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Study Information
Study Attribute Value
CEBS Accession Number: 002-01827-0002-0000-2
Chemical Name: Captan
CASRN: 133-06-2
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 985028_CA
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Positive 
Induced Rat Liver S9  1_S9  Weakly Positive 
No Activation  2  Positive 

Trial #:1   Activation: No Activation    Date: 12/10/1986    Harvest Time: 12.5 hour(s)   Trial Call: Positive   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Dimethyl Sulfoxide 
0         
 200 1 0.005 0.5 0 0.000 0.0 1 0.005 0.5 0 0.000 0.0
Test Chemical: Captan 
1         
 200 10 0.050 3.0 4 0.020 0.5 6 0.030 2.5 0 0.000 0.0 
1.6       
 200 13 0.065 6.0 5 0.025 2.0 8 0.040 4.0 0 0.000 0.0 
3         
 200 28 0.140 13.5 13 0.065 6.0 15 0.075 7.5 0 0.000 0.0 
5         
 0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Positive Control: Mitomycin-C 
 0.0625    
 200 37 0.185 17.5 16 0.080 8.0 21 0.105 10.5 0 0.000 0.0
Mitomycin-C 
 0.25      
 50 12 0.240 24.0 2 0.040 4.0 10 0.200 20.0 0 0.000 0.0
Trend: 5.777 4.348 3.840  
Probability: 0.000 0.000 0.000  


Trial #:1_S9   Activation: Induced Rat Liver S9    Date: 11/13/1986    Harvest Time: 13.5 hour(s)   Trial Call: Weakly Positive   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Dimethyl Sulfoxide 
0         
 200 2 0.010 1.0 0 0.000 0.0 2 0.010 1.0 0 0.000 0.0
Test Chemical: Captan 
3         
 200 3 0.015 1.5 2 0.010 1.0 1 0.005 0.5 0 0.000 0.0 
5         
 200 3 0.015 1.0 2 0.010 0.5 1 0.005 0.5 0 0.000 0.0 
10         
 200 15 0.075 6.0 4 0.020 2.0 10 0.050 3.5 1 0.005 1.0 
16         
 0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Positive Control: Cyclophosphamide 
2.5       
 200 34 0.170 16.0 11 0.055 5.0 23 0.115 11.0 0 0.000 0.0
Cyclophosphamide 
7.5       
 50 17 0.340 30.0 5 0.100 10.0 12 0.240 22.0 0 0.000 0.0
Trend: 3.167 1.930 2.170  
Probability: 0.001 0.027 0.015  


Trial #:2   Activation: No Activation    Date: 11/13/1986    Harvest Time: 12 hour(s)   Trial Call: Positive   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Dimethyl Sulfoxide 
0         
 200 2 0.010 1.0 1 0.005 0.5 1 0.005 0.5 0 0.000 0.0
Test Chemical: Captan 
1         
 200 6 0.030 2.5 2 0.010 1.0 4 0.020 1.5 0 0.000 0.0 
1.6       
 200 28 0.140 12.5 12 0.060 6.0 16 0.080 7.5 0 0.000 0.0 
3         
 200 30 0.150 13.0 22 0.110 9.5 8 0.040 3.5 0 0.000 0.0 
5         
 0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Positive Control: Mitomycin-C 
 0.0625    
 200 39 0.195 15.5 8 0.040 3.5 31 0.155 12.0 0 0.000 0.0
Mitomycin-C 
 0.25      
 50 27 0.540 36.0 12 0.240 18.0 15 0.300 26.0 0 0.000 0.0
Trend: 5.498 5.009 2.483  
Probability: 0.000 0.000 0.007