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Study Information
Study Attribute Value
CEBS Accession Number: 002-02161-0001-0000-3
Chemical Name: Ethylene glycol monoethyl ether (EGMEE)
CASRN: 110-80-5
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 032435_SCE
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Positive 
Induced Rat Liver S9  1_S9  Positive 

Trial #: 1    Activation: No Activation    Date: 09/09/1981    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Medium 
0         
 50 1048 444 0.424 8.88 25.5 0.000
Test Chemical Ethylene glycol monoethyl ether (EGMEE) 
951         
 50 1039 480 0.462 9.60 25.5 9.045 
3170         
 50 1041 676 0.649 13.52 25.5 53.276 
9510         
 50 1017 1368 1.345 27.36 25.5 217.500
Positive Control Mitomycin-C 
 0.005     
 50 1036 1583 1.528 31.66 25.5 260.661
Trend: 24.762        
Probability: 0.000        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 09/09/1981    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Medium 
0         
 50 1041 415 0.399 8.30 25.5 0.000
Test Chemical Ethylene glycol monoethyl ether (EGMEE) 
951         
 50 1042 454 0.436 9.08 25.5 9.293 
3170         
 50 1041 517 0.497 10.34 25.5 24.578 
9510         
 50 1031 609 0.591 12.18 25.5 48.170
Positive Control Cyclophosphamide 
1.5       
 50 1040 1408 1.354 28.16 25.5 239.603
Trend: 6.598        
Probability: 0.000