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Long-Term Individual Animal Neoplastic Diagnosis

Study Information:

Chemical Name: L-Ascorbic acid
CASRN: ="50-81-7"
Study Number: C54808
Exposure Route: Dosed-Feed
TDMS Number:
Sex: Female
Strain and Species: B6C3F1 Mice

Female Individual Animal Neoplastic Diagnoses
System Organ Site Treatment Group Number Examined Cage Number Animal Number Weeks on Study Lesion Found Lesion Name Lesion Qualifier Removal Reason
Alimentary System Intestine Large Colon 50000 PPM 49 NA 1_031 112.00 1 Fibrosarcoma Scheduled Sacrifice
Alimentary System Intestine Small Mesentery Nos Untreated Control NA NA 3_041 112.00 1 Hemangiosarcoma Scheduled Sacrifice
Alimentary System Intestine Small Peyers Patch Untreated Control NA NA 3_017 112.00 1 Lymphoma, Histiocytic-Malignant Type Scheduled Sacrifice
Alimentary System Liver Untreated Control 50 NA 3_023 112.00 1 Hepatoblastoma Scheduled Sacrifice
Alimentary System Liver Untreated Control 50 NA 3_025 112.00 1 Hepatocellular Carcinoma Scheduled Sacrifice
Alimentary System Liver Untreated Control 50 NA 3_028 112.00 1 Hepatocellular Adenoma Scheduled Sacrifice
Alimentary System Liver Untreated Control 50 NA 3_049 112.00 1 Hepatocellular Adenoma Scheduled Sacrifice
Alimentary System Liver 25000 PPM 49 NA 2_018 112.00 1 Hepatocellular Adenoma Scheduled Sacrifice
Alimentary System Liver 25000 PPM 49 NA 2_019 112.00 1 Lymphoma, Histiocytic-Malignant Type Scheduled Sacrifice
Alimentary System Liver 50000 PPM 50 NA 1_014 112.00 1 Hepatocellular Carcinoma Moribund Sacrifice
Alimentary System Liver 50000 PPM 50 NA 1_013 112.00 1 Hepatocellular Adenoma Scheduled Sacrifice
Alimentary System Liver 50000 PPM 50 NA 1_015 112.00 1 Hemangiosarcoma Scheduled Sacrifice
Alimentary System Liver 50000 PPM 50 NA 1_031 112.00 1 Hepatocellular Adenoma Scheduled Sacrifice
Alimentary System Pancreas Islets Untreated Control 49 NA 3_025 112.00 1 Islet-Cell Adenoma Scheduled Sacrifice
Alimentary System Pancreas Islets 50000 PPM 49 NA 1_011 112.00 1 Islet-Cell Adenoma Moribund Sacrifice
Alimentary System Stomach Cardiac Stomach Untreated Control 49 NA 3_022 112.00 1 Squamous Cell Papilloma Scheduled Sacrifice
All Others Unspecified Base Of Tail 50000 PPM NA NA 1_047 112.00 1 Sarcoma, Nos Scheduled Sacrifice
All Others Unspecified Chest 50000 PPM NA NA 1_020 112.00 1 Sarcoma, Nos Scheduled Sacrifice
All Others Unspecified Flank 50000 PPM NA NA 1_038 112.00 1 Sarcoma, Nos Natural Death
All Others Unspecified Lower Leg Nos 25000 PPM NA NA 2_012 112.00 1 Leiomyosarcoma Scheduled Sacrifice
All Others Unspecified Mediastinum Nos 25000 PPM NA NA 2_032 112.00 1 Sarcoma, Nos, Invasive Moribund Sacrifice
All Others Unspecified Multiple Organs Nos Untreated Control NA NA 3_001 112.00 1 Lymphoma, Histiocytic-Malignant Type Moribund Sacrifice
All Others Unspecified Multiple Organs Nos Untreated Control NA NA 3_021 112.00 1 Lymphoma, Lymphocytic-Malignant Type Moribund Sacrifice
All Others Unspecified Multiple Organs Nos Untreated Control NA NA 3_003 112.00 1 Lymphoma, Lymphocytic-Malignant Type Natural Death
All Others Unspecified Multiple Organs Nos Untreated Control NA NA 3_006 112.00 1 Lymphoma, Lymphocytic-Malignant Type Natural Death
All Others Unspecified Multiple Organs Nos Untreated Control NA NA 3_004 112.00 1 Lymphoma, Lymphocytic-Malignant Type Scheduled Sacrifice
All Others Unspecified Multiple Organs Nos Untreated Control NA NA 3_005 112.00 1 Lymphoma, Mixed-Malignant Type Scheduled Sacrifice
All Others Unspecified Multiple Organs Nos Untreated Control NA NA 3_009 112.00 1 Lymphoma, Histiocytic-Malignant Type Scheduled Sacrifice
All Others Unspecified Multiple Organs Nos Untreated Control NA NA 3_018 112.00 1 Leukemia, Lymphocytic Scheduled Sacrifice
All Others Unspecified Multiple Organs Nos Untreated Control NA NA 3_019 112.00 1 Leukemia, Lymphocytic Scheduled Sacrifice
All Others Unspecified Multiple Organs Nos Untreated Control NA NA 3_048 112.00 1 Lymphoma, Lymphocytic-Malignant Type Scheduled Sacrifice
All Others Unspecified Multiple Organs Nos Untreated Control NA NA 3_049 112.00 1 Leukemia, Lymphocytic Scheduled Sacrifice
All Others Unspecified Multiple Organs Nos 25000 PPM NA NA 2_002 112.00 1 Lymphoma, Lymphocytic-Malignant Type Natural Death
All Others Unspecified Multiple Organs Nos 25000 PPM NA NA 2_022 112.00 1 Lymphoma, Mixed-Malignant Type Natural Death
All Others Unspecified Multiple Organs Nos 25000 PPM NA NA 2_028 112.00 1 Lymphoma, Histiocytic-Malignant Type Natural Death
All Others Unspecified Multiple Organs Nos 25000 PPM NA NA 2_001 112.00 1 Lymphoma, Histiocytic-Malignant Type Scheduled Sacrifice
All Others Unspecified Multiple Organs Nos 25000 PPM NA NA 2_014 112.00 1 Lymphoma, Histiocytic-Malignant Type Scheduled Sacrifice
All Others Unspecified Multiple Organs Nos 25000 PPM NA NA 2_016 112.00 1 Lymphoma, Histiocytic-Malignant Type Scheduled Sacrifice
All Others Unspecified Multiple Organs Nos 25000 PPM NA NA 2_017 112.00 1 Lymphoma, Histiocytic-Malignant Type Scheduled Sacrifice
All Others Unspecified Multiple Organs Nos 25000 PPM NA NA 2_029 112.00 1 Lymphoma, Lymphocytic-Malignant Type Scheduled Sacrifice
All Others Unspecified Multiple Organs Nos 25000 PPM NA NA 2_034 112.00 1 Lymphoma, Nos-Malignant Scheduled Sacrifice
All Others Unspecified Multiple Organs Nos 25000 PPM NA NA 2_047 112.00 1 Lymphoma, Lymphocytic-Malignant Type Scheduled Sacrifice
All Others Unspecified Multiple Organs Nos 50000 PPM NA NA 1_014 112.00 1 Lymphoma, Histiocytic-Malignant Type Moribund Sacrifice
All Others Unspecified Multiple Organs Nos 50000 PPM NA NA 1_002 112.00 1 Lymphoma, Histiocytic-Malignant Type Natural Death
All Others Unspecified Multiple Organs Nos 50000 PPM NA NA 1_003 112.00 1 Leukemia, Granulocytic Natural Death
All Others Unspecified Multiple Organs Nos 50000 PPM NA NA 1_041 112.00 1 Lymphoma, Nos-Malignant Natural Death
All Others Unspecified Multiple Organs Nos 50000 PPM NA NA 1_013 112.00 1 Lymphoma, Histiocytic-Malignant Type Scheduled Sacrifice
All Others Unspecified Multiple Organs Nos 50000 PPM NA NA 1_020 112.00 1 Lymphoma, Lymphocytic-Malignant Type Scheduled Sacrifice
All Others Unspecified Multiple Organs Nos 50000 PPM NA NA 1_027 112.00 1 Lymphoma, Mixed-Malignant Type Scheduled Sacrifice
All Others Unspecified Multiple Organs Nos 50000 PPM NA NA 1_031 112.00 1 Lymphoma, Nos-Malignant Scheduled Sacrifice
All Others Unspecified Multiple Organs Nos 50000 PPM NA NA 1_034 112.00 1 Lymphoma, Nos-Malignant Scheduled Sacrifice
All Others Unspecified Multiple Organs Nos 50000 PPM NA NA 1_039 112.00 1 Lymphoma, Lymphocytic-Malignant Type Scheduled Sacrifice
All Others Unspecified Multiple Organs Nos 50000 PPM NA NA 1_047 112.00 1 Lymphoma, Lymphocytic-Malignant Type Scheduled Sacrifice
All Others Unspecified Multiple Organs Nos 50000 PPM NA NA 1_049 112.00 1 Lymphoma, Nos-Malignant Scheduled Sacrifice
All Others Unspecified Multiple Organs Nos 50000 PPM NA NA 1_050 112.00 1 Lymphoma, Nos-Malignant Scheduled Sacrifice
All Others Unspecified Shoulder Untreated Control NA NA 3_011 112.00 1 Osteosarcoma Scheduled Sacrifice
All Others Unspecified Thoracic Cavity Nos 25000 PPM NA NA 2_032 112.00 1 Sarcoma, Nos Moribund Sacrifice
All Others Unspecified Untreated Control NA NA 3_038 112.00 1 Leiomyosarcoma Moribund Sacrifice
All Others Unspecified Untreated Control NA NA 3_042 112.00 1 Basal-Cell Carcinoma Moribund Sacrifice
All Others Unspecified Untreated Control NA NA 3_010 112.00 1 Osteosarcoma, Invasive Natural Death
Endocrine System Adrenal gland Untreated Control 50 NA 3_027 112.00 1 Pheochromocytoma Scheduled Sacrifice
Endocrine System Adrenal gland Untreated Control 50 NA 3_048 112.00 1 Pheochromocytoma Scheduled Sacrifice
Endocrine System Adrenal gland 25000 PPM 48 NA 2_011 112.00 1 Cortical Adenoma Scheduled Sacrifice
Endocrine System Adrenal gland 25000 PPM 48 NA 2_023 112.00 1 Pheochromocytoma Scheduled Sacrifice
Endocrine System Adrenal gland 50000 PPM 50 NA 1_024 112.00 1 Cortical Adenoma Scheduled Sacrifice
Endocrine System Adrenal gland 50000 PPM 50 NA 1_025 112.00 1 Cortical Adenoma Scheduled Sacrifice
Endocrine System Pituitary gland Untreated Control 43 NA 3_045 112.00 1 Adenoma, Nos Moribund Sacrifice
Endocrine System Pituitary gland Untreated Control 43 NA 3_028 112.00 1 Adenoma, Nos Scheduled Sacrifice
Endocrine System Pituitary gland Untreated Control 43 NA 3_036 112.00 1 Carcinoma, Nos Scheduled Sacrifice
Endocrine System Pituitary gland 25000 PPM 42 NA 2_046 112.00 1 Chromophobe Adenoma Moribund Sacrifice
Endocrine System Pituitary gland 25000 PPM 42 NA 2_026 112.00 1 Chromophobe Adenoma Natural Death
Endocrine System Pituitary gland 50000 PPM 47 NA 1_039 112.00 1 Adenoma, Nos Scheduled Sacrifice
Endocrine System Thyroid Untreated Control 44 NA 3_036 112.00 1 Follicular-Cell Carcinoma Scheduled Sacrifice
Genital System Ovary Untreated Control 50 NA 3_049 112.00 1 Granulosa-Cell Tumor Scheduled Sacrifice
Genital System Ovary 25000 PPM 45 NA 2_025 112.00 1 Papillary Cystadenoma, Nos Scheduled Sacrifice
Genital System Ovary 25000 PPM 45 NA 2_044 112.00 1 Hemangioma Scheduled Sacrifice
Genital System Ovary 50000 PPM 46 NA 1_022 112.00 1 Teratoma, Nos Natural Death
Genital System Uterus Untreated Control 50 NA 3_007 112.00 1 Endometrial Stromal Polyp Natural Death
Genital System Uterus Untreated Control 50 NA 3_015 112.00 1 Hemangioma Scheduled Sacrifice
Genital System Uterus Untreated Control 50 NA 3_019 112.00 1 Endometrial Stromal Polyp Scheduled Sacrifice
Genital System Uterus Untreated Control 50 NA 3_020 112.00 1 Endometrial Stromal Polyp Scheduled Sacrifice
Genital System Uterus 25000 PPM 48 NA 2_027 112.00 1 Adenocarcinoma, Nos Natural Death
Genital System Uterus 25000 PPM 48 NA 2_033 112.00 1 Endometrial Stromal Polyp Scheduled Sacrifice
Genital System Uterus 25000 PPM 48 NA 2_035 112.00 1 Endometrial Stromal Polyp Scheduled Sacrifice
Genital System Uterus 50000 PPM 50 NA 1_024 112.00 1 Hemangiosarcoma Scheduled Sacrifice
Genital System Uterus 50000 PPM 50 NA 1_025 112.00 1 Hemangiosarcoma Scheduled Sacrifice
Genital System Uterus 50000 PPM 50 NA 1_042 112.00 1 Fibrosarcoma Scheduled Sacrifice
Hematopoietic System Bone marrow 50000 PPM 50 NA 1_008 112.00 1 Hemangiosarcoma Scheduled Sacrifice
Hematopoietic System Lymph node Bronchial Lymph Node 50000 PPM 43 NA 1_029 112.00 1 Lymphoma, Mixed-Malignant Type Scheduled Sacrifice
Hematopoietic System Lymph node Mandibular Lymph Node 50000 PPM 38 NA 1_023 112.00 1 Lymphoma, Lymphocytic-Malignant Type Scheduled Sacrifice
Hematopoietic System Lymph node Mesenteric Lymph Node Untreated Control 47 NA 3_023 112.00 1 Lymphoma, Histiocytic-Malignant Type Scheduled Sacrifice
Hematopoietic System Lymph node Mesenteric Lymph Node Untreated Control 47 NA 3_039 112.00 1 Lymphoma, Histiocytic-Malignant Type Scheduled Sacrifice
Hematopoietic System Lymph node Mesenteric Lymph Node 50000 PPM 49 NA 1_048 112.00 1 Lymphoma, Lymphocytic-Malignant Type Natural Death
Hematopoietic System Lymph node Mesenteric Lymph Node 50000 PPM 49 NA 1_024 112.00 1 Fibrosarcoma Scheduled Sacrifice
Hematopoietic System Lymph node Mesenteric Lymph Node 50000 PPM 49 NA 1_031 112.00 1 Fibrosarcoma, Invasive Scheduled Sacrifice
Hematopoietic System Lymph node Renal Lymph Node 50000 PPM 43 NA 1_046 112.00 1 Lymphoma, Lymphocytic-Malignant Type Scheduled Sacrifice
Hematopoietic System Spleen Untreated Control 50 NA 3_030 112.00 1 Hemangiosarcoma Scheduled Sacrifice
Hematopoietic System Spleen 25000 PPM 48 NA 2_030 112.00 1 Hemangiosarcoma Scheduled Sacrifice
Hematopoietic System Spleen 50000 PPM 50 NA 1_008 112.00 1 Hemangiosarcoma Scheduled Sacrifice
Hematopoietic System Thymus 25000 PPM 37 NA 2_025 112.00 1 Lymphoma, Lymphocytic-Malignant Type Scheduled Sacrifice
Integumentary System Mammary gland Untreated Control 37 NA 3_047 112.00 1 Acinar-Cell Carcinoma Scheduled Sacrifice
Integumentary System Mammary gland 50000 PPM 41 NA 1_029 112.00 1 Acinar-Cell Carcinoma Scheduled Sacrifice
Musculoskeletal System Bone Sacrum Untreated Control NA NA 3_010 112.00 1 Osteosarcoma Natural Death
Musculoskeletal System Skeletal muscle Leg 50000 PPM NA NA 1_048 112.00 1 Hemangiosarcoma Natural Death
Nervous System Brain Meninges Untreated Control 50 NA 3_010 112.00 1 Osteosarcoma, Metastatic Natural Death
Nervous System Spinal cord Untreated Control 1 NA 3_010 112.00 1 Osteosarcoma, Invasive Natural Death
Respiratory System Lung Untreated Control 49 NA 3_010 112.00 1 Osteosarcoma, Metastatic Natural Death
Respiratory System Lung Untreated Control 49 NA 3_011 112.00 1 Alveolar/Bronchiolar Adenoma Scheduled Sacrifice
Respiratory System Lung 25000 PPM 49 NA 2_005 112.00 1 Alveolar/Bronchiolar Carcinoma Scheduled Sacrifice
Respiratory System Lung 25000 PPM 49 NA 2_010 112.00 1 Alveolar/Bronchiolar Adenoma Scheduled Sacrifice
Respiratory System Lung 25000 PPM 49 NA 2_029 112.00 1 Alveolar/Bronchiolar Adenoma Scheduled Sacrifice
Respiratory System Lung 25000 PPM 49 NA 2_031 112.00 1 Alveolar/Bronchiolar Carcinoma Scheduled Sacrifice
Respiratory System Lung 50000 PPM 50 NA 1_033 112.00 1 Alveolar/Bronchiolar Adenoma Scheduled Sacrifice
Special Senses System Eye Lacrimal Gland 25000 PPM 2 NA 2_040 112.00 1 Adenoma, Nos Scheduled Sacrifice
Special Senses System Eye Lacrimal Gland 50000 PPM 2 NA 1_012 112.00 1 Adenocarcinoma, Nos Scheduled Sacrifice
Special Senses System Harderian gland Hardarian Gland Untreated Control NA NA 3_020 112.00 1 Adenoma, Nos Scheduled Sacrifice
Urinary System Kidney 25000 PPM 49 NA 2_011 112.00 1 Lymphoma, Undifferentiated-Malignant Type Scheduled Sacrifice