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Study Information
Study Attribute Value
CEBS Accession Number: 002-03218-0001-0000-7
Chemical Name: tris(2-Chloroethyl) phosphate
CASRN: 115-96-8
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 616376_SCE
Study Result: Equivocal

Study Result: Equivocal
Activation Trial Trial Call
No Activation  1  Negative 
Induced Rat Liver S9  1_S9  Positive 
Induced Rat Liver S9  2_S9  Negative 

Trial #: 1    Activation: No Activation    Date: 09/16/1982    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1049 474 0.452 9.48 26.0 0.000
Test Chemical tris(2-Chloroethyl) phosphate 
5         
 50 1031 537 0.521 10.74 26.0 15.269 
16         
 50 1045 518 0.496 10.36 26.0 9.701 
50         
 50 1038 516 0.497 10.32 26.0 10.014 
160         
 50 1043 532 0.510 10.64 26.0 12.882
Positive Control Mitomycin-C 
 0.005     
 25 525 616 1.173 24.64 26.0 159.668
Trend: 1.357        
Probability: 0.087        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 06/16/1982    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1046 414 0.396 8.28 26.0 0.000
Test Chemical tris(2-Chloroethyl) phosphate 
160         
 50 1049 458 0.437 9.16 26.0 10.312 
500         
 50 1035 503 0.486 10.06 26.0 22.789 
1600         
 50 1034 495 0.479 9.90 26.0 20.953
Positive Control Cyclophosphamide 
1.5       
 50 1046 1130 1.080 22.60 26.0 172.947
Trend: 3.207        
Probability: 0.001        

Trial #: 2_S9    Activation: Induced Rat Liver S9    Date: 12/08/1982    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1049 460 0.439 9.20 26.0 0.000
Test Chemical tris(2-Chloroethyl) phosphate 
1200         
 50 1050 467 0.445 9.34 26.0 1.425 
1400         
 50 1050 506 0.482 10.12 26.0 9.895 
1600         
 50 1051 531 0.505 10.62 26.0 15.215
Positive Control Cyclophosphamide 
1         
 50 1048 1061 1.012 21.22 26.0 130.872
Trend: 2.517        
Probability: 0.006