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Long-Term Individual Animal Non Neoplastic Diagnosis

Study Information:

Chemical Name:	Lindane
CASRN:	="58-89-9"
Study Number:	C00204
Exposure Route:	Dosed-Feed
TDMS Number:
Sex:	Female
Strain and Species:	B6C3F1 Mice

Female Individual Animal Non Neoplastic Diagnoses

System Organ Site Treatment Group Number Examined Cage Number Animal Number Weeks on Study Lesion Found Lesion Name Lesion Qualifier Removal Reason

Alimentary System Intestine Small Peyers Patch 80 PPM NA NA 2_211 95.00 1 Hyperplasia, Lymphoid Scheduled Sacrifice

Alimentary System Intestine Small Peyers Patch 80 PPM NA NA 2_236 95.00 1 Hyperplasia, Lymphoid Scheduled Sacrifice

Alimentary System Liver Bile Duct 160 PPM 32 NA 3_348 95.00 1 Cyst, Nos Scheduled Sacrifice

Alimentary System Liver Vehicle Control 10 NA 1_088 95.00 1 Metamorphosis, Fatty Scheduled Sacrifice

Alimentary System Pancreas 160 PPM 48 NA 3_347 95.00 1 Dilatation, Ducts Scheduled Sacrifice

Genital System Ovary Vehicle Control 7 NA 1_084 95.00 1 Inflammation, Suppurative Moribund Sacrifice

Genital System Ovary Vehicle Control 7 NA 1_085 95.00 1 Inflammation, Nos Scheduled Sacrifice

Genital System Ovary Vehicle Control 7 NA 1_089 95.00 1 Inflammation, Nos Scheduled Sacrifice

Genital System Ovary 80 PPM 42 NA 2_216 95.00 1 Inflammation, Nos Moribund Sacrifice

Genital System Ovary 80 PPM 42 NA 2_202 95.00 1 Inflammation, Nos Scheduled Sacrifice

Genital System Ovary 80 PPM 42 NA 2_208 95.00 1 Inflammation, Suppurative Scheduled Sacrifice

Genital System Ovary 80 PPM 42 NA 2_209 95.00 1 Inflammation, Suppurative Scheduled Sacrifice

Genital System Ovary 80 PPM 42 NA 2_212 95.00 1 Inflammation, Suppurative Scheduled Sacrifice

Genital System Ovary 80 PPM 42 NA 2_218 95.00 1 Inflammation, Suppurative Scheduled Sacrifice

Genital System Ovary 80 PPM 42 NA 2_220 95.00 1 Inflammation, Suppurative Scheduled Sacrifice

Genital System Ovary 80 PPM 42 NA 2_222 95.00 1 Inflammation, Suppurative Scheduled Sacrifice

Genital System Ovary 80 PPM 42 NA 2_225 95.00 1 Inflammation, Suppurative Scheduled Sacrifice

Genital System Ovary 80 PPM 42 NA 2_229 95.00 1 Inflammation, Suppurative Scheduled Sacrifice

Genital System Ovary 80 PPM 42 NA 2_231 95.00 1 Cyst, Follicular Nos Scheduled Sacrifice

Genital System Ovary 80 PPM 42 NA 2_232 95.00 1 Inflammation, Suppurative Scheduled Sacrifice

Genital System Ovary 80 PPM 42 NA 2_235 95.00 1 Cyst, Follicular Nos Scheduled Sacrifice

Genital System Ovary 80 PPM 42 NA 2_240 95.00 1 Inflammation, Suppurative Scheduled Sacrifice

Genital System Ovary 160 PPM 46 NA 3_302 95.00 1 Inflammation, Nos Scheduled Sacrifice

Genital System Ovary 160 PPM 46 NA 3_304 95.00 1 Cyst, Follicular Nos Scheduled Sacrifice

Genital System Ovary 160 PPM 46 NA 3_311 95.00 1 Inflammation, Suppurative Scheduled Sacrifice

Genital System Ovary 160 PPM 46 NA 3_314 95.00 1 Cyst, Follicular Nos Scheduled Sacrifice

Genital System Ovary 160 PPM 46 NA 3_319 95.00 1 Inflammation, Nos Scheduled Sacrifice

Genital System Ovary 160 PPM 46 NA 3_320 95.00 1 Inflammation, Nos Scheduled Sacrifice

Genital System Ovary 160 PPM 46 NA 3_322 95.00 1 Inflammation, Suppurative Scheduled Sacrifice

Genital System Ovary 160 PPM 46 NA 3_326 95.00 1 Inflammation, Nos Scheduled Sacrifice

Genital System Ovary 160 PPM 46 NA 3_329 95.00 1 Inflammation, Chronic Scheduled Sacrifice

Genital System Ovary 160 PPM 46 NA 3_339 95.00 1 Inflammation, Nos Scheduled Sacrifice

Genital System Uterus Endometrium 80 PPM 44 NA 2_228 95.00 1 Hyperplasia, Cystic Moribund Sacrifice

Genital System Uterus Endometrium 80 PPM 44 NA 2_211 95.00 1 Hyperplasia, Cystic Scheduled Sacrifice

Genital System Uterus Endometrium 80 PPM 44 NA 2_236 95.00 1 Hyperplasia, Cystic Scheduled Sacrifice

Genital System Uterus Endometrium 160 PPM 43 NA 3_301 95.00 1 Hyperplasia, Nos Natural Death

Genital System Uterus Endometrium 160 PPM 43 NA 3_318 95.00 1 Hyperplasia, Cystic Scheduled Sacrifice

Genital System Uterus Endometrium 160 PPM 43 NA 3_327 95.00 1 Hyperplasia, Focal Scheduled Sacrifice

Genital System Uterus Endometrium 160 PPM 43 NA 3_338 95.00 1 Hyperplasia, Cystic Scheduled Sacrifice

Genital System Uterus 80 PPM 44 NA 2_238 95.00 1 Hydrometra Scheduled Sacrifice

Hematopoietic System Spleen 80 PPM 49 NA 2_212 95.00 1 Hyperplasia, Lymphoid Scheduled Sacrifice

Hematopoietic System Spleen 80 PPM 49 NA 2_236 95.00 1 Hyperplasia, Lymphoid Scheduled Sacrifice

Hematopoietic System Spleen 160 PPM 48 NA 3_308 95.00 1 Hyperplasia, Lymphoid Scheduled Sacrifice

Hematopoietic System Spleen 160 PPM 48 NA 3_329 95.00 1 Hyperplasia, Lymphoid Scheduled Sacrifice

Hematopoietic System Spleen 160 PPM 48 NA 3_338 95.00 1 Hyperplasia, Nodular Scheduled Sacrifice

Hematopoietic System Spleen 160 PPM 48 NA 3_350 95.00 1 Hyperplasia, Lymphoid Scheduled Sacrifice

Urinary System Kidney Vehicle Control 10 NA 1_084 95.00 1 Inflammation, Interstitial Moribund Sacrifice

Urinary System Kidney Vehicle Control 10 NA 1_082 95.00 1 Inflammation, Interstitial Scheduled Sacrifice

Urinary System Kidney Vehicle Control 10 NA 1_085 95.00 1 Inflammation, Chronic Scheduled Sacrifice

Urinary System Kidney 160 PPM 47 NA 3_339 95.00 1 Inflammation, Chronic Scheduled Sacrifice

System	Organ	Site	Treatment Group	Number Examined	Cage Number	Animal Number	Weeks on Study	Lesion Found	Lesion Name	Removal Reason
Alimentary System	Intestine Small	Peyers Patch	80 PPM	NA	NA	2_211	95.00	1	Hyperplasia, Lymphoid	Scheduled Sacrifice
Alimentary System	Intestine Small	Peyers Patch	80 PPM	NA	NA	2_236	95.00	1	Hyperplasia, Lymphoid	Scheduled Sacrifice
Alimentary System	Liver	Bile Duct	160 PPM	32	NA	3_348	95.00	1	Cyst, Nos	Scheduled Sacrifice
Alimentary System	Liver		Vehicle Control	10	NA	1_088	95.00	1	Metamorphosis, Fatty	Scheduled Sacrifice
Alimentary System	Pancreas		160 PPM	48	NA	3_347	95.00	1	Dilatation, Ducts	Scheduled Sacrifice
Genital System	Ovary		Vehicle Control	7	NA	1_084	95.00	1	Inflammation, Suppurative	Moribund Sacrifice
Genital System	Ovary		Vehicle Control	7	NA	1_085	95.00	1	Inflammation, Nos	Scheduled Sacrifice
Genital System	Ovary		Vehicle Control	7	NA	1_089	95.00	1	Inflammation, Nos	Scheduled Sacrifice
Genital System	Ovary		80 PPM	42	NA	2_216	95.00	1	Inflammation, Nos	Moribund Sacrifice
Genital System	Ovary		80 PPM	42	NA	2_202	95.00	1	Inflammation, Nos	Scheduled Sacrifice
Genital System	Ovary		80 PPM	42	NA	2_208	95.00	1	Inflammation, Suppurative	Scheduled Sacrifice
Genital System	Ovary		80 PPM	42	NA	2_209	95.00	1	Inflammation, Suppurative	Scheduled Sacrifice
Genital System	Ovary		80 PPM	42	NA	2_212	95.00	1	Inflammation, Suppurative	Scheduled Sacrifice
Genital System	Ovary		80 PPM	42	NA	2_218	95.00	1	Inflammation, Suppurative	Scheduled Sacrifice
Genital System	Ovary		80 PPM	42	NA	2_220	95.00	1	Inflammation, Suppurative	Scheduled Sacrifice
Genital System	Ovary		80 PPM	42	NA	2_222	95.00	1	Inflammation, Suppurative	Scheduled Sacrifice
Genital System	Ovary		80 PPM	42	NA	2_225	95.00	1	Inflammation, Suppurative	Scheduled Sacrifice
Genital System	Ovary		80 PPM	42	NA	2_229	95.00	1	Inflammation, Suppurative	Scheduled Sacrifice
Genital System	Ovary		80 PPM	42	NA	2_231	95.00	1	Cyst, Follicular Nos	Scheduled Sacrifice
Genital System	Ovary		80 PPM	42	NA	2_232	95.00	1	Inflammation, Suppurative	Scheduled Sacrifice
Genital System	Ovary		80 PPM	42	NA	2_235	95.00	1	Cyst, Follicular Nos	Scheduled Sacrifice
Genital System	Ovary		80 PPM	42	NA	2_240	95.00	1	Inflammation, Suppurative	Scheduled Sacrifice
Genital System	Ovary		160 PPM	46	NA	3_302	95.00	1	Inflammation, Nos	Scheduled Sacrifice
Genital System	Ovary		160 PPM	46	NA	3_304	95.00	1	Cyst, Follicular Nos	Scheduled Sacrifice
Genital System	Ovary		160 PPM	46	NA	3_311	95.00	1	Inflammation, Suppurative	Scheduled Sacrifice
Genital System	Ovary		160 PPM	46	NA	3_314	95.00	1	Cyst, Follicular Nos	Scheduled Sacrifice
Genital System	Ovary		160 PPM	46	NA	3_319	95.00	1	Inflammation, Nos	Scheduled Sacrifice
Genital System	Ovary		160 PPM	46	NA	3_320	95.00	1	Inflammation, Nos	Scheduled Sacrifice
Genital System	Ovary		160 PPM	46	NA	3_322	95.00	1	Inflammation, Suppurative	Scheduled Sacrifice
Genital System	Ovary		160 PPM	46	NA	3_326	95.00	1	Inflammation, Nos	Scheduled Sacrifice
Genital System	Ovary		160 PPM	46	NA	3_329	95.00	1	Inflammation, Chronic	Scheduled Sacrifice
Genital System	Ovary		160 PPM	46	NA	3_339	95.00	1	Inflammation, Nos	Scheduled Sacrifice
Genital System	Uterus	Endometrium	80 PPM	44	NA	2_228	95.00	1	Hyperplasia, Cystic	Moribund Sacrifice
Genital System	Uterus	Endometrium	80 PPM	44	NA	2_211	95.00	1	Hyperplasia, Cystic	Scheduled Sacrifice
Genital System	Uterus	Endometrium	80 PPM	44	NA	2_236	95.00	1	Hyperplasia, Cystic	Scheduled Sacrifice
Genital System	Uterus	Endometrium	160 PPM	43	NA	3_301	95.00	1	Hyperplasia, Nos	Natural Death
Genital System	Uterus	Endometrium	160 PPM	43	NA	3_318	95.00	1	Hyperplasia, Cystic	Scheduled Sacrifice
Genital System	Uterus	Endometrium	160 PPM	43	NA	3_327	95.00	1	Hyperplasia, Focal	Scheduled Sacrifice
Genital System	Uterus	Endometrium	160 PPM	43	NA	3_338	95.00	1	Hyperplasia, Cystic	Scheduled Sacrifice
Genital System	Uterus		80 PPM	44	NA	2_238	95.00	1	Hydrometra	Scheduled Sacrifice
Hematopoietic System	Spleen		80 PPM	49	NA	2_212	95.00	1	Hyperplasia, Lymphoid	Scheduled Sacrifice
Hematopoietic System	Spleen		80 PPM	49	NA	2_236	95.00	1	Hyperplasia, Lymphoid	Scheduled Sacrifice
Hematopoietic System	Spleen		160 PPM	48	NA	3_308	95.00	1	Hyperplasia, Lymphoid	Scheduled Sacrifice
Hematopoietic System	Spleen		160 PPM	48	NA	3_329	95.00	1	Hyperplasia, Lymphoid	Scheduled Sacrifice
Hematopoietic System	Spleen		160 PPM	48	NA	3_338	95.00	1	Hyperplasia, Nodular	Scheduled Sacrifice
Hematopoietic System	Spleen		160 PPM	48	NA	3_350	95.00	1	Hyperplasia, Lymphoid	Scheduled Sacrifice
Urinary System	Kidney		Vehicle Control	10	NA	1_084	95.00	1	Inflammation, Interstitial	Moribund Sacrifice
Urinary System	Kidney		Vehicle Control	10	NA	1_082	95.00	1	Inflammation, Interstitial	Scheduled Sacrifice
Urinary System	Kidney		Vehicle Control	10	NA	1_085	95.00	1	Inflammation, Chronic	Scheduled Sacrifice
Urinary System	Kidney		160 PPM	47	NA	3_339	95.00	1	Inflammation, Chronic	Scheduled Sacrifice