2_4 BrdUrd tablet implant 21 hour 300.0_mg/kg_2_4 colchicine injection 23 hour 300.0_mg/kg_2_4 Common euthanasia protocol 0 hour 0.5_mg/kg_2_5 Mitomycin-C_0.5_mg/kg -1 hour 0.5_mg/kg_2_5 BrdUrd tablet implant 21 hour 0.5_mg/kg_2_5 colchicine injection 23 hour 0.5_mg/kg_2_5 Common euthanasia protocol ^ASSAY=GENETOX #PARTICIPANT_DISPLAY_NAME #STUDY_TIME #STUDY_TIME_UNIT #PROTOCOL_NAME #ANIMALS_EXAMINED #SCE_PER_CELL_MEAN[MEAN] #SCE_CELLS_EXAMINED #SCE_PER_CELL_MEAN #SCE_PER_CELL_MEAN[SEM] #SCE_PER_CELL_MEAN[PAIRWISE_PVALUE] #SCE_PER_CELL_MEAN[TREND_PVALUE] $PARTICIPANT_DISPLAY_NAME $STUDY_TIME $STUDY_TIME_UNIT $PROTOCOL_NAME $ANIMALS_EXAMINED $SCE_PER_CELL_MEAN[MEAN] $SCE_CELLS_EXAMINED $SCE_PER_CELL_MEAN $SCE_PER_CELL_MEAN[SEM] $SCE_PER_CELL_MEAN[PAIRWISE_PVALUE] $SCE_PER_CELL_MEAN[TREND_PVALUE] 0.0_mg/kg_1_1 23 hours Femur marrow cell slide preparation 4 5.43 0.412 0.0000 0.0_mg/kg_1_1_3351 23 hours Femur marrow cell slide preparation 25 5.22 0.516 0.0_mg/kg_1_1_3353 23 hours Femur marrow cell slide preparation 25 6.65 0.503 0.0_mg/kg_1_1_3354 23 hours Femur marrow cell slide preparation 25 4.88 0.518 0.0_mg/kg_1_1_3355 23 hours Femur marrow cell slide preparation 25 4.98 0.487 75.0_mg/kg_1_2 23 hours Femur marrow cell slide preparation 4 4.84 0.603 0.2227 75.0_mg/kg_1_2_3321 23 hours Femur marrow cell slide preparation 25 3.11 0.434 75.0_mg/kg_1_2_3322 23 hours Femur marrow cell slide preparation 25 5.94 0.611 75.0_mg/kg_1_2_3323 23 hours Femur marrow cell slide preparation 25 5.14 0.470 75.0_mg/kg_1_2_3324 23 hours Femur marrow cell slide preparation 25 5.13 0.469 150.0_mg/kg_1_3 23 hours Femur marrow cell slide preparation 4 4.08 0.333 0.0228 150.0_mg/kg_1_3_3326 23 hours Femur marrow cell slide preparation 25 4.29 0.500 150.0_mg/kg_1_3_3327 23 hours Femur marrow cell slide preparation 25 4.92 0.446 150.0_mg/kg_1_3_3328 23 hours Femur marrow cell slide preparation 25 3.72 0.521 150.0_mg/kg_1_3_3329 23 hours Femur marrow cell slide preparation 25 3.41 0.388 300.0_mg/kg_1_4 23 hours Femur marrow cell slide preparation 4 5.18 0.423 0.3404 300.0_mg/kg_1_4_3331 23 hours Femur marrow cell slide preparation 25 6.39 0.615 300.0_mg/kg_1_4_3332 23 hours Femur marrow cell slide preparation 25 5.11 0.539 300.0_mg/kg_1_4_3333 23 hours Femur marrow cell slide preparation 25 4.52 0.411 300.0_mg/kg_1_4_3334 23 hours Femur marrow cell slide preparation 25 4.69 0.444 0.5_mg/kg_1_5 23 hours Femur marrow cell slide preparation 4 9.08 0.669 0.0028 0.5_mg/kg_1_5_3356 23 hours Femur marrow cell slide preparation 25 9.34 0.799 0.5_mg/kg_1_5_3357 23 hours Femur marrow cell slide preparation 25 9.81 0.947 0.5_mg/kg_1_5_3358 23 hours Femur marrow cell slide preparation 25 10.04 0.742 0.5_mg/kg_1_5_3359 23 hours Femur marrow cell slide preparation 25 7.12 0.473 0.0_mg/kg_2_1 23 hours Femur marrow cell slide preparation 4 5.53 0.234 0.0000 0.0_mg/kg_2_1_4176 23 hours Femur marrow cell slide preparation 25 5.05 0.548 0.0_mg/kg_2_1_4177 23 hours Femur marrow cell slide preparation 25 5.82 0.494 0.0_mg/kg_2_1_4178 23 hours Femur marrow cell slide preparation 25 6.02 0.506 0.0_mg/kg_2_1_4179 23 hours Femur marrow cell slide preparation 25 5.21 0.577 75.0_mg/kg_2_2 23 hours Femur marrow cell slide preparation 4 6.23 0.514 0.1385 75.0_mg/kg_2_2_4166 23 hours Femur marrow cell slide preparation 25 6.75 0.505 75.0_mg/kg_2_2_4167 23 hours Femur marrow cell slide preparation 25 5.93 0.528 75.0_mg/kg_2_2_4168 23 hours Femur marrow cell slide preparation 25 7.30 0.727 75.0_mg/kg_2_2_4169 23 hours Femur marrow cell slide preparation 25 4.94 0.379 150.0_mg/kg_2_3 23 hours Femur marrow cell slide preparation 4 4.58 0.606 0.1107 150.0_mg/kg_2_3_4161 23 hours Femur marrow cell slide preparation 25 5.09 0.642 150.0_mg/kg_2_3_4162 23 hours Femur marrow cell slide preparation 25 3.49 0.434 150.0_mg/kg_2_3_4163 23 hours Femur marrow cell slide preparation 25 3.69 0.527 150.0_mg/kg_2_3_4164 23 hours Femur marrow cell slide preparation 25 6.05 0.515 300.0_mg/kg_2_4 23 hours Femur marrow cell slide preparation 4 5.24 0.247 0.2148 300.0_mg/kg_2_4_4156 23 hours Femur marrow cell slide preparation 25 4.80 0.479 300.0_mg/kg_2_4_4157 23 hours Femur marrow cell slide preparation 25 5.86 0.781 300.0_mg/kg_2_4_4158 23 hours Femur marrow cell slide preparation 25 5.40 0.507 300.0_mg/kg_2_4_4159 23 hours Femur marrow cell slide preparation 25 4.89 0.440 0.5_mg/kg_2_5 23 hours Femur marrow cell slide preparation 4 9.29 0.597 0.0023 0.5_mg/kg_2_5_4171 23 hours Femur marrow cell slide preparation 25 10.69 0.665 0.5_mg/kg_2_5_4172 23 hours Femur marrow cell slide preparation 25 9.73 0.763 0.5_mg/kg_2_5_4173 23 hours Femur marrow cell slide preparation 25 7.93 0.572 0.5_mg/kg_2_5_4174 23 hours Femur marrow cell slide preparation 25 8.78 0.639