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Botanical Safety Consortium Publications

Botanical dietary supplement use is widespread and growing, therefore, ensuring the safety of botanical products is a public health priority. The Botanical Safety Consortium (BSC) is a public-private partnership aimed at enhancing the toolkit for conducting the safety evaluation of botanicals. This partnership is the result of a Memorandum of Understanding between the US FDA, the National Institute of Environmental Health Sciences, and the Health and Environmental Sciences Institute. The BSC serves as a global forum for scientists from government, academia, consumer health groups, industry, and non-profit organizations to work collaboratively on adapting and integrating new approach methodologies (NAMs) into routine botanical safety assessments.

DOI: https://doi.org/10.22427/NTP-DATA-500-007-003-000-5

Publication

Citations

Muchiri RN, Van Breemen RB. 2024. Chemical standardization of milk thistle (Silybum marianum L.) extract using UHPLC-MS/MS and the method of standard addition. J Am Soc Mass Spectrom. 35(8):1726–1732. DOI: 10.1021/jasms.4c00125.rtl

Zeiger E, Mitchell CA, Pfuhler S, Liao Y, Witt KL. 2024. Within‐laboratory reproducibility of Ames test results: Are repeat tests necessary? Environ and Mol Mutagen. 65(3–4):116–120." DOI: 10.1002/em.22597.rtl

Liu Y, Lawless M, Li M, Fairman K, Embry MR, Mitchell CA. 2024. Prediction of physicochemical and pharmacokinetic properties of botanical constituents by computational models. J of Applied Toxicology. 44(8):1236–1245. DOI: 10.1002/jat.4617.rtl

Kanungo J, Sorkin BC, Krzykwa J, Mitchell CA, Embry M, Spencer P, Harry GJ, Cannon J, Liu F, McPherson CA, et al. 2024. Screening tools to evaluate the neurotoxic potential of botanicals: Building a strategy to assess safety. Expert Opinion on Drug Metabolism & Toxicology. 20(7):629–646. DOI: 10.1080/17425255.2024.2378895.rtl

Waidyanatha S, Collins BJ, Cristy T, Embry M, Gafner S, Johnson H, Kellogg J, Krzykwa J, Li S, Mitchell CA, et al. 2024. Advancing botanical safety: A strategy for selecting, sourcing, and characterizing botanicals for developing toxicological tools. Food and Chemical Toxicology. 186:114537. DOI: 10.1016/j.fct.2024.114537.rtl

Patel D, Sorkin BC, Mitchell CA, Embry MR, Rina-Kong S, Adams RE, DeTemple ER, Reddam A, Gafner S, Kelber O, et al. 2023. Improving the rigor and utility of botanical toxicity studies: Recommended resources. Regulatory Toxicology and Pharmacology. 144:105471. DOI: 10.1016/j.yrtph.2023.105471.rtl

Smith DJ, Bi H, Hamman J, Ma X, Mitchell C, Nyirenda K, Monera-Penduka T, Oketch-Rabah H, Paine MF, Pettit S, et al. 2023. Potential pharmacokinetic interactions with concurrent use of herbal medicines and a ritonavir-boosted COVID-19 protease inhibitor in low and middle-income countries. Front Pharmacol. 14:1210579. DOI: 10.3389/fphar.2023.1210579.rtl

Pearson A, Gafner S, Rider CV, Embry MR, Ferguson SS, Mitchell CA. 2022. Plant vs. kidney: Evaluating nephrotoxicity of botanicals with the latest toxicological tools. Current Opinion in Toxicology. 32:100371. DOI: 10.1016/j.cotox.2022.100371.rtl

Mitchell CA, Dever JT, Gafner S, Griffiths JC, Marsman DS, Rider C, Welch C, Embry MR. 2022. The Botanical Safety Consortium: A public-private partnership to enhance the botanical safety toolkit. Regulatory Toxicology and Pharmacology. 128:105090. DOI: 10.1016/j.yrtph.2021.105090.rtl

Roe AL, Dever JT, Gafner S, Marsman DS, Rider CV, Swift S. 2019. The Botanical Safety Consortium. Applied In Vitro Toxicology. 5(1):4–9. Roe AL, Dever JT, Gafner S, Marsman DS, Rider CV, Swift S. 2019. The Botanical Safety Consortium. Applied In Vitro Toxicology. 5(1):4–9. DOI: 10.1089/aivt.2018.29018.rtl