^STUDY !CHEMICAL_NAME=Melamine !STUDY_CONCLUSION=Positive (Nonstandard Protocol) !DEPOSITOR_STUDY_NUMBER=951364_CA !STRESSOR_TYPE=CHEMICAL !INSTITUTION=NTP !STUDY_TITLE=Cytogenetic study of Melamine in rodent Chromosome Aberrations Test !STUDY_DESIGN=Parallel !SUBJECT_TYPE=LAB_ANIMAL !OLD_NTP_STUDY_TYPE=ROD_CA !NTP_STUDY_TYPE=Genetic Toxicology - Rodent Cytogenetics !TIME_TYPE=Study !STUDY_VARIABLES=COMPOUND|DOSE|DOSE_UNIT|DOSE_DURATION|DOSE_DURATION_UNIT|TRIAL_RESULT|ASSAY_TRIAL|TREND_TEST_PVALUE|TREATMENT_GROUP_TYPE ^GROUP #GROUP_NAME #COMPARATOR_NAME #IS_CONTROL_GROUP #SUPER_GROUP_NAME #TREATMENT_GROUP_TYPE #DEPOSITOR_NAME #ASSAY_TRIAL #COMPOUND #SAMPLE_TIME #SEX #SPECIES_COMMON_NAME #ORGAN_NAME #STRAIN #DOSE #DOSE_UNIT #DOSE_DURATION #DOSE_DURATION_UNIT #DOSE_FREQUENCY #TRIAL_RESULT #TREND_TEST_PVALUE #START_DATE #CONTROL_SUBSTANCE_NAME $GROUP_NAME $COMPARATOR_NAME $IS_CONTROL_GROUP $SUPER_GROUP_NAME $TREATMENT_GROUP_TYPE $DEPOSITOR_NAME $ASSAY_TRIAL $COMPOUND $SAMPLE_TIME $SEX $SPECIES_COMMON_NAME $ORGAN_NAME $STRAIN $DOSE $DOSE_UNIT $DOSE_DURATION $DOSE_DURATION_UNIT $DOSE_FREQUENCY $TRIAL_RESULT $TREND_TEST_PVALUE $START_DATE $CONTROL_SUBSTANCE_NAME 1 1 1 36 Male Mouse Bone Marrow B6C3F1 36 hour 1/study 0.3583 1989-02-07 0.0_mg/kg_1_1 T 1 Vehicle Control 1 Corn Oil 0.0 mg/kg Corn Oil 150.0_mg/kg_1_2 0.0_mg/kg_1_1 1 Test Chemical 2 Melamine 150.0 mg/kg 300.0_mg/kg_1_3 0.0_mg/kg_1_1 1 Test Chemical 3 Melamine 300.0 mg/kg 600.0_mg/kg_1_4 0.0_mg/kg_1_1 1 Test Chemical 4 Melamine 600.0 mg/kg 25.0_mg/kg_1_5 0.0_mg/kg_1_1 T 1 Positive Control 5 Dimethylbenzanthracene 25.0 mg/kg Dimethylbenzanthracene ^SUBJECT #PARTICIPANT_DISPLAY_NAME #GROUP_NAME #DEPOSITOR_NAME #ANIMAL_STATUS $PARTICIPANT_DISPLAY_NAME $GROUP_NAME $DEPOSITOR_NAME $ANIMAL_STATUS 0.0_mg/kg_1_1_11060 0.0_mg/kg_1_1 11060 Normal 0.0_mg/kg_1_1_11069 0.0_mg/kg_1_1 11069 Normal 0.0_mg/kg_1_1_11073 0.0_mg/kg_1_1 11073 Normal 0.0_mg/kg_1_1_11075 0.0_mg/kg_1_1 11075 Normal 0.0_mg/kg_1_1_11082 0.0_mg/kg_1_1 11082 Normal 0.0_mg/kg_1_1_11084 0.0_mg/kg_1_1 11084 Normal 0.0_mg/kg_1_1_11094 0.0_mg/kg_1_1 11094 Normal 0.0_mg/kg_1_1_11096 0.0_mg/kg_1_1 11096 Normal 150.0_mg/kg_1_2_11058 150.0_mg/kg_1_2 11058 Normal 150.0_mg/kg_1_2_11061 150.0_mg/kg_1_2 11061 Normal 150.0_mg/kg_1_2_11064 150.0_mg/kg_1_2 11064 Normal 150.0_mg/kg_1_2_11077 150.0_mg/kg_1_2 11077 Normal 150.0_mg/kg_1_2_11079 150.0_mg/kg_1_2 11079 Normal 150.0_mg/kg_1_2_11088 150.0_mg/kg_1_2 11088 Normal 150.0_mg/kg_1_2_11089 150.0_mg/kg_1_2 11089 Normal 150.0_mg/kg_1_2_11100 150.0_mg/kg_1_2 11100 Normal 300.0_mg/kg_1_3_11057 300.0_mg/kg_1_3 11057 Normal 300.0_mg/kg_1_3_11072 300.0_mg/kg_1_3 11072 Normal 300.0_mg/kg_1_3_11074 300.0_mg/kg_1_3 11074 Normal 300.0_mg/kg_1_3_11081 300.0_mg/kg_1_3 11081 Normal 300.0_mg/kg_1_3_11085 300.0_mg/kg_1_3 11085 Normal 300.0_mg/kg_1_3_11090 300.0_mg/kg_1_3 11090 Normal 300.0_mg/kg_1_3_11092 300.0_mg/kg_1_3 11092 Normal 300.0_mg/kg_1_3_11107 300.0_mg/kg_1_3 11107 Normal 600.0_mg/kg_1_4_11066 600.0_mg/kg_1_4 11066 Normal 600.0_mg/kg_1_4_11067 600.0_mg/kg_1_4 11067 Normal 600.0_mg/kg_1_4_11070 600.0_mg/kg_1_4 11070 Normal 600.0_mg/kg_1_4_11086 600.0_mg/kg_1_4 11086 Normal 600.0_mg/kg_1_4_11091 600.0_mg/kg_1_4 11091 Normal 600.0_mg/kg_1_4_11098 600.0_mg/kg_1_4 11098 Normal 600.0_mg/kg_1_4_11099 600.0_mg/kg_1_4 11099 Normal 600.0_mg/kg_1_4_11108 600.0_mg/kg_1_4 11108 Normal 25.0_mg/kg_1_5_11065 25.0_mg/kg_1_5 11065 Normal 25.0_mg/kg_1_5_11068 25.0_mg/kg_1_5 11068 Normal 25.0_mg/kg_1_5_11076 25.0_mg/kg_1_5 11076 Normal 25.0_mg/kg_1_5_11078 25.0_mg/kg_1_5 11078 Normal 25.0_mg/kg_1_5_11083 25.0_mg/kg_1_5 11083 Normal 25.0_mg/kg_1_5_11095 25.0_mg/kg_1_5 11095 Normal 25.0_mg/kg_1_5_11102 25.0_mg/kg_1_5 11102 Normal 25.0_mg/kg_1_5_11104 25.0_mg/kg_1_5 11104 Normal ^STRESSOR_PROTOCOL=CHEM_STRESSOR_PROTOCOL #PROTOCOL_DISPLAY_NAME #PROTOCOL_DESC #STRESSOR_NAME #ROUTE_ADMIN #DOSE_PER_ADMIN #DOSE_PER_ADMIN_UNIT #DOSE_FREQUENCY #DOSE_FREQUENCY_UNIT #VEHICLE_NAME #IS_POSITIVE_CONTROL #IS_VEHICLE_CONTROL #IS_LABEL $PROTOCOL_DISPLAY_NAME $PROTOCOL_DESC $STRESSOR_NAME $ROUTE_ADMIN $DOSE_PER_ADMIN $DOSE_PER_ADMIN_UNIT $DOSE_FREQUENCY $DOSE_FREQUENCY_UNIT $VEHICLE_NAME $IS_POSITIVE_CONTROL $IS_VEHICLE_CONTROL $IS_LABEL Melamine_300.0_mg/kg Melamine Intraperitoneal Injection 300.0 mg/kg 1 per study Corn Oil Melamine_600.0_mg/kg Melamine Intraperitoneal Injection 600.0 mg/kg 1 per study Corn Oil Corn Oil_0.0_mg/kg No Stressor Intraperitoneal Injection 0.0 mg/kg 1 per study Corn Oil T Dimethylbenzanthracene_25.0_mg/kg Dimethylbenzanthracene Intraperitoneal Injection 25.0 mg/kg 1 per study Corn Oil T Melamine_150.0_mg/kg Melamine Intraperitoneal Injection 150.0 mg/kg 1 per study Corn Oil BrdUrd tablet implant BrdUrd subcutaneously implanted 1 per study T colchicine injection colchicine IP injection 1 per study T ^DISPOSITION=EUTHANASIA_PROTOCOL #PROTOCOL_DISPLAY_NAME $PROTOCOL_DISPLAY_NAME Common euthanasia protocol ^PREPARATION=LAB_ANIMAL_PREPARATION_PROTOCOL #PROTOCOL_DISPLAY_NAME #PROTOCOL_DESC #IS_TERMINAL #ORGAN #SPECIMEN_TYPE $PROTOCOL_DISPLAY_NAME $PROTOCOL_DESC $IS_TERMINAL $ORGAN $SPECIMEN_TYPE Femur marrow cell slide preparation One or both femurs were removed and the marrow was flushed out with phosphate-buffered saline (pH 7.0). The cells were treated with a hypotonic salt solution, fixed, and dropped onto chilled slides. After a 24 hour drying period, the slides were stained using fluorescence-plus-Giemsa and scored. T Bone marrow Cell ^TIMELINE #TIME_IN_STUDY #TIME_IN_STUDY_UNIT #GROUP_NAME #PROTOCOL_DISPLAY_NAME $TIME_IN_STUDY $TIME_IN_STUDY_UNIT $GROUP_NAME $PROTOCOL_DISPLAY_NAME 0 hour 0.0_mg/kg_1_1 Corn Oil_0.0_mg/kg 18 hour 0.0_mg/kg_1_1 BrdUrd tablet implant 34 hour 0.0_mg/kg_1_1 colchicine injection 36 hour 0.0_mg/kg_1_1 Common euthanasia protocol 0 hour 150.0_mg/kg_1_2 Melamine_150.0_mg/kg 18 hour 150.0_mg/kg_1_2 BrdUrd tablet implant 34 hour 150.0_mg/kg_1_2 colchicine injection 36 hour 150.0_mg/kg_1_2 Common euthanasia protocol 0 hour 300.0_mg/kg_1_3 Melamine_300.0_mg/kg 18 hour 300.0_mg/kg_1_3 BrdUrd tablet implant 34 hour 300.0_mg/kg_1_3 colchicine injection 36 hour 300.0_mg/kg_1_3 Common euthanasia protocol 0 hour 600.0_mg/kg_1_4 Melamine_600.0_mg/kg 18 hour 600.0_mg/kg_1_4 BrdUrd tablet implant 34 hour 600.0_mg/kg_1_4 colchicine injection 36 hour 600.0_mg/kg_1_4 Common euthanasia protocol 0 hour 25.0_mg/kg_1_5 Dimethylbenzanthracene_25.0_mg/kg 18 hour 25.0_mg/kg_1_5 BrdUrd tablet implant 34 hour 25.0_mg/kg_1_5 colchicine injection 36 hour 25.0_mg/kg_1_5 Common euthanasia protocol ^ASSAY=GENETOX #PARTICIPANT_DISPLAY_NAME #STUDY_TIME #STUDY_TIME_UNIT #PROTOCOL_NAME #CA_TOTAL_CELLS_EXAMINED #CA_CHROMATID_BREAK_NUMBER #CA_CHROMATID_GAP_NUMBER #CA_ISOCHROMATID_BREAK_NUMBER #CA_ISOCHROMATID_GAP_NUMBER #CA_CHROMATID_EXCHANGE_NUMBER #CA_CHROMOSOME_EXCHANGE_NUMBER #CA_OTHER_EXCHANGE_NUMBER #CA_PER_CELL_PLUS_GAP_NUMBER #CA_PER_CELL_MINUS_GAP_NUMBER #CA_PERCENT_CELL_PLUS_GAP_NUMBER #CA_PERCENT_CELL_MINUS_GAP_NUMBER #CA_TOTAL_ABERRATION #ANIMALS_EXAMINED #CA_CHROMATID_BREAK_NUMBER[MEAN] #CA_CHROMATID_GAP_NUMBER[MEAN] #CA_ISOCHROMATID_BREAK_NUMBER[MEAN] #CA_ISOCHROMATID_GAP_NUMBER[MEAN] #CA_CHROMATID_EXCHANGE_NUMBER[MEAN] #CA_CHROMOSOME_EXCHANGE_NUMBER[MEAN] #CA_OTHER_EXCHANGE_NUMBER[MEAN] #CA_PER_CELL_PLUS_GAP_NUMBER[MEAN] #CA_PER_CELL_PLUS_GAP_NUMBER[SEM] #CA_PER_CELL_MINUS_GAP_NUMBER[MEAN] #CA_PER_CELL_MINUS_GAP_NUMBER[SEM] #CA_PERCENT_CELL_PLUS_GAP_NUMBER[MEAN] #CA_PERCENT_CELL_PLUS_GAP_NUMBER[SEM] #CA_PERCENT_CELL_MINUS_GAP_NUMBER[MEAN] #CA_PERCENT_CELL_MINUS_GAP_NUMBER[SEM] #CA_TOTAL_ABERRATION[MEAN] #CA_PERCENT_CELL_MINUS_GAP_NUMBER[PAIRWISE_PVALUE] #CA_PERCENT_CELL_MINUS_GAP_NUMBER[TREND_PVALUE] $PARTICIPANT_DISPLAY_NAME $STUDY_TIME $STUDY_TIME_UNIT $PROTOCOL_NAME $CA_TOTAL_CELLS_EXAMINED $CA_CHROMATID_BREAK_NUMBER $CA_CHROMATID_GAP_NUMBER $CA_ISOCHROMATID_BREAK_NUMBER $CA_ISOCHROMATID_GAP_NUMBER $CA_CHROMATID_EXCHANGE_NUMBER $CA_CHROMOSOME_EXCHANGE_NUMBER $CA_OTHER_EXCHANGE_NUMBER $CA_PER_CELL_PLUS_GAP_NUMBER $CA_PER_CELL_MINUS_GAP_NUMBER $CA_PERCENT_CELL_PLUS_GAP_NUMBER $CA_PERCENT_CELL_MINUS_GAP_NUMBER $CA_TOTAL_ABERRATION $ANIMALS_EXAMINED $CA_CHROMATID_BREAK_NUMBER[MEAN] $CA_CHROMATID_GAP_NUMBER[MEAN] $CA_ISOCHROMATID_BREAK_NUMBER[MEAN] $CA_ISOCHROMATID_GAP_NUMBER[MEAN] $CA_CHROMATID_EXCHANGE_NUMBER[MEAN] $CA_CHROMOSOME_EXCHANGE_NUMBER[MEAN] $CA_OTHER_EXCHANGE_NUMBER[MEAN] $CA_PER_CELL_PLUS_GAP_NUMBER[MEAN] $CA_PER_CELL_PLUS_GAP_NUMBER[SEM] $CA_PER_CELL_MINUS_GAP_NUMBER[MEAN] $CA_PER_CELL_MINUS_GAP_NUMBER[SEM] $CA_PERCENT_CELL_PLUS_GAP_NUMBER[MEAN] $CA_PERCENT_CELL_PLUS_GAP_NUMBER[SEM] $CA_PERCENT_CELL_MINUS_GAP_NUMBER[MEAN] $CA_PERCENT_CELL_MINUS_GAP_NUMBER[SEM] $CA_TOTAL_ABERRATION[MEAN] $CA_PERCENT_CELL_MINUS_GAP_NUMBER[PAIRWISE_PVALUE] $CA_PERCENT_CELL_MINUS_GAP_NUMBER[TREND_PVALUE] 1 36 hours Femur marrow cell slide preparation 0.3583 0.0_mg/kg_1_1 36 hours Femur marrow cell slide preparation 8 0.4 1.1 0.0 0.0 0.0 0.0 0.1 0.03 0.01 0.01 0.00 3.00 0.85 0.75 0.37 1.6 0.0000 0.0_mg/kg_1_1_11060 36 hours Femur marrow cell slide preparation 50 0 4 0 0 0 0 0 0.08 0.00 8.00 0.00 4 0.0_mg/kg_1_1_11069 36 hours Femur marrow cell slide preparation 50 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00 0 0.0_mg/kg_1_1_11073 36 hours Femur marrow cell slide preparation 50 1 0 0 0 0 0 0 0.02 0.02 2.00 2.00 1 0.0_mg/kg_1_1_11075 36 hours Femur marrow cell slide preparation 50 0 2 0 0 0 0 0 0.04 0.00 4.00 0.00 2 0.0_mg/kg_1_1_11082 36 hours Femur marrow cell slide preparation 50 1 0 0 0 0 0 0 0.02 0.02 2.00 2.00 1 0.0_mg/kg_1_1_11084 36 hours Femur marrow cell slide preparation 50 0 1 0 0 0 0 0 0.02 0.00 2.00 0.00 1 0.0_mg/kg_1_1_11094 36 hours Femur marrow cell slide preparation 50 0 1 0 0 0 0 1 0.04 0.02 2.00 0.00 2 0.0_mg/kg_1_1_11096 36 hours Femur marrow cell slide preparation 50 1 1 0 0 0 0 0 0.04 0.02 4.00 2.00 2 150.0_mg/kg_1_2 36 hours Femur marrow cell slide preparation 8 0.5 1.1 0.0 0.0 0.0 0.0 0.1 0.04 0.01 0.01 0.01 2.75 0.92 1.25 0.75 1.8 0.2386 150.0_mg/kg_1_2_11058 36 hours Femur marrow cell slide preparation 50 0 1 0 0 0 0 0 0.02 0.00 2.00 0.00 1 150.0_mg/kg_1_2_11061 36 hours Femur marrow cell slide preparation 50 0 2 0 0 0 0 0 0.04 0.00 4.00 0.00 2 150.0_mg/kg_1_2_11064 36 hours Femur marrow cell slide preparation 50 1 0 0 0 0 0 0 0.02 0.02 2.00 2.00 1 150.0_mg/kg_1_2_11077 36 hours Femur marrow cell slide preparation 50 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00 0 150.0_mg/kg_1_2_11079 36 hours Femur marrow cell slide preparation 50 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00 0 150.0_mg/kg_1_2_11088 36 hours Femur marrow cell slide preparation 50 0 3 0 0 0 0 0 0.06 0.00 4.00 0.00 3 150.0_mg/kg_1_2_11089 36 hours Femur marrow cell slide preparation 50 2 3 0 0 0 0 1 0.12 0.06 8.00 6.00 6 150.0_mg/kg_1_2_11100 36 hours Femur marrow cell slide preparation 50 1 0 0 0 0 0 0 0.02 0.02 2.00 2.00 1 300.0_mg/kg_1_3 36 hours Femur marrow cell slide preparation 8 1.3 3.5 0.0 0.1 0.0 0.0 0.0 0.10 0.05 0.03 0.01 6.25 2.34 2.50 1.05 4.9 0.0251 300.0_mg/kg_1_3_11057 36 hours Femur marrow cell slide preparation 50 1 4 0 1 0 0 0 0.12 0.02 10.00 2.00 6 300.0_mg/kg_1_3_11072 36 hours Femur marrow cell slide preparation 50 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00 0 300.0_mg/kg_1_3_11074 36 hours Femur marrow cell slide preparation 50 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00 0 300.0_mg/kg_1_3_11081 36 hours Femur marrow cell slide preparation 50 3 3 0 0 0 0 0 0.12 0.06 8.00 6.00 6 300.0_mg/kg_1_3_11085 36 hours Femur marrow cell slide preparation 50 4 17 0 0 0 0 0 0.42 0.08 20.00 8.00 21 300.0_mg/kg_1_3_11090 36 hours Femur marrow cell slide preparation 50 1 2 0 0 0 0 0 0.06 0.02 6.00 2.00 3 300.0_mg/kg_1_3_11092 36 hours Femur marrow cell slide preparation 50 0 1 0 0 0 0 0 0.02 0.00 2.00 0.00 1 300.0_mg/kg_1_3_11107 36 hours Femur marrow cell slide preparation 50 1 1 0 0 0 0 0 0.04 0.02 4.00 2.00 2 600.0_mg/kg_1_4 36 hours Femur marrow cell slide preparation 8 0.5 2.4 0.0 0.0 0.0 0.0 0.0 0.06 0.02 0.01 0.00 5.75 1.75 1.00 0.38 2.9 0.3521 600.0_mg/kg_1_4_11066 36 hours Femur marrow cell slide preparation 50 1 7 0 0 0 0 0 0.16 0.02 16.00 2.00 8 600.0_mg/kg_1_4_11067 36 hours Femur marrow cell slide preparation 50 1 2 0 0 0 0 0 0.06 0.02 6.00 2.00 3 600.0_mg/kg_1_4_11070 36 hours Femur marrow cell slide preparation 50 1 1 0 0 0 0 0 0.04 0.02 4.00 2.00 2 600.0_mg/kg_1_4_11086 36 hours Femur marrow cell slide preparation 50 0 5 0 0 0 0 0 0.10 0.00 10.00 0.00 5 600.0_mg/kg_1_4_11091 36 hours Femur marrow cell slide preparation 50 0 1 0 0 0 0 0 0.02 0.00 2.00 0.00 1 600.0_mg/kg_1_4_11098 36 hours Femur marrow cell slide preparation 50 0 1 0 0 0 0 0 0.02 0.00 2.00 0.00 1 600.0_mg/kg_1_4_11099 36 hours Femur marrow cell slide preparation 50 1 1 0 0 0 0 0 0.04 0.02 4.00 2.00 2 600.0_mg/kg_1_4_11108 36 hours Femur marrow cell slide preparation 50 0 1 0 0 0 0 0 0.02 0.00 2.00 0.00 1 25.0_mg/kg_1_5 36 hours Femur marrow cell slide preparation 8 8.1 5.4 0.0 0.0 0.0 0.0 0.0 0.27 0.09 0.16 0.07 10.75 2.36 5.75 1.44 13.5 0.0000 25.0_mg/kg_1_5_11065 36 hours Femur marrow cell slide preparation 50 31 1 0 0 0 0 0 0.64 0.62 10.00 8.00 32 25.0_mg/kg_1_5_11068 36 hours Femur marrow cell slide preparation 50 4 1 0 0 0 0 0 0.10 0.08 10.00 8.00 5 25.0_mg/kg_1_5_11076 36 hours Femur marrow cell slide preparation 50 1 1 0 0 0 0 0 0.04 0.02 4.00 2.00 2 25.0_mg/kg_1_5_11078 36 hours Femur marrow cell slide preparation 50 10 24 0 0 0 0 0 0.68 0.20 26.00 12.00 34 25.0_mg/kg_1_5_11083 36 hours Femur marrow cell slide preparation 50 0 5 0 0 0 0 0 0.10 0.00 6.00 0.00 5 25.0_mg/kg_1_5_11095 36 hours Femur marrow cell slide preparation 50 2 4 0 0 0 0 0 0.12 0.04 8.00 2.00 6 25.0_mg/kg_1_5_11102 36 hours Femur marrow cell slide preparation 50 14 3 0 0 0 0 0 0.34 0.28 12.00 8.00 17 25.0_mg/kg_1_5_11104 36 hours Femur marrow cell slide preparation 50 3 4 0 0 0 0 0 0.14 0.06 10.00 6.00 7