If this is the first time you are viewing this file, please choose 'Save As' from the 'File' menu and resave this file as an Excel file type. This will greatly speed up future viewings of this file.

Long-Term Individual Animal Non Neoplastic Diagnosis

Study Information:

Chemical Name:	Parathion
CASRN:	="56-38-2"
Study Number:	C00226
Exposure Route:	Dosed-Feed
TDMS Number:
Sex:	Female
Strain and Species:	B6C3F1 Mice

Female Individual Animal Non Neoplastic Diagnoses

System Organ Site Treatment Group Number Examined Cage Number Animal Number Weeks on Study Lesion Found Lesion Name Lesion Qualifier Removal Reason

Alimentary System Liver 80 PPM 47 NA 2_203 95.00 1 Cytoplasmic Change, Basophilic Scheduled Sacrifice

Alimentary System Liver 80 PPM 47 NA 2_237 95.00 1 Cytoplasmic Change, Basophilic Scheduled Sacrifice

Alimentary System Liver 80 PPM 47 NA 2_246 95.00 1 Cytoplasmic Change, Basophilic Scheduled Sacrifice

Alimentary System Pancreas Vehicle Control 7 NA 1_183 95.00 1 Atrophy, Nos Scheduled Sacrifice

Alimentary System Pancreas Vehicle Control 7 NA 1_183 95.00 1 Cyst, Nos Scheduled Sacrifice

Alimentary System Pancreas 160 PPM 48 NA 3_344 95.00 1 Cyst, Nos Moribund Sacrifice

Alimentary System Pancreas 160 PPM 48 NA 3_301 95.00 1 Atrophy, Nos Scheduled Sacrifice

Genital System Ovary Vehicle Control 6 NA 1_187 95.00 1 Inflammation, Chronic Scheduled Sacrifice

Genital System Ovary 80 PPM 42 NA 2_211 95.00 1 Inflammation, Suppurative Scheduled Sacrifice

Genital System Ovary 80 PPM 42 NA 2_214 95.00 1 Abscess, Nos Scheduled Sacrifice

Genital System Ovary 80 PPM 42 NA 2_215 95.00 1 Abscess, Nos Scheduled Sacrifice

Genital System Ovary 80 PPM 42 NA 2_217 95.00 1 Abscess, Nos Scheduled Sacrifice

Genital System Ovary 80 PPM 42 NA 2_221 95.00 1 Abscess, Nos Scheduled Sacrifice

Genital System Ovary 80 PPM 42 NA 2_228 95.00 1 Abscess, Nos Scheduled Sacrifice

Genital System Ovary 80 PPM 42 NA 2_229 95.00 1 Abscess, Nos Scheduled Sacrifice

Genital System Ovary 80 PPM 42 NA 2_230 95.00 1 Abscess, Nos Scheduled Sacrifice

Genital System Ovary 80 PPM 42 NA 2_237 95.00 1 Abscess, Nos Scheduled Sacrifice

Genital System Ovary 80 PPM 42 NA 2_240 95.00 1 Abscess, Nos Scheduled Sacrifice

Genital System Ovary 160 PPM 45 NA 3_314 95.00 1 Abscess, Nos Scheduled Sacrifice

Genital System Ovary 160 PPM 45 NA 3_319 95.00 1 Abscess, Nos Scheduled Sacrifice

Genital System Ovary 160 PPM 45 NA 3_327 95.00 1 Abscess, Nos Scheduled Sacrifice

Genital System Ovary 160 PPM 45 NA 3_349 95.00 1 Abscess, Nos Scheduled Sacrifice

Genital System Uterus 80 PPM 46 NA 2_211 95.00 1 Abscess, Nos Scheduled Sacrifice

Genital System Uterus 80 PPM 46 NA 2_220 95.00 1 Inflammation, Suppurative Scheduled Sacrifice

Genital System Uterus 80 PPM 46 NA 2_224 95.00 1 Pyometra Scheduled Sacrifice

Genital System Uterus 80 PPM 46 NA 2_242 95.00 1 Pyometra Scheduled Sacrifice

Genital System Uterus 160 PPM 47 NA 3_313 95.00 1 Abscess, Nos Scheduled Sacrifice

Genital System Uterus 160 PPM 47 NA 3_334 95.00 1 Abscess, Nos Scheduled Sacrifice

Hematopoietic System Bone marrow 80 PPM 4 NA 2_215 95.00 1 Hyperplasia, Hematopoietic Scheduled Sacrifice

Hematopoietic System Bone marrow 80 PPM 4 NA 2_220 95.00 1 Hyperplasia, Hematopoietic Scheduled Sacrifice

Hematopoietic System Bone marrow 80 PPM 4 NA 2_227 95.00 1 Hyperplasia, Hematopoietic Scheduled Sacrifice

Hematopoietic System Lymph node Cervical Lymph Node Nos 160 PPM 47 NA 3_327 95.00 1 Inflammation, Suppurative Scheduled Sacrifice

Hematopoietic System Lymph node Mediastinal Lymph Node 160 PPM 47 NA 3_346 95.00 1 Granuloma, Pyogenic Scheduled Sacrifice

Hematopoietic System Lymph node Mesenteric Lymph Node 160 PPM 49 NA 3_346 95.00 1 Granuloma, Pyogenic Scheduled Sacrifice

Hematopoietic System Lymph node 160 PPM 47 NA 3_304 95.00 1 Abscess, Nos Scheduled Sacrifice

Hematopoietic System Spleen 160 PPM 49 NA 3_321 95.00 1 Metaplasia, Myeloid Moribund Sacrifice

Hematopoietic System Spleen 160 PPM 49 NA 3_336 95.00 1 Infarct, Nos Natural Death

Integumentary System Mammary gland 160 PPM 50 NA 3_321 95.00 1 Metaplasia, Osseous Moribund Sacrifice

Respiratory System Lung 160 PPM 49 NA 3_321 95.00 1 Metaplasia, Osseous Moribund Sacrifice

Respiratory System Lung 160 PPM 49 NA 3_346 95.00 1 Granuloma, Pyogenic Scheduled Sacrifice

Urinary System Kidney 80 PPM 46 NA 2_211 95.00 1 Inflammation, Chronic Scheduled Sacrifice

Urinary System Kidney 80 PPM 46 NA 2_243 95.00 1 Cyst, Nos Scheduled Sacrifice

Urinary System Kidney 80 PPM 46 NA 2_243 95.00 1 Inflammation, Chronic Scheduled Sacrifice

Urinary System Urinary bladder 80 PPM NA NA 2_243 95.00 1 Inflammation, Chronic Scheduled Sacrifice

System	Organ	Site	Treatment Group	Number Examined	Cage Number	Animal Number	Weeks on Study	Lesion Found	Lesion Name	Removal Reason
Alimentary System	Liver		80 PPM	47	NA	2_203	95.00	1	Cytoplasmic Change, Basophilic	Scheduled Sacrifice
Alimentary System	Liver		80 PPM	47	NA	2_237	95.00	1	Cytoplasmic Change, Basophilic	Scheduled Sacrifice
Alimentary System	Liver		80 PPM	47	NA	2_246	95.00	1	Cytoplasmic Change, Basophilic	Scheduled Sacrifice
Alimentary System	Pancreas		Vehicle Control	7	NA	1_183	95.00	1	Atrophy, Nos	Scheduled Sacrifice
Alimentary System	Pancreas		Vehicle Control	7	NA	1_183	95.00	1	Cyst, Nos	Scheduled Sacrifice
Alimentary System	Pancreas		160 PPM	48	NA	3_344	95.00	1	Cyst, Nos	Moribund Sacrifice
Alimentary System	Pancreas		160 PPM	48	NA	3_301	95.00	1	Atrophy, Nos	Scheduled Sacrifice
Genital System	Ovary		Vehicle Control	6	NA	1_187	95.00	1	Inflammation, Chronic	Scheduled Sacrifice
Genital System	Ovary		80 PPM	42	NA	2_211	95.00	1	Inflammation, Suppurative	Scheduled Sacrifice
Genital System	Ovary		80 PPM	42	NA	2_214	95.00	1	Abscess, Nos	Scheduled Sacrifice
Genital System	Ovary		80 PPM	42	NA	2_215	95.00	1	Abscess, Nos	Scheduled Sacrifice
Genital System	Ovary		80 PPM	42	NA	2_217	95.00	1	Abscess, Nos	Scheduled Sacrifice
Genital System	Ovary		80 PPM	42	NA	2_221	95.00	1	Abscess, Nos	Scheduled Sacrifice
Genital System	Ovary		80 PPM	42	NA	2_228	95.00	1	Abscess, Nos	Scheduled Sacrifice
Genital System	Ovary		80 PPM	42	NA	2_229	95.00	1	Abscess, Nos	Scheduled Sacrifice
Genital System	Ovary		80 PPM	42	NA	2_230	95.00	1	Abscess, Nos	Scheduled Sacrifice
Genital System	Ovary		80 PPM	42	NA	2_237	95.00	1	Abscess, Nos	Scheduled Sacrifice
Genital System	Ovary		80 PPM	42	NA	2_240	95.00	1	Abscess, Nos	Scheduled Sacrifice
Genital System	Ovary		160 PPM	45	NA	3_314	95.00	1	Abscess, Nos	Scheduled Sacrifice
Genital System	Ovary		160 PPM	45	NA	3_319	95.00	1	Abscess, Nos	Scheduled Sacrifice
Genital System	Ovary		160 PPM	45	NA	3_327	95.00	1	Abscess, Nos	Scheduled Sacrifice
Genital System	Ovary		160 PPM	45	NA	3_349	95.00	1	Abscess, Nos	Scheduled Sacrifice
Genital System	Uterus		80 PPM	46	NA	2_211	95.00	1	Abscess, Nos	Scheduled Sacrifice
Genital System	Uterus		80 PPM	46	NA	2_220	95.00	1	Inflammation, Suppurative	Scheduled Sacrifice
Genital System	Uterus		80 PPM	46	NA	2_224	95.00	1	Pyometra	Scheduled Sacrifice
Genital System	Uterus		80 PPM	46	NA	2_242	95.00	1	Pyometra	Scheduled Sacrifice
Genital System	Uterus		160 PPM	47	NA	3_313	95.00	1	Abscess, Nos	Scheduled Sacrifice
Genital System	Uterus		160 PPM	47	NA	3_334	95.00	1	Abscess, Nos	Scheduled Sacrifice
Hematopoietic System	Bone marrow		80 PPM	4	NA	2_215	95.00	1	Hyperplasia, Hematopoietic	Scheduled Sacrifice
Hematopoietic System	Bone marrow		80 PPM	4	NA	2_220	95.00	1	Hyperplasia, Hematopoietic	Scheduled Sacrifice
Hematopoietic System	Bone marrow		80 PPM	4	NA	2_227	95.00	1	Hyperplasia, Hematopoietic	Scheduled Sacrifice
Hematopoietic System	Lymph node	Cervical Lymph Node Nos	160 PPM	47	NA	3_327	95.00	1	Inflammation, Suppurative	Scheduled Sacrifice
Hematopoietic System	Lymph node	Mediastinal Lymph Node	160 PPM	47	NA	3_346	95.00	1	Granuloma, Pyogenic	Scheduled Sacrifice
Hematopoietic System	Lymph node	Mesenteric Lymph Node	160 PPM	49	NA	3_346	95.00	1	Granuloma, Pyogenic	Scheduled Sacrifice
Hematopoietic System	Lymph node		160 PPM	47	NA	3_304	95.00	1	Abscess, Nos	Scheduled Sacrifice
Hematopoietic System	Spleen		160 PPM	49	NA	3_321	95.00	1	Metaplasia, Myeloid	Moribund Sacrifice
Hematopoietic System	Spleen		160 PPM	49	NA	3_336	95.00	1	Infarct, Nos	Natural Death
Integumentary System	Mammary gland		160 PPM	50	NA	3_321	95.00	1	Metaplasia, Osseous	Moribund Sacrifice
Respiratory System	Lung		160 PPM	49	NA	3_321	95.00	1	Metaplasia, Osseous	Moribund Sacrifice
Respiratory System	Lung		160 PPM	49	NA	3_346	95.00	1	Granuloma, Pyogenic	Scheduled Sacrifice
Urinary System	Kidney		80 PPM	46	NA	2_211	95.00	1	Inflammation, Chronic	Scheduled Sacrifice
Urinary System	Kidney		80 PPM	46	NA	2_243	95.00	1	Cyst, Nos	Scheduled Sacrifice
Urinary System	Kidney		80 PPM	46	NA	2_243	95.00	1	Inflammation, Chronic	Scheduled Sacrifice
Urinary System	Urinary bladder		80 PPM	NA	NA	2_243	95.00	1	Inflammation, Chronic	Scheduled Sacrifice