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Internal dose of vanadium in rats following repeated exposure to vanadyl sulfate and sodium orthovanadate via drinking water

James M. Harrington, Laura G. Haines, Keith E. Levine, Chamindu Liyanapatirana, Amal S. Essader, Reshan A. Fernando, Veronica G. Robinson, Georgia K. Roberts, Matthew D. Stout, Michelle J. Hooth and Suramya Waidyanatha

Toxicology and Applied Pharmacology (2020)
DOI: https://doi.org/10.1016/j.taap.2021.1153955 PMID: 33421504

Corrigendum to “Internal dose of vanadium in rats following repeated exposure to vanadyl sulfate and sodium orthovanadate via drinking water” Toxicology and Applied Pharmacology 412 (2021) Authors: James M. Harrington, Laura G. Haines, Keith E. Levine, Chamindu Liyanapatirana, Amal S. Essader, Reshan A. Fernando, Veronica G. Robinson, Georgia K. Roberts, Matthew D. Stout, Michelle J. Hooth and Suramya Waidyanatha PMID: 33905758

DOI: https://doi.org/10.22427/NTP-DATA-002-02993-0008-0000-3

Publication

Abstract

Vanadium is a ubiquitous environmental contaminant that exists in multiple oxidation states. Humans are exposed to vanadyl (V4+) and vanadate (V5+) from dietary supplements, food, and drinking water and hence there is a concern for potential impacts on human health. The current investigation is aimed at identifying vanadium oxidation states in vivo and corresponding internal concentrations following exposure of rodents to vanadyl sulfate (V4+) or sodium metavanadate (V5+) via drinking water for 14 d. Analysis of plasma showed that the only vanadium present was V4+, regardless of the exposed compound suggesting conversion of V5+ to V4+ in vivo and/or instability of V5+ species in biological matrices. Based on total vanadium measurements, plasma, blood, and liver concentrations of vanadium were higher in male and female rats following exposure to V5+ than to V4+. Following exposure to either V4+ or V5+, the vanadium concentration in plasma was 2- to 3-fold higher than in blood suggesting plasma as a better matrix than blood for measuring internal concentrations of vanadium in future work. Liver to blood ratios were 4-7 demonstrating significant tissue retention following exposure to both compounds. In conclusion, these data point to potential differences in absorption and disposition properties of V4+ and V5+ salts and may explain the higher sensitivity in rats following drinking water exposure to V5+ than V4+ and highlights the importance of internal dose determination in toxicology studies.

Sodium Metavanadate

Tissue Concentration

Individual Animal Data

Vanadyl Sulfate

Tissue Concentration

Individual Animal Data

Related Publications

Publications

Roberts, G.K., Stout, M.D., Sayers, B., Fallacara, D.M., Hejtmancik, M.R., Waidyanatha, S., Hooth, M.J., 2016. 14-Day Toxicity Studies of Tetravalent and Pentavalent Vanadium Compounds in Harlan Sprague Dawley Rats and B6C3F1/N Mice via Drinking Water Exposure. Toxicol Rep 3, 531-538.
DOI: https://doi.org/10.1016/j.toxrep.2016.05.001 PMID: 28042531

Roberts, G.K., Stout, M.D., Sayers, B., Fallacara, D.M., Hejtmancik, M.R., Waidyanatha, S., Hooth, M.J., 2018. Clarification and lessons learned for reporting studies with hydrates. Citation: Roberts et al., 2016. Toxicology Reports 3: 531-538. Toxicol Rep 5, 207-208. DOI: DOI: https://doi.org/10.1016/j.toxrep.2017.12.023