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Hydroxyurea (127-07-1)

DOI: https://doi.org/10.22427/NTP-DATA-DTXSID6025438

Study Results

Genetic Toxicology

An overview of Genetic Toxicology Micronucleus Mice study conclusions related to Hydroxyurea (127-07-1).
Micronucleus - Mice
View
  • Male: Positive
An overview of Genetic Toxicology In Vivo Alkaline Comet Assay Mice study conclusions related to Hydroxyurea (127-07-1).
In Vivo Alkaline Comet Assay - Mice
View
  • Male: Positive
View
  • Male: Negative
An overview of Genetic Toxicology Drosophila Germ Cell Mutagenicity study conclusions related to Hydroxyurea (127-07-1).
Drosophila Germ Cell Mutagenicity
SLRL
An overview of Genetic Toxicology Bacterial Mutagenicity study conclusions related to Hydroxyurea (127-07-1).
Bacterial Mutagenicity
View
  • Negative

Citation Information

NTP. Hydroxyurea (127-07-1). Chemical Effects in Biological Systems (CEBS). Research Triangle Park, NC (USA): National Toxicology Program (NTP).

Related Links

Publications

Haworth, S., Lawlor, T., Mortelmans, K., Speck, W., and Zeiger, E. Salmonella mutagenicity test results for 250 chemicals Environ. Mutagen. Vol. 5 (Suppl 1) (1983) 3-142
Yoon, J.S., Mason, J.M., Valencia, R., Woodruff, R.C., and Zimmering, S. Chemical mutagenesis testing in Drosophila: IV. Results of 45 coded compounds tested for the National Toxicology Program. Environ. Mutagen. Vol. 7 (1985) 349-367
Effects of perinatal hydroxyurea treatment and investigation of maternal transfer and age-dependency of toxicokinetics in Sprague Dawley rats Madelyn Huang, Katie Turner, Molly Vallant, Yi Lu, Catherine Price, Timothy Fennell, Melanie A. Silinski, Suramya Waidyanatha, Kristen Ryan, Sherry R. Black, Reshan Fernando, Barry McIntyre

DOI: https://doi.org/10.22427/NTP-DATA-002-02275-0007-0000-5
Systematic Evaluation of the Application of Zebrafish in Toxicology (SEAZIT): Interlaboratory Study Dose Range Finding (DRF) data DOI: https://doi.org/10.22427/NTP-DATA-002-00102-0001-000-6

Study Data

Protocol

Genetic Toxicology Studies

Genetic Toxicity Evaluation of Hydroxyurea (127-07-1) in DNA Damage Study G10871B in B6C3F1 Mice
Summary and Individual Animal Data
Genetic Toxicity Evaluation of Hydroxyurea (127-07-1) in DNA Damage Study G10871C in B6C3F1 Mice
Summary and Individual Animal Data
Genetic Toxicity Evaluation of Hydroxyurea (127-07-1) in Micronucleus Study G10871 in B6C3F1 Mice
Summary and Individual Animal Data
Genetic Toxicity Evaluation of Hydroxyurea in Salmonella/E.coli Mutagenicity Test or Ames Test. Study 855066
Summary Data

Other NTP Studies

Screen for Developmental Toxicity in Zebrafish- Study 1
Results
Toxicokinetic Evaluation (K10871) of Hydroxyurea (DTXSID6025438) in Rat
Data

NTP Data Collections