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Study Information
Study Attribute Value
CEBS Accession Number: 002-02010-0001-0000-6
Chemical Name: Dichlorodiphenyltrichloroethane (DDT)
CASRN: 50-29-3
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 868203_SCE
Study Result: Negative

Study Result: Negative
Activation Trial Trial Call
No Activation  1  Negative 
Induced Rat Liver S9  1_S9  Negative 

Trial #: 1    Activation: No Activation    Date: 03/17/1987    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1045 422 0.404 8.44 26.0 0.000
Test Chemical Dichlorodiphenyltrichloroethane (DDT) 
 0.5       
 50 1050 432 0.411 8.64 26.0 1.882 
1.6       
 50 1047 469 0.448 9.38 26.0 10.925 
5         
 50 1051 462 0.440 9.24 26.0 8.854 
16         
 50 1027 426 0.415 8.52 26.0 2.717
Positive Control Mitomycin-C 
 0.0E-4    
 50 1046 558 0.533 11.16 26.0 32.101
Mitomycin-C 
 0.005     
 10 210 384 1.829 38.40 26.0 352.810
Trend: 0.798        
Probability: 0.213        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 03/17/1987    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1050 452 0.430 9.04 26.0 0.000
Test Chemical Dichlorodiphenyltrichloroethane (DDT) 
 0.5       
 50 1049 478 0.456 9.56 26.0 5.853 
1.6       
 50 1050 429 0.409 8.58 26.0 -5.088 
5         
 50 1050 464 0.442 9.28 26.0 2.655 
16         
 50 1051 483 0.460 9.66 26.0 6.757
Positive Control Cyclophosphamide 
 0.1       
 50 1051 567 0.539 11.34 26.0 25.323
Cyclophosphamide 
 0.6       
 10 210 202 0.962 20.20 26.0 123.451
Trend: 0.684        
Probability: 0.247