COVID-19 is an emerging, rapidly evolving situation.

Get the latest public health information from CDC and research information from NIH.

U.S. flag

An official website of the United States government

Dot gov

The .gov means it's official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you're on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Share This:
Study Information
Study Attribute Value
CEBS Accession Number: 002-02021-0001-0000-8
Chemical Name: Dieldrin
CASRN: 60-57-1
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 268228_SCE
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Positive 
Induced Rat Liver S9  1_S9  Questionable 
Induced Rat Liver S9  2_S9  Positive 

Trial #: 1    Activation: No Activation    Date: 05/25/1982    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1018 474 0.466 9.48 25.5 0.000
Test Chemical Dieldrin 
40         
 50 1018 633 0.622 12.66 33.5 33.544 
60         
 50 1032 596 0.578 11.92 33.5 24.033 
80         
 28 556 331 0.595 11.82 33.5 27.856
Positive Control Mitomycin-C 
 0.005     
 25 505 682 1.350 27.28 25.5 190.043
Trend: 3.195        
Probability: 0.001        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 05/03/1982    Trial Call: Questionable   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1035 510 0.493 10.20 25.5 0.000
Test Chemical Dieldrin 
300         
 50 1009 600 0.595 12.00 29.5 20.679 
400         
 50 1020 502 0.492 10.04 29.5 -0.121 
600         
 50 1030 525 0.510 10.50 29.5 3.441
Positive Control Cyclophosphamide 
1.5       
 25 518 972 1.876 38.88 25.5 280.809
Trend: -0.397        
Probability: 0.654        

Trial #: 2_S9    Activation: Induced Rat Liver S9    Date: 07/12/1982    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1026 414 0.404 8.28 25.5 0.000
Test Chemical Dieldrin 
500         
 50 1032 527 0.511 10.54 25.5 26.555 
600         
 50 1041 491 0.472 9.82 25.5 16.890 
800         
 50 1029 600 0.583 12.00 31.2 44.505
Positive Control Cyclophosphamide 
1.5       
 25 512 1156 2.258 46.24 25.5 459.545
Trend: 5.296        
Probability: 0.000