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Long-Term Individual Animal Neoplastic Diagnosis

Study Information:

Chemical Name:	Lindane
CASRN:	="58-89-9"
Study Number:	C00204
Exposure Route:	Dosed-Feed
TDMS Number:
Sex:	Male
Strain and Species:	B6C3F1 Mice

Male Individual Animal Neoplastic Diagnoses

System Organ Site Treatment Group Number Examined Cage Number Animal Number Weeks on Study Lesion Found Lesion Name Lesion Qualifier Removal Reason

Alimentary System Liver Vehicle Control 10 NA 1_100 95.00 1 Hepatocellular Carcinoma Moribund Sacrifice

Alimentary System Liver Vehicle Control 10 NA 1_092 95.00 1 Hepatocellular Carcinoma Scheduled Sacrifice

Alimentary System Liver Vehicle Control 10 NA 1_096 95.00 1 Neoplastic Nodule Scheduled Sacrifice

Alimentary System Liver 80 PPM 49 NA 2_254 95.00 1 Hepatocellular Carcinoma Moribund Sacrifice

Alimentary System Liver 80 PPM 49 NA 2_269 95.00 1 Hepatocellular Carcinoma Moribund Sacrifice

Alimentary System Liver 80 PPM 49 NA 2_295 95.00 1 Hepatocellular Carcinoma Moribund Sacrifice

Alimentary System Liver 80 PPM 49 NA 2_252 95.00 1 Hepatocellular Carcinoma Scheduled Sacrifice

Alimentary System Liver 80 PPM 49 NA 2_253 95.00 1 Hepatocellular Carcinoma Scheduled Sacrifice

Alimentary System Liver 80 PPM 49 NA 2_255 95.00 1 Hepatocellular Carcinoma Scheduled Sacrifice

Alimentary System Liver 80 PPM 49 NA 2_256 95.00 1 Hepatocellular Carcinoma Scheduled Sacrifice

Alimentary System Liver 80 PPM 49 NA 2_262 95.00 1 Hepatocellular Carcinoma Scheduled Sacrifice

Alimentary System Liver 80 PPM 49 NA 2_275 95.00 1 Hepatocellular Carcinoma Scheduled Sacrifice

Alimentary System Liver 80 PPM 49 NA 2_278 95.00 1 Hepatocellular Carcinoma Scheduled Sacrifice

Alimentary System Liver 80 PPM 49 NA 2_279 95.00 1 Hepatocellular Carcinoma Scheduled Sacrifice

Alimentary System Liver 80 PPM 49 NA 2_281 95.00 1 Hepatocellular Carcinoma Scheduled Sacrifice

Alimentary System Liver 80 PPM 49 NA 2_282 95.00 1 Hepatocellular Carcinoma Scheduled Sacrifice

Alimentary System Liver 80 PPM 49 NA 2_284 95.00 1 Hepatocellular Carcinoma Scheduled Sacrifice

Alimentary System Liver 80 PPM 49 NA 2_286 95.00 1 Hepatocellular Carcinoma Scheduled Sacrifice

Alimentary System Liver 80 PPM 49 NA 2_288 95.00 1 Hepatocellular Carcinoma Scheduled Sacrifice

Alimentary System Liver 80 PPM 49 NA 2_289 95.00 1 Hepatocellular Carcinoma Scheduled Sacrifice

Alimentary System Liver 80 PPM 49 NA 2_291 95.00 1 Hepatocellular Carcinoma Scheduled Sacrifice

Alimentary System Liver 80 PPM 49 NA 2_300 95.00 1 Hepatocellular Carcinoma Scheduled Sacrifice

Alimentary System Liver 160 PPM 46 NA 3_379 95.00 1 Hepatocellular Carcinoma Moribund Sacrifice

Alimentary System Liver 160 PPM 46 NA 3_353 95.00 1 Hepatocellular Carcinoma Scheduled Sacrifice

Alimentary System Liver 160 PPM 46 NA 3_370 95.00 1 Hepatocellular Carcinoma Scheduled Sacrifice

Alimentary System Liver 160 PPM 46 NA 3_372 95.00 1 Neoplastic Nodule Scheduled Sacrifice

Alimentary System Liver 160 PPM 46 NA 3_375 95.00 1 Hepatocellular Carcinoma Scheduled Sacrifice

Alimentary System Liver 160 PPM 46 NA 3_378 95.00 1 Hepatocellular Carcinoma Scheduled Sacrifice

Alimentary System Liver 160 PPM 46 NA 3_382 95.00 1 Hepatocellular Carcinoma Scheduled Sacrifice

Alimentary System Liver 160 PPM 46 NA 3_392 95.00 1 Hepatocellular Carcinoma Scheduled Sacrifice

Alimentary System Liver 160 PPM 46 NA 3_394 95.00 1 Hepatocellular Carcinoma Scheduled Sacrifice

Alimentary System Liver 160 PPM 46 NA 3_400 95.00 1 Hepatocellular Carcinoma Scheduled Sacrifice

All Others Unspecified Diaphragm Nos 80 PPM NA NA 2_275 95.00 1 Hepatocellular Carcinoma, Metastatic Scheduled Sacrifice

All Others Unspecified Multiple Organs Nos 160 PPM NA NA 3_395 95.00 1 Lymphoma, Nos-Malignant Scheduled Sacrifice

All Others Unspecified 160 PPM NA NA 3_364 95.00 1 Hemangioma Moribund Sacrifice

Genital System Epididymis 80 PPM 49 NA 2_269 95.00 1 Hepatocellular Carcinoma, Metastatic Moribund Sacrifice

Integumentary System Skin 160 PPM 47 NA 3_358 95.00 1 Fibrous Histiocytoma Scheduled Sacrifice

Respiratory System Lung Vehicle Control 10 NA 1_100 95.00 1 Alveolar/Bronchiolar Adenoma Moribund Sacrifice

Respiratory System Lung Vehicle Control 10 NA 1_095 95.00 1 Alveolar/Bronchiolar Adenoma Scheduled Sacrifice

Respiratory System Lung 80 PPM 50 NA 2_269 95.00 1 Hepatocellular Carcinoma, Metastatic Moribund Sacrifice

Respiratory System Lung 80 PPM 50 NA 2_295 95.00 1 Hepatocellular Carcinoma, Metastatic Moribund Sacrifice

Respiratory System Lung 80 PPM 50 NA 2_257 95.00 1 Alveolar/Bronchiolar Adenoma Scheduled Sacrifice

Respiratory System Lung 80 PPM 50 NA 2_260 95.00 1 Alveolar/Bronchiolar Adenoma Scheduled Sacrifice

Respiratory System Lung 160 PPM 47 NA 3_359 95.00 1 Alveolar/Bronchiolar Adenoma Scheduled Sacrifice

Respiratory System Lung 160 PPM 47 NA 3_372 95.00 1 Alveolar/Bronchiolar Adenoma Scheduled Sacrifice

Respiratory System Lung 160 PPM 47 NA 3_381 95.00 1 Alveolar/Bronchiolar Adenoma Scheduled Sacrifice

System	Organ	Site	Treatment Group	Number Examined	Cage Number	Animal Number	Weeks on Study	Lesion Found	Lesion Name	Removal Reason
Alimentary System	Liver		Vehicle Control	10	NA	1_100	95.00	1	Hepatocellular Carcinoma	Moribund Sacrifice
Alimentary System	Liver		Vehicle Control	10	NA	1_092	95.00	1	Hepatocellular Carcinoma	Scheduled Sacrifice
Alimentary System	Liver		Vehicle Control	10	NA	1_096	95.00	1	Neoplastic Nodule	Scheduled Sacrifice
Alimentary System	Liver		80 PPM	49	NA	2_254	95.00	1	Hepatocellular Carcinoma	Moribund Sacrifice
Alimentary System	Liver		80 PPM	49	NA	2_269	95.00	1	Hepatocellular Carcinoma	Moribund Sacrifice
Alimentary System	Liver		80 PPM	49	NA	2_295	95.00	1	Hepatocellular Carcinoma	Moribund Sacrifice
Alimentary System	Liver		80 PPM	49	NA	2_252	95.00	1	Hepatocellular Carcinoma	Scheduled Sacrifice
Alimentary System	Liver		80 PPM	49	NA	2_253	95.00	1	Hepatocellular Carcinoma	Scheduled Sacrifice
Alimentary System	Liver		80 PPM	49	NA	2_255	95.00	1	Hepatocellular Carcinoma	Scheduled Sacrifice
Alimentary System	Liver		80 PPM	49	NA	2_256	95.00	1	Hepatocellular Carcinoma	Scheduled Sacrifice
Alimentary System	Liver		80 PPM	49	NA	2_262	95.00	1	Hepatocellular Carcinoma	Scheduled Sacrifice
Alimentary System	Liver		80 PPM	49	NA	2_275	95.00	1	Hepatocellular Carcinoma	Scheduled Sacrifice
Alimentary System	Liver		80 PPM	49	NA	2_278	95.00	1	Hepatocellular Carcinoma	Scheduled Sacrifice
Alimentary System	Liver		80 PPM	49	NA	2_279	95.00	1	Hepatocellular Carcinoma	Scheduled Sacrifice
Alimentary System	Liver		80 PPM	49	NA	2_281	95.00	1	Hepatocellular Carcinoma	Scheduled Sacrifice
Alimentary System	Liver		80 PPM	49	NA	2_282	95.00	1	Hepatocellular Carcinoma	Scheduled Sacrifice
Alimentary System	Liver		80 PPM	49	NA	2_284	95.00	1	Hepatocellular Carcinoma	Scheduled Sacrifice
Alimentary System	Liver		80 PPM	49	NA	2_286	95.00	1	Hepatocellular Carcinoma	Scheduled Sacrifice
Alimentary System	Liver		80 PPM	49	NA	2_288	95.00	1	Hepatocellular Carcinoma	Scheduled Sacrifice
Alimentary System	Liver		80 PPM	49	NA	2_289	95.00	1	Hepatocellular Carcinoma	Scheduled Sacrifice
Alimentary System	Liver		80 PPM	49	NA	2_291	95.00	1	Hepatocellular Carcinoma	Scheduled Sacrifice
Alimentary System	Liver		80 PPM	49	NA	2_300	95.00	1	Hepatocellular Carcinoma	Scheduled Sacrifice
Alimentary System	Liver		160 PPM	46	NA	3_379	95.00	1	Hepatocellular Carcinoma	Moribund Sacrifice
Alimentary System	Liver		160 PPM	46	NA	3_353	95.00	1	Hepatocellular Carcinoma	Scheduled Sacrifice
Alimentary System	Liver		160 PPM	46	NA	3_370	95.00	1	Hepatocellular Carcinoma	Scheduled Sacrifice
Alimentary System	Liver		160 PPM	46	NA	3_372	95.00	1	Neoplastic Nodule	Scheduled Sacrifice
Alimentary System	Liver		160 PPM	46	NA	3_375	95.00	1	Hepatocellular Carcinoma	Scheduled Sacrifice
Alimentary System	Liver		160 PPM	46	NA	3_378	95.00	1	Hepatocellular Carcinoma	Scheduled Sacrifice
Alimentary System	Liver		160 PPM	46	NA	3_382	95.00	1	Hepatocellular Carcinoma	Scheduled Sacrifice
Alimentary System	Liver		160 PPM	46	NA	3_392	95.00	1	Hepatocellular Carcinoma	Scheduled Sacrifice
Alimentary System	Liver		160 PPM	46	NA	3_394	95.00	1	Hepatocellular Carcinoma	Scheduled Sacrifice
Alimentary System	Liver		160 PPM	46	NA	3_400	95.00	1	Hepatocellular Carcinoma	Scheduled Sacrifice
All Others	Unspecified	Diaphragm Nos	80 PPM	NA	NA	2_275	95.00	1	Hepatocellular Carcinoma, Metastatic	Scheduled Sacrifice
All Others	Unspecified	Multiple Organs Nos	160 PPM	NA	NA	3_395	95.00	1	Lymphoma, Nos-Malignant	Scheduled Sacrifice
All Others	Unspecified		160 PPM	NA	NA	3_364	95.00	1	Hemangioma	Moribund Sacrifice
Genital System	Epididymis		80 PPM	49	NA	2_269	95.00	1	Hepatocellular Carcinoma, Metastatic	Moribund Sacrifice
Integumentary System	Skin		160 PPM	47	NA	3_358	95.00	1	Fibrous Histiocytoma	Scheduled Sacrifice
Respiratory System	Lung		Vehicle Control	10	NA	1_100	95.00	1	Alveolar/Bronchiolar Adenoma	Moribund Sacrifice
Respiratory System	Lung		Vehicle Control	10	NA	1_095	95.00	1	Alveolar/Bronchiolar Adenoma	Scheduled Sacrifice
Respiratory System	Lung		80 PPM	50	NA	2_269	95.00	1	Hepatocellular Carcinoma, Metastatic	Moribund Sacrifice
Respiratory System	Lung		80 PPM	50	NA	2_295	95.00	1	Hepatocellular Carcinoma, Metastatic	Moribund Sacrifice
Respiratory System	Lung		80 PPM	50	NA	2_257	95.00	1	Alveolar/Bronchiolar Adenoma	Scheduled Sacrifice
Respiratory System	Lung		80 PPM	50	NA	2_260	95.00	1	Alveolar/Bronchiolar Adenoma	Scheduled Sacrifice
Respiratory System	Lung		160 PPM	47	NA	3_359	95.00	1	Alveolar/Bronchiolar Adenoma	Scheduled Sacrifice
Respiratory System	Lung		160 PPM	47	NA	3_372	95.00	1	Alveolar/Bronchiolar Adenoma	Scheduled Sacrifice
Respiratory System	Lung		160 PPM	47	NA	3_381	95.00	1	Alveolar/Bronchiolar Adenoma	Scheduled Sacrifice