^STUDY !CHEMICAL_NAME=Acrylamide !STUDY_CONCLUSION=Positive !DEPOSITOR_STUDY_NUMBER=549305_SCE !STRESSOR_TYPE=CHEMICAL !INSTITUTION=NTP !STUDY_TITLE=Cytogenetic study of Acrylamide in rodent Sister Chromatid Exchange Test !STUDY_DESIGN=Parallel !SUBJECT_TYPE=LAB_ANIMAL !OLD_NTP_STUDY_TYPE=ROD_SCE !NTP_STUDY_TYPE=Genetic Toxicology - Rodent Cytogenetics !TIME_TYPE=Study !STUDY_VARIABLES=COMPOUND|DOSE|DOSE_UNIT|DOSE_DURATION|DOSE_DURATION_UNIT|TRIAL_RESULT|ASSAY_TRIAL|TREND_TEST_PVALUE|TREATMENT_GROUP_TYPE ^GROUP #GROUP_NAME #COMPARATOR_NAME #IS_CONTROL_GROUP #SUPER_GROUP_NAME #TREATMENT_GROUP_TYPE #DEPOSITOR_NAME #ASSAY_TRIAL #COMPOUND #SAMPLE_TIME #SEX #SPECIES_COMMON_NAME #ORGAN_NAME #STRAIN #DOSE #DOSE_UNIT #DOSE_DURATION #DOSE_DURATION_UNIT #DOSE_FREQUENCY #TRIAL_RESULT #TREND_TEST_PVALUE #START_DATE #CONTROL_SUBSTANCE_NAME $GROUP_NAME $COMPARATOR_NAME $IS_CONTROL_GROUP $SUPER_GROUP_NAME $TREATMENT_GROUP_TYPE $DEPOSITOR_NAME $ASSAY_TRIAL $COMPOUND $SAMPLE_TIME $SEX $SPECIES_COMMON_NAME $ORGAN_NAME $STRAIN $DOSE $DOSE_UNIT $DOSE_DURATION $DOSE_DURATION_UNIT $DOSE_FREQUENCY $TRIAL_RESULT $TREND_TEST_PVALUE $START_DATE $CONTROL_SUBSTANCE_NAME 1 1 1 23 Male Mouse Bone Marrow B6C3F1 23 hour 1/study Positive 1985-11-14 0.0_mg/kg_1_1 T 1 Vehicle Control 1 Phosphate Buffered Saline 0.0 mg/kg Phosphate Buffered Saline 40.0_mg/kg_1_2 0.0_mg/kg_1_1 1 Test Chemical 2 Acrylamide 40.0 mg/kg 80.0_mg/kg_1_3 0.0_mg/kg_1_1 1 Test Chemical 3 Acrylamide 80.0 mg/kg 160.0_mg/kg_1_4 0.0_mg/kg_1_1 1 Test Chemical 4 Acrylamide 160.0 mg/kg 0.5_mg/kg_1_5 0.0_mg/kg_1_1 T 1 Positive Control 5 Mitomycin-C 0.5 mg/kg Mitomycin-C 2 2 2 42 Male Mouse Bone Marrow B6C3F1 42 hour 1/study Positive 1987-08-18 0.0_mg/kg_2_1 T 2 Vehicle Control 1 Phosphate Buffered Saline 0.0 mg/kg Phosphate Buffered Saline 40.0_mg/kg_2_2 0.0_mg/kg_2_1 2 Test Chemical 2 Acrylamide 40.0 mg/kg 80.0_mg/kg_2_3 0.0_mg/kg_2_1 2 Test Chemical 3 Acrylamide 80.0 mg/kg 160.0_mg/kg_2_4 0.0_mg/kg_2_1 2 Test Chemical 4 Acrylamide 160.0 mg/kg 0.5_mg/kg_2_5 0.0_mg/kg_2_1 T 2 Positive Control 5 Mitomycin-C 0.5 mg/kg Mitomycin-C ^SUBJECT #PARTICIPANT_DISPLAY_NAME #GROUP_NAME #DEPOSITOR_NAME #ANIMAL_STATUS $PARTICIPANT_DISPLAY_NAME $GROUP_NAME $DEPOSITOR_NAME $ANIMAL_STATUS 0.0_mg/kg_1_1_2842 0.0_mg/kg_1_1 2842 Normal 0.0_mg/kg_1_1_2846 0.0_mg/kg_1_1 2846 Normal 0.0_mg/kg_1_1_2850 0.0_mg/kg_1_1 2850 Normal 0.0_mg/kg_1_1_2856 0.0_mg/kg_1_1 2856 Normal 40.0_mg/kg_1_2_2832 40.0_mg/kg_1_2 2832 Normal 40.0_mg/kg_1_2_2839 40.0_mg/kg_1_2 2839 Normal 40.0_mg/kg_1_2_2852 40.0_mg/kg_1_2 2852 Normal 40.0_mg/kg_1_2_2858 40.0_mg/kg_1_2 2858 Normal 80.0_mg/kg_1_3_2833 80.0_mg/kg_1_3 2833 Normal 80.0_mg/kg_1_3_2843 80.0_mg/kg_1_3 2843 Normal 80.0_mg/kg_1_3_2848 80.0_mg/kg_1_3 2848 Normal 80.0_mg/kg_1_3_2853 80.0_mg/kg_1_3 2853 Normal 160.0_mg/kg_1_4_2836 160.0_mg/kg_1_4 2836 Normal 160.0_mg/kg_1_4_2837 160.0_mg/kg_1_4 2837 Normal 160.0_mg/kg_1_4_2855 160.0_mg/kg_1_4 2855 Normal 160.0_mg/kg_1_4_2860 160.0_mg/kg_1_4 2860 Normal 0.5_mg/kg_1_5_2831 0.5_mg/kg_1_5 2831 Normal 0.5_mg/kg_1_5_2835 0.5_mg/kg_1_5 2835 Normal 0.5_mg/kg_1_5_2841 0.5_mg/kg_1_5 2841 Normal 0.5_mg/kg_1_5_2849 0.5_mg/kg_1_5 2849 Normal 0.0_mg/kg_2_1_5965 0.0_mg/kg_2_1 5965 Normal 0.0_mg/kg_2_1_5978 0.0_mg/kg_2_1 5978 Normal 0.0_mg/kg_2_1_5992 0.0_mg/kg_2_1 5992 Normal 40.0_mg/kg_2_2_5966 40.0_mg/kg_2_2 5966 Normal 40.0_mg/kg_2_2_5982 40.0_mg/kg_2_2 5982 Normal 40.0_mg/kg_2_2_6006 40.0_mg/kg_2_2 6006 Normal 40.0_mg/kg_2_2_6018 40.0_mg/kg_2_2 6018 Normal 80.0_mg/kg_2_3_5956 80.0_mg/kg_2_3 5956 Normal 80.0_mg/kg_2_3_5957 80.0_mg/kg_2_3 5957 Normal 80.0_mg/kg_2_3_6008 80.0_mg/kg_2_3 6008 Normal 80.0_mg/kg_2_3_6020 80.0_mg/kg_2_3 6020 Normal 160.0_mg/kg_2_4_5948 160.0_mg/kg_2_4 5948 Normal 160.0_mg/kg_2_4_5985 160.0_mg/kg_2_4 5985 Normal 160.0_mg/kg_2_4_6016 160.0_mg/kg_2_4 6016 Normal 0.5_mg/kg_2_5_5946 0.5_mg/kg_2_5 5946 Normal 0.5_mg/kg_2_5_5975 0.5_mg/kg_2_5 5975 Normal 0.5_mg/kg_2_5_6000 0.5_mg/kg_2_5 6000 Normal 0.5_mg/kg_2_5_6017 0.5_mg/kg_2_5 6017 Normal ^STRESSOR_PROTOCOL=CHEM_STRESSOR_PROTOCOL #PROTOCOL_DISPLAY_NAME #PROTOCOL_DESC #STRESSOR_NAME #ROUTE_ADMIN #DOSE_PER_ADMIN #DOSE_PER_ADMIN_UNIT #DOSE_FREQUENCY #DOSE_FREQUENCY_UNIT #VEHICLE_NAME #IS_POSITIVE_CONTROL #IS_VEHICLE_CONTROL #IS_LABEL $PROTOCOL_DISPLAY_NAME $PROTOCOL_DESC $STRESSOR_NAME $ROUTE_ADMIN $DOSE_PER_ADMIN $DOSE_PER_ADMIN_UNIT $DOSE_FREQUENCY $DOSE_FREQUENCY_UNIT $VEHICLE_NAME $IS_POSITIVE_CONTROL $IS_VEHICLE_CONTROL $IS_LABEL Acrylamide_160.0_mg/kg Acrylamide Intraperitoneal Injection 160.0 mg/kg 1 per study Phosphate Buffered Saline Acrylamide_40.0_mg/kg Acrylamide Intraperitoneal Injection 40.0 mg/kg 1 per study Phosphate Buffered Saline Mitomycin-C_0.5_mg/kg Mitomycin-C Intraperitoneal Injection 0.5 mg/kg 1 per study Phosphate Buffered Saline T Acrylamide_80.0_mg/kg Acrylamide Intraperitoneal Injection 80.0 mg/kg 1 per study Phosphate Buffered Saline Phosphate Buffered Saline_0.0_mg/kg No Stressor Intraperitoneal Injection 0.0 mg/kg 1 per study Phosphate Buffered Saline T BrdUrd tablet implant BrdUrd subcutaneously implanted 1 per study T colchicine injection colchicine IP injection 1 per study T ^DISPOSITION=EUTHANASIA_PROTOCOL #PROTOCOL_DISPLAY_NAME $PROTOCOL_DISPLAY_NAME Common euthanasia protocol ^PREPARATION=LAB_ANIMAL_PREPARATION_PROTOCOL #PROTOCOL_DISPLAY_NAME #PROTOCOL_DESC #IS_TERMINAL #ORGAN #SPECIMEN_TYPE $PROTOCOL_DISPLAY_NAME $PROTOCOL_DESC $IS_TERMINAL $ORGAN $SPECIMEN_TYPE Femur marrow cell slide preparation One or both femurs were removed and the marrow was flushed out with phosphate-buffered saline (pH 7.0). The cells were treated with a hypotonic salt solution, fixed, and dropped onto chilled slides. After a 24 hour drying period, the slides were stained using fluorescence-plus-Giemsa and scored. T Bone marrow Cell ^TIMELINE #TIME_IN_STUDY #TIME_IN_STUDY_UNIT #GROUP_NAME #PROTOCOL_DISPLAY_NAME $TIME_IN_STUDY $TIME_IN_STUDY_UNIT $GROUP_NAME $PROTOCOL_DISPLAY_NAME 0 hour 0.0_mg/kg_1_1 Phosphate Buffered Saline_0.0_mg/kg -1 hour 0.0_mg/kg_1_1 BrdUrd tablet implant 21 hour 0.0_mg/kg_1_1 colchicine injection 23 hour 0.0_mg/kg_1_1 Common euthanasia protocol 0 hour 40.0_mg/kg_1_2 Acrylamide_40.0_mg/kg -1 hour 40.0_mg/kg_1_2 BrdUrd tablet implant 21 hour 40.0_mg/kg_1_2 colchicine injection 23 hour 40.0_mg/kg_1_2 Common euthanasia protocol 0 hour 80.0_mg/kg_1_3 Acrylamide_80.0_mg/kg -1 hour 80.0_mg/kg_1_3 BrdUrd tablet implant 21 hour 80.0_mg/kg_1_3 colchicine injection 23 hour 80.0_mg/kg_1_3 Common euthanasia protocol 0 hour 160.0_mg/kg_1_4 Acrylamide_160.0_mg/kg -1 hour 160.0_mg/kg_1_4 BrdUrd tablet implant 21 hour 160.0_mg/kg_1_4 colchicine injection 23 hour 160.0_mg/kg_1_4 Common euthanasia protocol 0 hour 0.5_mg/kg_1_5 Mitomycin-C_0.5_mg/kg -1 hour 0.5_mg/kg_1_5 BrdUrd tablet implant 21 hour 0.5_mg/kg_1_5 colchicine injection 23 hour 0.5_mg/kg_1_5 Common euthanasia protocol 0 hour 0.0_mg/kg_2_1 Phosphate Buffered Saline_0.0_mg/kg 18 hour 0.0_mg/kg_2_1 BrdUrd tablet implant 40 hour 0.0_mg/kg_2_1 colchicine injection 42 hour 0.0_mg/kg_2_1 Common euthanasia protocol 0 hour 40.0_mg/kg_2_2 Acrylamide_40.0_mg/kg 18 hour 40.0_mg/kg_2_2 BrdUrd tablet implant 40 hour 40.0_mg/kg_2_2 colchicine injection 42 hour 40.0_mg/kg_2_2 Common euthanasia protocol 0 hour 80.0_mg/kg_2_3 Acrylamide_80.0_mg/kg 18 hour 80.0_mg/kg_2_3 BrdUrd tablet implant 40 hour 80.0_mg/kg_2_3 colchicine injection 42 hour 80.0_mg/kg_2_3 Common euthanasia protocol 0 hour 160.0_mg/kg_2_4 Acrylamide_160.0_mg/kg 18 hour 160.0_mg/kg_2_4 BrdUrd tablet implant 40 hour 160.0_mg/kg_2_4 colchicine injection 42 hour 160.0_mg/kg_2_4 Common euthanasia protocol 0 hour 0.5_mg/kg_2_5 Mitomycin-C_0.5_mg/kg 18 hour 0.5_mg/kg_2_5 BrdUrd tablet implant 40 hour 0.5_mg/kg_2_5 colchicine injection 42 hour 0.5_mg/kg_2_5 Common euthanasia protocol ^ASSAY=GENETOX #PARTICIPANT_DISPLAY_NAME #STUDY_TIME #STUDY_TIME_UNIT #PROTOCOL_NAME #ANIMALS_EXAMINED #SCE_PER_CELL_MEAN[MEAN] #SCE_CELLS_EXAMINED #SCE_PER_CELL_MEAN #SCE_PER_CELL_MEAN[SEM] #SCE_PER_CELL_MEAN[PAIRWISE_PVALUE] #SCE_PER_CELL_MEAN[TREND_PVALUE] $PARTICIPANT_DISPLAY_NAME $STUDY_TIME $STUDY_TIME_UNIT $PROTOCOL_NAME $ANIMALS_EXAMINED $SCE_PER_CELL_MEAN[MEAN] $SCE_CELLS_EXAMINED $SCE_PER_CELL_MEAN $SCE_PER_CELL_MEAN[SEM] $SCE_PER_CELL_MEAN[PAIRWISE_PVALUE] $SCE_PER_CELL_MEAN[TREND_PVALUE] 0.0_mg/kg_1_1 23 hours Femur marrow cell slide preparation 4 3.93 0.168 0.0000 0.0_mg/kg_1_1_2842 23 hours Femur marrow cell slide preparation 25 3.64 0.293 0.0_mg/kg_1_1_2846 23 hours Femur marrow cell slide preparation 25 4.41 0.524 0.0_mg/kg_1_1_2850 23 hours Femur marrow cell slide preparation 25 3.83 0.361 0.0_mg/kg_1_1_2856 23 hours Femur marrow cell slide preparation 25 3.81 0.461 40.0_mg/kg_1_2 23 hours Femur marrow cell slide preparation 4 8.04 0.691 0.0037 40.0_mg/kg_1_2_2832 23 hours Femur marrow cell slide preparation 25 8.73 0.938 40.0_mg/kg_1_2_2839 23 hours Femur marrow cell slide preparation 25 7.85 0.638 40.0_mg/kg_1_2_2852 23 hours Femur marrow cell slide preparation 25 9.39 0.678 40.0_mg/kg_1_2_2858 23 hours Femur marrow cell slide preparation 25 6.20 0.763 80.0_mg/kg_1_3 23 hours Femur marrow cell slide preparation 4 8.75 0.419 0.0002 80.0_mg/kg_1_3_2833 23 hours Femur marrow cell slide preparation 25 8.04 0.748 80.0_mg/kg_1_3_2843 23 hours Femur marrow cell slide preparation 24 8.79 0.883 80.0_mg/kg_1_3_2848 23 hours Femur marrow cell slide preparation 25 8.25 0.754 80.0_mg/kg_1_3_2853 23 hours Femur marrow cell slide preparation 25 9.92 0.958 160.0_mg/kg_1_4 23 hours Femur marrow cell slide preparation 4 13.91 0.570 0.0001 160.0_mg/kg_1_4_2836 23 hours Femur marrow cell slide preparation 25 14.84 1.201 160.0_mg/kg_1_4_2837 23 hours Femur marrow cell slide preparation 25 12.41 0.838 160.0_mg/kg_1_4_2855 23 hours Femur marrow cell slide preparation 25 13.60 1.174 160.0_mg/kg_1_4_2860 23 hours Femur marrow cell slide preparation 25 14.75 0.954 0.5_mg/kg_1_5 23 hours Femur marrow cell slide preparation 4 9.40 0.748 0.0020 0.5_mg/kg_1_5_2831 23 hours Femur marrow cell slide preparation 25 10.46 0.579 0.5_mg/kg_1_5_2835 23 hours Femur marrow cell slide preparation 25 7.29 0.876 0.5_mg/kg_1_5_2841 23 hours Femur marrow cell slide preparation 25 9.37 0.751 0.5_mg/kg_1_5_2849 23 hours Femur marrow cell slide preparation 25 10.46 0.946 0.0_mg/kg_2_1 42 hours Femur marrow cell slide preparation 3 5.17 0.932 0.0000 0.0_mg/kg_2_1_5965 42 hours Femur marrow cell slide preparation 25 3.36 0.347 0.0_mg/kg_2_1_5978 42 hours Femur marrow cell slide preparation 25 6.46 0.654 0.0_mg/kg_2_1_5992 42 hours Femur marrow cell slide preparation 24 5.70 0.570 40.0_mg/kg_2_2 42 hours Femur marrow cell slide preparation 4 6.18 0.834 0.2275 40.0_mg/kg_2_2_5966 42 hours Femur marrow cell slide preparation 25 5.88 0.540 40.0_mg/kg_2_2_5982 42 hours Femur marrow cell slide preparation 26 4.67 0.351 40.0_mg/kg_2_2_6006 42 hours Femur marrow cell slide preparation 25 8.57 1.105 40.0_mg/kg_2_2_6018 42 hours Femur marrow cell slide preparation 25 5.66 0.525 80.0_mg/kg_2_3 42 hours Femur marrow cell slide preparation 4 6.94 0.095 0.1001 80.0_mg/kg_2_3_5956 42 hours Femur marrow cell slide preparation 25 7.18 0.607 80.0_mg/kg_2_3_5957 42 hours Femur marrow cell slide preparation 25 6.95 0.499 80.0_mg/kg_2_3_6008 42 hours Femur marrow cell slide preparation 25 6.79 0.542 80.0_mg/kg_2_3_6020 42 hours Femur marrow cell slide preparation 25 6.78 0.533 160.0_mg/kg_2_4 42 hours Femur marrow cell slide preparation 3 9.42 0.295 0.0176 160.0_mg/kg_2_4_5948 42 hours Femur marrow cell slide preparation 25 9.14 0.596 160.0_mg/kg_2_4_5985 42 hours Femur marrow cell slide preparation 25 9.11 0.718 160.0_mg/kg_2_4_6016 42 hours Femur marrow cell slide preparation 25 10.01 0.679 0.5_mg/kg_2_5 42 hours Femur marrow cell slide preparation 4 4.00 0.145 0.1658 0.5_mg/kg_2_5_5946 42 hours Femur marrow cell slide preparation 24 4.42 0.421 0.5_mg/kg_2_5_5975 42 hours Femur marrow cell slide preparation 24 3.83 0.360 0.5_mg/kg_2_5_6000 42 hours Femur marrow cell slide preparation 23 3.80 0.477 0.5_mg/kg_2_5_6017 42 hours Femur marrow cell slide preparation 25 3.91 0.345