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Long-Term Individual Animal Neoplastic Diagnosis

Study Information:

Chemical Name:	Parathion
CASRN:	="56-38-2"
Study Number:	C00226
Exposure Route:	Dosed-Feed
TDMS Number:
Sex:	Male
Strain and Species:	B6C3F1 Mice

Male Individual Animal Neoplastic Diagnoses

System Organ Site Treatment Group Number Examined Cage Number Animal Number Weeks on Study Lesion Found Lesion Name Lesion Qualifier Removal Reason

Alimentary System Intestine Small Ileum 80 PPM 48 NA 2_263 95.00 1 Lymphoma, Lymphocytic-Malignant Type Scheduled Sacrifice

Alimentary System Liver Vehicle Control 10 NA 1_195 95.00 1 Neoplastic Nodule Scheduled Sacrifice

Alimentary System Liver Vehicle Control 10 NA 1_197 95.00 1 Hepatocellular Carcinoma Scheduled Sacrifice

Alimentary System Liver 80 PPM 48 NA 2_259 95.00 1 Hepatocellular Carcinoma Moribund Sacrifice

Alimentary System Liver 80 PPM 48 NA 2_258 95.00 1 Neoplastic Nodule Scheduled Sacrifice

Alimentary System Liver 80 PPM 48 NA 2_271 95.00 1 Neoplastic Nodule Scheduled Sacrifice

Alimentary System Liver 80 PPM 48 NA 2_277 95.00 1 Neoplastic Nodule Scheduled Sacrifice

Alimentary System Liver 80 PPM 48 NA 2_287 95.00 1 Hepatocellular Carcinoma Scheduled Sacrifice

Alimentary System Liver 80 PPM 48 NA 2_296 95.00 1 Hepatocellular Carcinoma Scheduled Sacrifice

Alimentary System Liver 160 PPM 47 NA 3_372 95.00 1 Hepatocellular Carcinoma Moribund Sacrifice

Alimentary System Liver 160 PPM 47 NA 3_354 95.00 1 Neoplastic Nodule Scheduled Sacrifice

Alimentary System Liver 160 PPM 47 NA 3_364 95.00 1 Neoplastic Nodule Scheduled Sacrifice

Alimentary System Liver 160 PPM 47 NA 3_370 95.00 1 Neoplastic Nodule Scheduled Sacrifice

Alimentary System Liver 160 PPM 47 NA 3_371 95.00 1 Neoplastic Nodule Scheduled Sacrifice

Alimentary System Liver 160 PPM 47 NA 3_376 95.00 1 Neoplastic Nodule Scheduled Sacrifice

Alimentary System Liver 160 PPM 47 NA 3_381 95.00 1 Neoplastic Nodule Scheduled Sacrifice

Alimentary System Liver 160 PPM 47 NA 3_385 95.00 1 Neoplastic Nodule Scheduled Sacrifice

Alimentary System Liver 160 PPM 47 NA 3_391 95.00 1 Neoplastic Nodule Scheduled Sacrifice

All Others Unspecified Tail 80 PPM NA NA 2_283 95.00 1 Fibrosarcoma Moribund Sacrifice

Endocrine System Thyroid 80 PPM 40 NA 2_299 95.00 1 Carcinoma, Nos Scheduled Sacrifice

Hematopoietic System Lymph node Mesenteric Lymph Node 80 PPM 47 NA 2_275 95.00 1 Lymphoma, Lymphocytic-Malignant Type Scheduled Sacrifice

Hematopoietic System Spleen 80 PPM 49 NA 2_275 95.00 1 Lymphoma, Lymphocytic-Malignant Type Scheduled Sacrifice

Integumentary System Skin 80 PPM 49 NA 2_273 95.00 1 Melanoma, Malignant Scheduled Sacrifice

Respiratory System Lung 80 PPM 49 NA 2_260 95.00 1 Alveolar/Bronchiolar Adenoma Scheduled Sacrifice

Respiratory System Lung 80 PPM 49 NA 2_261 95.00 1 Alveolar/Bronchiolar Adenoma Scheduled Sacrifice

Respiratory System Lung 80 PPM 49 NA 2_279 95.00 1 Alveolar/Bronchiolar Adenoma Scheduled Sacrifice

Respiratory System Lung 160 PPM 47 NA 3_354 95.00 1 Alveolar/Bronchiolar Adenoma Scheduled Sacrifice

Respiratory System Lung 160 PPM 47 NA 3_370 95.00 1 Alveolar/Bronchiolar Adenoma Scheduled Sacrifice

Respiratory System Lung 160 PPM 47 NA 3_374 95.00 1 Alveolar/Bronchiolar Adenoma Scheduled Sacrifice

Respiratory System Lung 160 PPM 47 NA 3_386 95.00 1 Alveolar/Bronchiolar Adenoma Scheduled Sacrifice

Respiratory System Lung 160 PPM 47 NA 3_387 95.00 1 Alveolar/Bronchiolar Adenoma Scheduled Sacrifice

System	Organ	Site	Treatment Group	Number Examined	Cage Number	Animal Number	Weeks on Study	Lesion Found	Lesion Name	Removal Reason
Alimentary System	Intestine Small	Ileum	80 PPM	48	NA	2_263	95.00	1	Lymphoma, Lymphocytic-Malignant Type	Scheduled Sacrifice
Alimentary System	Liver		Vehicle Control	10	NA	1_195	95.00	1	Neoplastic Nodule	Scheduled Sacrifice
Alimentary System	Liver		Vehicle Control	10	NA	1_197	95.00	1	Hepatocellular Carcinoma	Scheduled Sacrifice
Alimentary System	Liver		80 PPM	48	NA	2_259	95.00	1	Hepatocellular Carcinoma	Moribund Sacrifice
Alimentary System	Liver		80 PPM	48	NA	2_258	95.00	1	Neoplastic Nodule	Scheduled Sacrifice
Alimentary System	Liver		80 PPM	48	NA	2_271	95.00	1	Neoplastic Nodule	Scheduled Sacrifice
Alimentary System	Liver		80 PPM	48	NA	2_277	95.00	1	Neoplastic Nodule	Scheduled Sacrifice
Alimentary System	Liver		80 PPM	48	NA	2_287	95.00	1	Hepatocellular Carcinoma	Scheduled Sacrifice
Alimentary System	Liver		80 PPM	48	NA	2_296	95.00	1	Hepatocellular Carcinoma	Scheduled Sacrifice
Alimentary System	Liver		160 PPM	47	NA	3_372	95.00	1	Hepatocellular Carcinoma	Moribund Sacrifice
Alimentary System	Liver		160 PPM	47	NA	3_354	95.00	1	Neoplastic Nodule	Scheduled Sacrifice
Alimentary System	Liver		160 PPM	47	NA	3_364	95.00	1	Neoplastic Nodule	Scheduled Sacrifice
Alimentary System	Liver		160 PPM	47	NA	3_370	95.00	1	Neoplastic Nodule	Scheduled Sacrifice
Alimentary System	Liver		160 PPM	47	NA	3_371	95.00	1	Neoplastic Nodule	Scheduled Sacrifice
Alimentary System	Liver		160 PPM	47	NA	3_376	95.00	1	Neoplastic Nodule	Scheduled Sacrifice
Alimentary System	Liver		160 PPM	47	NA	3_381	95.00	1	Neoplastic Nodule	Scheduled Sacrifice
Alimentary System	Liver		160 PPM	47	NA	3_385	95.00	1	Neoplastic Nodule	Scheduled Sacrifice
Alimentary System	Liver		160 PPM	47	NA	3_391	95.00	1	Neoplastic Nodule	Scheduled Sacrifice
All Others	Unspecified	Tail	80 PPM	NA	NA	2_283	95.00	1	Fibrosarcoma	Moribund Sacrifice
Endocrine System	Thyroid		80 PPM	40	NA	2_299	95.00	1	Carcinoma, Nos	Scheduled Sacrifice
Hematopoietic System	Lymph node	Mesenteric Lymph Node	80 PPM	47	NA	2_275	95.00	1	Lymphoma, Lymphocytic-Malignant Type	Scheduled Sacrifice
Hematopoietic System	Spleen		80 PPM	49	NA	2_275	95.00	1	Lymphoma, Lymphocytic-Malignant Type	Scheduled Sacrifice
Integumentary System	Skin		80 PPM	49	NA	2_273	95.00	1	Melanoma, Malignant	Scheduled Sacrifice
Respiratory System	Lung		80 PPM	49	NA	2_260	95.00	1	Alveolar/Bronchiolar Adenoma	Scheduled Sacrifice
Respiratory System	Lung		80 PPM	49	NA	2_261	95.00	1	Alveolar/Bronchiolar Adenoma	Scheduled Sacrifice
Respiratory System	Lung		80 PPM	49	NA	2_279	95.00	1	Alveolar/Bronchiolar Adenoma	Scheduled Sacrifice
Respiratory System	Lung		160 PPM	47	NA	3_354	95.00	1	Alveolar/Bronchiolar Adenoma	Scheduled Sacrifice
Respiratory System	Lung		160 PPM	47	NA	3_370	95.00	1	Alveolar/Bronchiolar Adenoma	Scheduled Sacrifice
Respiratory System	Lung		160 PPM	47	NA	3_374	95.00	1	Alveolar/Bronchiolar Adenoma	Scheduled Sacrifice
Respiratory System	Lung		160 PPM	47	NA	3_386	95.00	1	Alveolar/Bronchiolar Adenoma	Scheduled Sacrifice
Respiratory System	Lung		160 PPM	47	NA	3_387	95.00	1	Alveolar/Bronchiolar Adenoma	Scheduled Sacrifice