If this is the first time you are viewing this file, please choose 'Save As' from the 'File' menu and resave this file as an Excel file type. This will greatly speed up future viewings of this file.

Long-Term Individual Animal Neoplastic Diagnosis

Study Information:

Chemical Name: L-Ascorbic acid
CASRN: ="50-81-7"
Study Number: C54808
Exposure Route: Dosed-Feed
TDMS Number:
Sex: Male
Strain and Species: B6C3F1 Mice

Male Individual Animal Neoplastic Diagnoses
System Organ Site Treatment Group Number Examined Cage Number Animal Number Weeks on Study Lesion Found Lesion Name Lesion Qualifier Removal Reason
Alimentary System Liver Untreated Control 50 NA 3_024 112.00 1 Hepatocellular Carcinoma Moribund Sacrifice
Alimentary System Liver Untreated Control 50 NA 3_036 112.00 1 Hepatocellular Carcinoma Moribund Sacrifice
Alimentary System Liver Untreated Control 50 NA 3_014 112.00 1 Hepatocellular Carcinoma Natural Death
Alimentary System Liver Untreated Control 50 NA 3_032 112.00 1 Hemangiosarcoma Natural Death
Alimentary System Liver Untreated Control 50 NA 3_032 112.00 1 Hepatocellular Carcinoma Natural Death
Alimentary System Liver Untreated Control 50 NA 3_001 112.00 1 Hepatocellular Carcinoma Scheduled Sacrifice
Alimentary System Liver Untreated Control 50 NA 3_006 112.00 1 Hepatocellular Adenoma Scheduled Sacrifice
Alimentary System Liver Untreated Control 50 NA 3_021 112.00 1 Hepatocellular Adenoma Scheduled Sacrifice
Alimentary System Liver Untreated Control 50 NA 3_025 112.00 1 Hepatocellular Adenoma Scheduled Sacrifice
Alimentary System Liver Untreated Control 50 NA 3_026 112.00 1 Hepatocellular Carcinoma Scheduled Sacrifice
Alimentary System Liver Untreated Control 50 NA 3_028 112.00 1 Hepatocellular Carcinoma Scheduled Sacrifice
Alimentary System Liver Untreated Control 50 NA 3_030 112.00 1 Hepatocellular Adenoma Scheduled Sacrifice
Alimentary System Liver Untreated Control 50 NA 3_037 112.00 1 Hepatocellular Carcinoma Scheduled Sacrifice
Alimentary System Liver Untreated Control 50 NA 3_038 112.00 1 Hepatocellular Adenoma Scheduled Sacrifice
Alimentary System Liver Untreated Control 50 NA 3_045 112.00 1 Hepatocellular Carcinoma Scheduled Sacrifice
Alimentary System Liver Untreated Control 50 NA 3_046 112.00 1 Hepatocellular Carcinoma Scheduled Sacrifice
Alimentary System Liver Untreated Control 50 NA 3_048 112.00 1 Hepatocellular Adenoma Scheduled Sacrifice
Alimentary System Liver 25000 PPM 49 NA 2_014 112.00 1 Hepatocellular Carcinoma Moribund Sacrifice
Alimentary System Liver 25000 PPM 49 NA 2_029 112.00 1 Hepatocellular Carcinoma Moribund Sacrifice
Alimentary System Liver 25000 PPM 49 NA 2_035 112.00 1 Hepatocellular Carcinoma Natural Death
Alimentary System Liver 25000 PPM 49 NA 2_042 112.00 1 Hemangiosarcoma Natural Death
Alimentary System Liver 25000 PPM 49 NA 2_047 112.00 1 Hepatocellular Carcinoma Natural Death
Alimentary System Liver 25000 PPM 49 NA 2_003 112.00 1 Hemangiosarcoma Scheduled Sacrifice
Alimentary System Liver 25000 PPM 49 NA 2_005 112.00 1 Hepatocellular Adenoma Scheduled Sacrifice
Alimentary System Liver 25000 PPM 49 NA 2_009 112.00 1 Hepatocellular Carcinoma Scheduled Sacrifice
Alimentary System Liver 25000 PPM 49 NA 2_011 112.00 1 Hepatocellular Carcinoma Scheduled Sacrifice
Alimentary System Liver 25000 PPM 49 NA 2_016 112.00 1 Hepatocellular Carcinoma Scheduled Sacrifice
Alimentary System Liver 25000 PPM 49 NA 2_025 112.00 1 Hepatocellular Adenoma Scheduled Sacrifice
Alimentary System Liver 25000 PPM 49 NA 2_026 112.00 1 Hepatocellular Adenoma Scheduled Sacrifice
Alimentary System Liver 25000 PPM 49 NA 2_027 112.00 1 Hepatocellular Carcinoma Scheduled Sacrifice
Alimentary System Liver 25000 PPM 49 NA 2_030 112.00 1 Hepatocellular Carcinoma Scheduled Sacrifice
Alimentary System Liver 25000 PPM 49 NA 2_037 112.00 1 Hepatocellular Adenoma Scheduled Sacrifice
Alimentary System Liver 25000 PPM 49 NA 2_040 112.00 1 Hepatocellular Carcinoma Scheduled Sacrifice
Alimentary System Liver 25000 PPM 49 NA 2_044 112.00 1 Hepatocellular Carcinoma Scheduled Sacrifice
Alimentary System Liver 25000 PPM 49 NA 2_046 112.00 1 Hepatocellular Carcinoma Scheduled Sacrifice
Alimentary System Liver 50000 PPM 50 NA 1_005 112.00 1 Hepatocellular Adenoma Scheduled Sacrifice
Alimentary System Liver 50000 PPM 50 NA 1_008 112.00 1 Hepatocellular Carcinoma Scheduled Sacrifice
Alimentary System Liver 50000 PPM 50 NA 1_009 112.00 1 Hepatocellular Carcinoma Scheduled Sacrifice
Alimentary System Liver 50000 PPM 50 NA 1_010 112.00 1 Hepatocellular Adenoma Scheduled Sacrifice
Alimentary System Liver 50000 PPM 50 NA 1_016 112.00 1 Hepatocellular Carcinoma Scheduled Sacrifice
Alimentary System Liver 50000 PPM 50 NA 1_017 112.00 1 Hepatocellular Adenoma Scheduled Sacrifice
Alimentary System Liver 50000 PPM 50 NA 1_019 112.00 1 Hepatocellular Adenoma Scheduled Sacrifice
Alimentary System Liver 50000 PPM 50 NA 1_024 112.00 1 Hepatocellular Adenoma Scheduled Sacrifice
Alimentary System Liver 50000 PPM 50 NA 1_025 112.00 1 Hepatocellular Adenoma Scheduled Sacrifice
Alimentary System Liver 50000 PPM 50 NA 1_028 112.00 1 Hepatocellular Carcinoma Scheduled Sacrifice
Alimentary System Liver 50000 PPM 50 NA 1_039 112.00 1 Hepatocellular Adenoma Scheduled Sacrifice
Alimentary System Liver 50000 PPM 50 NA 1_042 112.00 1 Hepatocellular Adenoma Scheduled Sacrifice
Alimentary System Liver 50000 PPM 50 NA 1_046 112.00 1 Hepatocellular Adenoma Scheduled Sacrifice
Alimentary System Pancreas Islets 25000 PPM 48 NA 2_038 112.00 1 Islet-Cell Adenoma Scheduled Sacrifice
Alimentary System Pancreas 50000 PPM 50 NA 1_003 112.00 1 Hemangioma Scheduled Sacrifice
Alimentary System Stomach Cardiac Stomach 50000 PPM 48 NA 1_011 112.00 1 Squamous Cell Papilloma Scheduled Sacrifice
All Others Unspecified Head 25000 PPM NA NA 2_031 112.00 1 Osteosarcoma Natural Death
All Others Unspecified Multiple Organs Nos Untreated Control NA NA 3_033 112.00 1 Lymphoma, Histiocytic-Malignant Type Moribund Sacrifice
All Others Unspecified Multiple Organs Nos Untreated Control NA NA 3_035 112.00 1 Lymphoma, Lymphocytic-Malignant Type Moribund Sacrifice
All Others Unspecified Multiple Organs Nos Untreated Control NA NA 3_016 112.00 1 Lymphoma, Histiocytic-Malignant Type Natural Death
All Others Unspecified Multiple Organs Nos Untreated Control NA NA 3_041 112.00 1 Leukemia, Undifferentiated Natural Death
All Others Unspecified Multiple Organs Nos Untreated Control NA NA 3_042 112.00 1 Lymphoma, Histiocytic-Malignant Type Natural Death
All Others Unspecified Multiple Organs Nos Untreated Control NA NA 3_001 112.00 1 Lymphoma, Lymphocytic-Malignant Type Scheduled Sacrifice
All Others Unspecified Multiple Organs Nos Untreated Control NA NA 3_030 112.00 1 Lymphoma, Mixed-Malignant Type Scheduled Sacrifice
All Others Unspecified Multiple Organs Nos 25000 PPM NA NA 2_031 112.00 1 Leukemia, Eosinophilic Natural Death
All Others Unspecified Multiple Organs Nos 25000 PPM NA NA 2_042 112.00 1 Lymphoma, Lymphocytic-Malignant Type Natural Death
All Others Unspecified Multiple Organs Nos 25000 PPM NA NA 2_005 112.00 1 Lymphoma, Histiocytic-Malignant Type Scheduled Sacrifice
All Others Unspecified Multiple Organs Nos 25000 PPM NA NA 2_019 112.00 1 Lymphoma, Mixed-Malignant Type Scheduled Sacrifice
All Others Unspecified Multiple Organs Nos 25000 PPM NA NA 2_025 112.00 1 Lymphoma, Histiocytic-Malignant Type Scheduled Sacrifice
All Others Unspecified Multiple Organs Nos 25000 PPM NA NA 2_043 112.00 1 Lymphoma, Histiocytic-Malignant Type Scheduled Sacrifice
All Others Unspecified Multiple Organs Nos 25000 PPM NA NA 2_045 112.00 1 Lymphoma, Histiocytic-Malignant Type Scheduled Sacrifice
All Others Unspecified Multiple Organs Nos 50000 PPM NA NA 1_001 112.00 1 Lymphoma, Histiocytic-Malignant Type Scheduled Sacrifice
All Others Unspecified Multiple Organs Nos 50000 PPM NA NA 1_005 112.00 1 Lymphoma, Histiocytic-Malignant Type Scheduled Sacrifice
All Others Unspecified Multiple Organs Nos 50000 PPM NA NA 1_006 112.00 1 Lymphoma, Histiocytic-Malignant Type Scheduled Sacrifice
All Others Unspecified Pelvis Untreated Control NA NA 3_004 112.00 1 Fibrosarcoma Scheduled Sacrifice
All Others Unspecified 25000 PPM NA NA 2_033 112.00 1 Fibrosarcoma Scheduled Sacrifice
Endocrine System Adrenal gland Untreated Control 50 NA 3_010 112.00 1 Cortical Adenoma Scheduled Sacrifice
Endocrine System Adrenal gland Untreated Control 50 NA 3_011 112.00 1 Cortical Adenoma Scheduled Sacrifice
Endocrine System Adrenal gland 25000 PPM 49 NA 2_014 112.00 1 Pheochromocytoma Moribund Sacrifice
Endocrine System Adrenal gland 25000 PPM 49 NA 2_013 112.00 1 Cortical Adenoma Scheduled Sacrifice
Endocrine System Adrenal gland 25000 PPM 49 NA 2_027 112.00 1 Pheochromocytoma Scheduled Sacrifice
Endocrine System Adrenal gland 25000 PPM 49 NA 2_048 112.00 1 Cortical Adenoma Scheduled Sacrifice
Endocrine System Thyroid Untreated Control 48 NA 3_013 112.00 1 Follicular-Cell Adenoma Scheduled Sacrifice
Endocrine System Thyroid 50000 PPM 49 NA 1_043 112.00 1 Follicular-Cell Adenoma Scheduled Sacrifice
Genital System Testis 25000 PPM 49 NA 2_015 112.00 1 Interstitial-Cell Tumor Scheduled Sacrifice
Genital System Testis 50000 PPM 50 NA 1_019 112.00 1 Interstitial-Cell Tumor Scheduled Sacrifice
Hematopoietic System Bone marrow 25000 PPM 49 NA 2_042 112.00 1 Hemangiosarcoma Natural Death
Hematopoietic System Lymph node Untreated Control 36 NA 3_017 112.00 1 Lymphoma, Mixed-Malignant Type Moribund Sacrifice
Hematopoietic System Lymph node 25000 PPM 41 NA 2_047 112.00 1 Lymphoma, Histiocytic-Malignant Type Natural Death
Hematopoietic System Spleen Untreated Control 50 NA 3_038 112.00 1 Lymphoma, Lymphocytic-Malignant Type Scheduled Sacrifice
Hematopoietic System Spleen 25000 PPM 49 NA 2_002 112.00 1 Hemangiosarcoma Scheduled Sacrifice
Hematopoietic System Spleen 25000 PPM 49 NA 2_048 112.00 1 Hemangiosarcoma Scheduled Sacrifice
Nervous System Brain 25000 PPM 49 NA 2_031 112.00 1 Osteosarcoma, Invasive Natural Death
Respiratory System Lung Untreated Control 49 NA 3_035 112.00 1 Alveolar/Bronchiolar Carcinoma Moribund Sacrifice
Respiratory System Lung Untreated Control 49 NA 3_006 112.00 1 Alveolar/Bronchiolar Adenoma Scheduled Sacrifice
Respiratory System Lung Untreated Control 49 NA 3_018 112.00 1 Alveolar/Bronchiolar Carcinoma Scheduled Sacrifice
Respiratory System Lung Untreated Control 49 NA 3_029 112.00 1 Alveolar/Bronchiolar Adenoma Scheduled Sacrifice
Respiratory System Lung Untreated Control 49 NA 3_045 112.00 1 Alveolar/Bronchiolar Adenoma Scheduled Sacrifice
Respiratory System Lung 25000 PPM 49 NA 2_014 112.00 1 Hepatocellular Carcinoma, Metastatic Moribund Sacrifice
Respiratory System Lung 25000 PPM 49 NA 2_031 112.00 1 Osteosarcoma, Metastatic Natural Death
Respiratory System Lung 25000 PPM 49 NA 2_002 112.00 1 Alveolar/Bronchiolar Adenoma Scheduled Sacrifice
Respiratory System Lung 25000 PPM 49 NA 2_027 112.00 1 Hepatocellular Carcinoma, Metastatic Scheduled Sacrifice
Respiratory System Lung 25000 PPM 49 NA 2_036 112.00 1 Alveolar/Bronchiolar Adenoma Scheduled Sacrifice
Respiratory System Lung 25000 PPM 49 NA 2_040 112.00 1 Hepatocellular Carcinoma, Metastatic Scheduled Sacrifice
Respiratory System Lung 25000 PPM 49 NA 2_041 112.00 1 Alveolar/Bronchiolar Carcinoma Scheduled Sacrifice
Respiratory System Lung 25000 PPM 49 NA 2_046 112.00 1 Hepatocellular Carcinoma, Metastatic Scheduled Sacrifice
Respiratory System Lung 25000 PPM 49 NA 2_048 112.00 1 Alveolar/Bronchiolar Adenoma Scheduled Sacrifice
Respiratory System Lung 50000 PPM 49 NA 1_018 112.00 1 Alveolar/Bronchiolar Carcinoma Moribund Sacrifice
Respiratory System Lung 50000 PPM 49 NA 1_008 112.00 1 Alveolar/Bronchiolar Carcinoma Scheduled Sacrifice
Respiratory System Lung 50000 PPM 49 NA 1_008 112.00 1 Hepatocellular Carcinoma, Metastatic Scheduled Sacrifice
Respiratory System Lung 50000 PPM 49 NA 1_009 112.00 1 Hepatocellular Carcinoma, Metastatic Scheduled Sacrifice
Respiratory System Lung 50000 PPM 49 NA 1_012 112.00 1 Alveolar/Bronchiolar Carcinoma Scheduled Sacrifice
Respiratory System Lung 50000 PPM 49 NA 1_013 112.00 1 Alveolar/Bronchiolar Adenoma Scheduled Sacrifice
Respiratory System Lung 50000 PPM 49 NA 1_020 112.00 1 Alveolar/Bronchiolar Adenoma Scheduled Sacrifice
Respiratory System Lung 50000 PPM 49 NA 1_034 112.00 1 Alveolar/Bronchiolar Carcinoma Scheduled Sacrifice
Respiratory System Lung 50000 PPM 49 NA 1_039 112.00 1 Alveolar/Bronchiolar Carcinoma Scheduled Sacrifice
Respiratory System Lung 50000 PPM 49 NA 1_046 112.00 1 Alveolar/Bronchiolar Adenoma Scheduled Sacrifice
Special Senses System Ear Untreated Control 50 NA 3_002 112.00 1 Neurofibrosarcoma Scheduled Sacrifice
Special Senses System Eye Lacrimal Gland 25000 PPM 2 NA 2_006 112.00 1 Adenoma, Nos Scheduled Sacrifice
Special Senses System Eye Lacrimal Gland 25000 PPM 2 NA 2_038 112.00 1 Adenoma, Nos Scheduled Sacrifice
Special Senses System Eye Lacrimal Gland 25000 PPM 2 NA 2_048 112.00 1 Adenoma, Nos Scheduled Sacrifice
Urinary System Kidney Cortex 50000 PPM 50 NA 1_004 112.00 1 Adenoma, Nos Scheduled Sacrifice