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Long-Term Individual Animal Non Neoplastic Diagnosis

Study Information:

Chemical Name:	Lindane
CASRN:	="58-89-9"
Study Number:	C00204
Exposure Route:	Dosed-Feed
TDMS Number:
Sex:	Male
Strain and Species:	B6C3F1 Mice

Male Individual Animal Non Neoplastic Diagnoses

System Organ Site Treatment Group Number Examined Cage Number Animal Number Weeks on Study Lesion Found Lesion Name Lesion Qualifier Removal Reason

Alimentary System Liver Bile Duct Vehicle Control 10 NA 1_095 95.00 1 Dilatation, Nos Scheduled Sacrifice

Alimentary System Liver 160 PPM 46 NA 3_361 95.00 1 Cloudy Swelling Scheduled Sacrifice

Alimentary System Liver 160 PPM 46 NA 3_363 95.00 1 Clear-Cell Change Scheduled Sacrifice

Alimentary System Liver 160 PPM 46 NA 3_366 95.00 1 Cloudy Swelling Scheduled Sacrifice

Alimentary System Liver 160 PPM 46 NA 3_368 95.00 1 Cloudy Swelling Scheduled Sacrifice

Alimentary System Liver 160 PPM 46 NA 3_395 95.00 1 Inflammation, Chronic Scheduled Sacrifice

Hematopoietic System Lymph node Cervical Lymph Node Nos 160 PPM 37 NA 3_396 95.00 1 Inflammation, Focal Scheduled Sacrifice

Hematopoietic System Spleen 80 PPM 50 NA 2_294 95.00 1 Hyperplasia, Lymphoid Scheduled Sacrifice

Hematopoietic System Spleen 160 PPM 47 NA 3_397 95.00 1 Congestion, Passive Scheduled Sacrifice

Urinary System Kidney 80 PPM 50 NA 2_258 95.00 1 Nephrosis, Hydro Moribund Sacrifice

Urinary System Kidney 160 PPM 47 NA 3_366 95.00 1 Inflammation, Chronic Focal Scheduled Sacrifice

System	Organ	Site	Treatment Group	Number Examined	Cage Number	Animal Number	Weeks on Study	Lesion Found	Lesion Name	Removal Reason
Alimentary System	Liver	Bile Duct	Vehicle Control	10	NA	1_095	95.00	1	Dilatation, Nos	Scheduled Sacrifice
Alimentary System	Liver		160 PPM	46	NA	3_361	95.00	1	Cloudy Swelling	Scheduled Sacrifice
Alimentary System	Liver		160 PPM	46	NA	3_363	95.00	1	Clear-Cell Change	Scheduled Sacrifice
Alimentary System	Liver		160 PPM	46	NA	3_366	95.00	1	Cloudy Swelling	Scheduled Sacrifice
Alimentary System	Liver		160 PPM	46	NA	3_368	95.00	1	Cloudy Swelling	Scheduled Sacrifice
Alimentary System	Liver		160 PPM	46	NA	3_395	95.00	1	Inflammation, Chronic	Scheduled Sacrifice
Hematopoietic System	Lymph node	Cervical Lymph Node Nos	160 PPM	37	NA	3_396	95.00	1	Inflammation, Focal	Scheduled Sacrifice
Hematopoietic System	Spleen		80 PPM	50	NA	2_294	95.00	1	Hyperplasia, Lymphoid	Scheduled Sacrifice
Hematopoietic System	Spleen		160 PPM	47	NA	3_397	95.00	1	Congestion, Passive	Scheduled Sacrifice
Urinary System	Kidney		80 PPM	50	NA	2_258	95.00	1	Nephrosis, Hydro	Moribund Sacrifice
Urinary System	Kidney		160 PPM	47	NA	3_366	95.00	1	Inflammation, Chronic Focal	Scheduled Sacrifice