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Long-Term Individual Animal Non Neoplastic Diagnosis
Study Information:
| Chemical Name: | Parathion |
|---|
| CASRN: | ="56-38-2" |
|---|
| Study Number: | C00226 |
|---|
| Exposure Route: | Dosed-Feed |
|---|
| TDMS Number: | |
|---|
| Sex: | Female |
|---|
| Strain and Species: | Osborne Mendel Rats |
|---|
Female Individual Animal Non Neoplastic Diagnoses
| System |
Organ |
Site |
Treatment Group |
Number Examined |
Cage Number |
Animal Number |
Weeks on Study |
Lesion Found |
Lesion Name |
Lesion Qualifier |
Removal Reason |
| Alimentary System |
Liver |
Bile Duct |
20 PPM |
50 |
NA |
2_105 |
120.00 |
1 |
Hyperplasia, Nos |
|
Moribund Sacrifice |
| Alimentary System |
Liver |
|
20 PPM |
49 |
NA |
2_120 |
120.00 |
1 |
Metamorphosis, Fatty |
|
Moribund Sacrifice |
| Alimentary System |
Liver |
|
20 PPM |
49 |
NA |
2_126 |
120.00 |
1 |
Metamorphosis, Fatty |
|
Moribund Sacrifice |
| Alimentary System |
Liver |
|
20 PPM |
49 |
NA |
2_106 |
120.00 |
1 |
Focal Cellular Change |
|
Scheduled Sacrifice |
| Alimentary System |
Liver |
|
20 PPM |
49 |
NA |
2_139 |
120.00 |
1 |
Metamorphosis, Fatty |
|
Scheduled Sacrifice |
| Alimentary System |
Liver |
|
40 PPM |
48 |
NA |
3_160 |
120.00 |
1 |
Metamorphosis, Fatty |
|
Moribund Sacrifice |
| Alimentary System |
Liver |
|
40 PPM |
48 |
NA |
3_151 |
120.00 |
1 |
Metamorphosis, Fatty |
|
Natural Death |
| Alimentary System |
Liver |
|
40 PPM |
48 |
NA |
3_155 |
120.00 |
1 |
Metamorphosis, Fatty |
|
Scheduled Sacrifice |
| Alimentary System |
Liver |
|
40 PPM |
48 |
NA |
3_198 |
120.00 |
1 |
Focal Cellular Change |
|
Scheduled Sacrifice |
| Alimentary System |
Stomach |
Gastrosplenic Ligament |
40 PPM |
47 |
NA |
3_168 |
120.00 |
1 |
Necrosis, Fat |
|
Moribund Sacrifice |
| Alimentary System |
Stomach |
|
40 PPM |
47 |
NA |
3_174 |
120.00 |
1 |
Mineralization |
|
Moribund Sacrifice |
| Cardiovascular System |
Heart |
Myocardium Nos |
40 PPM |
49 |
NA |
3_160 |
120.00 |
1 |
Inflammation, Chronic |
|
Moribund Sacrifice |
| Cardiovascular System |
Heart |
Myocardium Nos |
40 PPM |
49 |
NA |
3_174 |
120.00 |
1 |
Inflammation, Chronic |
|
Moribund Sacrifice |
| Endocrine System |
Adrenal gland |
|
Vehicle Control |
10 |
NA |
1_295 |
120.00 |
1 |
Angiectasis |
|
Moribund Sacrifice |
| Endocrine System |
Adrenal gland |
|
20 PPM |
47 |
NA |
2_103 |
120.00 |
1 |
Angiectasis |
|
Scheduled Sacrifice |
| Endocrine System |
Adrenal gland |
|
20 PPM |
47 |
NA |
2_128 |
120.00 |
1 |
Angiectasis |
|
Scheduled Sacrifice |
| Endocrine System |
Thyroid |
|
20 PPM |
45 |
NA |
2_116 |
120.00 |
1 |
Hyperplasia, Follicular Cell |
|
Scheduled Sacrifice |
| Genital System |
Uterus |
Endometrium |
20 PPM |
49 |
NA |
2_148 |
120.00 |
1 |
Hyperplasia, Cystic |
|
Scheduled Sacrifice |
| Genital System |
Uterus |
|
20 PPM |
49 |
NA |
2_123 |
120.00 |
1 |
Hydrometra |
|
Natural Death |
| Genital System |
Uterus |
|
20 PPM |
49 |
NA |
2_118 |
120.00 |
1 |
Cyst, Nos |
|
Scheduled Sacrifice |
| Genital System |
Uterus |
|
20 PPM |
49 |
NA |
2_147 |
120.00 |
1 |
Cyst, Nos |
|
Scheduled Sacrifice |
| Hematopoietic System |
Bone marrow |
|
20 PPM |
2 |
NA |
2_113 |
120.00 |
1 |
Hypoplasia, Nos |
|
Moribund Sacrifice |
| Hematopoietic System |
Bone marrow |
|
20 PPM |
2 |
NA |
2_114 |
120.00 |
1 |
Hyperplasia, Nos |
|
Scheduled Sacrifice |
| Hematopoietic System |
Bone marrow |
|
40 PPM |
2 |
NA |
3_168 |
120.00 |
1 |
Hyperplasia, Nos |
|
Moribund Sacrifice |
| Hematopoietic System |
Bone marrow |
|
40 PPM |
2 |
NA |
3_179 |
120.00 |
1 |
Hyperplasia, Erythroid |
|
Scheduled Sacrifice |
| Hematopoietic System |
Spleen |
|
40 PPM |
49 |
NA |
3_174 |
120.00 |
1 |
Hyperplasia, Focal |
|
Moribund Sacrifice |
| Hematopoietic System |
Spleen |
|
40 PPM |
49 |
NA |
3_176 |
120.00 |
1 |
Hyperplasia, Focal |
|
Natural Death |
| Hematopoietic System |
Thymus |
|
20 PPM |
13 |
NA |
2_131 |
120.00 |
1 |
Cyst, Ultimobranchial |
|
Scheduled Sacrifice |
| Hematopoietic System |
Thymus |
|
20 PPM |
13 |
NA |
2_137 |
120.00 |
1 |
Cyst, Ultimobranchial |
|
Scheduled Sacrifice |
| Integumentary System |
Mammary gland |
|
20 PPM |
18 |
NA |
2_116 |
120.00 |
1 |
Necrosis, Central |
|
Scheduled Sacrifice |
| Integumentary System |
Skin |
|
20 PPM |
49 |
NA |
2_112 |
120.00 |
1 |
Acanthosis |
|
Moribund Sacrifice |
| Integumentary System |
Skin |
|
20 PPM |
49 |
NA |
2_112 |
120.00 |
1 |
Fibrosis |
|
Moribund Sacrifice |
| Integumentary System |
Skin |
|
20 PPM |
49 |
NA |
2_112 |
120.00 |
1 |
Ulcer, Nos |
|
Moribund Sacrifice |
| Integumentary System |
Skin |
|
20 PPM |
49 |
NA |
2_124 |
120.00 |
1 |
Fibrosis |
|
Moribund Sacrifice |
| Integumentary System |
Skin |
|
20 PPM |
49 |
NA |
2_124 |
120.00 |
1 |
Ulcer, Focal |
|
Moribund Sacrifice |
| Integumentary System |
Skin |
|
20 PPM |
49 |
NA |
2_118 |
120.00 |
1 |
Acanthosis |
|
Scheduled Sacrifice |
| Integumentary System |
Skin |
|
20 PPM |
49 |
NA |
2_118 |
120.00 |
1 |
Fibrosis |
|
Scheduled Sacrifice |
| Integumentary System |
Skin |
|
20 PPM |
49 |
NA |
2_149 |
120.00 |
1 |
Ulcer, Focal |
|
Scheduled Sacrifice |
| Integumentary System |
Skin |
|
40 PPM |
48 |
NA |
3_181 |
120.00 |
1 |
Ulcer, Nos |
|
Scheduled Sacrifice |
| Urinary System |
Kidney |
Pelvis |
Vehicle Control |
10 |
NA |
1_300 |
120.00 |
1 |
Inflammation, Suppurative |
|
Scheduled Sacrifice |
| Urinary System |
Kidney |
|
Vehicle Control |
10 |
NA |
1_298 |
120.00 |
1 |
Inflammation, Chronic |
|
Moribund Sacrifice |
| Urinary System |
Kidney |
|
Vehicle Control |
10 |
NA |
1_294 |
120.00 |
1 |
Hamartoma |
|
Scheduled Sacrifice |
| Urinary System |
Kidney |
|
20 PPM |
48 |
NA |
2_103 |
120.00 |
1 |
Inflammation, Chronic |
|
Scheduled Sacrifice |
| Urinary System |
Kidney |
|
20 PPM |
48 |
NA |
2_136 |
120.00 |
1 |
Infarct, Nos |
|
Scheduled Sacrifice |
| Urinary System |
Kidney |
|
20 PPM |
48 |
NA |
2_139 |
120.00 |
1 |
Inflammation, Chronic |
|
Scheduled Sacrifice |
| Urinary System |
Kidney |
|
40 PPM |
48 |
NA |
3_168 |
120.00 |
1 |
Inflammation, Chronic |
|
Moribund Sacrifice |
| Urinary System |
Kidney |
|
40 PPM |
48 |
NA |
3_186 |
120.00 |
1 |
Inflammation, Chronic |
|
Scheduled Sacrifice |
| Urinary System |
Kidney |
|
40 PPM |
48 |
NA |
3_188 |
120.00 |
1 |
Inflammation, Chronic |
|
Scheduled Sacrifice |
| Urinary System |
Kidney |
|
40 PPM |
48 |
NA |
3_194 |
120.00 |
1 |
Inflammation, Chronic |
|
Scheduled Sacrifice |