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Study Information
Study Attribute Value
CEBS Accession Number: 002-02010-0002-0000-7
Chemical Name: Dichlorodiphenyltrichloroethane (DDT)
CASRN: 50-29-3
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 868203_CA
Study Result: Negative

Study Result: Negative
Activation Trial Trial Call
No Activation  1  Negative 
Induced Rat Liver S9  1_S9  Negative 
Induced Rat Liver S9  2_S9  Positive 

Trial #:1   Activation: No Activation    Date: 06/16/1987    Harvest Time: 12 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Dimethyl Sulfoxide 
0         
 200 1 0.005 0.5 0 0.000 0.0 1 0.005 0.5 0 0.000 0.0
Test Chemical: Dichlorodiphenyltrichloroethane (DDT) 
10         
 200 4 0.020 2.0 1 0.005 0.5 3 0.015 1.5 0 0.000 0.0 
16         
 200 2 0.010 1.0 1 0.005 0.5 1 0.005 0.5 0 0.000 0.0 
30         
 200 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Positive Control: Mitomycin-C 
 0.0625    
 200 49 0.245 22.0 22 0.110 10.5 27 0.135 12.5 0 0.000 0.0
Mitomycin-C 
 0.25      
 50 20 0.400 34.0 4 0.080 8.0 16 0.320 28.0 0 0.000 0.0
Trend: -0.872 -0.046 -1.002  
Probability: 0.809 0.518 0.842  


Trial #:1_S9   Activation: Induced Rat Liver S9    Date: 02/04/1988    Harvest Time: 13 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Dimethyl Sulfoxide 
0         
 200 1 0.005 0.5 0 0.000 0.0 1 0.005 0.5 0 0.000 0.0
Test Chemical: Dichlorodiphenyltrichloroethane (DDT) 
10         
 200 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 
16         
 200 2 0.010 1.0 0 0.000 0.0 2 0.010 1.0 0 0.000 0.0 
30         
 200 3 0.015 1.5 0 0.000 0.0 3 0.015 1.5 0 0.000 0.0
Positive Control: Cyclophosphamide 
2.5       
 200 22 0.110 10.5 3 0.015 1.5 19 0.095 9.0 0 0.000 0.0
Cyclophosphamide 
7.5       
 50 18 0.360 32.0 2 0.040 4.0 16 0.320 28.0 0 0.000 0.0
Trend: 1.459 0.000 1.459  
Probability: 0.072 0.000 0.072  


Trial #:2_S9   Activation: Induced Rat Liver S9    Date: 06/16/1987    Harvest Time: 13 hour(s)   Trial Call: Positive   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Dimethyl Sulfoxide 
0         
 200 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Test Chemical: Dichlorodiphenyltrichloroethane (DDT) 
10         
 200 4 0.020 2.0 0 0.000 0.0 4 0.020 2.0 0 0.000 0.0 
16         
 200 6 0.030 3.0 0 0.000 0.0 6 0.030 3.0 0 0.000 0.0 
30         
 200 7 0.035 3.0 1 0.005 0.5 6 0.030 2.5 0 0.000 0.0
Positive Control: Cyclophosphamide 
2.5       
 200 38 0.190 18.0 3 0.015 1.5 35 0.175 16.5 0 0.000 0.0
Cyclophosphamide 
5         
 50 15 0.300 28.0 3 0.060 6.0 12 0.240 24.0 0 0.000 0.0
Trend: 2.222 1.393 1.931  
Probability: 0.013 0.082 0.027