Disposition and Metabolism of 2,2’-Dimorpholinodiethyl Ether in Harlan Sprague Dawley Rats and B6C3F1/N Mice after Oral, Intravenous Administration, and Dermal Application

Jacob D. McDonald, J. Michael Sanders, C. Edwin Garner, Melanie Doyle-Eisele, Benjamin C. Moeller and Suramya Waidyanatha

https://doi.org/10.22427/NTP-DATA-002-02085-0009-0000-6

Radiolabel Description:
Carbon-14 on the ring carbons adjacent to the nitrogen; 2,2'-Dimorpholinodiethyl ether, [morpholine-2,6-¹⁴C]-

Vehicles:
Intravenous, saline; Oral, purified water; Dermal, ethanol.

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ADME Data

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Data Summary - Male Rats

• Dermal Single Dose Group I (20 mg/kg, Study Duration 72 hours) (52 KB)
• Gavage Single Dose Group A (20 mg/kg, Study Duration 24 hours) (49 KB)
• Gavage Single Dose Group B (20 mg/kg, Study Duration 72 hours) (53 KB)
• Gavage Single Dose Group C (200 mg/kg, Study Duration 72 hours) (52 KB)
• IV Single Dose Group G (20 mg/kg, Study Duration 24 hours) (48 KB)

Data Summary - Female Rats

• Gavage Single Dose Group S (20 mg/kg, Study Duration 24 hours) (67 KB)

Data Summary - Male Mice

• Dermal Single Dose Group R (20 mg/kg, Study Duration 72 hours) (50 KB)
• Gavage Single Dose Group K (20 mg/kg, Study Duration 72 hours) (53 KB)
• Gavage Single Dose Group L (200 mg/kg, Study Duration 72 hours) (69 KB)
• Gavage Single Dose Group N (20 mg/kg, Study Duration 24 hours) (51 KB)
• IV Single Dose Group P (20 mg/kg, Study Duration 24 hours) (47 KB)

Data Summary - Female Mice

• Gavage Single Dose Group T (20 mg/kg, Study Duration 24 hours) (52 KB)