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Study Information
Study Attribute Value
CEBS Accession Number: 002-02340-0017-0000-9
Chemical Name: L-Ascorbic acid
CASRN: 50-81-7
NTP Study Type: Genetic Toxicology - Rodent Cytogenetics
NTP Study ID: 592095_CA
Study Result: Positive

Test Type Start Date Sample Time (h) Species Sex Tissue Protocol Trend Test P
CA 08/16/88 17 Mouse Male Bone Marrow Intraperitoneal Injection x 1/study, 17 hour 0.0031
Test Group Dose
(mg/kg)		 n Percent Cells w/ Aberrations
(Mean ± SEM)		 Pairwise P
Positive Control Mitomycin-C 
1         
 8 13.50 ± 1.50 0.0000
Test Chemical L-Ascorbic acid 
500         
 8 2.25 ± 0.70 0.0405
  
1000         
 8 2.25 ± 1.03 0.0405
  
2000         
 8 3.75 ± 1.67 0.0021
Vehicle Control No Stressor 
 0         
 8 0.75 ± 0.37 0.0000


Test Type Start Date Sample Time (h) Species Sex Tissue Protocol Trend Test P
CA 09/14/88 36 Mouse Male Bone Marrow Intraperitoneal Injection x 1/study, 36 hour 0.0010
Test Group Dose
(mg/kg)		 n Percent Cells w/ Aberrations
(Mean ± SEM)		 Pairwise P
Positive Control Mitomycin-C 
1         
 8 13.25 ± 1.69 0.0000
Test Chemical L-Ascorbic acid 
500         
 8 1.25 ± 0.53 0.3687
  
1000         
 6 2.33 ± 0.95 0.0802
  
2000         
 8 4.00 ± 1.08 0.0040
Vehicle Control No Stressor 
 0         
 8 1.00 ± 0.53 0.0000


Footnotes:
IP/IJ: Intraperitoneal Injection
INHAL: Inhalation
n: Number of animals analyzed