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Study Information
Study Attribute Value
CEBS Accession Number: 002-01617-0001-0000-8
Chemical Name: Aldicarb
CASRN: 116-06-3
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 512453_SCE
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Weakly Positive 
No Activation  2  Positive 
Induced Rat Liver S9  1_S9  Weakly Positive 
Induced Rat Liver S9  2_S9  Questionable 

Trial #: 1    Activation: No Activation    Date: 08/23/1983    Trial Call: Weakly Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Negative (Not Specified) 
0         
 50 1048 422 0.403 8.44 26.0 -9.657
Dimethyl Sulfoxide 
0         
 50 1050 468 0.446 9.36 26.0 0.000
Test Chemical Aldicarb 
5         
 50 1047 442 0.422 8.84 26.0 -5.285 
16         
 50 1049 465 0.443 9.30 26.0 -0.546 
50         
 50 1046 531 0.508 10.62 26.0 13.895 
160         
 50 1046 506 0.484 10.12 26.0 8.533 
500         
 50 1043 663 0.636 13.26 26.0 42.617 
1600         
 0 0 0 0.000 0.00 0.0 N/A
Positive Control Mitomycin-C 
 0.01      
 50 1048 3129 2.986 62.58 26.0 569.866
Trend: 6.606        
Probability: 0.000        

Trial #: 2    Activation: No Activation    Date: 11/15/1983    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1040 410 0.394 8.20 26.0 0.000
Negative (Not Specified) 
0         
 50 1047 396 0.378 7.92 26.0 -4.060
Test Chemical Aldicarb 
100         
 50 1044 478 0.458 9.56 26.0 16.139 
250         
 50 1043 508 0.487 10.16 26.0 23.546 
500         
 50 1038 556 0.536 11.12 26.0 35.871 
1000         
 50 1047 610 0.583 12.20 31.0 47.786 
2000         
 0 0 0 0.000 0.00 36.0 N/A
Positive Control Mitomycin-C 
 0.005     
 50 1052 1890 1.797 37.80 26.0 355.717
Trend: 6.595        
Probability: 0.000        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 08/23/1983    Trial Call: Weakly Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1038 342 0.329 6.84 26.0 0.000
Negative (Not Specified) 
0         
 50 1040 383 0.368 7.66 26.0 11.773
Test Chemical Aldicarb 
50         
 50 1044 390 0.374 7.80 26.0 13.380 
160         
 50 1041 353 0.339 7.06 26.0 2.919 
500         
 50 1043 382 0.366 7.64 26.0 11.160 
1600         
 50 1037 421 0.406 8.42 26.0 23.218 
5000         
 50 1037 396 0.382 7.92 26.0 15.901
Positive Control Cyclophosphamide 
1.5       
 50 1042 1245 1.195 24.90 26.0 262.638
Trend: 2.457        
Probability: 0.007        

Trial #: 2_S9    Activation: Induced Rat Liver S9    Date: 11/15/1983    Trial Call: Questionable   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1042 438 0.420 8.76 26.0 0.000
Negative (Not Specified) 
0         
 50 1048 404 0.385 8.08 26.0 -8.291
Test Chemical Aldicarb 
1600         
 50 1045 399 0.382 7.98 26.0 -9.166 
3000         
 50 1045 453 0.433 9.06 26.0 3.128 
4000         
 50 1030 469 0.455 9.38 26.0 8.325 
5000         
 50 1043 489 0.469 9.78 26.0 11.537
Positive Control Cyclophosphamide 
1.5       
 50 1050 3078 2.931 61.56 26.0 597.386
Trend: 2.659        
Probability: 0.004