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Study Information
Study Attribute Value
CEBS Accession Number: 002-01179-0002-0000-2
Chemical Name: 2,3,7,8-Tetrachlorodibenzo-p-dioxin
CASRN: 1746-01-6
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 764904_CA
Study Result: Negative

Study Result: Negative
Activation Trial Trial Call
No Activation  1  Negative 
Induced Rat Liver S9  1_S9  Negative 

Trial #:1   Activation: No Activation    Date: 06/23/1982    Harvest Time: 21.5 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 100 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Ethanol 
0         
 100 4 0.040 4.0 2 0.020 2.0 2 0.020 2.0 0 0.000 0.0
Test Chemical: 2,3,7,8-Tetrachlorodibenzo-p-dioxin 
 0.6       
 100 2 0.020 2.0 0 0.000 0.0 1 0.010 1.0 1 0.010 1.0 
 0.7       
 100 1 0.010 1.0 1 0.010 1.0 0 0.000 0.0 0 0.000 0.0 
 0.8       
 100 2 0.020 2.0 2 0.020 2.0 0 0.000 0.0 0 0.000 0.0
Positive Control: Mitomycin-C 
 0.062     
 50 14 0.280 22.0 7 0.140 14.0 7 0.140 10.0 0 0.000 0.0
Trend: -1.074 0.193 -1.828  
Probability: 0.859 0.424 0.966  


Trial #:1_S9   Activation: Induced Rat Liver S9    Date: 06/10/1982    Harvest Time: 10.5 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 100 5 0.050 5.0 3 0.030 3.0 0 0.000 0.0 2 0.020 2.0
Ethanol 
0         
 100 3 0.030 3.0 1 0.010 1.0 1 0.010 1.0 1 0.010 1.0
Test Chemical: 2,3,7,8-Tetrachlorodibenzo-p-dioxin 
 0.4       
 100 5 0.050 5.0 1 0.010 1.0 4 0.040 4.0 0 0.000 0.0 
 0.6       
 100 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 
 0.8       
 100 6 0.060 5.0 1 0.010 1.0 3 0.030 2.0 2 0.020 2.0
Positive Control: Cyclophosphamide 
50         
 50 13 0.260 22.0 6 0.120 10.0 7 0.140 12.0 0 0.000 0.0
Trend: -0.013 -0.319 -0.267  
Probability: 0.505 0.625 0.605