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2-Ethylhexyl diphenyl phosphate (1241-94-7)

DOI: https://doi.org/10.22427/NTP-DATA-DTXSID1025300

Study Results

Genetic Toxicology

An overview of Genetic Toxicology Bacterial Mutagenicity study conclusions related to 2-Ethylhexyl diphenyl phosphate (1241-94-7).
Bacterial Mutagenicity
View
  • Negative

Citation Information

NTP. 2-Ethylhexyl diphenyl phosphate (1241-94-7). Chemical Effects in Biological Systems (CEBS). Research Triangle Park, NC (USA): National Toxicology Program (NTP).

Related Links

Publications

NIEHS-02 NIEHS Report on In Vivo Repeat Dose Biological Potency Study of 2-Ethylhexyl Diphenyl Phosphate (CAS No. 1241-94-7) in Male Sprague Dawley Rats (Hsd: Sprague Dawley SD) (Gavage Studies)
Zeiger, E., Haworth, S., Mortelmans, K., and Speck, W. Mutagenicity testing of Di(2-ethylhexyl)phthalate and related chemicals in Salmonella Environ. Mutagen. Vol. 7 (1985) 213-232
Ryan KR, Sirenko O, Parham F, Hsieh JH, Cromwell EF, Tice RR, Behl M. Neurite outgrowth in human induced pluripotent stem cell-derived neurons as a high-throughput screen for developmental neurotoxicity or neurotoxicity. Neurotoxicology. 2016 Mar;53:271-281. doi: 10.1016/j.neuro.2016.02.003. Epub 2016 Feb 4. PMID: 26854185
Behl M, Rice JR, Smith MV, Co CA, Bridge MF, Hsieh JH, Freedman JH, Boyd WA. Editor's Highlight: Comparative Toxicity of Organophosphate Flame Retardants and Polybrominated Diphenyl Ethers to Caenorhabditis elegans. Toxicol Sci. 2016 Dec;154(2):241-252. doi: 10.1093/toxsci/kfw162. Epub 2016 Aug 26. PMID: 27566445
Sirenko O, Grimm FA, Ryan KR, Iwata Y, Chiu WA, Parham F, Wignall JA, Anson B, Cromwell EF, Behl M, Rusyn I, Tice RR. In vitro cardiotoxicity assessment of environmental chemicals using an organotypic human induced pluripotent stem cell-derived model. Toxicol Appl Pharmacol. 2017 May 1;322:60-74. doi: 10.1016/j.taap.2017.02.020. Epub 2017 Mar 1. PMID: 28259702
Nyffeler J, Dolde X, Krebs A, Pinto-Gil K, Pastor M, Behl M, Waldmann T, Leist M. Combination of multiple neural crest migration assays to identify environmental toxicants from a proof-of-concept chemical library. Arch Toxicol. 2017 Nov;91(11):3613-3632. doi: 10.1007/s00204-017-1977-y. Epub 2017 May 5. PMID: 28477266
Glazer L, Hawkey AB, Wells CN, Drastal M, Odamah KA, Behl M, Levin ED. Developmental Exposure to Low Concentrations of Organophosphate Flame Retardants Causes Life-Long Behavioral Alterations in Zebrafish. Toxicol Sci. 2018 Oct 1;165(2):487-498. doi: 10.1093/toxsci/kfy173. PMID: 29982741
Sirenko O, Parham F, Dea S, Sodhi N, Biesmans S, Mora-Castilla S, Ryan K, Behl M, Chandy G, Crittenden C, Vargas-Hurlston S, Guicherit O, Gordon R, Zanella F, Carromeu C. Functional and Mechanistic Neurotoxicity Profiling Using Human iPSC-Derived Neural 3D Cultures. Toxicol Sci. 2019 Jan 1;167(1):58-76. doi: 10.1093/toxsci/kfy218. PMID: 30169818
Alzualde A, Behl M, Sipes NS, Hsieh JH, Alday A, Tice RR, Paules RS, Muriana A, Quevedo C. Toxicity profiling of flame retardants in zebrafish embryos using a battery of assays for developmental toxicity, neurotoxicity, cardiotoxicity and hepatotoxicity toward human relevance. Neurotoxicol Teratol. 2018 Nov-Dec;70:40-50. doi: 10.1016/j.ntt.2018.10.002. Epub 2018 Oct 9. PMID: 30312655
Quevedo C, Behl M, Ryan K, Paules RS, Alday A, Muriana A, Alzualde A. Detection and Prioritization of Developmentally Neurotoxic and/or Neurotoxic Compounds Using Zebrafish. Toxicol Sci. 2019 Mar 1;168(1):225-240. doi: 10.1093/toxsci/kfy291. PMID: 30521027
Zhang S, Ireland D, Sipes NS, Behl M, Collins ES. Screening for neurotoxic potential of 15 flame retardants using freshwater planarians. Neurotoxicol Teratol. 2019 May-Jun;73:54-66. doi: 10.1016/j.ntt.2019.03.003. Epub 2019 Mar 31. PMID: 30943442
Klose J, Pahl M, Bartmann K, Bendt F, Blum J, Dolde X, Förster N, Holzer AK, Hübenthal U, Keßel HE, Koch K, Masjosthusmann S, Schneider S, Stürzl LC, Woeste S, Rossi A, Covaci A, Behl M, Leist M, Tigges J, Fritsche E. Neurodevelopmental toxicity assessment of flame retardants using a human DNT in vitro testing battery. Cell Biol Toxicol. 2022 Oct;38(5):781-807. doi: 10.1007/s10565-021-09603-2. Epub 2021 May 10. PMID: 33969458
Emond C, DeVito MJ, Birnbaum LS. A PBPK model describing the pharmacokinetics of γ-HBCD exposure in mice. Toxicol Appl Pharmacol. 2021 Oct 1;428:115678. doi: 10.1016/j.taap.2021.115678. Epub 2021 Aug 11. PMID: 34390738
Jarema KA, Hunter DL, Shaffer RM, Behl M, Padilla S. Acute and developmental behavioral effects of flame retardants and related chemicals in zebrafish. Neurotoxicol Teratol. 2015 Nov-Dec;52(Pt B):194-209. doi: 10.1016/j.ntt.2015.08.010. Epub 2015 Sep 5. PMID: 26348672
Behl M, Hsieh JH, Shafer TJ, Mundy WR, Rice JR, Boyd WA, Freedman JH, Hunter ES 3rd, Jarema KA, Padilla S, Tice RR. Use of alternative assays to identify and prioritize organophosphorus flame retardants for potential developmental and neurotoxicity. Neurotoxicol Teratol. 2015 Nov-Dec;52(Pt B):181-93. doi: 10.1016/j.ntt.2015.09.003. Epub 2015 Sep 18. PMID: 26386178

Study Data

Protocol

Toxicity and Carcinogenicity Studies

5-Day Evaluation of the Toxicity (C10674) of 2-Ethylhexyl Diphenyl Phosphate (EHDP) (1241-94-7) on Harlan Sprague-Dawley Rats Exposed via Gavage
Study Tables
Individual Animal Data
Protocol

Genetic Toxicology Studies

Genetic Toxicity Evaluation of 2-Ethylhexyl Diphenyl Phosphate in Salmonella/E.coli Mutagenicity Test or Ames Test. Study 644636
Summary Data

Other NTP Studies

Screen for Developmental Toxicity in Zebrafish- Study 1
Results

NTP Data Collections