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Long-Term Individual Animal Non Neoplastic Diagnosis

Study Information:

Chemical Name: Parathion
CASRN: ="56-38-2"
Study Number: C00226
Exposure Route: Dosed-Feed
TDMS Number:
Sex: Male
Strain and Species: Osborne Mendel Rats

Male Individual Animal Non Neoplastic Diagnoses
System Organ Site Treatment Group Number Examined Cage Number Animal Number Weeks on Study Lesion Found Lesion Name Lesion Qualifier Removal Reason
Alimentary System Intestine Small Mesentery Nos Vehicle Control NA NA 1_286 120.00 1 Periarteritis Scheduled Sacrifice
Alimentary System Intestine Small Mesentery Nos 80 PPM NA NA 3_066 120.00 1 Periarteritis Natural Death
Alimentary System Intestine Small Mesentery Nos 80 PPM NA NA 3_080 120.00 1 Periarteritis Scheduled Sacrifice
Alimentary System Liver Bile Duct Vehicle Control 10 NA 1_283 120.00 1 Hyperplasia, Nos Scheduled Sacrifice
Alimentary System Liver Vehicle Control 10 NA 1_283 120.00 1 Cirrhosis, Biliary Scheduled Sacrifice
Alimentary System Liver 40 PPM 50 NA 2_009 120.00 1 Angiectasis Moribund Sacrifice
Alimentary System Liver 40 PPM 50 NA 2_014 120.00 1 Focal Cellular Change Moribund Sacrifice
Alimentary System Liver 40 PPM 50 NA 2_010 120.00 1 Congestion, Nos Natural Death
Alimentary System Liver 40 PPM 50 NA 2_033 120.00 1 Scar Natural Death
Alimentary System Liver 40 PPM 50 NA 2_001 120.00 1 Hepatocytomegaly Scheduled Sacrifice
Alimentary System Liver 40 PPM 50 NA 2_001 120.00 1 Metamorphosis, Fatty Scheduled Sacrifice
Alimentary System Liver 40 PPM 50 NA 2_002 120.00 1 Hemorrhage Scheduled Sacrifice
Alimentary System Liver 40 PPM 50 NA 2_017 120.00 1 Metamorphosis, Fatty Scheduled Sacrifice
Alimentary System Liver 80 PPM 49 NA 3_099 120.00 1 Metamorphosis, Fatty Moribund Sacrifice
Alimentary System Liver 80 PPM 49 NA 3_066 120.00 1 Metamorphosis, Fatty Natural Death
Alimentary System Liver 80 PPM 49 NA 3_086 120.00 1 Focal Cellular Change Natural Death
Alimentary System Liver 80 PPM 49 NA 3_086 120.00 1 Metamorphosis, Fatty Natural Death
Alimentary System Liver 80 PPM 49 NA 3_100 120.00 1 Congestion, Nos Natural Death
Alimentary System Liver 80 PPM 49 NA 3_059 120.00 1 Angiectasis Scheduled Sacrifice
Alimentary System Liver 80 PPM 49 NA 3_061 120.00 1 Angiectasis Scheduled Sacrifice
Alimentary System Liver 80 PPM 49 NA 3_063 120.00 1 Angiectasis Scheduled Sacrifice
Alimentary System Liver 80 PPM 49 NA 3_076 120.00 1 Angiectasis Scheduled Sacrifice
Alimentary System Liver 80 PPM 49 NA 3_079 120.00 1 Angiectasis Scheduled Sacrifice
Alimentary System Liver 80 PPM 49 NA 3_085 120.00 1 Focal Cellular Change Scheduled Sacrifice
Alimentary System Pancreas Vehicle Control 9 NA 1_287 120.00 1 Atrophy, Nos Moribund Sacrifice
Alimentary System Pancreas 40 PPM 49 NA 2_002 120.00 1 Inflammation, Chronic Scheduled Sacrifice
Alimentary System Pancreas 80 PPM 46 NA 3_097 120.00 1 Atrophy, Nos Moribund Sacrifice
Alimentary System Pancreas 80 PPM 46 NA 3_079 120.00 1 Periarteritis Scheduled Sacrifice
Alimentary System Pancreas 80 PPM 46 NA 3_080 120.00 1 Periarteritis Scheduled Sacrifice
Alimentary System Pancreas 80 PPM 46 NA 3_082 120.00 1 Inflammation, Chronic Scheduled Sacrifice
Alimentary System Pancreas 80 PPM 46 NA 3_082 120.00 1 Periarteritis Scheduled Sacrifice
Alimentary System Pancreas 80 PPM 46 NA 3_093 120.00 1 Periarteritis Scheduled Sacrifice
Alimentary System Stomach 80 PPM 46 NA 3_085 120.00 1 Mineralization Scheduled Sacrifice
All Others Unspecified Pelvis 80 PPM NA NA 3_070 120.00 1 Abscess, Nos Scheduled Sacrifice
Cardiovascular System Blood vessel Aorta Nos 80 PPM 48 NA 3_086 120.00 1 Arteriosclerosis, Nos Natural Death
Cardiovascular System Heart Myocardium Nos 40 PPM 50 NA 2_026 120.00 1 Inflammation, Chronic Moribund Sacrifice
Cardiovascular System Heart Myocardium Nos 80 PPM 48 NA 3_060 120.00 1 Inflammation, Chronic Focal Moribund Sacrifice
Cardiovascular System Heart Myocardium Nos 80 PPM 48 NA 3_075 120.00 1 Inflammation, Chronic Focal Scheduled Sacrifice
Cardiovascular System Heart Myocardium Nos 80 PPM 48 NA 3_077 120.00 1 Inflammation, Chronic Focal Scheduled Sacrifice
Cardiovascular System Heart Myocardium Nos 80 PPM 48 NA 3_085 120.00 1 Inflammation, Chronic Scheduled Sacrifice
Cardiovascular System Heart 40 PPM 50 NA 2_010 120.00 1 Scar Natural Death
Endocrine System Adrenal gland 40 PPM 49 NA 2_026 120.00 1 Angiectasis Moribund Sacrifice
Endocrine System Adrenal gland 40 PPM 49 NA 2_026 120.00 1 Thrombosis, Nos Moribund Sacrifice
Endocrine System Parathyroid gland 80 PPM 29 NA 3_086 120.00 1 Hyperplasia, Nos Natural Death
Endocrine System Parathyroid gland 80 PPM 29 NA 3_085 120.00 1 Hyperplasia, Nos Scheduled Sacrifice
Endocrine System Pituitary gland 40 PPM 42 NA 2_025 120.00 1 Cyst, Nos Scheduled Sacrifice
Endocrine System Pituitary gland 80 PPM 43 NA 3_074 120.00 1 Cyst, Multiple Scheduled Sacrifice
Genital System Prostate 40 PPM 44 NA 2_026 120.00 1 Inflammation, Chronic Moribund Sacrifice
Genital System Prostate 40 PPM 44 NA 2_011 120.00 1 Inflammation, Chronic Scheduled Sacrifice
Genital System Prostate 40 PPM 44 NA 2_027 120.00 1 Inflammation, Chronic Scheduled Sacrifice
Genital System Prostate 80 PPM 46 NA 3_070 120.00 1 Inflammation, Chronic Scheduled Sacrifice
Genital System Testis Tunica Vaginalis 40 PPM NA NA 2_023 120.00 1 Hyperplasia, Nos Scheduled Sacrifice
Genital System Testis Vehicle Control 10 NA 1_288 120.00 1 Atrophy, Nos Scheduled Sacrifice
Genital System Testis 40 PPM 47 NA 2_001 120.00 1 Atrophy, Nos Scheduled Sacrifice
Genital System Testis 40 PPM 47 NA 2_001 120.00 1 Edema, Nos Scheduled Sacrifice
Genital System Testis 40 PPM 47 NA 2_002 120.00 1 Atrophy, Nos Scheduled Sacrifice
Genital System Testis 40 PPM 47 NA 2_002 120.00 1 Edema, Nos Scheduled Sacrifice
Genital System Testis 40 PPM 47 NA 2_011 120.00 1 Edema, Nos Scheduled Sacrifice
Genital System Testis 40 PPM 47 NA 2_021 120.00 1 Atrophy, Nos Scheduled Sacrifice
Genital System Testis 40 PPM 47 NA 2_021 120.00 1 Edema, Nos Scheduled Sacrifice
Genital System Testis 40 PPM 47 NA 2_023 120.00 1 Atrophy, Nos Scheduled Sacrifice
Genital System Testis 40 PPM 47 NA 2_023 120.00 1 Edema, Nos Scheduled Sacrifice
Genital System Testis 40 PPM 47 NA 2_030 120.00 1 Edema, Nos Scheduled Sacrifice
Genital System Testis 40 PPM 47 NA 2_039 120.00 1 Edema, Nos Scheduled Sacrifice
Genital System Testis 40 PPM 47 NA 2_049 120.00 1 Edema, Nos Scheduled Sacrifice
Genital System Testis 40 PPM 47 NA 2_050 120.00 1 Edema, Nos Scheduled Sacrifice
Genital System Testis 80 PPM 48 NA 3_086 120.00 1 Atrophy, Nos Natural Death
Genital System Testis 80 PPM 48 NA 3_056 120.00 1 Atrophy, Nos Scheduled Sacrifice
Genital System Testis 80 PPM 48 NA 3_083 120.00 1 Edema, Nos Scheduled Sacrifice
Genital System Testis 80 PPM 48 NA 3_091 120.00 1 Edema, Nos Scheduled Sacrifice
Hematopoietic System Bone marrow 40 PPM 1 NA 2_042 120.00 1 Atrophy, Nos Moribund Sacrifice
Hematopoietic System Bone marrow 80 PPM 1 NA 3_084 120.00 1 Hyperplasia, Nos Scheduled Sacrifice
Hematopoietic System Lymph node Mandibular Lymph Node 80 PPM 31 NA 3_088 120.00 1 Melanin Moribund Sacrifice
Hematopoietic System Lymph node 80 PPM 34 NA 3_095 120.00 1 Inflammation, Acute/Chronic Moribund Sacrifice
Hematopoietic System Spleen 40 PPM 50 NA 2_042 120.00 1 Atrophy, Nos Moribund Sacrifice
Hematopoietic System Spleen 40 PPM 50 NA 2_045 120.00 1 Congestion, Nos Natural Death
Hematopoietic System Spleen 40 PPM 50 NA 2_045 120.00 1 Thrombosis, Nos Natural Death
Hematopoietic System Spleen 40 PPM 50 NA 2_034 120.00 1 Accessory Spleen Scheduled Sacrifice
Hematopoietic System Spleen 80 PPM 47 NA 3_052 120.00 1 Metaplasia, Myeloid Moribund Sacrifice
Hematopoietic System Spleen 80 PPM 47 NA 3_099 120.00 1 Infarct, Nos Moribund Sacrifice
Hematopoietic System Spleen 80 PPM 47 NA 3_099 120.00 1 Metaplasia, Myeloid Moribund Sacrifice
Hematopoietic System Spleen 80 PPM 47 NA 3_066 120.00 1 Infarct, Nos Natural Death
Hematopoietic System Spleen 80 PPM 47 NA 3_084 120.00 1 Metaplasia, Myeloid Scheduled Sacrifice
Hematopoietic System Spleen 80 PPM 47 NA 3_085 120.00 1 Hamartoma Scheduled Sacrifice
Hematopoietic System Spleen 80 PPM 47 NA 3_091 120.00 1 Infarct, Nos Scheduled Sacrifice
Integumentary System Skin Vehicle Control 10 NA 1_288 120.00 1 Ulcer, Nos Scheduled Sacrifice
Musculoskeletal System Bone Palatine Bone Vehicle Control NA NA 1_287 120.00 1 Fracture, Nos Moribund Sacrifice
Musculoskeletal System Bone Vehicle Control NA NA 1_288 120.00 1 Exostosis Scheduled Sacrifice
Respiratory System Lung 40 PPM 50 NA 2_024 120.00 1 Congestion, Nos Moribund Sacrifice
Respiratory System Lung 40 PPM 50 NA 2_029 120.00 1 Congestion, Nos Natural Death
Respiratory System Lung 40 PPM 50 NA 2_029 120.00 1 Edema, Nos Natural Death
Respiratory System Lung 40 PPM 50 NA 2_045 120.00 1 Congestion, Nos Natural Death
Respiratory System Lung 80 PPM 48 NA 3_095 120.00 1 Alveolar Macrophages Moribund Sacrifice
Respiratory System Lung 80 PPM 48 NA 3_095 120.00 1 Lipoidosis Moribund Sacrifice
Respiratory System Lung 80 PPM 48 NA 3_057 120.00 1 Atelectasis Natural Death
Urinary System Kidney Pelvis 40 PPM 48 NA 2_011 120.00 1 Inflammation, Suppurative Scheduled Sacrifice
Urinary System Kidney Vehicle Control 10 NA 1_287 120.00 1 Inflammation, Chronic Moribund Sacrifice
Urinary System Kidney Vehicle Control 10 NA 1_289 120.00 1 Inflammation, Chronic Moribund Sacrifice
Urinary System Kidney Vehicle Control 10 NA 1_283 120.00 1 Inflammation, Chronic Scheduled Sacrifice
Urinary System Kidney Vehicle Control 10 NA 1_284 120.00 1 Inflammation, Chronic Scheduled Sacrifice
Urinary System Kidney Vehicle Control 10 NA 1_285 120.00 1 Inflammation, Chronic Scheduled Sacrifice
Urinary System Kidney Vehicle Control 10 NA 1_286 120.00 1 Inflammation, Chronic Scheduled Sacrifice
Urinary System Kidney 40 PPM 48 NA 2_014 120.00 1 Inflammation, Chronic Moribund Sacrifice
Urinary System Kidney 40 PPM 48 NA 2_007 120.00 1 Inflammation, Chronic Natural Death
Urinary System Kidney 40 PPM 48 NA 2_044 120.00 1 Inflammation, Chronic Natural Death
Urinary System Kidney 40 PPM 48 NA 2_002 120.00 1 Inflammation, Chronic Scheduled Sacrifice
Urinary System Kidney 40 PPM 48 NA 2_017 120.00 1 Inflammation, Chronic Scheduled Sacrifice
Urinary System Kidney 40 PPM 48 NA 2_027 120.00 1 Inflammation, Chronic Scheduled Sacrifice
Urinary System Kidney 40 PPM 48 NA 2_040 120.00 1 Inflammation, Chronic Scheduled Sacrifice
Urinary System Kidney 80 PPM 48 NA 3_090 120.00 1 Inflammation, Chronic Moribund Sacrifice
Urinary System Kidney 80 PPM 48 NA 3_066 120.00 1 Inflammation, Chronic Natural Death
Urinary System Kidney 80 PPM 48 NA 3_086 120.00 1 Inflammation, Chronic Natural Death
Urinary System Kidney 80 PPM 48 NA 3_058 120.00 1 Inflammation, Chronic Scheduled Sacrifice
Urinary System Kidney 80 PPM 48 NA 3_079 120.00 1 Inflammation, Chronic Scheduled Sacrifice
Urinary System Kidney 80 PPM 48 NA 3_080 120.00 1 Inflammation, Chronic Scheduled Sacrifice
Urinary System Kidney 80 PPM 48 NA 3_085 120.00 1 Inflammation, Chronic Scheduled Sacrifice
Urinary System Kidney 80 PPM 48 NA 3_093 120.00 1 Inflammation, Chronic Scheduled Sacrifice
Urinary System Kidney 80 PPM 48 NA 3_094 120.00 1 Inflammation, Chronic Scheduled Sacrifice
Urinary System Urinary bladder 40 PPM NA NA 2_011 120.00 1 Calculus, Unknown Gross Or Micro Scheduled Sacrifice
Urinary System Urinary bladder 40 PPM NA NA 2_011 120.00 1 Hyperplasia, Epithelial Scheduled Sacrifice
Urinary System Urinary bladder 80 PPM NA NA 3_063 120.00 1 Hyperplasia, Epithelial Scheduled Sacrifice