If this is the first time you are viewing this file, please choose 'Save As' from the 'File' menu and resave this file as an Excel file type. This will greatly speed up future viewings of this file.

Long-Term Individual Animal Non Neoplastic Diagnosis

Study Information:

Chemical Name: Lindane
CASRN: ="58-89-9"
Study Number: C00204
Exposure Route: Dosed-Feed
TDMS Number:
Sex: Male
Strain and Species: Osborne Mendel Rats

Male Individual Animal Non Neoplastic Diagnoses
System Organ Site Treatment Group Number Examined Cage Number Animal Number Weeks on Study Lesion Found Lesion Name Lesion Qualifier Removal Reason
Alimentary System Intestine Small Mesentery Nos 320 PPM NA NA 2_005 114.00 1 Periarteritis Moribund Sacrifice
Alimentary System Intestine Small Mesentery Nos 320 PPM NA NA 2_018 114.00 1 Periarteritis Moribund Sacrifice
Alimentary System Intestine Small Mesentery Nos 320 PPM NA NA 2_009 114.00 1 Periarteritis Natural Death
Alimentary System Intestine Small Mesentery Nos 640 PPM NA NA 3_086 114.00 1 Periarteritis Moribund Sacrifice
Alimentary System Intestine Small Mesentery Nos 640 PPM NA NA 3_088 114.00 1 Periarteritis Natural Death
Alimentary System Intestine Small Mesentery Nos 640 PPM NA NA 3_060 114.00 1 Periarteritis Scheduled Sacrifice
Alimentary System Intestine Small Mesentery Nos 640 PPM NA NA 3_083 114.00 1 Periarteritis Scheduled Sacrifice
Alimentary System Liver Bile Duct Vehicle Control 10 NA 1_081 114.00 1 Hyperplasia, Nos Scheduled Sacrifice
Alimentary System Liver Bile Duct Vehicle Control 10 NA 1_083 114.00 1 Inflammation, Chronic Focal Scheduled Sacrifice
Alimentary System Liver Bile Duct Vehicle Control 10 NA 1_088 114.00 1 Hyperplasia, Nos Scheduled Sacrifice
Alimentary System Liver Bile Duct 320 PPM 50 NA 2_002 114.00 1 Inflammation, Chronic Focal Scheduled Sacrifice
Alimentary System Liver Bile Duct 320 PPM 50 NA 2_022 114.00 1 Inflammation, Chronic Scheduled Sacrifice
Alimentary System Liver Bile Duct 320 PPM 50 NA 2_048 114.00 1 Inflammation, Chronic Focal Scheduled Sacrifice
Alimentary System Liver Bile Duct 640 PPM 50 NA 3_072 114.00 1 Dilatation, Nos Moribund Sacrifice
Alimentary System Liver Bile Duct 640 PPM 50 NA 3_055 114.00 1 Hyperplasia, Nos Scheduled Sacrifice
Alimentary System Liver Bile Duct 640 PPM 50 NA 3_068 114.00 1 Hyperplasia, Focal Scheduled Sacrifice
Alimentary System Liver Bile Duct 640 PPM 50 NA 3_083 114.00 1 Hyperplasia, Nos Scheduled Sacrifice
Alimentary System Liver Bile Duct 640 PPM 50 NA 3_091 114.00 1 Hyperplasia, Nos Scheduled Sacrifice
Alimentary System Liver Bile Duct 640 PPM 50 NA 3_097 114.00 1 Hyperplasia, Focal Scheduled Sacrifice
Alimentary System Liver Vehicle Control 10 NA 1_087 114.00 1 Clear-Cell Change Moribund Sacrifice
Alimentary System Liver 320 PPM 45 NA 2_005 114.00 1 Metamorphosis, Fatty Moribund Sacrifice
Alimentary System Liver 320 PPM 45 NA 2_027 114.00 1 Angiectasis Moribund Sacrifice
Alimentary System Liver 320 PPM 45 NA 2_009 114.00 1 Metamorphosis, Fatty Natural Death
Alimentary System Liver 320 PPM 45 NA 2_011 114.00 1 Clear-Cell Change Scheduled Sacrifice
Alimentary System Liver 320 PPM 45 NA 2_031 114.00 1 Metamorphosis, Fatty Scheduled Sacrifice
Alimentary System Liver 640 PPM 45 NA 3_062 114.00 1 Metamorphosis, Fatty Moribund Sacrifice
Alimentary System Liver 640 PPM 45 NA 3_074 114.00 1 Metamorphosis, Fatty Moribund Sacrifice
Alimentary System Liver 640 PPM 45 NA 3_079 114.00 1 Metamorphosis, Fatty Moribund Sacrifice
Alimentary System Liver 640 PPM 45 NA 3_086 114.00 1 Metamorphosis, Fatty Moribund Sacrifice
Alimentary System Liver 640 PPM 45 NA 3_094 114.00 1 Necrosis, Focal Moribund Sacrifice
Alimentary System Liver 640 PPM 45 NA 3_090 114.00 1 Cirrhosis, Nos Natural Death
Alimentary System Liver 640 PPM 45 NA 3_054 114.00 1 Clear-Cell Change Scheduled Sacrifice
Alimentary System Liver 640 PPM 45 NA 3_055 114.00 1 Metamorphosis, Fatty Scheduled Sacrifice
Alimentary System Liver 640 PPM 45 NA 3_064 114.00 1 Angiectasis Scheduled Sacrifice
Alimentary System Liver 640 PPM 45 NA 3_069 114.00 1 Degeneration, Ballooning Scheduled Sacrifice
Alimentary System Liver 640 PPM 45 NA 3_098 114.00 1 Angiectasis Scheduled Sacrifice
Alimentary System Pancreas Vehicle Control 9 NA 1_082 114.00 1 Inflammation, Chronic Scheduled Sacrifice
Alimentary System Stomach Mucosa 320 PPM 43 NA 2_005 114.00 1 Calcification, Dystrophic Moribund Sacrifice
Alimentary System Stomach Vehicle Control 9 NA 1_085 114.00 1 Erosion Moribund Sacrifice
Alimentary System Stomach 640 PPM 38 NA 3_086 114.00 1 Calcification, Dystrophic Moribund Sacrifice
Alimentary System Stomach 640 PPM 38 NA 3_094 114.00 1 Erosion Moribund Sacrifice
Cardiovascular System Heart Endocardium Nos 320 PPM 46 NA 2_011 114.00 1 Fibrosis, Focal Scheduled Sacrifice
Cardiovascular System Heart Endocardium Nos 640 PPM 46 NA 3_090 114.00 1 Sclerosis Natural Death
Cardiovascular System Heart Myocardium Nos Vehicle Control 9 NA 1_089 114.00 1 Inflammation, Chronic Focal Scheduled Sacrifice
Endocrine System Adrenal gland Cortex Nos Vehicle Control 10 NA 1_086 114.00 1 Hyperplasia, Focal Scheduled Sacrifice
Endocrine System Adrenal gland Cortex Nos 320 PPM 38 NA 2_020 114.00 1 Hyperplasia, Focal Scheduled Sacrifice
Endocrine System Parathyroid gland 320 PPM 23 NA 2_005 114.00 1 Hyperplasia, Nos Moribund Sacrifice
Endocrine System Parathyroid gland 640 PPM 28 NA 3_052 114.00 1 Hyperplasia, Nos Moribund Sacrifice
Endocrine System Parathyroid gland 640 PPM 28 NA 3_074 114.00 1 Hyperplasia, Nos Moribund Sacrifice
Endocrine System Pituitary gland Vehicle Control 10 NA 1_083 114.00 1 Cyst, Nos Scheduled Sacrifice
Endocrine System Pituitary gland Vehicle Control 10 NA 1_088 114.00 1 Cyst, Nos Scheduled Sacrifice
Endocrine System Pituitary gland 320 PPM 32 NA 2_014 114.00 1 Degeneration, Cystic Moribund Sacrifice
Endocrine System Pituitary gland 320 PPM 32 NA 2_027 114.00 1 Cyst, Nos Moribund Sacrifice
Endocrine System Pituitary gland 320 PPM 32 NA 2_024 114.00 1 Cyst, Nos Scheduled Sacrifice
Endocrine System Pituitary gland 640 PPM 34 NA 3_074 114.00 1 Cyst, Nos Moribund Sacrifice
Endocrine System Pituitary gland 640 PPM 34 NA 3_086 114.00 1 Degeneration, Cystic Moribund Sacrifice
Endocrine System Pituitary gland 640 PPM 34 NA 3_094 114.00 1 Cyst, Nos Moribund Sacrifice
Endocrine System Pituitary gland 640 PPM 34 NA 3_054 114.00 1 Cyst, Nos Scheduled Sacrifice
Endocrine System Pituitary gland 640 PPM 34 NA 3_066 114.00 1 Hyperplasia, Focal Scheduled Sacrifice
Endocrine System Pituitary gland 640 PPM 34 NA 3_073 114.00 1 Angiectasis Scheduled Sacrifice
Endocrine System Pituitary gland 640 PPM 34 NA 3_077 114.00 1 Cyst, Nos Scheduled Sacrifice
Endocrine System Thyroid Vehicle Control 6 NA 1_085 114.00 1 Hyperplasia, Follicular Cell Moribund Sacrifice
Endocrine System Thyroid 320 PPM 37 NA 2_012 114.00 1 Hyperplasia, C Cell Moribund Sacrifice
Endocrine System Thyroid 320 PPM 37 NA 2_013 114.00 1 Hyperplasia, Follicular Cell Natural Death
Endocrine System Thyroid 320 PPM 37 NA 2_033 114.00 1 Hyperplasia, C Cell Natural Death
Endocrine System Thyroid 320 PPM 37 NA 2_002 114.00 1 Hyperplasia, Follicular Cell Scheduled Sacrifice
Endocrine System Thyroid 320 PPM 37 NA 2_021 114.00 1 Hyperplasia, Follicular Cell Scheduled Sacrifice
Endocrine System Thyroid 320 PPM 37 NA 2_022 114.00 1 Hyperplasia, Follicular Cell Scheduled Sacrifice
Endocrine System Thyroid 320 PPM 37 NA 2_025 114.00 1 Hyperplasia, C Cell Scheduled Sacrifice
Endocrine System Thyroid 640 PPM 37 NA 3_057 114.00 1 Hyperplasia, C Cell Scheduled Sacrifice
Endocrine System Thyroid 640 PPM 37 NA 3_057 114.00 1 Hyperplasia, Follicular Cell Scheduled Sacrifice
Endocrine System Thyroid 640 PPM 37 NA 3_065 114.00 1 Hyperplasia, Follicular Cell Scheduled Sacrifice
Endocrine System Thyroid 640 PPM 37 NA 3_066 114.00 1 Hyperplasia, Follicular Cell Scheduled Sacrifice
Genital System Prostate Vehicle Control 9 NA 1_085 114.00 1 Inflammation, Suppurative Moribund Sacrifice
Genital System Prostate 320 PPM 38 NA 2_011 114.00 1 Inflammation, Chronic Scheduled Sacrifice
Genital System Prostate 640 PPM 37 NA 3_062 114.00 1 Inflammation, Acute Moribund Sacrifice
Genital System Prostate 640 PPM 37 NA 3_074 114.00 1 Inflammation, Acute Moribund Sacrifice
Genital System Prostate 640 PPM 37 NA 3_081 114.00 1 Inflammation, Acute Moribund Sacrifice
Genital System Testis Tubule 320 PPM 43 NA 2_005 114.00 1 Degeneration, Nos Moribund Sacrifice
Genital System Testis Vehicle Control 10 NA 1_081 114.00 1 Atrophy, Nos Scheduled Sacrifice
Genital System Testis Vehicle Control 10 NA 1_086 114.00 1 Atrophy, Nos Scheduled Sacrifice
Genital System Testis Vehicle Control 10 NA 1_088 114.00 1 Atrophy, Nos Scheduled Sacrifice
Genital System Testis Vehicle Control 10 NA 1_089 114.00 1 Atrophy, Nos Scheduled Sacrifice
Genital System Testis 320 PPM 43 NA 2_005 114.00 1 Periarteritis Moribund Sacrifice
Genital System Testis 320 PPM 43 NA 2_012 114.00 1 Atrophy, Diffuse Moribund Sacrifice
Genital System Testis 320 PPM 43 NA 2_027 114.00 1 Atrophy, Focal Moribund Sacrifice
Genital System Testis 320 PPM 43 NA 2_011 114.00 1 Atrophy, Nos Scheduled Sacrifice
Genital System Testis 640 PPM 44 NA 3_072 114.00 1 Atrophy, Nos Moribund Sacrifice
Genital System Testis 640 PPM 44 NA 3_074 114.00 1 Atrophy, Nos Moribund Sacrifice
Genital System Testis 640 PPM 44 NA 3_078 114.00 1 Atrophy, Nos Moribund Sacrifice
Genital System Testis 640 PPM 44 NA 3_086 114.00 1 Atrophy, Nos Moribund Sacrifice
Genital System Testis 640 PPM 44 NA 3_086 114.00 1 Periarteritis Moribund Sacrifice
Genital System Testis 640 PPM 44 NA 3_089 114.00 1 Atrophy, Nos Moribund Sacrifice
Genital System Testis 640 PPM 44 NA 3_060 114.00 1 Atrophy, Nos Scheduled Sacrifice
Genital System Testis 640 PPM 44 NA 3_080 114.00 1 Atrophy, Nos Scheduled Sacrifice
Genital System Testis 640 PPM 44 NA 3_092 114.00 1 Atrophy, Nos Scheduled Sacrifice
Hematopoietic System Lymph node Mesenteric Lymph Node Vehicle Control 8 NA 1_086 114.00 1 Inflammation, Nos Scheduled Sacrifice
Hematopoietic System Lymph node Vehicle Control 10 NA 1_086 114.00 1 Inflammation, Nos Scheduled Sacrifice
Hematopoietic System Spleen 320 PPM 44 NA 2_013 114.00 1 Hemorrhage Natural Death
Hematopoietic System Spleen 320 PPM 44 NA 2_030 114.00 1 Hemorrhage Natural Death
Hematopoietic System Spleen 320 PPM 44 NA 2_030 114.00 1 Hypoplasia, Lymphoid Natural Death
Hematopoietic System Spleen 320 PPM 44 NA 2_030 114.00 1 Sclerosis Natural Death
Hematopoietic System Spleen 320 PPM 44 NA 2_024 114.00 1 Inflammation, Granulomatous Scheduled Sacrifice
Hematopoietic System Spleen 640 PPM 44 NA 3_094 114.00 1 Hematopoiesis Moribund Sacrifice
Hematopoietic System Spleen 640 PPM 44 NA 3_090 114.00 1 Sclerosis Natural Death
Integumentary System Skin Vehicle Control 9 NA 1_086 114.00 1 Acanthosis Scheduled Sacrifice
Integumentary System Skin Vehicle Control 9 NA 1_086 114.00 1 Hyperkeratosis Scheduled Sacrifice
Respiratory System Lung 320 PPM 46 NA 2_009 114.00 1 Atelectasis Natural Death
Respiratory System Lung 320 PPM 46 NA 2_024 114.00 1 Pneumonia, Chronic Murine Scheduled Sacrifice
Respiratory System Lung 640 PPM 46 NA 3_090 114.00 1 Necrosis, Focal Natural Death
Urinary System Kidney Papilla 640 PPM 46 NA 3_081 114.00 1 Calcium Deposit Moribund Sacrifice
Urinary System Kidney Vehicle Control 10 NA 1_084 114.00 1 Inflammation, Chronic Moribund Sacrifice
Urinary System Kidney Vehicle Control 10 NA 1_085 114.00 1 Inflammation, Chronic Moribund Sacrifice
Urinary System Kidney Vehicle Control 10 NA 1_082 114.00 1 Inflammation, Chronic Scheduled Sacrifice
Urinary System Kidney Vehicle Control 10 NA 1_083 114.00 1 Inflammation, Chronic Scheduled Sacrifice
Urinary System Kidney Vehicle Control 10 NA 1_089 114.00 1 Inflammation, Chronic Scheduled Sacrifice
Urinary System Kidney 320 PPM 46 NA 2_005 114.00 1 Inflammation, Chronic Moribund Sacrifice
Urinary System Kidney 320 PPM 46 NA 2_006 114.00 1 Inflammation, Chronic Moribund Sacrifice
Urinary System Kidney 320 PPM 46 NA 2_007 114.00 1 Pyelonephritis, Chronic Moribund Sacrifice
Urinary System Kidney 320 PPM 46 NA 2_012 114.00 1 Inflammation, Chronic Moribund Sacrifice
Urinary System Kidney 320 PPM 46 NA 2_018 114.00 1 Inflammation, Chronic Moribund Sacrifice
Urinary System Kidney 320 PPM 46 NA 2_027 114.00 1 Inflammation, Chronic Moribund Sacrifice
Urinary System Kidney 320 PPM 46 NA 2_047 114.00 1 Inflammation, Chronic Moribund Sacrifice
Urinary System Kidney 320 PPM 46 NA 2_009 114.00 1 Inflammation, Chronic Natural Death
Urinary System Kidney 320 PPM 46 NA 2_013 114.00 1 Inflammation, Chronic Natural Death
Urinary System Kidney 320 PPM 46 NA 2_001 114.00 1 Inflammation, Chronic Scheduled Sacrifice
Urinary System Kidney 320 PPM 46 NA 2_002 114.00 1 Inflammation, Chronic Scheduled Sacrifice
Urinary System Kidney 320 PPM 46 NA 2_003 114.00 1 Inflammation, Chronic Scheduled Sacrifice
Urinary System Kidney 320 PPM 46 NA 2_011 114.00 1 Inflammation, Chronic Scheduled Sacrifice
Urinary System Kidney 320 PPM 46 NA 2_015 114.00 1 Inflammation, Chronic Scheduled Sacrifice
Urinary System Kidney 320 PPM 46 NA 2_020 114.00 1 Inflammation, Chronic Scheduled Sacrifice
Urinary System Kidney 320 PPM 46 NA 2_022 114.00 1 Inflammation, Chronic Scheduled Sacrifice
Urinary System Kidney 320 PPM 46 NA 2_024 114.00 1 Hamartoma Scheduled Sacrifice
Urinary System Kidney 320 PPM 46 NA 2_024 114.00 1 Inflammation, Chronic Scheduled Sacrifice
Urinary System Kidney 320 PPM 46 NA 2_029 114.00 1 Inflammation, Chronic Scheduled Sacrifice
Urinary System Kidney 320 PPM 46 NA 2_031 114.00 1 Inflammation, Chronic Scheduled Sacrifice
Urinary System Kidney 320 PPM 46 NA 2_040 114.00 1 Inflammation, Diffuse Scheduled Sacrifice
Urinary System Kidney 320 PPM 46 NA 2_042 114.00 1 Inflammation, Chronic Scheduled Sacrifice
Urinary System Kidney 320 PPM 46 NA 2_044 114.00 1 Inflammation, Chronic Scheduled Sacrifice
Urinary System Kidney 320 PPM 46 NA 2_046 114.00 1 Inflammation, Chronic Scheduled Sacrifice
Urinary System Kidney 320 PPM 46 NA 2_048 114.00 1 Inflammation, Chronic Scheduled Sacrifice
Urinary System Kidney 640 PPM 46 NA 3_052 114.00 1 Inflammation, Chronic Moribund Sacrifice
Urinary System Kidney 640 PPM 46 NA 3_062 114.00 1 Inflammation, Chronic Moribund Sacrifice
Urinary System Kidney 640 PPM 46 NA 3_063 114.00 1 Inflammation, Chronic Moribund Sacrifice
Urinary System Kidney 640 PPM 46 NA 3_072 114.00 1 Inflammation, Chronic Moribund Sacrifice
Urinary System Kidney 640 PPM 46 NA 3_074 114.00 1 Inflammation, Chronic Moribund Sacrifice
Urinary System Kidney 640 PPM 46 NA 3_078 114.00 1 Inflammation, Chronic Moribund Sacrifice
Urinary System Kidney 640 PPM 46 NA 3_079 114.00 1 Inflammation, Chronic Moribund Sacrifice
Urinary System Kidney 640 PPM 46 NA 3_086 114.00 1 Inflammation, Chronic Moribund Sacrifice
Urinary System Kidney 640 PPM 46 NA 3_089 114.00 1 Inflammation, Chronic Moribund Sacrifice
Urinary System Kidney 640 PPM 46 NA 3_088 114.00 1 Inflammation, Chronic Natural Death
Urinary System Kidney 640 PPM 46 NA 3_090 114.00 1 Inflammation, Chronic Natural Death
Urinary System Kidney 640 PPM 46 NA 3_054 114.00 1 Inflammation, Chronic Scheduled Sacrifice
Urinary System Kidney 640 PPM 46 NA 3_056 114.00 1 Inflammation, Chronic Scheduled Sacrifice
Urinary System Kidney 640 PPM 46 NA 3_057 114.00 1 Inflammation, Chronic Scheduled Sacrifice
Urinary System Kidney 640 PPM 46 NA 3_059 114.00 1 Inflammation, Chronic Scheduled Sacrifice
Urinary System Kidney 640 PPM 46 NA 3_060 114.00 1 Inflammation, Chronic Scheduled Sacrifice
Urinary System Kidney 640 PPM 46 NA 3_061 114.00 1 Inflammation, Chronic Scheduled Sacrifice
Urinary System Kidney 640 PPM 46 NA 3_064 114.00 1 Inflammation, Chronic Scheduled Sacrifice
Urinary System Kidney 640 PPM 46 NA 3_065 114.00 1 Inflammation, Chronic Scheduled Sacrifice
Urinary System Kidney 640 PPM 46 NA 3_066 114.00 1 Inflammation, Chronic Scheduled Sacrifice
Urinary System Kidney 640 PPM 46 NA 3_068 114.00 1 Inflammation, Chronic Scheduled Sacrifice
Urinary System Kidney 640 PPM 46 NA 3_069 114.00 1 Inflammation, Chronic Scheduled Sacrifice
Urinary System Kidney 640 PPM 46 NA 3_077 114.00 1 Inflammation, Chronic Scheduled Sacrifice
Urinary System Kidney 640 PPM 46 NA 3_080 114.00 1 Inflammation, Chronic Scheduled Sacrifice
Urinary System Kidney 640 PPM 46 NA 3_083 114.00 1 Inflammation, Chronic Scheduled Sacrifice
Urinary System Kidney 640 PPM 46 NA 3_085 114.00 1 Inflammation, Chronic Scheduled Sacrifice
Urinary System Kidney 640 PPM 46 NA 3_087 114.00 1 Inflammation, Chronic Scheduled Sacrifice
Urinary System Kidney 640 PPM 46 NA 3_097 114.00 1 Inflammation, Chronic Scheduled Sacrifice
Urinary System Urethra Vehicle Control NA NA 1_085 114.00 1 Inflammation, Suppurative Moribund Sacrifice
Urinary System Urinary bladder Vehicle Control NA NA 1_085 114.00 1 Inflammation, Acute Moribund Sacrifice