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Study Information
Study Attribute Value
CEBS Accession Number: 002-02889-0002-0000-1
Chemical Name: Tetrakis(hydroxymethyl)phosphonium sulfate
CASRN: 55566-30-8
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 322690_CA
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Positive 
Induced Rat Liver S9  1_S9  Positive 
No Activation  2  Positive 

Trial #:1   Activation: No Activation    Date: 02/12/1987    Harvest Time: 20.3 hour(s)   Trial Call: Positive   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 100 4 0.040 4.0 0 0.000 0.0 4 0.040 4.0 0 0.000 0.0
Dimethyl Sulfoxide 
0         
 100 2 0.020 2.0 2 0.020 2.0 0 0.000 0.0 0 0.000 0.0
Test Chemical: Tetrakis(hydroxymethyl)phosphonium sulfate 
7.5       
 100 33 0.330 17.0 16 0.160 10.0 7 0.070 6.0 10 0.100 1.0 
10.1       
 100 44 0.440 29.0 26 0.260 20.0 18 0.180 12.0 0 0.000 0.0 
12.6       
 50 40 0.800 46.0 26 0.520 34.0 14 0.280 24.0 0 0.000 0.0
Positive Control: Mitomycin-C 
 0.05      
 100 18 0.180 17.0 5 0.050 5.0 13 0.130 12.0 0 0.000 0.0
Mitomycin-C 
 0.08      
 25 10 0.400 32.0 5 0.200 20.0 5 0.200 16.0 0 0.000 0.0
Trend: 6.765 5.645 5.027  
Probability: 0.000 0.000 0.000  


Trial #:1_S9   Activation: Induced Rat Liver S9    Date: 01/20/1987    Harvest Time: 20.5 hour(s)   Trial Call: Positive   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 200 1 0.005 0.5 1 0.005 0.5 0 0.000 0.0 0 0.000 0.0
Dimethyl Sulfoxide 
0         
 200 1 0.005 0.5 1 0.005 0.5 0 0.000 0.0 0 0.000 0.0
Test Chemical: Tetrakis(hydroxymethyl)phosphonium sulfate 
7.5       
 200 136 0.680 30.0 88 0.440 23.5 48 0.240 16.0 0 0.000 0.0 
10.1       
 25 32 1.280 44.0 11 0.440 28.0 11 0.440 32.0 10 0.400 4.0 
12.6       
 10 24 2.400 70.0 15 1.500 70.0 9 0.900 40.0 0 0.000 0.0
Positive Control: Cyclophosphamide 
6.25      
 200 52 0.260 18.5 16 0.080 6.5 36 0.180 14.0 0 0.000 0.0
Cyclophosphamide 
12.5       
 25 37 1.480 60.0 13 0.520 40.0 14 0.560 44.0 10 0.400 4.0
Trend: 9.281 8.210 7.259  
Probability: 0.000 0.000 0.000  


Trial #:2   Activation: No Activation    Date: 01/20/1987    Harvest Time: 20.5 hour(s)   Trial Call: Positive   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 200 19 0.095 3.0 1 0.005 0.5 18 0.090 2.5 0 0.000 0.0
Dimethyl Sulfoxide 
0         
 200 4 0.020 2.0 1 0.005 0.5 3 0.015 1.5 0 0.000 0.0
Test Chemical: Tetrakis(hydroxymethyl)phosphonium sulfate 
5         
 100 32 0.320 24.0 19 0.190 15.0 13 0.130 12.0 0 0.000 0.0 
7.5       
 100 61 0.610 34.0 25 0.250 21.0 26 0.260 22.0 10 0.100 1.0 
10.1       
 10 35 3.500 50.0 1 0.100 10.0 4 0.400 20.0 30 3.000 30.0 
12.6       
 0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Positive Control: Mitomycin-C 
 0.05      
 200 99 0.495 31.0 21 0.105 10.5 68 0.340 25.5 10 0.050 0.5
Mitomycin-C 
 0.08      
 50 25 0.500 32.0 9 0.180 12.0 16 0.320 26.0 0 0.000 0.0
Trend: 7.864 5.575 5.795  
Probability: 0.000 0.000 0.000