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CEBS Release Notes

NOVEMBER 2026 Data Release

  1. Updates to report TOX-107
  2. Added Study Views for TOX-108 studies
  3. Added VCU reports to appropriate Test Article pages
  4. Rerelease of ToxCompl+ to add link to Postgres Database
  5. Rereleased of page Developmental Neurotoxicity (DNT) Health Effect Research Publications to add more references
  6. Added step section data to beta-Myrcene Wistar Han Rat study listing

SEPTEMBER 2026 Data Release

  1. Release of Study Views for TR-606
  2. Updates for Ginkgo Biloba page
  3. Release manuscript DrugMatrix and TG-Gates In vivo Data Integration
  4. Updates to Organ Weights file for Benzonitrile
  5. Update Abstract on manuscript ToxPipe
  6. Add new reference to manuscript Developmental Neurotoxicity (DNT) Health Effect Research Publications
  7. Add file Current Pesticides Analyzed in Rodent Feed to Radiofrequency report
  8. Release TOX-108 report
  9. Release pages for ORBIT study close outs

JULY 2026 Data Release

  1. Release of manuscript Zebrafish Behavioral Assessment as a First-Tier Whole-Organism NAM for Developmental Neurotoxicity: A Multi-Laboratory Evaluation
  2. Update manuscript Evaluation of 2,2’-Dimorpholinodiethyl Ether (DMDEE) in Pathology, Perinatal, and Genotoxicity Studies to add Internal Concentration data
  3. Release of TR-606: alpha Pinene
  4. Updated manuscript Developmental Neurotoxicity (DNT) Health Effect Research Publications to add references for Phase I
  5. Updated DTT Integrated High Value Datasets page to include new section for Decision Ready Datasets and updated 4 Genetox datasets

JUNE 2026 Data Release

  1. Release of manuscript ToxPipe
  2. Release of manuscript Oral toxicokinetics of the indoor air pollutant, α-pinene, and its genotoxic metabolite, α-pinene oxide, in rodents and comparison to inhalation route of exposure
  3. Release of manuscript Prioritizing chemicals for developmental neurotoxicity by integrating data from an in vitro assay battery covering key cellular events in neurodevelopment
  4. Release of manuscript Immune System Evaluation of Echinacea Purpurea Root Extract in Female Harlan Sprague Dawley (Hsd:Sprague Dawley SD) Rats
  5. Release of manuscript Evaluation of 2,2’-Dimorpholinodiethyl Ether (DMDEE) in Pathology, Perinatal, and Genotoxicity Studies
  6. Release of manuscript Immunotoxicity studies on the insecticide 2-((1-(4-Phenoxyphenoxy)propan-2yl)oxy)pyridine (MPEP) in Hsd:Harlan Sprague Dawley SD rats
  7. Release of update of NIEHS In Vivo Repeat Dose Biological Potency Studies
  8. Release of TR-605: Sulfolane
  9. Update DDD file for Assay
  10. Added new data for Transcriptomic Biomarker data collection for Adrenal Gland, Esophagus, Mammary Gland, Ovary, Peripheral Nerve, Testis
  11. Added Phase 2 data to Transcriptomic Biomarker data collection for Liver and Lung
  12. Update manuscript Transcriptomic Biomarker of Toxicological Effect for Phase 2 data
  13. Release of manuscript Perinatal and Three-month Toxicity Study of Triphenyl Phosphate (CASRN 115-86-6) Administered in Feed to Sprague Dawley (Hsd:Sprague Dawley® SD®) Rats

MAY 2026 Data Release

  1. Update Lab Report file to remove signatures in paper titled Assessment of Dermal and Respiratory Sensitization Potential of Phthalic Anhydride and Phthalic Acid Using the GARD™skin and GARD™air Assays
  2. Correct citation information in Sulfolane paper titled Comparison of sulfolane effects in Sprague Dawley rats, B6C3F1/N mice, and Hartley guinea pigs after 28 days of exposure via oral gavage
  3. Add 2 Chronic studies to TR-391 page
  4. Update DDD file for Locators

APRIL 2026 Data Release

  1. Release of NIEHS-12 and NIEHS-13 DCB reports
  2. Release of manuscript Investigation of the Potential of Bisphenol A Substitutes to Induce Allergic Contact Sensitization Using OECD Defined Approaches
  3. Updated filenames for Bacterial Reverse Mutation and In Vitrol Micronucleus on the DTT Integrated Data page to use the word Test instead of Subject.
  4. Update of Data Dictionary for Assay and the Update Summary

MARCH 2026

  1. Release of Evaluation of the Chronic Toxicity and Carcinogenicity (C55221D) of Sodium Fluoride (7681-49-4) in F344 Rats (Ionizing Radiation and Drinking Water Study)
  2. Release of Comparative investigation of the potential of glyphosate and glyphosate-based formulations (GBFs) to cause oxidative stress and DNA damage in human skin and liver cell systems
  3. Release of Transcriptomic perturbations in placental gene expression following developmental exposure to perfluorooctanoic acid (PFOA) or hexafluoropropylene oxide-dimer acid (HFPO-DA or GenX) in CD-1 mice are consistent with placental insufficiency
  4. Updated G06 reports added to DMDEE page

FEBRUARY 2026

  1. Release of manuscript Assessment of Dermal and Respiratory Sensitization Potential of Phthalic Anhydride and Phthalic Acid Using the GARD™skin and GARD™air Assays
  2. Release of DrugMatrix data titled ToxCompl
  3. Add file F1 Biological Sampling Cohort - Plasma concentrations to DART-05 report
  4. Several Data Collections updated
  5. New data collection Toxicokinetic Studies was added
  6. Update of Data Dictionary for Tissue, Locator, Morphology, Modifier and Test Article

SEPTEMBER 2025 Data Release

  1. Release of manuscript Urban air temperature at high spatiotemporal resolution on major US cities
  2. Release of manuscript Automating Data Extraction from Scientific Literature and General PDF Files Using Large Language Models and KNIME: An Application in Toxicology
  3. Release of Immunotoxicity Assessment of Multiwalled Carbon Nanotubes Following Whole-Body Inhalation Exposure for 30 and 90 Days in B6C3F1/N Mice and 30 Days in HSD:Harlan Sprague Dawley SD® Rats
  4. Update of Data Dictionary for Tissue, Locator, Morphology and Modifier. Biological Physical has been removed
  5. Release of In Vivo Micronucleus Assay IAD and Summary Data Collections

AUGUST 2025 Data Release

  1. Release of manuscript Development and Testing of a Novel Whole-body Exposure System for Investigative Studies of Radiofrequency Radiation in Rodents
  2. Release of page containing clinical observation videos Development and Testing of a Novel Whole-body Exposure System for Investigative Studies of Radiofrequency Radiation in Rodents - Video Clinical Observations
  3. Release NICEATM-3: Report on the Validation of the Electrophilic Allergen Screening Assay (EASA) for the Identification of Potential Skin Sensitizers
  4. Release NIEHS In Vivo Repeat Dose Biological Potency Studies
  5. Release updated DTT Data Dictionary 2022-Present updated for Test Articles
  6. Release updated Data Collections to add Tissue Disposition IAD and Terminal Bodyweight and new section for Genetic Toxicology Data

JULY 2025 Data Release

  1. Updated NTP/DTT Data Collections and the Data Collections webpage
  2. Updated Clinical Chemistry, Hematology, Organ Weight, Histopathology, Chemistry Lists and Test Article DDD
  3. Changing In-Life Bodyweight Data Collection to Terminal BodyWeight only
  4. Corrected link to abstract in NIEHS-11 publication page.
  5. Release of manuscript Chronic PFAS Exposure Induces Chemotherapy Resistance by Promoting Mitochondria-Related Alterations in Ovarian Cancer Cells

JUNE 2025 Data Release

  1. Release of manuscript Artificial Intelligence (AI)-Driven Morphological Assessment of Zebrafish Larvae for Developmental Toxicity Chemical Screening
    2. G94043B
  2. Added Historical Control file for Blood Micronucleus to TOX-106 Genetox study G94043B
  3. Released updated Chemistry Lists Dataset
  4. Released NICEATM-06: Evaluation of the GARD(TM)skin Sensitization Test Method Using Substances of Regulatory Interest

MAY 2025 Data Release

  1. Update of MGRAPH-5: Occupational Exposure to Cancer Chemotherapy Agents - remove link to MGRAPH-6 under Other Studies and restore the Data Link
  2. Update of MGRAPH-6: Sarin: Potential Long-term Neurological Effects - remove link to MGRAPH-6 under Other Studies and restore the Data Link
  3. Update of MGRAPH-7: Traffic-related Air Pollution and Hypertensive Disorders of Pregnancy - remove link to MGRAPH-6 under Other Studies and restore the Data Link
  4. Update NIEHS-01: NIEHS Report on Evaluating Features and Application of Neurodevelopmental Tests in Epidemiological Studies to remove link to NIEHS-01 under Other Studies
  5. Release paper about TOX21
  6. Release of sub paper "Improving the Human Hazard Characteristics of Chemicals: A Tox 21 Update"
  7. Release of paper "A surface sampling and liquid chromatography mass spectrometry method for the analysis of quaternary ammonium compounds collected from public transportation buses in New Jersey"
  8. Reproductive and developmental toxicity following exposure to organophosphate ester flame retardants and plasticizers, triphenyl phosphate and isopropylated phenyl phosphate, in Sprague Dawley rats
  9. Released NICEATM-05: Evaluation of Substances of Regulatory Interest Using Non-Animal Skin Sensitization Test Methods

APRIL 2025 Data Release

  1. April Data Dictionary Update
  2. Update of MGRAPH-5: Occupational Exposure to Cancer Chemotherapy Agents
  3. Update of MGRAPH-6: Sarin: Potential Long-term Neurological Effects
  4. Update of MGRAPH-7: Traffic-related Air Pollution and Hypertensive Disorders of Pregnancy

MARCH 2025 Data Release

  1. Update to Suppression of the T-dependent Antibody Response Following Oral Exposure to Selected Polycyclic Aromatic Compounds in B6C3F1/N Mice
  2. Update to NTP/DTT Data Collections 2024-Present
  3. Update to DART – Rabbit Historical Control Data (2015-2018)

FEBRUARY 2025 Data Release

  1. Release of Developmental Immunotoxicity Study of Tris(chloropropyl) phosphate (TCPP) in Hsd:Sprague Dawley SD Rats Exposed Through Dosed Feed
  2. Release of Suppression of the T-dependent Antibody Response Following Oral Exposure to Selected Polycyclic Aromatic Compounds in B6C3F1/N Mice
  3. Update to RR-12: Crumb Rubber CRM09132016 Mesh 400 (CRUMBRUBBERMESH400), Crumb Rubber CRM12052016 Combined Mesh 14-80 (CRUMBRUBBERCOMBINED) abstract link
  4. Update to RR-14: Crumb Rubber CRM09132016 Mesh 400 (CRUMBRUBBERMESH400), Crumb Rubber CRM12052016 Combined Mesh 14-80 (CRUMBRUBBERCOMBINED) abstract link
  5. Update to Comparative toxicity and liver transcriptomics of legacy and emerging brominated flame retardants following 5-day exposure in the rat link
  6. February Data Dictionary Update

JANUARY 2025 Data Release

  1. Release of Unraveling Human Hepatocellular Responses to PFAS and Aqueous Film-Forming Foams (AFFFs) for Molecular Hazard Prioritization and In Vivo Translation

Previous Years Information

Old Release Information