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Long-Term Individual Animal Neoplastic Diagnosis

Study Information:

Chemical Name:	Lindane
CASRN:	="58-89-9"
Study Number:	C00204
Exposure Route:	Dosed-Feed
TDMS Number:
Sex:	Female
Strain and Species:	B6C3F1 Mice

Female Individual Animal Neoplastic Diagnoses

System Organ Site Treatment Group Number Examined Cage Number Animal Number Weeks on Study Lesion Found Lesion Name Lesion Qualifier Removal Reason

Alimentary System Intestine Large Cecum, Colon 160 PPM 1 NA 3_318 95.00 1 Sarcoma, Nos Scheduled Sacrifice

Alimentary System Liver Vehicle Control 10 NA 1_085 95.00 1 Neoplastic Nodule Scheduled Sacrifice

Alimentary System Liver 80 PPM 47 NA 2_201 95.00 1 Hepatocellular Carcinoma Scheduled Sacrifice

Alimentary System Liver 80 PPM 47 NA 2_205 95.00 1 Neoplastic Nodule Scheduled Sacrifice

Alimentary System Liver 80 PPM 47 NA 2_224 95.00 1 Hepatocellular Carcinoma Scheduled Sacrifice

Alimentary System Liver 80 PPM 47 NA 2_241 95.00 1 Neoplastic Nodule Scheduled Sacrifice

Alimentary System Liver 160 PPM 46 NA 3_328 95.00 1 Hepatocellular Carcinoma Scheduled Sacrifice

Alimentary System Liver 160 PPM 46 NA 3_329 95.00 1 Hepatocellular Carcinoma Scheduled Sacrifice

Alimentary System Liver 160 PPM 46 NA 3_334 95.00 1 Hepatocellular Carcinoma Scheduled Sacrifice

Endocrine System Adrenal gland 80 PPM 46 NA 2_216 95.00 1 Cortical Carcinoma Moribund Sacrifice

Endocrine System Thyroid 160 PPM 41 NA 3_304 95.00 1 Follicular-Cell Adenoma Scheduled Sacrifice

Endocrine System Thyroid 160 PPM 41 NA 3_322 95.00 1 Follicular-Cell Adenoma Scheduled Sacrifice

Genital System Uterus 160 PPM 43 NA 3_325 95.00 1 Sarcoma, Nos Scheduled Sacrifice

Hematopoietic System Spleen Vehicle Control 8 NA 1_088 95.00 1 Fibrous Histiocytoma Scheduled Sacrifice

Integumentary System Mammary gland Vehicle Control 2 NA 1_084 95.00 1 Adenoma, Nos Moribund Sacrifice

Musculoskeletal System Bone Sacrum 80 PPM NA NA 2_237 95.00 1 Osteosarcoma Natural Death

Respiratory System Lung Vehicle Control 10 NA 1_090 95.00 1 Alveolar/Bronchiolar Carcinoma Scheduled Sacrifice

Respiratory System Lung 80 PPM 48 NA 2_237 95.00 1 Osteosarcoma, Metastatic Natural Death

Respiratory System Lung 80 PPM 48 NA 2_232 95.00 1 Alveolar/Bronchiolar Adenoma Scheduled Sacrifice

Respiratory System Lung 160 PPM 48 NA 3_328 95.00 1 Alveolar/Bronchiolar Adenoma Scheduled Sacrifice

Respiratory System Lung 160 PPM 48 NA 3_337 95.00 1 Alveolar/Bronchiolar Adenoma Scheduled Sacrifice

System	Organ	Site	Treatment Group	Number Examined	Cage Number	Animal Number	Weeks on Study	Lesion Found	Lesion Name	Removal Reason
Alimentary System	Intestine Large	Cecum, Colon	160 PPM	1	NA	3_318	95.00	1	Sarcoma, Nos	Scheduled Sacrifice
Alimentary System	Liver		Vehicle Control	10	NA	1_085	95.00	1	Neoplastic Nodule	Scheduled Sacrifice
Alimentary System	Liver		80 PPM	47	NA	2_201	95.00	1	Hepatocellular Carcinoma	Scheduled Sacrifice
Alimentary System	Liver		80 PPM	47	NA	2_205	95.00	1	Neoplastic Nodule	Scheduled Sacrifice
Alimentary System	Liver		80 PPM	47	NA	2_224	95.00	1	Hepatocellular Carcinoma	Scheduled Sacrifice
Alimentary System	Liver		80 PPM	47	NA	2_241	95.00	1	Neoplastic Nodule	Scheduled Sacrifice
Alimentary System	Liver		160 PPM	46	NA	3_328	95.00	1	Hepatocellular Carcinoma	Scheduled Sacrifice
Alimentary System	Liver		160 PPM	46	NA	3_329	95.00	1	Hepatocellular Carcinoma	Scheduled Sacrifice
Alimentary System	Liver		160 PPM	46	NA	3_334	95.00	1	Hepatocellular Carcinoma	Scheduled Sacrifice
Endocrine System	Adrenal gland		80 PPM	46	NA	2_216	95.00	1	Cortical Carcinoma	Moribund Sacrifice
Endocrine System	Thyroid		160 PPM	41	NA	3_304	95.00	1	Follicular-Cell Adenoma	Scheduled Sacrifice
Endocrine System	Thyroid		160 PPM	41	NA	3_322	95.00	1	Follicular-Cell Adenoma	Scheduled Sacrifice
Genital System	Uterus		160 PPM	43	NA	3_325	95.00	1	Sarcoma, Nos	Scheduled Sacrifice
Hematopoietic System	Spleen		Vehicle Control	8	NA	1_088	95.00	1	Fibrous Histiocytoma	Scheduled Sacrifice
Integumentary System	Mammary gland		Vehicle Control	2	NA	1_084	95.00	1	Adenoma, Nos	Moribund Sacrifice
Musculoskeletal System	Bone	Sacrum	80 PPM	NA	NA	2_237	95.00	1	Osteosarcoma	Natural Death
Respiratory System	Lung		Vehicle Control	10	NA	1_090	95.00	1	Alveolar/Bronchiolar Carcinoma	Scheduled Sacrifice
Respiratory System	Lung		80 PPM	48	NA	2_237	95.00	1	Osteosarcoma, Metastatic	Natural Death
Respiratory System	Lung		80 PPM	48	NA	2_232	95.00	1	Alveolar/Bronchiolar Adenoma	Scheduled Sacrifice
Respiratory System	Lung		160 PPM	48	NA	3_328	95.00	1	Alveolar/Bronchiolar Adenoma	Scheduled Sacrifice
Respiratory System	Lung		160 PPM	48	NA	3_337	95.00	1	Alveolar/Bronchiolar Adenoma	Scheduled Sacrifice