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Study Information
Study Attribute Value
CEBS Accession Number: 002-01969-0001-0000-8
Chemical Name: Di(2-ethylhexyl) phthalate
CASRN: 117-81-7
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 008270_SCE
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Weakly Positive 
No Activation  2  Positive 
Induced Rat Liver S9  1_S9  Negative 

Trial #: 1    Activation: No Activation    Date: 04/25/1984    Trial Call: Weakly Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Ethanol 
0         
 50 1041 511 0.491 10.22 26.0 0.000
Negative (Not Specified) 
0         
 50 1042 493 0.473 9.86 26.0 -3.615
Test Chemical Di(2-ethylhexyl) phthalate 
 0.99      
 50 1047 480 0.458 9.60 26.0 -6.605 
3.33      
 50 1038 593 0.571 11.86 34.5 16.382 
9.99      
 50 1047 701 0.670 14.02 34.5 36.396 
33.3       
 0 0 0 0.000 0.00 0.0 N/A
Positive Control Mitomycin-C 
 0.0015    
 50 1048 895 0.854 17.90 26.0 73.977
Mitomycin-C 
 0.01      
 5 104 295 2.837 59.00 26.0 477.855
Trend: 6.322        
Probability: 0.000        

Trial #: 2    Activation: No Activation    Date: 06/06/1984    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Negative (Not Specified) 
0         
 100 2067 1069 0.517 10.69 26.0 8.585
Ethanol 
0         
 100 2045 974 0.476 9.74 26.0 0.000
Test Chemical Di(2-ethylhexyl) phthalate 
10.2       
 50 1030 622 0.604 12.44 33.8 26.791 
15.3       
 50 1025 601 0.586 12.02 33.8 23.108 
20.4       
 50 1029 580 0.564 11.60 33.8 18.344 
25.5       
 0 0 0 0.000 0.00 33.8 N/A
Positive Control Mitomycin-C 
 0.0015    
 50 1026 841 0.820 16.82 26.0 72.101
Mitomycin-C 
 0.01      
 5 104 233 2.240 46.60 26.0 370.389
Trend: 3.604        
Probability: 0.000        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 04/25/1984    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Negative (Not Specified) 
0         
 50 1037 534 0.515 10.68 26.0 -12.585
Ethanol 
0         
 50 1044 615 0.589 12.30 26.0 0.000
Test Chemical Di(2-ethylhexyl) phthalate 
9.99      
 50 1035 662 0.640 13.24 26.0 8.578 
3330         
 50 1046 628 0.600 12.56 26.0 1.919 
9990         
 50 1045 548 0.524 10.96 26.0 -10.980
Positive Control Cyclophosphamide 
 0.4       
 50 1045 676 0.647 13.52 26.0 9.814
Cyclophosphamide 
2         
 5 105 148 1.410 29.60 26.0 139.275
Trend: -1.856        
Probability: 0.968