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Long-Term Individual Animal Non Neoplastic Diagnosis

Study Information:

Chemical Name:	Parathion
CASRN:	="56-38-2"
Study Number:	C00226
Exposure Route:	Dosed-Feed
TDMS Number:
Sex:	Male
Strain and Species:	B6C3F1 Mice

Male Individual Animal Non Neoplastic Diagnoses

System Organ Site Treatment Group Number Examined Cage Number Animal Number Weeks on Study Lesion Found Lesion Name Lesion Qualifier Removal Reason

Alimentary System Liver 80 PPM 48 NA 2_257 95.00 1 Necrosis, Focal Scheduled Sacrifice

Alimentary System Liver 80 PPM 48 NA 2_265 95.00 1 Angiectasis Scheduled Sacrifice

Alimentary System Liver 80 PPM 48 NA 2_300 95.00 1 Cytoplasmic Change, Basophilic Scheduled Sacrifice

Alimentary System Liver 160 PPM 47 NA 3_366 95.00 1 Angiectasis Scheduled Sacrifice

Genital System Preputial gland 160 PPM NA NA 3_352 95.00 1 Cyst, Nos Scheduled Sacrifice

Genital System Prostate 160 PPM 43 NA 3_356 95.00 1 Inflammation, Suppurative Moribund Sacrifice

Genital System Prostate 160 PPM 43 NA 3_369 95.00 1 Inflammation, Suppurative Natural Death

Hematopoietic System Bone marrow 160 PPM 1 NA 3_395 95.00 1 Hyperplasia, Hematopoietic Natural Death

Hematopoietic System Lymph node Mesenteric Lymph Node 80 PPM 47 NA 2_290 95.00 1 Hemorrhage Scheduled Sacrifice

Hematopoietic System Lymph node Mesenteric Lymph Node 80 PPM 47 NA 2_299 95.00 1 Hemorrhage Scheduled Sacrifice

Hematopoietic System Lymph node Mesenteric Lymph Node 80 PPM 47 NA 2_299 95.00 1 Inflammation, Granulomatous Scheduled Sacrifice

Integumentary System Skin Vehicle Control 10 NA 1_194 95.00 1 Inflammation, Chronic Scheduled Sacrifice

Integumentary System Skin 160 PPM 47 NA 3_369 95.00 1 Abscess, Nos Natural Death

Urinary System Kidney Pelvis 160 PPM 48 NA 3_356 95.00 1 Inflammation, Suppurative Moribund Sacrifice

Urinary System Urinary bladder 160 PPM NA NA 3_356 95.00 1 Inflammation, Suppurative Moribund Sacrifice

Urinary System Urinary bladder 160 PPM NA NA 3_369 95.00 1 Inflammation, Suppurative Natural Death

System	Organ	Site	Treatment Group	Number Examined	Cage Number	Animal Number	Weeks on Study	Lesion Found	Lesion Name	Removal Reason
Alimentary System	Liver		80 PPM	48	NA	2_257	95.00	1	Necrosis, Focal	Scheduled Sacrifice
Alimentary System	Liver		80 PPM	48	NA	2_265	95.00	1	Angiectasis	Scheduled Sacrifice
Alimentary System	Liver		80 PPM	48	NA	2_300	95.00	1	Cytoplasmic Change, Basophilic	Scheduled Sacrifice
Alimentary System	Liver		160 PPM	47	NA	3_366	95.00	1	Angiectasis	Scheduled Sacrifice
Genital System	Preputial gland		160 PPM	NA	NA	3_352	95.00	1	Cyst, Nos	Scheduled Sacrifice
Genital System	Prostate		160 PPM	43	NA	3_356	95.00	1	Inflammation, Suppurative	Moribund Sacrifice
Genital System	Prostate		160 PPM	43	NA	3_369	95.00	1	Inflammation, Suppurative	Natural Death
Hematopoietic System	Bone marrow		160 PPM	1	NA	3_395	95.00	1	Hyperplasia, Hematopoietic	Natural Death
Hematopoietic System	Lymph node	Mesenteric Lymph Node	80 PPM	47	NA	2_290	95.00	1	Hemorrhage	Scheduled Sacrifice
Hematopoietic System	Lymph node	Mesenteric Lymph Node	80 PPM	47	NA	2_299	95.00	1	Hemorrhage	Scheduled Sacrifice
Hematopoietic System	Lymph node	Mesenteric Lymph Node	80 PPM	47	NA	2_299	95.00	1	Inflammation, Granulomatous	Scheduled Sacrifice
Integumentary System	Skin		Vehicle Control	10	NA	1_194	95.00	1	Inflammation, Chronic	Scheduled Sacrifice
Integumentary System	Skin		160 PPM	47	NA	3_369	95.00	1	Abscess, Nos	Natural Death
Urinary System	Kidney	Pelvis	160 PPM	48	NA	3_356	95.00	1	Inflammation, Suppurative	Moribund Sacrifice
Urinary System	Urinary bladder		160 PPM	NA	NA	3_356	95.00	1	Inflammation, Suppurative	Moribund Sacrifice
Urinary System	Urinary bladder		160 PPM	NA	NA	3_369	95.00	1	Inflammation, Suppurative	Natural Death