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Study Information
Study Attribute Value
CEBS Accession Number: 002-02340-0004-0000-5
Chemical Name: L-Ascorbic acid
CASRN: 50-81-7
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 395917_CA
Study Result: Negative

Study Result: Negative
Activation Trial Trial Call
No Activation  1  Negative 
Induced Rat Liver S9  1_S9  Negative 
Induced Rat Liver S9  2_S9  Negative 

Trial #:1   Activation: No Activation    Date: 11/03/1988    Harvest Time: 14.5 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Water 
0         
 200 3 0.015 1.5 3 0.015 1.5 0 0.000 0.0 0 0.000 0.0
Test Chemical: L-Ascorbic acid 
503         
 200 1 0.005 0.5 0 0.000 0.0 1 0.005 0.5 0 0.000 0.0 
1081         
 200 4 0.020 1.5 1 0.005 0.5 3 0.015 1.5 0 0.000 0.0 
2325         
 200 9 0.045 4.0 3 0.015 0.5 6 0.030 2.5 0 0.000 0.0
Positive Control: Mitomycin-C 
 0.1       
 200 36 0.180 16.0 21 0.105 9.5 15 0.075 7.5 0 0.000 0.0
Mitomycin-C 
 0.4       
 50 30 0.600 44.0 11 0.220 20.0 19 0.380 32.0 0 0.000 0.0
Trend: 1.982 -1.003 2.549  
Probability: 0.024 0.842 0.005  


Trial #:1_S9   Activation: Induced Rat Liver S9    Date: 11/03/1988    Harvest Time: 14.5 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Water 
0         
 200 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Test Chemical: L-Ascorbic acid 
1081         
 200 4 0.020 1.5 1 0.005 0.5 2 0.010 1.0 1 0.005 1.0 
2325         
 200 8 0.040 4.0 1 0.005 0.5 7 0.035 3.5 0 0.000 0.0 
5000         
 50 96 1.920 60.0 49 0.980 52.0 27 0.540 36.0 20 0.400 2.0
Positive Control: Cyclophosphamide 
5         
 200 33 0.165 13.0 14 0.070 6.0 19 0.095 8.0 0 0.000 0.0
Cyclophosphamide 
15         
 50 16 0.320 32.0 8 0.160 16.0 8 0.160 16.0 0 0.000 0.0
Trend: 10.495 9.919 8.052  
Probability: 0.000 0.000 0.000  


Trial #:2_S9   Activation: Induced Rat Liver S9    Date: 11/16/1988    Harvest Time: 14.5 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Water 
0         
 200 1 0.005 0.5 0 0.000 0.0 1 0.005 0.5 0 0.000 0.0
Test Chemical: L-Ascorbic acid 
2325         
 200 2 0.010 1.0 0 0.000 0.0 2 0.010 1.0 0 0.000 0.0 
3500         
 200 2 0.010 1.0 1 0.005 0.5 1 0.005 0.5 0 0.000 0.0 
5000         
 50 78 1.560 60.0 35 0.700 44.0 23 0.460 34.0 20 0.400 2.0
Positive Control: Cyclophosphamide 
5         
 200 37 0.185 16.0 15 0.075 7.5 22 0.110 10.5 0 0.000 0.0
Cyclophosphamide 
15         
 50 38 0.760 46.0 12 0.240 24.0 16 0.320 30.0 10 0.200 1.0
Trend: 9.882 9.007 6.969  
Probability: 0.000 0.000 0.000