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Study Information
Study Attribute Value
CEBS Accession Number: 002-03218-0002-0000-8
Chemical Name: tris(2-Chloroethyl) phosphate
CASRN: 115-96-8
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 616376_CA
Study Result: Negative

Study Result: Negative
Activation Trial Trial Call
No Activation  1  Negative 
Induced Rat Liver S9  1_S9  Negative 

Trial #:1   Activation: No Activation    Date: 06/16/1982    Harvest Time: 14 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Dimethyl Sulfoxide 
0         
 100 6 0.060 6.0 0 0.000 0.0 6 0.060 6.0 0 0.000 0.0
Test Chemical: tris(2-Chloroethyl) phosphate 
160         
 100 10 0.100 10.0 2 0.020 2.0 8 0.080 8.0 0 0.000 0.0 
500         
 100 11 0.110 10.0 4 0.040 4.0 7 0.070 7.0 0 0.000 0.0 
1600         
 100 9 0.090 9.0 3 0.030 3.0 6 0.060 6.0 0 0.000 0.0
Positive Control: Mitomycin-C 
 0.15      
 50 32 0.640 38.0 3 0.060 6.0 29 0.580 36.0 0 0.000 0.0
Trend: 0.711 1.655 -0.090  
Probability: 0.239 0.049 0.536  


Trial #:1_S9   Activation: Induced Rat Liver S9    Date: 06/16/1982    Harvest Time: 14 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Dimethyl Sulfoxide 
0         
 100 4 0.040 4.0 1 0.010 1.0 3 0.030 3.0 0 0.000 0.0
Test Chemical: tris(2-Chloroethyl) phosphate 
160         
 100 11 0.110 10.0 3 0.030 3.0 8 0.080 7.0 0 0.000 0.0 
500         
 100 9 0.090 7.0 2 0.020 2.0 7 0.070 6.0 0 0.000 0.0 
1600         
 100 10 0.100 8.0 2 0.020 1.0 8 0.080 8.0 0 0.000 0.0
Positive Control: Cyclophosphamide 
15         
 100 29 0.290 24.0 8 0.080 8.0 21 0.210 18.0 0 0.000 0.0
Trend: 0.777 -0.172 1.320  
Probability: 0.218 0.568 0.093