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Long-Term Individual Animal Non Neoplastic Diagnosis

Study Information:

Chemical Name:	Lindane
CASRN:	="58-89-9"
Study Number:	C00204
Exposure Route:	Dosed-Feed
TDMS Number:
Sex:	Female
Strain and Species:	Osborne Mendel Rats

Female Individual Animal Non Neoplastic Diagnoses

System Organ Site Treatment Group Number Examined Cage Number Animal Number Weeks on Study Lesion Found Lesion Name Lesion Qualifier Removal Reason

Alimentary System Esophagus 320 PPM 15 NA 2_145 114.00 1 Hyperkeratosis Moribund Sacrifice

Alimentary System Esophagus 640 PPM 12 NA 3_168 115.00 1 Hyperkeratosis Moribund Sacrifice

Alimentary System Liver Bile Duct 640 PPM 50 NA 3_154 115.00 1 Inflammation, Nos Scheduled Sacrifice

Alimentary System Liver Bile Duct 640 PPM 50 NA 3_189 115.00 1 Hyperplasia, Nos Scheduled Sacrifice

Alimentary System Liver 320 PPM 48 NA 2_118 114.00 1 Metamorphosis, Fatty Moribund Sacrifice

Alimentary System Liver 320 PPM 48 NA 2_106 114.00 1 Clear-Cell Change Scheduled Sacrifice

Alimentary System Liver 320 PPM 48 NA 2_116 114.00 1 Clear-Cell Change Scheduled Sacrifice

Alimentary System Liver 320 PPM 48 NA 2_117 114.00 1 Angiectasis Scheduled Sacrifice

Alimentary System Liver 320 PPM 48 NA 2_120 114.00 1 Angiectasis Scheduled Sacrifice

Alimentary System Liver 320 PPM 48 NA 2_122 114.00 1 Angiectasis Scheduled Sacrifice

Alimentary System Liver 320 PPM 48 NA 2_129 114.00 1 Angiectasis Scheduled Sacrifice

Alimentary System Liver 320 PPM 48 NA 2_138 114.00 1 Clear-Cell Change Scheduled Sacrifice

Alimentary System Liver 320 PPM 48 NA 2_144 114.00 1 Clear-Cell Change Scheduled Sacrifice

Alimentary System Liver 320 PPM 48 NA 2_150 114.00 1 Clear-Cell Change Scheduled Sacrifice

Alimentary System Liver 320 PPM 48 NA 2_150 114.00 1 Metamorphosis, Fatty Scheduled Sacrifice

Alimentary System Liver 640 PPM 45 NA 3_152 115.00 1 Metamorphosis, Fatty Scheduled Sacrifice

Alimentary System Liver 640 PPM 45 NA 3_155 115.00 1 Metamorphosis, Fatty Scheduled Sacrifice

Alimentary System Liver 640 PPM 45 NA 3_160 115.00 1 Angiectasis Scheduled Sacrifice

Alimentary System Liver 640 PPM 45 NA 3_164 115.00 1 Angiectasis Scheduled Sacrifice

Alimentary System Liver 640 PPM 45 NA 3_171 115.00 1 Clear-Cell Change Scheduled Sacrifice

Alimentary System Liver 640 PPM 45 NA 3_176 115.00 1 Cytoplasmic Change, Basophilic Scheduled Sacrifice

Alimentary System Liver 640 PPM 45 NA 3_187 115.00 1 Clear-Cell Change Scheduled Sacrifice

Alimentary System Liver 640 PPM 45 NA 3_194 115.00 1 Clear-Cell Change Scheduled Sacrifice

Alimentary System Liver 640 PPM 45 NA 3_197 115.00 1 Cytoplasmic Change, Basophilic Scheduled Sacrifice

Alimentary System Liver 640 PPM 45 NA 3_200 115.00 1 Clear-Cell Change Scheduled Sacrifice

Alimentary System Salivary gland 320 PPM 45 NA 2_135 114.00 1 Degeneration, Cystic Moribund Sacrifice

Endocrine System Adrenal gland Vehicle Control 9 NA 1_097 114.00 1 Angiectasis Scheduled Sacrifice

Endocrine System Adrenal gland 320 PPM 45 NA 2_102 114.00 1 Angiectasis Moribund Sacrifice

Endocrine System Adrenal gland 320 PPM 45 NA 2_141 114.00 1 Degeneration, Cystic Scheduled Sacrifice

Endocrine System Adrenal gland 640 PPM 44 NA 3_183 115.00 1 Hemorrhage Moribund Sacrifice

Endocrine System Adrenal gland 640 PPM 44 NA 3_176 115.00 1 Degeneration, Cystic Scheduled Sacrifice

Endocrine System Pituitary gland 640 PPM 41 NA 3_175 115.00 1 Cyst, Nos Scheduled Sacrifice

Endocrine System Thyroid Vehicle Control 8 NA 1_093 114.00 1 Hyperplasia, C Cell Moribund Sacrifice

Endocrine System Thyroid 320 PPM 44 NA 2_120 114.00 1 Hyperplasia, Follicular Cell Scheduled Sacrifice

Endocrine System Thyroid 320 PPM 44 NA 2_149 114.00 1 Hyperplasia, Follicular Cell Scheduled Sacrifice

Endocrine System Thyroid 640 PPM 42 NA 3_152 115.00 1 Hyperplasia, Follicular Cell Scheduled Sacrifice

Endocrine System Thyroid 640 PPM 42 NA 3_169 115.00 1 Hyperplasia, Follicular Cell Scheduled Sacrifice

Endocrine System Thyroid 640 PPM 42 NA 3_198 115.00 1 Hyperplasia, Follicular Cell Scheduled Sacrifice

Genital System Uterus 320 PPM 47 NA 2_143 114.00 1 Hydrometra Moribund Sacrifice

Hematopoietic System Lymph node Abdominal Lymph Node 320 PPM 37 NA 2_135 114.00 1 Inflammation, Chronic Moribund Sacrifice

Hematopoietic System Lymph node Mesenteric Lymph Node Vehicle Control 9 NA 1_095 114.00 1 Inflammation, Nos Scheduled Sacrifice

Integumentary System Mammary gland Vehicle Control 5 NA 1_097 114.00 1 Adenosis Scheduled Sacrifice

Integumentary System Mammary gland Vehicle Control 5 NA 1_097 114.00 1 Hyperplasia, Nos Scheduled Sacrifice

Integumentary System Skin 320 PPM 49 NA 2_138 114.00 1 Granuloma, Nos Scheduled Sacrifice

Respiratory System Lung 320 PPM 48 NA 2_145 114.00 1 Inflammation, Nos Moribund Sacrifice

Respiratory System Lung 640 PPM 47 NA 3_156 115.00 1 Abscess, Nos Moribund Sacrifice

Respiratory System Lung 640 PPM 47 NA 3_181 115.00 1 Inflammation, Focal Moribund Sacrifice

Respiratory System Lung 640 PPM 47 NA 3_186 115.00 1 Inflammation, Chronic Moribund Sacrifice

Respiratory System Lung 640 PPM 47 NA 3_177 115.00 1 Inflammation, Chronic Scheduled Sacrifice

Urinary System Kidney Pelvis 320 PPM 46 NA 2_102 114.00 1 Metaplasia, Nos Moribund Sacrifice

Urinary System Kidney 320 PPM 46 NA 2_135 114.00 1 Inflammation, Chronic Moribund Sacrifice

Urinary System Kidney 320 PPM 46 NA 2_109 114.00 1 Inflammation, Chronic Scheduled Sacrifice

Urinary System Kidney 320 PPM 46 NA 2_144 114.00 1 Inflammation, Chronic Scheduled Sacrifice

Urinary System Kidney 640 PPM 48 NA 3_161 115.00 1 Inflammation, Chronic Moribund Sacrifice

Urinary System Kidney 640 PPM 48 NA 3_163 115.00 1 Inflammation, Chronic Moribund Sacrifice

Urinary System Kidney 640 PPM 48 NA 3_185 115.00 1 Inflammation, Chronic Moribund Sacrifice

Urinary System Kidney 640 PPM 48 NA 3_190 115.00 1 Inflammation, Chronic Moribund Sacrifice

Urinary System Kidney 640 PPM 48 NA 3_155 115.00 1 Cyst, Nos Scheduled Sacrifice

Urinary System Kidney 640 PPM 48 NA 3_176 115.00 1 Inflammation, Chronic Scheduled Sacrifice

System	Organ	Site	Treatment Group	Number Examined	Cage Number	Animal Number	Weeks on Study	Lesion Found	Lesion Name	Removal Reason
Alimentary System	Esophagus		320 PPM	15	NA	2_145	114.00	1	Hyperkeratosis	Moribund Sacrifice
Alimentary System	Esophagus		640 PPM	12	NA	3_168	115.00	1	Hyperkeratosis	Moribund Sacrifice
Alimentary System	Liver	Bile Duct	640 PPM	50	NA	3_154	115.00	1	Inflammation, Nos	Scheduled Sacrifice
Alimentary System	Liver	Bile Duct	640 PPM	50	NA	3_189	115.00	1	Hyperplasia, Nos	Scheduled Sacrifice
Alimentary System	Liver		320 PPM	48	NA	2_118	114.00	1	Metamorphosis, Fatty	Moribund Sacrifice
Alimentary System	Liver		320 PPM	48	NA	2_106	114.00	1	Clear-Cell Change	Scheduled Sacrifice
Alimentary System	Liver		320 PPM	48	NA	2_116	114.00	1	Clear-Cell Change	Scheduled Sacrifice
Alimentary System	Liver		320 PPM	48	NA	2_117	114.00	1	Angiectasis	Scheduled Sacrifice
Alimentary System	Liver		320 PPM	48	NA	2_120	114.00	1	Angiectasis	Scheduled Sacrifice
Alimentary System	Liver		320 PPM	48	NA	2_122	114.00	1	Angiectasis	Scheduled Sacrifice
Alimentary System	Liver		320 PPM	48	NA	2_129	114.00	1	Angiectasis	Scheduled Sacrifice
Alimentary System	Liver		320 PPM	48	NA	2_138	114.00	1	Clear-Cell Change	Scheduled Sacrifice
Alimentary System	Liver		320 PPM	48	NA	2_144	114.00	1	Clear-Cell Change	Scheduled Sacrifice
Alimentary System	Liver		320 PPM	48	NA	2_150	114.00	1	Clear-Cell Change	Scheduled Sacrifice
Alimentary System	Liver		320 PPM	48	NA	2_150	114.00	1	Metamorphosis, Fatty	Scheduled Sacrifice
Alimentary System	Liver		640 PPM	45	NA	3_152	115.00	1	Metamorphosis, Fatty	Scheduled Sacrifice
Alimentary System	Liver		640 PPM	45	NA	3_155	115.00	1	Metamorphosis, Fatty	Scheduled Sacrifice
Alimentary System	Liver		640 PPM	45	NA	3_160	115.00	1	Angiectasis	Scheduled Sacrifice
Alimentary System	Liver		640 PPM	45	NA	3_164	115.00	1	Angiectasis	Scheduled Sacrifice
Alimentary System	Liver		640 PPM	45	NA	3_171	115.00	1	Clear-Cell Change	Scheduled Sacrifice
Alimentary System	Liver		640 PPM	45	NA	3_176	115.00	1	Cytoplasmic Change, Basophilic	Scheduled Sacrifice
Alimentary System	Liver		640 PPM	45	NA	3_187	115.00	1	Clear-Cell Change	Scheduled Sacrifice
Alimentary System	Liver		640 PPM	45	NA	3_194	115.00	1	Clear-Cell Change	Scheduled Sacrifice
Alimentary System	Liver		640 PPM	45	NA	3_197	115.00	1	Cytoplasmic Change, Basophilic	Scheduled Sacrifice
Alimentary System	Liver		640 PPM	45	NA	3_200	115.00	1	Clear-Cell Change	Scheduled Sacrifice
Alimentary System	Salivary gland		320 PPM	45	NA	2_135	114.00	1	Degeneration, Cystic	Moribund Sacrifice
Endocrine System	Adrenal gland		Vehicle Control	9	NA	1_097	114.00	1	Angiectasis	Scheduled Sacrifice
Endocrine System	Adrenal gland		320 PPM	45	NA	2_102	114.00	1	Angiectasis	Moribund Sacrifice
Endocrine System	Adrenal gland		320 PPM	45	NA	2_141	114.00	1	Degeneration, Cystic	Scheduled Sacrifice
Endocrine System	Adrenal gland		640 PPM	44	NA	3_183	115.00	1	Hemorrhage	Moribund Sacrifice
Endocrine System	Adrenal gland		640 PPM	44	NA	3_176	115.00	1	Degeneration, Cystic	Scheduled Sacrifice
Endocrine System	Pituitary gland		640 PPM	41	NA	3_175	115.00	1	Cyst, Nos	Scheduled Sacrifice
Endocrine System	Thyroid		Vehicle Control	8	NA	1_093	114.00	1	Hyperplasia, C Cell	Moribund Sacrifice
Endocrine System	Thyroid		320 PPM	44	NA	2_120	114.00	1	Hyperplasia, Follicular Cell	Scheduled Sacrifice
Endocrine System	Thyroid		320 PPM	44	NA	2_149	114.00	1	Hyperplasia, Follicular Cell	Scheduled Sacrifice
Endocrine System	Thyroid		640 PPM	42	NA	3_152	115.00	1	Hyperplasia, Follicular Cell	Scheduled Sacrifice
Endocrine System	Thyroid		640 PPM	42	NA	3_169	115.00	1	Hyperplasia, Follicular Cell	Scheduled Sacrifice
Endocrine System	Thyroid		640 PPM	42	NA	3_198	115.00	1	Hyperplasia, Follicular Cell	Scheduled Sacrifice
Genital System	Uterus		320 PPM	47	NA	2_143	114.00	1	Hydrometra	Moribund Sacrifice
Hematopoietic System	Lymph node	Abdominal Lymph Node	320 PPM	37	NA	2_135	114.00	1	Inflammation, Chronic	Moribund Sacrifice
Hematopoietic System	Lymph node	Mesenteric Lymph Node	Vehicle Control	9	NA	1_095	114.00	1	Inflammation, Nos	Scheduled Sacrifice
Integumentary System	Mammary gland		Vehicle Control	5	NA	1_097	114.00	1	Adenosis	Scheduled Sacrifice
Integumentary System	Mammary gland		Vehicle Control	5	NA	1_097	114.00	1	Hyperplasia, Nos	Scheduled Sacrifice
Integumentary System	Skin		320 PPM	49	NA	2_138	114.00	1	Granuloma, Nos	Scheduled Sacrifice
Respiratory System	Lung		320 PPM	48	NA	2_145	114.00	1	Inflammation, Nos	Moribund Sacrifice
Respiratory System	Lung		640 PPM	47	NA	3_156	115.00	1	Abscess, Nos	Moribund Sacrifice
Respiratory System	Lung		640 PPM	47	NA	3_181	115.00	1	Inflammation, Focal	Moribund Sacrifice
Respiratory System	Lung		640 PPM	47	NA	3_186	115.00	1	Inflammation, Chronic	Moribund Sacrifice
Respiratory System	Lung		640 PPM	47	NA	3_177	115.00	1	Inflammation, Chronic	Scheduled Sacrifice
Urinary System	Kidney	Pelvis	320 PPM	46	NA	2_102	114.00	1	Metaplasia, Nos	Moribund Sacrifice
Urinary System	Kidney		320 PPM	46	NA	2_135	114.00	1	Inflammation, Chronic	Moribund Sacrifice
Urinary System	Kidney		320 PPM	46	NA	2_109	114.00	1	Inflammation, Chronic	Scheduled Sacrifice
Urinary System	Kidney		320 PPM	46	NA	2_144	114.00	1	Inflammation, Chronic	Scheduled Sacrifice
Urinary System	Kidney		640 PPM	48	NA	3_161	115.00	1	Inflammation, Chronic	Moribund Sacrifice
Urinary System	Kidney		640 PPM	48	NA	3_163	115.00	1	Inflammation, Chronic	Moribund Sacrifice
Urinary System	Kidney		640 PPM	48	NA	3_185	115.00	1	Inflammation, Chronic	Moribund Sacrifice
Urinary System	Kidney		640 PPM	48	NA	3_190	115.00	1	Inflammation, Chronic	Moribund Sacrifice
Urinary System	Kidney		640 PPM	48	NA	3_155	115.00	1	Cyst, Nos	Scheduled Sacrifice
Urinary System	Kidney		640 PPM	48	NA	3_176	115.00	1	Inflammation, Chronic	Scheduled Sacrifice