^STUDY !CHEMICAL_NAME=Acrylamide !STUDY_CONCLUSION=Positive (Nonstandard Protocol) !DEPOSITOR_STUDY_NUMBER=549305_CA !STRESSOR_TYPE=CHEMICAL !INSTITUTION=NTP !STUDY_TITLE=Cytogenetic study of Acrylamide in rodent Chromosome Aberrations Test !STUDY_DESIGN=Parallel !SUBJECT_TYPE=LAB_ANIMAL !OLD_NTP_STUDY_TYPE=ROD_CA !NTP_STUDY_TYPE=Genetic Toxicology - Rodent Cytogenetics !TIME_TYPE=Study !STUDY_VARIABLES=COMPOUND|DOSE|DOSE_UNIT|DOSE_DURATION|DOSE_DURATION_UNIT|TRIAL_RESULT|ASSAY_TRIAL|TREND_TEST_PVALUE|TREATMENT_GROUP_TYPE ^GROUP #GROUP_NAME #COMPARATOR_NAME #IS_CONTROL_GROUP #SUPER_GROUP_NAME #TREATMENT_GROUP_TYPE #DEPOSITOR_NAME #ASSAY_TRIAL #COMPOUND #SAMPLE_TIME #SEX #SPECIES_COMMON_NAME #ORGAN_NAME #STRAIN #DOSE #DOSE_UNIT #DOSE_DURATION #DOSE_DURATION_UNIT #DOSE_FREQUENCY #TRIAL_RESULT #TREND_TEST_PVALUE #START_DATE #CONTROL_SUBSTANCE_NAME $GROUP_NAME $COMPARATOR_NAME $IS_CONTROL_GROUP $SUPER_GROUP_NAME $TREATMENT_GROUP_TYPE $DEPOSITOR_NAME $ASSAY_TRIAL $COMPOUND $SAMPLE_TIME $SEX $SPECIES_COMMON_NAME $ORGAN_NAME $STRAIN $DOSE $DOSE_UNIT $DOSE_DURATION $DOSE_DURATION_UNIT $DOSE_FREQUENCY $TRIAL_RESULT $TREND_TEST_PVALUE $START_DATE $CONTROL_SUBSTANCE_NAME 1 1 1 17 Male Mouse Bone Marrow B6C3F1 17 hour 1/study 0.0033 1985-12-05 0.0_mg/kg_1_1 T 1 Vehicle Control 1 Phosphate Buffered Saline 0.0 mg/kg Phosphate Buffered Saline 40.0_mg/kg_1_2 0.0_mg/kg_1_1 1 Test Chemical 2 Acrylamide 40.0 mg/kg 80.0_mg/kg_1_3 0.0_mg/kg_1_1 1 Test Chemical 3 Acrylamide 80.0 mg/kg 160.0_mg/kg_1_4 0.0_mg/kg_1_1 1 Test Chemical 4 Acrylamide 160.0 mg/kg 1.0_mg/kg_1_5 0.0_mg/kg_1_1 T 1 Positive Control 5 Mitomycin-C 1.0 mg/kg Mitomycin-C ^SUBJECT #PARTICIPANT_DISPLAY_NAME #GROUP_NAME #DEPOSITOR_NAME #ANIMAL_STATUS $PARTICIPANT_DISPLAY_NAME $GROUP_NAME $DEPOSITOR_NAME $ANIMAL_STATUS 0.0_mg/kg_1_1_2864 0.0_mg/kg_1_1 2864 Normal 0.0_mg/kg_1_1_2865 0.0_mg/kg_1_1 2865 Normal 0.0_mg/kg_1_1_2872 0.0_mg/kg_1_1 2872 Normal 0.0_mg/kg_1_1_2877 0.0_mg/kg_1_1 2877 Normal 0.0_mg/kg_1_1_2880 0.0_mg/kg_1_1 2880 Normal 0.0_mg/kg_1_1_2884 0.0_mg/kg_1_1 2884 Normal 0.0_mg/kg_1_1_2895 0.0_mg/kg_1_1 2895 Normal 0.0_mg/kg_1_1_2898 0.0_mg/kg_1_1 2898 Normal 40.0_mg/kg_1_2_2874 40.0_mg/kg_1_2 2874 Normal 40.0_mg/kg_1_2_2881 40.0_mg/kg_1_2 2881 Normal 40.0_mg/kg_1_2_2883 40.0_mg/kg_1_2 2883 Normal 40.0_mg/kg_1_2_2893 40.0_mg/kg_1_2 2893 Normal 40.0_mg/kg_1_2_2901 40.0_mg/kg_1_2 2901 Normal 40.0_mg/kg_1_2_2905 40.0_mg/kg_1_2 2905 Normal 40.0_mg/kg_1_2_2906 40.0_mg/kg_1_2 2906 Normal 80.0_mg/kg_1_3_2861 80.0_mg/kg_1_3 2861 Normal 80.0_mg/kg_1_3_2875 80.0_mg/kg_1_3 2875 Normal 80.0_mg/kg_1_3_2878 80.0_mg/kg_1_3 2878 Normal 80.0_mg/kg_1_3_2897 80.0_mg/kg_1_3 2897 Normal 80.0_mg/kg_1_3_2900 80.0_mg/kg_1_3 2900 Normal 80.0_mg/kg_1_3_2904 80.0_mg/kg_1_3 2904 Normal 80.0_mg/kg_1_3_2908 80.0_mg/kg_1_3 2908 Normal 160.0_mg/kg_1_4_2863 160.0_mg/kg_1_4 2863 Normal 160.0_mg/kg_1_4_2867 160.0_mg/kg_1_4 2867 Normal 160.0_mg/kg_1_4_2870 160.0_mg/kg_1_4 2870 Normal 160.0_mg/kg_1_4_2876 160.0_mg/kg_1_4 2876 Normal 160.0_mg/kg_1_4_2885 160.0_mg/kg_1_4 2885 Normal 160.0_mg/kg_1_4_2887 160.0_mg/kg_1_4 2887 Normal 160.0_mg/kg_1_4_2891 160.0_mg/kg_1_4 2891 Normal 160.0_mg/kg_1_4_2907 160.0_mg/kg_1_4 2907 Normal 1.0_mg/kg_1_5_2862 1.0_mg/kg_1_5 2862 Normal 1.0_mg/kg_1_5_2866 1.0_mg/kg_1_5 2866 Normal 1.0_mg/kg_1_5_2873 1.0_mg/kg_1_5 2873 Normal 1.0_mg/kg_1_5_2879 1.0_mg/kg_1_5 2879 Normal 1.0_mg/kg_1_5_2886 1.0_mg/kg_1_5 2886 Normal 1.0_mg/kg_1_5_2890 1.0_mg/kg_1_5 2890 Normal 1.0_mg/kg_1_5_2896 1.0_mg/kg_1_5 2896 Normal 1.0_mg/kg_1_5_2902 1.0_mg/kg_1_5 2902 Normal ^STRESSOR_PROTOCOL=CHEM_STRESSOR_PROTOCOL #PROTOCOL_DISPLAY_NAME #PROTOCOL_DESC #STRESSOR_NAME #ROUTE_ADMIN #DOSE_PER_ADMIN #DOSE_PER_ADMIN_UNIT #DOSE_FREQUENCY #DOSE_FREQUENCY_UNIT #VEHICLE_NAME #IS_POSITIVE_CONTROL #IS_VEHICLE_CONTROL #IS_LABEL $PROTOCOL_DISPLAY_NAME $PROTOCOL_DESC $STRESSOR_NAME $ROUTE_ADMIN $DOSE_PER_ADMIN $DOSE_PER_ADMIN_UNIT $DOSE_FREQUENCY $DOSE_FREQUENCY_UNIT $VEHICLE_NAME $IS_POSITIVE_CONTROL $IS_VEHICLE_CONTROL $IS_LABEL Acrylamide_160.0_mg/kg Acrylamide Intraperitoneal Injection 160.0 mg/kg 1 per study Phosphate Buffered Saline Acrylamide_40.0_mg/kg Acrylamide Intraperitoneal Injection 40.0 mg/kg 1 per study Phosphate Buffered Saline Acrylamide_80.0_mg/kg Acrylamide Intraperitoneal Injection 80.0 mg/kg 1 per study Phosphate Buffered Saline Mitomycin-C_1.0_mg/kg Mitomycin-C Intraperitoneal Injection 1.0 mg/kg 1 per study Phosphate Buffered Saline T Phosphate Buffered Saline_0.0_mg/kg No Stressor Intraperitoneal Injection 0.0 mg/kg 1 per study Phosphate Buffered Saline T BrdUrd tablet implant BrdUrd subcutaneously implanted 1 per study T colchicine injection colchicine IP injection 1 per study T ^DISPOSITION=EUTHANASIA_PROTOCOL #PROTOCOL_DISPLAY_NAME $PROTOCOL_DISPLAY_NAME Common euthanasia protocol ^PREPARATION=LAB_ANIMAL_PREPARATION_PROTOCOL #PROTOCOL_DISPLAY_NAME #PROTOCOL_DESC #IS_TERMINAL #ORGAN #SPECIMEN_TYPE $PROTOCOL_DISPLAY_NAME $PROTOCOL_DESC $IS_TERMINAL $ORGAN $SPECIMEN_TYPE Femur marrow cell slide preparation One or both femurs were removed and the marrow was flushed out with phosphate-buffered saline (pH 7.0). The cells were treated with a hypotonic salt solution, fixed, and dropped onto chilled slides. After a 24 hour drying period, the slides were stained using fluorescence-plus-Giemsa and scored. T Bone marrow Cell ^TIMELINE #TIME_IN_STUDY #TIME_IN_STUDY_UNIT #GROUP_NAME #PROTOCOL_DISPLAY_NAME $TIME_IN_STUDY $TIME_IN_STUDY_UNIT $GROUP_NAME $PROTOCOL_DISPLAY_NAME 0 hour 0.0_mg/kg_1_1 Phosphate Buffered Saline_0.0_mg/kg -1 hour 0.0_mg/kg_1_1 BrdUrd tablet implant 15 hour 0.0_mg/kg_1_1 colchicine injection 17 hour 0.0_mg/kg_1_1 Common euthanasia protocol 0 hour 40.0_mg/kg_1_2 Acrylamide_40.0_mg/kg -1 hour 40.0_mg/kg_1_2 BrdUrd tablet implant 15 hour 40.0_mg/kg_1_2 colchicine injection 17 hour 40.0_mg/kg_1_2 Common euthanasia protocol 0 hour 80.0_mg/kg_1_3 Acrylamide_80.0_mg/kg -1 hour 80.0_mg/kg_1_3 BrdUrd tablet implant 15 hour 80.0_mg/kg_1_3 colchicine injection 17 hour 80.0_mg/kg_1_3 Common euthanasia protocol 0 hour 160.0_mg/kg_1_4 Acrylamide_160.0_mg/kg -1 hour 160.0_mg/kg_1_4 BrdUrd tablet implant 15 hour 160.0_mg/kg_1_4 colchicine injection 17 hour 160.0_mg/kg_1_4 Common euthanasia protocol 0 hour 1.0_mg/kg_1_5 Mitomycin-C_1.0_mg/kg -1 hour 1.0_mg/kg_1_5 BrdUrd tablet implant 15 hour 1.0_mg/kg_1_5 colchicine injection 17 hour 1.0_mg/kg_1_5 Common euthanasia protocol ^ASSAY=GENETOX #PARTICIPANT_DISPLAY_NAME #STUDY_TIME #STUDY_TIME_UNIT #PROTOCOL_NAME #CA_TOTAL_CELLS_EXAMINED #CA_CHROMATID_BREAK_NUMBER #CA_CHROMATID_GAP_NUMBER #CA_ISOCHROMATID_BREAK_NUMBER #CA_ISOCHROMATID_GAP_NUMBER #CA_CHROMATID_EXCHANGE_NUMBER #CA_CHROMOSOME_EXCHANGE_NUMBER #CA_OTHER_EXCHANGE_NUMBER #CA_PER_CELL_PLUS_GAP_NUMBER #CA_PER_CELL_MINUS_GAP_NUMBER #CA_PERCENT_CELL_PLUS_GAP_NUMBER #CA_PERCENT_CELL_MINUS_GAP_NUMBER #CA_TOTAL_ABERRATION #ANIMALS_EXAMINED #CA_CHROMATID_BREAK_NUMBER[MEAN] #CA_CHROMATID_GAP_NUMBER[MEAN] #CA_ISOCHROMATID_BREAK_NUMBER[MEAN] #CA_ISOCHROMATID_GAP_NUMBER[MEAN] #CA_CHROMATID_EXCHANGE_NUMBER[MEAN] #CA_CHROMOSOME_EXCHANGE_NUMBER[MEAN] #CA_OTHER_EXCHANGE_NUMBER[MEAN] #CA_PER_CELL_PLUS_GAP_NUMBER[MEAN] #CA_PER_CELL_PLUS_GAP_NUMBER[SEM] #CA_PER_CELL_MINUS_GAP_NUMBER[MEAN] #CA_PER_CELL_MINUS_GAP_NUMBER[SEM] #CA_PERCENT_CELL_PLUS_GAP_NUMBER[MEAN] #CA_PERCENT_CELL_PLUS_GAP_NUMBER[SEM] #CA_PERCENT_CELL_MINUS_GAP_NUMBER[MEAN] #CA_PERCENT_CELL_MINUS_GAP_NUMBER[SEM] #CA_TOTAL_ABERRATION[MEAN] #CA_PERCENT_CELL_MINUS_GAP_NUMBER[PAIRWISE_PVALUE] #CA_PERCENT_CELL_MINUS_GAP_NUMBER[TREND_PVALUE] $PARTICIPANT_DISPLAY_NAME $STUDY_TIME $STUDY_TIME_UNIT $PROTOCOL_NAME $CA_TOTAL_CELLS_EXAMINED $CA_CHROMATID_BREAK_NUMBER $CA_CHROMATID_GAP_NUMBER $CA_ISOCHROMATID_BREAK_NUMBER $CA_ISOCHROMATID_GAP_NUMBER $CA_CHROMATID_EXCHANGE_NUMBER $CA_CHROMOSOME_EXCHANGE_NUMBER $CA_OTHER_EXCHANGE_NUMBER $CA_PER_CELL_PLUS_GAP_NUMBER $CA_PER_CELL_MINUS_GAP_NUMBER $CA_PERCENT_CELL_PLUS_GAP_NUMBER $CA_PERCENT_CELL_MINUS_GAP_NUMBER $CA_TOTAL_ABERRATION $ANIMALS_EXAMINED $CA_CHROMATID_BREAK_NUMBER[MEAN] $CA_CHROMATID_GAP_NUMBER[MEAN] $CA_ISOCHROMATID_BREAK_NUMBER[MEAN] $CA_ISOCHROMATID_GAP_NUMBER[MEAN] $CA_CHROMATID_EXCHANGE_NUMBER[MEAN] $CA_CHROMOSOME_EXCHANGE_NUMBER[MEAN] $CA_OTHER_EXCHANGE_NUMBER[MEAN] $CA_PER_CELL_PLUS_GAP_NUMBER[MEAN] $CA_PER_CELL_PLUS_GAP_NUMBER[SEM] $CA_PER_CELL_MINUS_GAP_NUMBER[MEAN] $CA_PER_CELL_MINUS_GAP_NUMBER[SEM] $CA_PERCENT_CELL_PLUS_GAP_NUMBER[MEAN] $CA_PERCENT_CELL_PLUS_GAP_NUMBER[SEM] $CA_PERCENT_CELL_MINUS_GAP_NUMBER[MEAN] $CA_PERCENT_CELL_MINUS_GAP_NUMBER[SEM] $CA_TOTAL_ABERRATION[MEAN] $CA_PERCENT_CELL_MINUS_GAP_NUMBER[PAIRWISE_PVALUE] $CA_PERCENT_CELL_MINUS_GAP_NUMBER[TREND_PVALUE] 1 17 hours Femur marrow cell slide preparation 0.0033 0.0_mg/kg_1_1 17 hours Femur marrow cell slide preparation 8 0.5 0.6 0.0 0.0 0.0 0.0 0.1 0.03 0.01 0.01 0.01 2.00 1.00 1.00 0.53 1.3 0.0000 0.0_mg/kg_1_1_2864 17 hours Femur marrow cell slide preparation 50 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00 0 0.0_mg/kg_1_1_2865 17 hours Femur marrow cell slide preparation 50 0 0 0 0 0 0 1 0.02 0.02 0.00 0.00 1 0.0_mg/kg_1_1_2872 17 hours Femur marrow cell slide preparation 50 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00 0 0.0_mg/kg_1_1_2877 17 hours Femur marrow cell slide preparation 50 2 3 0 0 0 0 0 0.10 0.04 8.00 4.00 5 0.0_mg/kg_1_1_2880 17 hours Femur marrow cell slide preparation 50 1 1 0 0 0 0 0 0.04 0.02 4.00 2.00 2 0.0_mg/kg_1_1_2884 17 hours Femur marrow cell slide preparation 50 1 0 0 0 0 0 0 0.02 0.02 2.00 2.00 1 0.0_mg/kg_1_1_2895 17 hours Femur marrow cell slide preparation 50 0 1 0 0 0 0 0 0.02 0.00 2.00 0.00 1 0.0_mg/kg_1_1_2898 17 hours Femur marrow cell slide preparation 50 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00 0 40.0_mg/kg_1_2 17 hours Femur marrow cell slide preparation 7 1.4 1.1 0.0 0.0 0.0 0.0 0.3 0.06 0.03 0.03 0.02 4.29 1.77 2.86 1.22 2.9 0.0304 40.0_mg/kg_1_2_2874 17 hours Femur marrow cell slide preparation 50 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00 0 40.0_mg/kg_1_2_2881 17 hours Femur marrow cell slide preparation 50 3 0 0 0 0 0 1 0.08 0.08 6.00 6.00 4 40.0_mg/kg_1_2_2883 17 hours Femur marrow cell slide preparation 50 4 4 0 0 0 0 1 0.18 0.10 12.00 8.00 9 40.0_mg/kg_1_2_2893 17 hours Femur marrow cell slide preparation 50 1 1 0 0 0 0 0 0.04 0.02 4.00 2.00 2 40.0_mg/kg_1_2_2901 17 hours Femur marrow cell slide preparation 50 2 3 0 0 0 0 0 0.10 0.04 8.00 4.00 5 40.0_mg/kg_1_2_2905 17 hours Femur marrow cell slide preparation 50 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00 0 40.0_mg/kg_1_2_2906 17 hours Femur marrow cell slide preparation 50 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00 0 80.0_mg/kg_1_3 17 hours Femur marrow cell slide preparation 7 0.6 1.0 0.0 0.0 0.0 0.0 0.3 0.04 0.01 0.02 0.01 2.86 0.96 1.14 0.59 1.9 0.4247 80.0_mg/kg_1_3_2861 17 hours Femur marrow cell slide preparation 50 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00 0 80.0_mg/kg_1_3_2875 17 hours Femur marrow cell slide preparation 50 1 2 0 0 0 0 0 0.06 0.02 6.00 2.00 3 80.0_mg/kg_1_3_2878 17 hours Femur marrow cell slide preparation 50 0 1 0 0 0 0 1 0.04 0.02 2.00 0.00 2 80.0_mg/kg_1_3_2897 17 hours Femur marrow cell slide preparation 50 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00 0 80.0_mg/kg_1_3_2900 17 hours Femur marrow cell slide preparation 50 2 2 0 0 0 0 0 0.08 0.04 6.00 4.00 4 80.0_mg/kg_1_3_2904 17 hours Femur marrow cell slide preparation 50 0 2 0 0 0 0 0 0.04 0.00 4.00 0.00 2 80.0_mg/kg_1_3_2908 17 hours Femur marrow cell slide preparation 50 1 0 0 0 0 0 1 0.04 0.04 2.00 2.00 2 160.0_mg/kg_1_4 17 hours Femur marrow cell slide preparation 8 1.6 0.5 0.0 0.0 0.0 0.0 0.4 0.05 0.01 0.04 0.01 5.00 0.85 4.25 1.03 2.5 0.0020 160.0_mg/kg_1_4_2863 17 hours Femur marrow cell slide preparation 50 4 0 0 0 0 0 0 0.08 0.08 8.00 8.00 4 160.0_mg/kg_1_4_2867 17 hours Femur marrow cell slide preparation 50 0 2 0 0 0 0 0 0.04 0.00 4.00 0.00 2 160.0_mg/kg_1_4_2870 17 hours Femur marrow cell slide preparation 50 2 0 0 0 0 0 1 0.06 0.06 6.00 6.00 3 160.0_mg/kg_1_4_2876 17 hours Femur marrow cell slide preparation 50 2 0 0 0 0 0 0 0.04 0.04 4.00 4.00 2 160.0_mg/kg_1_4_2885 17 hours Femur marrow cell slide preparation 50 1 0 0 0 0 0 0 0.02 0.02 2.00 2.00 1 160.0_mg/kg_1_4_2887 17 hours Femur marrow cell slide preparation 50 1 2 0 0 0 0 0 0.06 0.02 6.00 4.00 3 160.0_mg/kg_1_4_2891 17 hours Femur marrow cell slide preparation 50 2 0 0 0 0 0 2 0.08 0.08 8.00 8.00 4 160.0_mg/kg_1_4_2907 17 hours Femur marrow cell slide preparation 50 1 0 0 0 0 0 0 0.02 0.02 2.00 2.00 1 1.0_mg/kg_1_5 17 hours Femur marrow cell slide preparation 8 3.3 1.4 0.3 0.0 0.0 0.0 0.4 0.11 0.02 0.08 0.01 8.50 1.72 6.50 1.18 5.3 0.0000 1.0_mg/kg_1_5_2862 17 hours Femur marrow cell slide preparation 50 3 0 1 0 0 0 0 0.08 0.08 8.00 8.00 4 1.0_mg/kg_1_5_2866 17 hours Femur marrow cell slide preparation 50 2 0 0 0 0 0 1 0.06 0.06 4.00 4.00 3 1.0_mg/kg_1_5_2873 17 hours Femur marrow cell slide preparation 50 2 1 0 0 0 0 0 0.06 0.04 2.00 2.00 3 1.0_mg/kg_1_5_2879 17 hours Femur marrow cell slide preparation 50 1 1 0 0 0 0 0 0.04 0.02 4.00 2.00 2 1.0_mg/kg_1_5_2886 17 hours Femur marrow cell slide preparation 50 4 1 1 0 0 0 1 0.14 0.12 12.00 10.00 7 1.0_mg/kg_1_5_2890 17 hours Femur marrow cell slide preparation 50 4 2 0 0 0 0 0 0.12 0.08 10.00 8.00 6 1.0_mg/kg_1_5_2896 17 hours Femur marrow cell slide preparation 50 6 4 0 0 0 0 0 0.20 0.12 16.00 10.00 10 1.0_mg/kg_1_5_2902 17 hours Femur marrow cell slide preparation 50 4 2 0 0 0 0 1 0.14 0.10 12.00 8.00 7