DART-08: Developmental and Reproductive Toxicity
Growth and Clinical Finding Tables (I), Pathology Tables (PA), Developmental and Reproductive Tables (R) from NTP Modified One Generation Dose Range Finding Study, Modified One Generation Main Study Studies
DOI:
https://doi.org/10.22427/NTP-DATA-DART-08
Pup Body Weight tables (R19/R19G/R19C) were added on September 4, 2020.
Analysis for Gross Pathology table (PA46R) was updated on 14Aug2020. The following tables were updated on November 4, 2020 for clarity in presentation and statistical updates: I04G, I06, R09, R10, R19, R19C and R19G. Gross Pathology table (PA46R) was replaced on November 9, 2020 with additional analysis included.
The R03 report for the Main Study was replaced on January 7,2021.
The following tables were replaced for the Main study on February 3, 2021 due to reanalysis of data: I03, I03C, I04, I04G, and PA06. The Dose range finding study tables (I06 and I08) were reanalyzed and replaced on February 3, 2021.
Individual Animal Andrology Data file for Modified One Generation study replaced on March 30, 2021 due to the inclusion of a value for testis weight for animal 2101 that should have been excluded as an outlier.
PA06R table for Modified One Generation study replaced on March 30,2021 in order to correct the N value for the F2 male 3750 ppm group for left testis and left epididymis weights.
Note: The study data are being disseminated prior to external peer review under applicable information quality guidelines and do not represent and should not be construed to represent any final NTP determination or policy.
The R06 table for Modified One Generation Main Study was updated on April 21, 2021.
Pup Body Weight tables (R19/R19G/R19C) were added on September 4, 2020.
Analysis for Gross Pathology table (PA46R) was updated on 14Aug2020. The following tables were updated on November 4, 2020 for clarity in presentation and statistical updates: I04G, I06, R09, R10, R19, R19C and R19G. Gross Pathology table (PA46R) was replaced on November 9, 2020 with additional analysis included.
The R03 report for the Main Study was replaced on January 7,2021.
The following tables were replaced for the Main study on February 3, 2021 due to reanalysis of data: I03, I03C, I04, I04G, and PA06. The Dose range finding study tables (I06 and I08) were reanalyzed and replaced on February 3, 2021.
Individual Animal Andrology Data file for Modified One Generation study replaced on March 30, 2021 due to the inclusion of a value for testis weight for animal 2101 that should have been excluded as an outlier.
PA06R table for Modified One Generation study replaced on March 30,2021 in order to correct the N value for the F2 male 3750 ppm group for left testis and left epididymis weights.
Note: The study data are being disseminated prior to external peer review under applicable information quality guidelines and do not represent and should not be construed to represent any final NTP determination or policy.
The R06 table for Modified One Generation Main Study was updated on April 21, 2021.
DART-08: Bisphenol AF
Modified One Generation Dose Range Finding Study
Modified One Generation Toxicity Dose Range Finding Study Tables
- I01 - Animal Removal Summary (47 KB)
- I02 - Animal Removals (313 KB)
- I03 - Growth Curve (637 KB)
- I03C - Growth Curve (657 KB)
- I04 - Mean Body Weights and Survival (206 KB)
- I04G - Mean Body Weight Gain (116 KB)
- I05 - Clinical Observations Summary (88 KB)
- I05P - Pup Clinical Observations Summary (174 KB)
- I06 - Mean Feed Consumption (116 KB)
- I08 - Mean Test Compound Consumption (94 KB)
- PA46 - Summary of Gross Pathology (104 KB)
- R01 - Multigeneration Cross Reference (916 KB)
- R02 - Reproductive Performance Summary (42 KB)
- R03 - Summary of Litter Data (92 KB)
- R19 - Pup Mean Body Weight Summary (198 KB)
- R19C - Pup Growth Curve (884 KB)
- R19G - Pup Mean Body Weight Gain (152 KB)
- R20 - Pup Necropsy Summary (123 KB)
Modified One Generation Toxicity Dose Range Finding Individual Animal Data
- Individual Animal Body Weight Data (40 KB)
- Individual Animal Clinical Observations Data (76 KB)
- Individual Animal Consumption Data (37 KB)
- Individual Animal Gross Pathology Data (5 KB)
- Individual Animal Litter Data (48 KB)
- Individual Animal Pup Body Weight Data (80 KB)
- Individual Animal Pup Clinical Observations Data (333 KB)
- Individual Animal Pup Necropsy Data (7 KB)
- Individual Animal Removal Reasons Data (6 KB)
- Individual Animal Reproductive Performance Data (8 KB)
Modified One Generation Main Study
Modified One Generation Toxicity Study Tables
- F1 All Cohorts Vaginal Cytology Plots (81 KB)
- F1 All Cohorts Vaginal Cytology Summary 2020-08-20 (25 KB)
- F2 Vaginal Cytology Summary 2020-08-20 (35 KB)
- I01 - Animal Removal Summary (170 KB)
- I02 - Animal Removals (4 MB)
- I03 - Growth Curve (2 MB)
- I03C - Growth Curve (2 MB)
- I04 - Mean Body Weight Summary (531 KB)
- I04G - Mean Body Weight Gain (366 KB)
- I05 - Clinical Observations Summary (486 KB)
- I05P - Pup Clinical Observations Summary (358 KB)
- I06 - Mean Feed Consumption (487 KB)
- I08 - Mean Test Compound Consumption (357 KB)
- PA02R - Neoplastic Lesion Summary with Percent and Litter Incidence (1 MB)
- PA03R - Non-Neoplastic Lesion Summary with Percent and Litter Incidence (1 MB)
- PA05R - Incidence Rates of Neoplastic Lesions with Litter Incidence Systemic Lesions Abridged (1 MB)
- PA06R - Organ Weights Summary (279 KB)
- PA08R - Statistical Analysis of Neoplastic Lesions with Litter Incidence (906 KB)
- PA10R - Statistical Analysis of Non-Neoplastic Lesions with Litter Incidence (1 MB)
- PA14 - Individual Animal Pathology Data (5 MB)
- PA18R - Non-Neoplastic Lesion Summary with Mean Severity Grade and Litter Incidence (1 MB)
- PA41 - Clinical Chemistry Summary (145 KB)
- PA43 - Hematology Summary (174 KB)
- PA46R - Summary of Gross Pathology with Litter Incidence (1 MB)
- PA48 - Summary of Tissue Concentration (68 KB)
- R01 - Multigeneration Cross Reference (4 MB)
- R02 - Reproductive Performance Summary (71 KB)
- R03 - Summary of Litter Data (138 KB)
- R04 - Anogenital Distance Summary (59 KB)
- R06 - Andrology Summary (75 KB)
- R09 - Uterine Content Summary (76 KB)
- R10 - Fetal Defects (132 KB)
- R11 - Fetal Defect Summary (76 KB)
- R13 - Fetal Defect Cross Reference Summary (107 KB)
- R14 - Developmental Markers Summary (74 KB)
- R14C - Time to Attainment Curves for Testicular Descent (430 KB)
- R16 - Pubertal Markers Summary (101 KB)
- R16C - Time to Attainment Curves for Pubertal Markers (3 MB)
- R19 - Pup Mean Body Weight Summary (365 KB)
- R19C - Pup Growth Curve (1 MB)
- R19G - Pup Mean Body Weight Gain (265 KB)
- R20 - Pup Necropsy Summary (230 KB)
- Vaginal Cytology Markov Model (238 KB)
Modified One Generation Toxicity Individual Animal Data
- F1 Fertility Cohort Vaginal Cytology Plots (96 KB)
- F1 Prechronic Cohort Vaginal Cytology Plots (59 KB)
- F1 Prenatal Cohort Vaginal Cytology Plots (70 KB)
- Individual Animal Andrology Data (23 KB)
- Individual Animal Body Weight Data (573 KB)
- Individual Animal Clinical Chemistry Data (114 KB)
- Individual Animal Clinical Observations Data (3 MB)
- Individual Animal Consumption Data (677 KB)
- Individual Animal Developmental Markers Data (163 KB)
- Individual Animal Gross Pathology Data (404 KB)
- Individual Animal Hematolgy Data (167 KB)
- Individual Animal Histopathology Data (168 KB)
- Individual Animal Litter Data (219 KB)
- Individual Animal Organ Weight Data (93 KB)
- Individual Animal Pup Body Weight Data (452 KB)
- Individual Animal Pup Clinical Observations Data (2 MB)
- Individual Animal Pup Necropsy Data (16 KB)
- Individual Animal Removal Reasons Data (47 KB)
- Individual Animal Reproductive Performance Data (19 KB)
- Individual Animal Teratology Dam Data (9 KB)
- Individual Animal Teratology Fetal Weight Data (28 KB)
- Individual Animal Teratology Implant Findings Data (129 KB)
- Individual Animal Tissue Concentration Data (30 KB)
Genetox Data
- BPAF Ames Data (24 KB)
- BPAF Rat Micronucleus Data (21 KB)