^STUDY !CHEMICAL_NAME=Dimethyl morpholinophosphoramidate !STUDY_CONCLUSION=Not a Valid Test !DEPOSITOR_STUDY_NUMBER=963445_SCE !STRESSOR_TYPE=CHEMICAL !INSTITUTION=NTP !STUDY_TITLE=Cytogenetic study of Dimethyl morpholinophosphoramidate in rodent Sister Chromatid Exchange Test !STUDY_DESIGN=Parallel !SUBJECT_TYPE=LAB_ANIMAL !OLD_NTP_STUDY_TYPE=ROD_SCE !NTP_STUDY_TYPE=Genetic Toxicology - Rodent Cytogenetics !TIME_TYPE=Study !STUDY_VARIABLES=COMPOUND|DOSE|DOSE_UNIT|DOSE_DURATION|DOSE_DURATION_UNIT|TRIAL_RESULT|ASSAY_TRIAL|TREND_TEST_PVALUE|TREATMENT_GROUP_TYPE ^GROUP #GROUP_NAME #COMPARATOR_NAME #IS_CONTROL_GROUP #SUPER_GROUP_NAME #TREATMENT_GROUP_TYPE #DEPOSITOR_NAME #ASSAY_TRIAL #COMPOUND #SAMPLE_TIME #SEX #SPECIES_COMMON_NAME #ORGAN_NAME #STRAIN #DOSE #DOSE_UNIT #DOSE_DURATION #DOSE_DURATION_UNIT #DOSE_FREQUENCY #TRIAL_RESULT #TREND_TEST_PVALUE #START_DATE #CONTROL_SUBSTANCE_NAME $GROUP_NAME $COMPARATOR_NAME $IS_CONTROL_GROUP $SUPER_GROUP_NAME $TREATMENT_GROUP_TYPE $DEPOSITOR_NAME $ASSAY_TRIAL $COMPOUND $SAMPLE_TIME $SEX $SPECIES_COMMON_NAME $ORGAN_NAME $STRAIN $DOSE $DOSE_UNIT $DOSE_DURATION $DOSE_DURATION_UNIT $DOSE_FREQUENCY $TRIAL_RESULT $TREND_TEST_PVALUE $START_DATE $CONTROL_SUBSTANCE_NAME 1 1 1 23 Male Mouse Bone Marrow B6C3F1 23 hour 1/study Equivocal 1989-08-29 0.0_mg/kg_1_1 T 1 Vehicle Control 1 Phosphate Buffered Saline 0.0 mg/kg Phosphate Buffered Saline 2000.0_mg/kg_1_2 0.0_mg/kg_1_1 1 Test Chemical 2 Dimethyl morpholinophosphoramidate 2000.0 mg/kg 4000.0_mg/kg_1_3 0.0_mg/kg_1_1 1 Test Chemical 3 Dimethyl morpholinophosphoramidate 4000.0 mg/kg 0.5_mg/kg_1_4 0.0_mg/kg_1_1 T 1 Positive Control 4 Mitomycin-C 0.5 mg/kg Mitomycin-C ^SUBJECT #PARTICIPANT_DISPLAY_NAME #GROUP_NAME #DEPOSITOR_NAME #ANIMAL_STATUS $PARTICIPANT_DISPLAY_NAME $GROUP_NAME $DEPOSITOR_NAME $ANIMAL_STATUS 0.0_mg/kg_1_1_12961 0.0_mg/kg_1_1 12961 Normal 0.0_mg/kg_1_1_12968 0.0_mg/kg_1_1 12968 Normal 0.0_mg/kg_1_1_12971 0.0_mg/kg_1_1 12971 Normal 0.0_mg/kg_1_1_12979 0.0_mg/kg_1_1 12979 Normal 2000.0_mg/kg_1_2_12976 2000.0_mg/kg_1_2 12976 Normal 2000.0_mg/kg_1_2_12982 2000.0_mg/kg_1_2 12982 Normal 2000.0_mg/kg_1_2_12983 2000.0_mg/kg_1_2 12983 Normal 4000.0_mg/kg_1_3_12964 4000.0_mg/kg_1_3 12964 Normal 4000.0_mg/kg_1_3_12965 4000.0_mg/kg_1_3 12965 Normal 4000.0_mg/kg_1_3_12966 4000.0_mg/kg_1_3 12966 Normal 4000.0_mg/kg_1_3_12978 4000.0_mg/kg_1_3 12978 Normal 0.5_mg/kg_1_4_12960 0.5_mg/kg_1_4 12960 Normal 0.5_mg/kg_1_4_12962 0.5_mg/kg_1_4 12962 Normal 0.5_mg/kg_1_4_12972 0.5_mg/kg_1_4 12972 Normal 0.5_mg/kg_1_4_12973 0.5_mg/kg_1_4 12973 Normal ^STRESSOR_PROTOCOL=CHEM_STRESSOR_PROTOCOL #PROTOCOL_DISPLAY_NAME #PROTOCOL_DESC #STRESSOR_NAME #ROUTE_ADMIN #DOSE_PER_ADMIN #DOSE_PER_ADMIN_UNIT #DOSE_FREQUENCY #DOSE_FREQUENCY_UNIT #VEHICLE_NAME #IS_POSITIVE_CONTROL #IS_VEHICLE_CONTROL #IS_LABEL $PROTOCOL_DISPLAY_NAME $PROTOCOL_DESC $STRESSOR_NAME $ROUTE_ADMIN $DOSE_PER_ADMIN $DOSE_PER_ADMIN_UNIT $DOSE_FREQUENCY $DOSE_FREQUENCY_UNIT $VEHICLE_NAME $IS_POSITIVE_CONTROL $IS_VEHICLE_CONTROL $IS_LABEL Dimethyl morpholinophosphoramidate_2000.0_mg/kg Dimethyl morpholinophosphoramidate Intraperitoneal Injection 2000.0 mg/kg 1 per study Phosphate Buffered Saline Mitomycin-C_0.5_mg/kg Mitomycin-C Intraperitoneal Injection 0.5 mg/kg 1 per study Phosphate Buffered Saline T Phosphate Buffered Saline_0.0_mg/kg No Stressor Intraperitoneal Injection 0.0 mg/kg 1 per study Phosphate Buffered Saline T Dimethyl morpholinophosphoramidate_4000.0_mg/kg Dimethyl morpholinophosphoramidate Intraperitoneal Injection 4000.0 mg/kg 1 per study Phosphate Buffered Saline BrdUrd tablet implant BrdUrd subcutaneously implanted 1 per study T colchicine injection colchicine IP injection 1 per study T ^DISPOSITION=EUTHANASIA_PROTOCOL #PROTOCOL_DISPLAY_NAME $PROTOCOL_DISPLAY_NAME Common euthanasia protocol ^PREPARATION=LAB_ANIMAL_PREPARATION_PROTOCOL #PROTOCOL_DISPLAY_NAME #PROTOCOL_DESC #IS_TERMINAL #ORGAN #SPECIMEN_TYPE $PROTOCOL_DISPLAY_NAME $PROTOCOL_DESC $IS_TERMINAL $ORGAN $SPECIMEN_TYPE Femur marrow cell slide preparation One or both femurs were removed and the marrow was flushed out with phosphate-buffered saline (pH 7.0). The cells were treated with a hypotonic salt solution, fixed, and dropped onto chilled slides. After a 24 hour drying period, the slides were stained using fluorescence-plus-Giemsa and scored. T Bone marrow Cell ^TIMELINE #TIME_IN_STUDY #TIME_IN_STUDY_UNIT #GROUP_NAME #PROTOCOL_DISPLAY_NAME $TIME_IN_STUDY $TIME_IN_STUDY_UNIT $GROUP_NAME $PROTOCOL_DISPLAY_NAME 0 hour 0.0_mg/kg_1_1 Phosphate Buffered Saline_0.0_mg/kg -1 hour 0.0_mg/kg_1_1 BrdUrd tablet implant 21 hour 0.0_mg/kg_1_1 colchicine injection 23 hour 0.0_mg/kg_1_1 Common euthanasia protocol 0 hour 2000.0_mg/kg_1_2 Dimethyl morpholinophosphoramidate_2000.0_mg/kg -1 hour 2000.0_mg/kg_1_2 BrdUrd tablet implant 21 hour 2000.0_mg/kg_1_2 colchicine injection 23 hour 2000.0_mg/kg_1_2 Common euthanasia protocol 0 hour 4000.0_mg/kg_1_3 Dimethyl morpholinophosphoramidate_4000.0_mg/kg -1 hour 4000.0_mg/kg_1_3 BrdUrd tablet implant 21 hour 4000.0_mg/kg_1_3 colchicine injection 23 hour 4000.0_mg/kg_1_3 Common euthanasia protocol 0 hour 0.5_mg/kg_1_4 Mitomycin-C_0.5_mg/kg -1 hour 0.5_mg/kg_1_4 BrdUrd tablet implant 21 hour 0.5_mg/kg_1_4 colchicine injection 23 hour 0.5_mg/kg_1_4 Common euthanasia protocol ^ASSAY=GENETOX #PARTICIPANT_DISPLAY_NAME #STUDY_TIME #STUDY_TIME_UNIT #PROTOCOL_NAME #ANIMALS_EXAMINED #SCE_PER_CELL_MEAN[MEAN] #SCE_CELLS_EXAMINED #SCE_PER_CELL_MEAN #SCE_PER_CELL_MEAN[SEM] #SCE_PER_CELL_MEAN[PAIRWISE_PVALUE] #SCE_PER_CELL_MEAN[TREND_PVALUE] $PARTICIPANT_DISPLAY_NAME $STUDY_TIME $STUDY_TIME_UNIT $PROTOCOL_NAME $ANIMALS_EXAMINED $SCE_PER_CELL_MEAN[MEAN] $SCE_CELLS_EXAMINED $SCE_PER_CELL_MEAN $SCE_PER_CELL_MEAN[SEM] $SCE_PER_CELL_MEAN[PAIRWISE_PVALUE] $SCE_PER_CELL_MEAN[TREND_PVALUE] 0.0_mg/kg_1_1 23 hours Femur marrow cell slide preparation 4 4.90 0.289 0.0000 0.0_mg/kg_1_1_12961 23 hours Femur marrow cell slide preparation 25 4.24 0.308 0.0_mg/kg_1_1_12968 23 hours Femur marrow cell slide preparation 25 4.93 0.515 0.0_mg/kg_1_1_12971 23 hours Femur marrow cell slide preparation 25 5.64 0.643 0.0_mg/kg_1_1_12979 23 hours Femur marrow cell slide preparation 25 4.78 0.297 2000.0_mg/kg_1_2 23 hours Femur marrow cell slide preparation 3 5.32 0.684 0.3054 2000.0_mg/kg_1_2_12976 23 hours Femur marrow cell slide preparation 25 6.69 0.509 2000.0_mg/kg_1_2_12982 23 hours Femur marrow cell slide preparation 25 4.73 0.455 2000.0_mg/kg_1_2_12983 23 hours Femur marrow cell slide preparation 25 4.55 0.299 4000.0_mg/kg_1_3 23 hours Femur marrow cell slide preparation 4 5.89 0.337 0.0341 4000.0_mg/kg_1_3_12964 23 hours Femur marrow cell slide preparation 25 6.40 0.658 4000.0_mg/kg_1_3_12965 23 hours Femur marrow cell slide preparation 25 6.48 0.477 4000.0_mg/kg_1_3_12966 23 hours Femur marrow cell slide preparation 25 5.60 0.597 4000.0_mg/kg_1_3_12978 23 hours Femur marrow cell slide preparation 25 5.07 0.470 0.5_mg/kg_1_4 23 hours Femur marrow cell slide preparation 4 10.48 0.996 0.0042 0.5_mg/kg_1_4_12960 23 hours Femur marrow cell slide preparation 25 7.87 0.634 0.5_mg/kg_1_4_12962 23 hours Femur marrow cell slide preparation 25 10.92 0.744 0.5_mg/kg_1_4_12972 23 hours Femur marrow cell slide preparation 25 12.70 1.009 0.5_mg/kg_1_4_12973 23 hours Femur marrow cell slide preparation 25 10.41 0.624