^STUDY !CHEMICAL_NAME=Furfural !STUDY_CONCLUSION=Negative !DEPOSITOR_STUDY_NUMBER=991433_SCE !STRESSOR_TYPE=CHEMICAL !INSTITUTION=NTP !STUDY_TITLE=Cytogenetic study of Furfural in rodent Sister Chromatid Exchange Test !STUDY_DESIGN=Parallel !SUBJECT_TYPE=LAB_ANIMAL !OLD_NTP_STUDY_TYPE=ROD_SCE !NTP_STUDY_TYPE=Genetic Toxicology - Rodent Cytogenetics !TIME_TYPE=Study !STUDY_VARIABLES=COMPOUND|DOSE|DOSE_UNIT|DOSE_DURATION|DOSE_DURATION_UNIT|TRIAL_RESULT|ASSAY_TRIAL|TREND_TEST_PVALUE|TREATMENT_GROUP_TYPE ^GROUP #GROUP_NAME #COMPARATOR_NAME #IS_CONTROL_GROUP #SUPER_GROUP_NAME #TREATMENT_GROUP_TYPE #DEPOSITOR_NAME #ASSAY_TRIAL #COMPOUND #SAMPLE_TIME #SEX #SPECIES_COMMON_NAME #ORGAN_NAME #STRAIN #DOSE #DOSE_UNIT #DOSE_DURATION #DOSE_DURATION_UNIT #DOSE_FREQUENCY #TRIAL_RESULT #TREND_TEST_PVALUE #START_DATE #CONTROL_SUBSTANCE_NAME $GROUP_NAME $COMPARATOR_NAME $IS_CONTROL_GROUP $SUPER_GROUP_NAME $TREATMENT_GROUP_TYPE $DEPOSITOR_NAME $ASSAY_TRIAL $COMPOUND $SAMPLE_TIME $SEX $SPECIES_COMMON_NAME $ORGAN_NAME $STRAIN $DOSE $DOSE_UNIT $DOSE_DURATION $DOSE_DURATION_UNIT $DOSE_FREQUENCY $TRIAL_RESULT $TREND_TEST_PVALUE $START_DATE $CONTROL_SUBSTANCE_NAME 1 1 1 23 Male Mouse Bone Marrow B6C3F1 23 hour 1/study Negative 1987-02-12 0.0_mg/kg_1_1 T 1 Vehicle Control 1 Phosphate Buffered Saline 0.0 mg/kg Phosphate Buffered Saline 50.0_mg/kg_1_2 0.0_mg/kg_1_1 1 Test Chemical 2 Furfural 50.0 mg/kg 100.0_mg/kg_1_3 0.0_mg/kg_1_1 1 Test Chemical 3 Furfural 100.0 mg/kg 200.0_mg/kg_1_4 0.0_mg/kg_1_1 1 Test Chemical 4 Furfural 200.0 mg/kg 0.5_mg/kg_1_5 0.0_mg/kg_1_1 T 1 Positive Control 5 Mitomycin-C 0.5 mg/kg Mitomycin-C 2 2 2 42 Male Mouse Bone Marrow B6C3F1 42 hour 1/study Negative 1987-08-18 0.0_mg/kg_2_1 T 2 Vehicle Control 1 Phosphate Buffered Saline 0.0 mg/kg Phosphate Buffered Saline 50.0_mg/kg_2_2 0.0_mg/kg_2_1 2 Test Chemical 2 Furfural 50.0 mg/kg 100.0_mg/kg_2_3 0.0_mg/kg_2_1 2 Test Chemical 3 Furfural 100.0 mg/kg 200.0_mg/kg_2_4 0.0_mg/kg_2_1 2 Test Chemical 4 Furfural 200.0 mg/kg 0.5_mg/kg_2_5 0.0_mg/kg_2_1 T 2 Positive Control 5 Mitomycin-C 0.5 mg/kg Mitomycin-C ^SUBJECT #PARTICIPANT_DISPLAY_NAME #GROUP_NAME #DEPOSITOR_NAME #ANIMAL_STATUS $PARTICIPANT_DISPLAY_NAME $GROUP_NAME $DEPOSITOR_NAME $ANIMAL_STATUS 0.0_mg/kg_1_1_4712 0.0_mg/kg_1_1 4712 Normal 0.0_mg/kg_1_1_4727 0.0_mg/kg_1_1 4727 Normal 0.0_mg/kg_1_1_4732 0.0_mg/kg_1_1 4732 Normal 0.0_mg/kg_1_1_4743 0.0_mg/kg_1_1 4743 Normal 50.0_mg/kg_1_2_4721 50.0_mg/kg_1_2 4721 Normal 50.0_mg/kg_1_2_4729 50.0_mg/kg_1_2 4729 Normal 50.0_mg/kg_1_2_4737 50.0_mg/kg_1_2 4737 Normal 50.0_mg/kg_1_2_4738 50.0_mg/kg_1_2 4738 Normal 100.0_mg/kg_1_3_4711 100.0_mg/kg_1_3 4711 Normal 100.0_mg/kg_1_3_4728 100.0_mg/kg_1_3 4728 Normal 100.0_mg/kg_1_3_4730 100.0_mg/kg_1_3 4730 Normal 100.0_mg/kg_1_3_4750 100.0_mg/kg_1_3 4750 Normal 200.0_mg/kg_1_4_4723 200.0_mg/kg_1_4 4723 Normal 200.0_mg/kg_1_4_4733 200.0_mg/kg_1_4 4733 Normal 200.0_mg/kg_1_4_4736 200.0_mg/kg_1_4 4736 Normal 200.0_mg/kg_1_4_4747 200.0_mg/kg_1_4 4747 Normal 0.5_mg/kg_1_5_4708 0.5_mg/kg_1_5 4708 Normal 0.5_mg/kg_1_5_4742 0.5_mg/kg_1_5 4742 Normal 0.5_mg/kg_1_5_4744 0.5_mg/kg_1_5 4744 Normal 0.5_mg/kg_1_5_4758 0.5_mg/kg_1_5 4758 Normal 0.0_mg/kg_2_1_5965 0.0_mg/kg_2_1 5965 Normal 0.0_mg/kg_2_1_5978 0.0_mg/kg_2_1 5978 Normal 0.0_mg/kg_2_1_5992 0.0_mg/kg_2_1 5992 Normal 50.0_mg/kg_2_2_5953 50.0_mg/kg_2_2 5953 Normal 50.0_mg/kg_2_2_5960 50.0_mg/kg_2_2 5960 Normal 50.0_mg/kg_2_2_5967 50.0_mg/kg_2_2 5967 Normal 50.0_mg/kg_2_2_5981 50.0_mg/kg_2_2 5981 Normal 100.0_mg/kg_2_3_5949 100.0_mg/kg_2_3 5949 Normal 100.0_mg/kg_2_3_5972 100.0_mg/kg_2_3 5972 Normal 100.0_mg/kg_2_3_5996 100.0_mg/kg_2_3 5996 Normal 100.0_mg/kg_2_3_6014 100.0_mg/kg_2_3 6014 Normal 200.0_mg/kg_2_4_5963 200.0_mg/kg_2_4 5963 Normal 200.0_mg/kg_2_4_5970 200.0_mg/kg_2_4 5970 Normal 200.0_mg/kg_2_4_6005 200.0_mg/kg_2_4 6005 Normal 200.0_mg/kg_2_4_6013 200.0_mg/kg_2_4 6013 Normal 0.5_mg/kg_2_5_5946 0.5_mg/kg_2_5 5946 Normal 0.5_mg/kg_2_5_5975 0.5_mg/kg_2_5 5975 Normal 0.5_mg/kg_2_5_6000 0.5_mg/kg_2_5 6000 Normal 0.5_mg/kg_2_5_6017 0.5_mg/kg_2_5 6017 Normal ^STRESSOR_PROTOCOL=CHEM_STRESSOR_PROTOCOL #PROTOCOL_DISPLAY_NAME #PROTOCOL_DESC #STRESSOR_NAME #ROUTE_ADMIN #DOSE_PER_ADMIN #DOSE_PER_ADMIN_UNIT #DOSE_FREQUENCY #DOSE_FREQUENCY_UNIT #VEHICLE_NAME #IS_POSITIVE_CONTROL #IS_VEHICLE_CONTROL #IS_LABEL $PROTOCOL_DISPLAY_NAME $PROTOCOL_DESC $STRESSOR_NAME $ROUTE_ADMIN $DOSE_PER_ADMIN $DOSE_PER_ADMIN_UNIT $DOSE_FREQUENCY $DOSE_FREQUENCY_UNIT $VEHICLE_NAME $IS_POSITIVE_CONTROL $IS_VEHICLE_CONTROL $IS_LABEL Furfural_200.0_mg/kg Furfural Intraperitoneal Injection 200.0 mg/kg 1 per study Phosphate Buffered Saline Mitomycin-C_0.5_mg/kg Mitomycin-C Intraperitoneal Injection 0.5 mg/kg 1 per study Phosphate Buffered Saline T Phosphate Buffered Saline_0.0_mg/kg No Stressor Intraperitoneal Injection 0.0 mg/kg 1 per study Phosphate Buffered Saline T Furfural_50.0_mg/kg Furfural Intraperitoneal Injection 50.0 mg/kg 1 per study Phosphate Buffered Saline Furfural_100.0_mg/kg Furfural Intraperitoneal Injection 100.0 mg/kg 1 per study Phosphate Buffered Saline BrdUrd tablet implant BrdUrd subcutaneously implanted 1 per study T colchicine injection colchicine IP injection 1 per study T ^DISPOSITION=EUTHANASIA_PROTOCOL #PROTOCOL_DISPLAY_NAME $PROTOCOL_DISPLAY_NAME Common euthanasia protocol ^PREPARATION=LAB_ANIMAL_PREPARATION_PROTOCOL #PROTOCOL_DISPLAY_NAME #PROTOCOL_DESC #IS_TERMINAL #ORGAN #SPECIMEN_TYPE $PROTOCOL_DISPLAY_NAME $PROTOCOL_DESC $IS_TERMINAL $ORGAN $SPECIMEN_TYPE Femur marrow cell slide preparation One or both femurs were removed and the marrow was flushed out with phosphate-buffered saline (pH 7.0). The cells were treated with a hypotonic salt solution, fixed, and dropped onto chilled slides. After a 24 hour drying period, the slides were stained using fluorescence-plus-Giemsa and scored. T Bone marrow Cell ^TIMELINE #TIME_IN_STUDY #TIME_IN_STUDY_UNIT #GROUP_NAME #PROTOCOL_DISPLAY_NAME $TIME_IN_STUDY $TIME_IN_STUDY_UNIT $GROUP_NAME $PROTOCOL_DISPLAY_NAME 0 hour 0.0_mg/kg_1_1 Phosphate Buffered Saline_0.0_mg/kg -1 hour 0.0_mg/kg_1_1 BrdUrd tablet implant 21 hour 0.0_mg/kg_1_1 colchicine injection 23 hour 0.0_mg/kg_1_1 Common euthanasia protocol 0 hour 50.0_mg/kg_1_2 Furfural_50.0_mg/kg -1 hour 50.0_mg/kg_1_2 BrdUrd tablet implant 21 hour 50.0_mg/kg_1_2 colchicine injection 23 hour 50.0_mg/kg_1_2 Common euthanasia protocol 0 hour 100.0_mg/kg_1_3 Furfural_100.0_mg/kg -1 hour 100.0_mg/kg_1_3 BrdUrd tablet implant 21 hour 100.0_mg/kg_1_3 colchicine injection 23 hour 100.0_mg/kg_1_3 Common euthanasia protocol 0 hour 200.0_mg/kg_1_4 Furfural_200.0_mg/kg -1 hour 200.0_mg/kg_1_4 BrdUrd tablet implant 21 hour 200.0_mg/kg_1_4 colchicine injection 23 hour 200.0_mg/kg_1_4 Common euthanasia protocol 0 hour 0.5_mg/kg_1_5 Mitomycin-C_0.5_mg/kg -1 hour 0.5_mg/kg_1_5 BrdUrd tablet implant 21 hour 0.5_mg/kg_1_5 colchicine injection 23 hour 0.5_mg/kg_1_5 Common euthanasia protocol 0 hour 0.0_mg/kg_2_1 Phosphate Buffered Saline_0.0_mg/kg 18 hour 0.0_mg/kg_2_1 BrdUrd tablet implant 40 hour 0.0_mg/kg_2_1 colchicine injection 42 hour 0.0_mg/kg_2_1 Common euthanasia protocol 0 hour 50.0_mg/kg_2_2 Furfural_50.0_mg/kg 18 hour 50.0_mg/kg_2_2 BrdUrd tablet implant 40 hour 50.0_mg/kg_2_2 colchicine injection 42 hour 50.0_mg/kg_2_2 Common euthanasia protocol 0 hour 100.0_mg/kg_2_3 Furfural_100.0_mg/kg 18 hour 100.0_mg/kg_2_3 BrdUrd tablet implant 40 hour 100.0_mg/kg_2_3 colchicine injection 42 hour 100.0_mg/kg_2_3 Common euthanasia protocol 0 hour 200.0_mg/kg_2_4 Furfural_200.0_mg/kg 18 hour 200.0_mg/kg_2_4 BrdUrd tablet implant 40 hour 200.0_mg/kg_2_4 colchicine injection 42 hour 200.0_mg/kg_2_4 Common euthanasia protocol 0 hour 0.5_mg/kg_2_5 Mitomycin-C_0.5_mg/kg 18 hour 0.5_mg/kg_2_5 BrdUrd tablet implant 40 hour 0.5_mg/kg_2_5 colchicine injection 42 hour 0.5_mg/kg_2_5 Common euthanasia protocol ^ASSAY=GENETOX #PARTICIPANT_DISPLAY_NAME #STUDY_TIME #STUDY_TIME_UNIT #PROTOCOL_NAME #ANIMALS_EXAMINED #SCE_PER_CELL_MEAN[MEAN] #SCE_CELLS_EXAMINED #SCE_PER_CELL_MEAN #SCE_PER_CELL_MEAN[SEM] #SCE_PER_CELL_MEAN[PAIRWISE_PVALUE] #SCE_PER_CELL_MEAN[TREND_PVALUE] $PARTICIPANT_DISPLAY_NAME $STUDY_TIME $STUDY_TIME_UNIT $PROTOCOL_NAME $ANIMALS_EXAMINED $SCE_PER_CELL_MEAN[MEAN] $SCE_CELLS_EXAMINED $SCE_PER_CELL_MEAN $SCE_PER_CELL_MEAN[SEM] $SCE_PER_CELL_MEAN[PAIRWISE_PVALUE] $SCE_PER_CELL_MEAN[TREND_PVALUE] 0.0_mg/kg_1_1 23 hours Femur marrow cell slide preparation 4 4.02 0.216 0.0000 0.0_mg/kg_1_1_4712 23 hours Femur marrow cell slide preparation 23 3.59 0.452 0.0_mg/kg_1_1_4727 23 hours Femur marrow cell slide preparation 24 4.32 0.440 0.0_mg/kg_1_1_4732 23 hours Femur marrow cell slide preparation 25 4.43 0.378 0.0_mg/kg_1_1_4743 23 hours Femur marrow cell slide preparation 23 3.67 0.727 50.0_mg/kg_1_2 23 hours Femur marrow cell slide preparation 4 4.84 0.477 0.0932 50.0_mg/kg_1_2_4721 23 hours Femur marrow cell slide preparation 25 4.79 0.385 50.0_mg/kg_1_2_4729 23 hours Femur marrow cell slide preparation 25 4.35 0.433 50.0_mg/kg_1_2_4737 23 hours Femur marrow cell slide preparation 25 6.17 0.624 50.0_mg/kg_1_2_4738 23 hours Femur marrow cell slide preparation 24 4.00 0.430 100.0_mg/kg_1_3 23 hours Femur marrow cell slide preparation 4 3.44 0.392 0.1301 100.0_mg/kg_1_3_4711 23 hours Femur marrow cell slide preparation 23 2.95 0.320 100.0_mg/kg_1_3_4728 23 hours Femur marrow cell slide preparation 25 4.59 0.380 100.0_mg/kg_1_3_4730 23 hours Femur marrow cell slide preparation 25 2.97 0.309 100.0_mg/kg_1_3_4750 23 hours Femur marrow cell slide preparation 24 3.21 0.334 200.0_mg/kg_1_4 23 hours Femur marrow cell slide preparation 4 4.18 0.291 0.3289 200.0_mg/kg_1_4_4723 23 hours Femur marrow cell slide preparation 25 4.37 0.463 200.0_mg/kg_1_4_4733 23 hours Femur marrow cell slide preparation 24 3.68 0.416 200.0_mg/kg_1_4_4736 23 hours Femur marrow cell slide preparation 25 3.73 0.476 200.0_mg/kg_1_4_4747 23 hours Femur marrow cell slide preparation 25 4.91 0.503 0.5_mg/kg_1_5 23 hours Femur marrow cell slide preparation 4 7.11 0.494 0.0021 0.5_mg/kg_1_5_4708 23 hours Femur marrow cell slide preparation 25 6.23 0.658 0.5_mg/kg_1_5_4742 23 hours Femur marrow cell slide preparation 25 6.31 0.690 0.5_mg/kg_1_5_4744 23 hours Femur marrow cell slide preparation 25 7.73 0.763 0.5_mg/kg_1_5_4758 23 hours Femur marrow cell slide preparation 25 8.18 0.512 0.0_mg/kg_2_1 42 hours Femur marrow cell slide preparation 3 5.17 0.932 0.0000 0.0_mg/kg_2_1_5965 42 hours Femur marrow cell slide preparation 25 3.36 0.347 0.0_mg/kg_2_1_5978 42 hours Femur marrow cell slide preparation 25 6.46 0.654 0.0_mg/kg_2_1_5992 42 hours Femur marrow cell slide preparation 24 5.70 0.570 50.0_mg/kg_2_2 42 hours Femur marrow cell slide preparation 4 4.30 0.273 0.2257 50.0_mg/kg_2_2_5953 42 hours Femur marrow cell slide preparation 25 5.09 0.427 50.0_mg/kg_2_2_5960 42 hours Femur marrow cell slide preparation 25 3.84 0.323 50.0_mg/kg_2_2_5967 42 hours Femur marrow cell slide preparation 25 4.17 0.350 50.0_mg/kg_2_2_5981 42 hours Femur marrow cell slide preparation 25 4.10 0.361 100.0_mg/kg_2_3 42 hours Femur marrow cell slide preparation 4 3.83 0.343 0.1434 100.0_mg/kg_2_3_5949 42 hours Femur marrow cell slide preparation 25 2.95 0.298 100.0_mg/kg_2_3_5972 42 hours Femur marrow cell slide preparation 25 3.65 0.308 100.0_mg/kg_2_3_5996 42 hours Femur marrow cell slide preparation 25 4.34 0.439 100.0_mg/kg_2_3_6014 42 hours Femur marrow cell slide preparation 24 4.42 0.420 200.0_mg/kg_2_4 42 hours Femur marrow cell slide preparation 4 4.05 0.315 0.1742 200.0_mg/kg_2_4_5963 42 hours Femur marrow cell slide preparation 25 4.79 0.511 200.0_mg/kg_2_4_5970 42 hours Femur marrow cell slide preparation 24 3.32 0.348 200.0_mg/kg_2_4_6005 42 hours Femur marrow cell slide preparation 25 4.26 0.391 200.0_mg/kg_2_4_6013 42 hours Femur marrow cell slide preparation 25 3.78 0.386 0.5_mg/kg_2_5 42 hours Femur marrow cell slide preparation 4 4.00 0.145 0.1658 0.5_mg/kg_2_5_5946 42 hours Femur marrow cell slide preparation 24 4.42 0.421 0.5_mg/kg_2_5_5975 42 hours Femur marrow cell slide preparation 24 3.83 0.360 0.5_mg/kg_2_5_6000 42 hours Femur marrow cell slide preparation 23 3.80 0.477 0.5_mg/kg_2_5_6017 42 hours Femur marrow cell slide preparation 25 3.91 0.345