Acrylamide (79-06-1)
DOI: https://doi.org/10.22427/NTP-DATA-DTXSID5020027
Study Results
Chronic Bioassay Level of Evidence
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Genetic Toxicology
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| Micronucleus - Mice |
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| Micronucleus - Rats |
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| Mammalian Cell Cytogenetics | |
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| CA | SCE |
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| In Vivo Alkaline Comet Assay - Mice |
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| Drosophila Germ Cell Mutagenicity | |
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| SLRL | RT |
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Publications
TR-575
Toxicology and Carcinogenesis Studies of Acrylamide (CASRN 79-06-1) in F344/N Rats and B6C3F1 Mice (Feed and Drinking Water Studies)
Zeiger E, Anderson B, Haworth S, Lawlor T, Mortelmans K, Speck W. Salmonella mutagenicity tests: III. Results from the testing of 255 chemicals. Environ Mutagen. 1987;9 Suppl 9:1-109.
Teratologic Evaluation of Acrylamide Administered to CD-1 Mice on Gestational Days 6 through 17
Teratologic Evaluation of Acrylamide Administered to Sprague-Dawley (CD) Rats on Gestational Days 6 through 20
Ghanayem BI, Witt KL, Kissling GE, Tice RR, Recio L.
Absence of acrylamide-induced genotoxicity in CYP2E1-null mice: evidence consistent with a glycidamide-mediated effect. Mutat Res. 2005 Oct 15;578(1-2):284-97.
Witt KL, Livanos E, Kissling GE, Torous DK, Caspary W, Tice RR, Recio L. Comparison of flow cytometry- and microscopy-based methods for measuring micronucleated reticulocyte frequencies in rodents treated with nongenotoxic and genotoxic chemicals. Mutat Res. 2008 Jan 8;649(1-2):101-13. Epub 2007 Aug 11.
Foureman, P., Mason, J.M., Valencia, R., Zimmering, S. Chemical Mutagenesis Testing in Drosophila. X. Results of 70 coded compounds tested for the National Toxicology Program. Environ. Molec. Mutagen. Vol. 23 (1994) 208-227
Evaluation of 5-Day In Vivo Rat Liver and Kidney with High-Throughput Transcriptomics for Estimating Benchmark Doses of Apical Outcomes
William M. Gwinn, Scott S. Auerbach, Fred Parham, Matthew D. Stout, Suramya Waidyanatha, Esra Mutlu, Brad Collins, Richard S Paules, B. Alex Merrick, Stephen Ferguson, Sreenivasa Ramaiahgari, John R. Bucher, Barney Sparrow, Heather Toy, Jenni Gorospe, Nick Machesky, Ruchir R. Shah, Michele R. Balik-Meisner, Deepak Mav, Dhiral P. Phadke, Georgia Roberts, Michael J. DeVito
CEBS DOI: https://doi.org/10.22427/NTP-DATA-002-00058-0002-0000-7
GEO No.: GSE147072: https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE147072
BioProject No.: PRJNA612884: https://www.ncbi.nlm.nih.gov/bioproject/?term=PRJNA612884
SRA No.: SRP253005: https://www.ncbi.nlm.nih.gov/sra?term=SRP253005
CEBS DOI: https://doi.org/10.22427/NTP-DATA-002-00058-0002-0000-7
GEO No.: GSE147072: https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE147072
BioProject No.: PRJNA612884: https://www.ncbi.nlm.nih.gov/bioproject/?term=PRJNA612884
SRA No.: SRP253005: https://www.ncbi.nlm.nih.gov/sra?term=SRP253005
Study Data
Toxicity and Carcinogenicity Studies
5-day study (C10949) of Acrylamide (79-06-1) delivered via Gavage in HSD Rat
Study Tables
- I01 - Animal Removal Summary (31 kB)
- I03 - Growth Curve (329 kB)
- I03C - Growth Curve (338 kB)
- I04 -Mean Body Weight Summary (65 kB)
- I04G - Mean Body Weight Gain (53 kB)
- I05 - Clinical Observations Summary (40 kB)
- PA06 - Organ Weights Summary (56 kB)
Individual Animal Data
3-Month Evaluation of the Toxicity (C20313) of Acrylamide (79-06-1) in F344/NCTR Rats Exposed via Dosed Water
Pathology Tables
- E01 - Animal Removal Summary By Treatment Group
- P02 - Incidence Rates Of Neoplasms By Anatomic Site (a)
- P03 - Incidence Rates Of Non-Neoplastic Lesions By Anatomic Site(a)
- P04 - Neoplasms By Individual Animal
- P05 - Incidence Rates Of Neoplasms By Anatomic Site (Systemic Lesions Abridged) (a)
- P07 - Neoplasms By Individual Animal (Systemic Lesions Abridged)
- P09 - Non-Neoplastic Lesions By Individual Animal
- P10 - Statistical Analysis Of Non-Neoplastic Lesions
- P11 - Statistical Analysis of Survival Data
- P15 - Slide/Block Inventory
- P17 - Neoplasms By Individual Animal (Systemic Lesions Abridged)
- P18 - Incidence Rates Of Non-neoplastic Lesions By Anatomic Site (a) With Average Severity Grades[b]
- P40 - Survival Curves
Individual Animal Data
- P14 - Female,Male Individual Animal Pathology Data
- Male Individual Animal Body Weight Data
- Male Individual Animal Organ Weight Data
- Male Individual Animal Pathology Data Non Neoplastic
- Male Individual Animal Survival Data
- Female Individual Animal Body Weight Data
- Female Individual Animal Organ Weight Data
- Female Individual Animal Pathology Data Non Neoplastic
- Female Individual Animal Survival Data
3-Month Evaluation of the Toxicity (C20313B) of Acrylamide (79-06-1) in F344/NCTR Rats Exposed via Dosed Feed
Pathology Tables
- E01 - Animal Removal Summary By Treatment Group
- P02 - Incidence Rates Of Neoplasms By Anatomic Site (a)
- P03 - Incidence Rates Of Non-Neoplastic Lesions By Anatomic Site(a)
- P04 - Neoplasms By Individual Animal
- P05 - Incidence Rates Of Neoplasms By Anatomic Site (Systemic Lesions Abridged) (a)
- P07 - Neoplasms By Individual Animal (Systemic Lesions Abridged)
- P09 - Non-Neoplastic Lesions By Individual Animal
- P10 - Statistical Analysis Of Non-Neoplastic Lesions
- P11 - Statistical Analysis of Survival Data
- P15 - Slide/Block Inventory
- P17 - Neoplasms By Individual Animal (Systemic Lesions Abridged)
- P18 - Incidence Rates Of Non-neoplastic Lesions By Anatomic Site (a) With Average Severity Grades[b]
- P40 - Survival Curves
Individual Animal Data
- P14 - Female,Male Individual Animal Pathology Data
- Male Individual Animal Body Weight Data
- Male Individual Animal Organ Weight Data
- Male Individual Animal Pathology Data Non Neoplastic
- Male Individual Animal Survival Data
- Female Individual Animal Body Weight Data
- Female Individual Animal Organ Weight Data
- Female Individual Animal Pathology Data Non Neoplastic
- Female Individual Animal Survival Data
3-Month Evaluation of the Toxicity (C20313) of Acrylamide (79-06-1) in B6C3F1/NCTR Mice Exposed via Dosed Water
Study Tables
- E01 - Animal Removal Summary By Treatment Group (12 kB)
- P02 - Incidence Rates of Neoplasms by Anatomic Site (34 kB)
- P03 - Incidence Rates of Non-Neoplastic Lesions by Anatomic Site (33 kB)
- P04 - Neoplasms by Individual Animal (222 kB)
- P05 - Incidence Rates of Neoplasms by Anatomic Sites (Systemic Lesions Abridged) (35 kB)
- P07 - Neoplasms by Individual Animal (Systemic Lesions Abridged) (223 kB)
- P09 - Non-Neoplastic Lesions by Individual Animal (203 kB)
- P10 - Statistical Analysis of Non-Neoplastic Lesions (75 kB)
- P11 - Statistical Analysis of Survival Data (27 kB)
- P14 - Individual Animal Pathology Data (220 kB)
- P17 - Neoplasms By Individual Animal (Systemic Lesions Abridged) (217 kB)
- P18 - Incidence Rates of Non-Neoplastic Lesions by Anatomic Site with Average Severity Grades (34 kB)
- P40 - Survival Curves (392 kB)
Lab Pathology Reports
- Appendix 11: Pathology Report (28 mB)
- Genotoxicity and Carcinogenicity of Acrylamide and its Metabolite, glycidamide in Rodents: 13-week Toxicity Study (52 mB)
Individual Animal Data
- Female Individual Animal Non Neoplastic Pathology Data (18 kB)
- Female Individual Animal Organ Weight Data (23 kB)
- Female Individual Animal Survival Data (9 kB)
- Male Individual Animal Non Neoplastic Pathology Data (15 kB)
- Male Individual Animal Organ Weight Data (23 kB)
- Male Individual Animal Survival Data (9 kB)
3-Month Evaluation of the Toxicity (C20313B) of Acrylamide (79-06-1) in B6C3F1/NCTR Mice Exposed via Dosed Feed
Study Tables
- E01 - Animal Removal Summary By Treatment Group (13 kB)
- P02 - Incidence Rates of Neoplasms by Anatomic Site (34 kB)
- P03 - Incidence Rates of Non-Neoplastic Lesions by Anatomic Site (33 kB)
- P04 - Neoplasms by Individual Animal (257 kB)
- P05 - Incidence Rates of Neoplasms by Anatomic Sites (Systemic Lesions Abridged) (35 kB)
- P07 - Neoplasms by Individual Animal (Systemic Lesions Abridged) (258 kB)
- P09 - Non-Neoplastic Lesions by Individual Animal (219 kB)
- P11 - Statistical Analysis of Survival Data (27 kB)
- P14 - Individual Animal Pathology Data (221 kB)
- P17 - Neoplasms By Individual Animal (Systemic Lesions Abridged) (253 kB)
- P18 - Incidence Rates of Non-Neoplastic Lesions by Anatomic Site with Average Severity Grades (34 kB)
- P40 - Survival Curves (412 kB)
Lab Pathology Reports
- Appendix 11: Pathology Report (28 mB)
- Genotoxicity and Carcinogenicity of Acrylamide and its Metabolite, glycidamide in Rodents: 13-week Toxicity Study (52 mB)
Individual Animal Data
- Female Individual Animal Non Neoplastic Pathology Data (16 kB)
- Female Individual Animal Organ Weight Data (23 kB)
- Female Individual Animal Survival Data (9 kB)
- Male Individual Animal Non Neoplastic Pathology Data (12 kB)
- Male Individual Animal Organ Weight Data (23 kB)
- Male Individual Animal Survival Data (9 kB)
Evaluation of the Chronic Toxicity and Carcinogenicity (C20313) of Acrylamide (79-06-1) in F344/NCTR Rats Exposed via Dosed Water
Study Tables
- P03 - Incidence Rates of Non-Neoplastic Lesions by Anatomic Site (71 kB)
- P04 - Neoplasms by Individual Animal (1 mB)
- P05 - Incidence Rates of Neoplasms by Anatomic Sites (Systemic Lesions Abridged) (53 kB)
- P09 - Non-Neoplastic Lesions by Individual Animal (1 mB)
- P14 - Individual Animal Pathology Data (2 mB)
- P18 - Incidence Rates of Non-Neoplastic Lesions by Anatomic Site with Average Severity Grades (73 kB)
- P40 - Survival Curves (92 kB)
Individual Animal Data
- Female Individual Animal Neoplastic Pathology Data (314 kB)
- Female Individual Animal Non Neoplastic Pathology Data (1 mB)
- Female Individual Animal Organ Weight Data (68 kB)
- Female Individual Animal Survival Data (40 kB)
- Male Individual Animal Neoplastic Pathology Data (497 kB)
- Male Individual Animal Non Neoplastic Pathology Data (1 mB)
- Male Individual Animal Organ Weight Data (68 kB)
- Male Individual Animal Survival Data (40 kB)
Evaluation of the Chronic Toxicity and Carcinogenicity (C20313) of Acrylamide (79-06-1) in B6C3F1/NCTR Mice Exposed via Dosed Water
Study Tables
- P03 - Incidence Rates of Non-Neoplastic Lesions by Anatomic Site (69 kB)
- P04 - Neoplasms by Individual Animal (951 kB)
- P05 - Incidence Rates of Neoplasms by Anatomic Sites (Systemic Lesions Abridged) (50 kB)
- P09 - Non-Neoplastic Lesions by Individual Animal (1 mB)
- P14 - Individual Animal Pathology Data (2 mB)
- P18 - Incidence Rates of Non-Neoplastic Lesions by Anatomic Site with Average Severity Grades (71 kB)
- P40 - Survival Curves (85 kB)
Individual Animal Data
- Female Individual Animal Neoplastic Pathology Data (220 kB)
- Female Individual Animal Non Neoplastic Pathology Data (979 kB)
- Female Individual Animal Organ Weight Data (68 kB)
- Female Individual Animal Survival Data (40 kB)
- Male Individual Animal Neoplastic Pathology Data (162 kB)
- Male Individual Animal Non Neoplastic Pathology Data (766 kB)
- Male Individual Animal Organ Weight Data (68 kB)
- Male Individual Animal Survival Data (40 kB)
Genetic Toxicology Studies
Genetic Toxicity Evaluation of Acrylamide (79-06-1) in DNA Damage Study G10949D in C57B1/6J Mice
Summary and Individual Animal Data
Genetic Toxicity Evaluation of Acrylamide (79-06-1) in Micronucleus Study A75648 in B6C3F1 Mice
Summary and Individual Animal Data
Genetic Toxicity Evaluation of Acrylamide (79-06-1) in Micronucleus Study A97370 in F344 Rats
Summary and Individual Animal Data
Genetic Toxicity Evaluation of Acrylamide (79-06-1) in Micronucleus Study F12535 in 129 Sv/Ev Mice
Summary and Individual Animal Data
Genetic Toxicity Evaluation of Acrylamide (79-06-1) in Micronucleus Study F75142 in 129 Sv/Ev Mice
Summary and Individual Animal Data
Genetic Toxicity Evaluation of Acrylamide (79-06-1) in Micronucleus Study F75648 in B6C3F1 Mice
Summary and Individual Animal Data
Genetic Toxicity Evaluation of Acrylamide (79-06-1) in Micronucleus Study F97370 in F344 Rats
Summary and Individual Animal Data
Genetic Toxicity Evaluation of Acrylamide (79-06-1) in Micronucleus Study G10949 in C57BL/6 Mice
Summary and Individual Animal Data
Genetic Toxicity Evaluation of Acrylamide in Salmonella/E.coli Mutagenicity Test or Ames Test. Study 440483
Summary Data
- G06 - Ames Summary Data (128 KB)
Genetic Toxicity Evaluation of Acrylamide in Salmonella/E.coli Mutagenicity Test or Ames Test. Study 965355
Summary Data
- G06 - Ames Summary Data (136 KB)
Other NTP Studies
ADME/TK Evaluation (S0008) of Acrylamide (79-06-1) in F344 Rats Exposed via Gavage Administration and Intravenous Injection Bile Study
Prenatal Developmental Toxicity Study (TER88048) of Acrylamide (79-06-1) in Sprague-Dawley Rats Exposed via Gavage
Individual and Summary Data
- Dam Data: Dam Body Weights (19 kB)
- Dam Data: Dam Pregnancy Status (3 kB)
- Dam Data: Organ Weights (21 kB)
- Fetal Data: All Malformations (529 kB)
- Fetal Data: All Variations (529 kB)
- Fetal Data: Fetal Body Weights (524 kB)
- Live Litter: All Litter (526 kB)
- Live Litter: Live Litter (529 kB)
Prenatal Developmental Toxicity Study (TER89049) of Acrylamide (79-06-1) in Swiss CD-1 Mice Exposed via Gavage
Individual and Summary Data
- Dam Data: Dam Body Weights (18 kB)
- Dam Data: Dam Pregnancy Status (3 kB)
- Dam Data: Organ Weights (23 kB)
- Fetal Data: All Malformations (509 kB)
- Fetal Data: All Variations (509 kB)
- Fetal Data: Fetal Body Weights (504 kB)
- Live Litter: All Litter (506 kB)
- Live Litter: Live Litter (509 kB)
Screen for Developmental Toxicity in Zebrafish- Study 1
Results
- Zebrafish 2,3,7,8-Tetrachlorodibenzo-p-dioxin CASRN 1746-01-6 (28 kB)
- Zebrafish 1-Ethyl-3-methylimidazolium diethylphosphate CASRN 848641-69-0 (21 kB)
- Zebrafish 1-Methyl-4-phenylpyridinium iodide CASRN 36913-39-0 (21 kB)
- Zebrafish 2,2',4,4',5,5'-Hexabromodiphenyl ether (BDE-153) CASRN 68631-49-2 (21 kB)
- Zebrafish 2,2',4,4',5-Pentabromodiphenyl ether (BDE-99) CASRN 60348-60-9 (22 kB)
- Zebrafish 2,2',4,4'-Tetrabromodiphenyl ether CASRN 5436-43-1 (28 kB)
- Zebrafish 2-Ethylhexyl diphenyl phosphate (EHDP) CASRN 1241-94-7 (28 kB)
- Zebrafish 2-Ethylhexyl-2,3,4,5-tetrabromobenzoate (TBB) CASRN 183658-27-7 (21 kB)
- Zebrafish 2-Methoxyethanol CASRN 109-86-4 (22 kB)
- Zebrafish 3,3'-Iminodipropionitrile CASRN 111-94-4 (22 kB)
- Zebrafish 3,3’,5,5’-Tetrabromobisphenol A CASRN 79-94-7 (28 kB)
- Zebrafish 4-H-Cyclopenta(d,e,f)phenanthrene CASRN 203-64-5 (28 kB)
- Zebrafish 5-Fluorouracil CASRN 51-21-8 (21 kB)
- Zebrafish 5-nitro-2-furaldehyde semicarbazone CASRN 59-87-0 (23 kB)
- Zebrafish 6-Hydroxydopamine hydrochloride CASRN 28094-15-7 (21 kB)
- Zebrafish 6-Propyl-2-thiouracil CASRN 51-52-5 (21 kB)
- Zebrafish Acenaphthene CASRN 83-32-9 (28 kB)
- Zebrafish Acenaphthylene CASRN 208-96-8 (28 kB)
- Zebrafish Acetaminophen (4-hydroxyacetanilide) CASRN 103-90-2 (22 kB)
- Zebrafish Acetic acid, manganese (2+) salt CASRN 638-38-0 (22 kB)
- Zebrafish Acetylsalicylic acid CASRN 50-78-2 (21 kB)
- Zebrafish Acrylamide CASRN 79-06-1 (22 kB)
- Zebrafish Aldicarb CASRN 116-06-3 (28 kB)
- Zebrafish Amoxicillin CASRN 26787-78-0 (21 kB)
- Zebrafish Anthracene CASRN 120-12-7 (21 kB)
- Zebrafish Auramine O CASRN 2465-27-2 (28 kB)
- Zebrafish Benz(a)anthracene CASRN 56-55-3 (27 kB)
- Zebrafish Benzo(a)pyrene CASRN 50-32-8 (27 kB)
- Zebrafish Benzo(b)fluoranthene CASRN 205-99-2 (28 kB)
- Zebrafish Benzo(e)pyrene CASRN 192-97-2 (28 kB)
- Zebrafish Benzo(k)fluoranthene CASRN 207-08-9 (27 kB)
- Zebrafish Benzog,h,i perylene CASRN 191-24-2 (21 kB)
- Zebrafish Berberine chloride CASRN 633-65-8 (21 kB)
- Zebrafish Bis(2-ethylhexyl) 3,4,5,6- tetrabromophthalate (TBPH) CASRN 26040-51-7 (21 kB)
- Zebrafish Bis(tributyltin)oxide CASRN 56-35-9 (28 kB)
- Zebrafish Bisphenol A CASRN 80-05-7 (27 kB)
- Zebrafish Bisphenol AF CASRN 1478-61-1 (28 kB)
- Zebrafish Bisphenol S CASRN 80-09-1 (21 kB)
- Zebrafish Captan CASRN 133-06-2 (27 kB)
- Zebrafish Carbamic acid, butyl-, 3-iodo-2-propynyl ester CASRN 55406-53-6 (28 kB)
- Zebrafish Carbaryl CASRN 63-25-2 (27 kB)
- Zebrafish Chlorpyrifos (Dursban) CASRN 2921-88-2 (27 kB)
- Zebrafish Chrysene CASRN 218-01-9 (21 kB)
- Zebrafish Colchicine CASRN 64-86-8 (27 kB)
- Zebrafish D-Glucitol CASRN 50-70-4 (21 kB)
- Zebrafish Deltamethrin CASRN 52918-63-5 (45 kB)
- Zebrafish Di(2-ethylhexyl) phthalate CASRN 117-81-7 (22 kB)
- Zebrafish Diazepam CASRN 439-14-5 (28 kB)
- Zebrafish Dibenz a,c anthracene CASRN 215-58-7 (21 kB)
- Zebrafish Dibenz(a,h)anthracene CASRN 53-70-3 (27 kB)
- Zebrafish Dichlorodiphenyltrichloroethane (DDT) CASRN 50-29-3 (28 kB)
- Zebrafish Dieldrin CASRN 60-57-1 (27 kB)
- Zebrafish Diethylstilbestrol CASRN 56-53-1 (28 kB)
- Zebrafish Estradiol CASRN 50-28-2 (28 kB)
- Zebrafish Firemaster 550 CASRN 860302-33-6 (28 kB)
- Zebrafish Fluorene CASRN 86-73-7 (28 kB)
- Zebrafish Heptachlor CASRN 76-44-8 (28 kB)
- Zebrafish Hexachlorophene CASRN 70-30-4 (28 kB)
- Zebrafish Hydroxyurea CASRN 127-07-1 (21 kB)
- Zebrafish Isodecyl diphenyl phosphate CASRN 29761-21-5 (27 kB)
- Zebrafish L-Ascorbic acid CASRN 50-81-7 (21 kB)
- Zebrafish Lead (II) acetate trihydrate CASRN 6080-56-4 (27 kB)
- Zebrafish Lindane CASRN 58-89-9 (27 kB)
- Zebrafish MPEP CASRN 95737-68-1 (29 kB)
- Zebrafish Manganese, tricarbonyl (1,2,3,4,5-.eta.)-1-methyl-2,4-cyclopentadien-1-yl- CASRN 12108-13-3 (21 kB)
- Zebrafish Methyl mercuric (II) chloride CASRN 115-09-3 (46 kB)
- Zebrafish Naphthalene CASRN 91-20-3 (27 kB)
- Zebrafish Parathion CASRN 56-38-2 (28 kB)
- Zebrafish Permethrin CASRN 52645-53-1 (27 kB)
- Zebrafish Phenanthrene CASRN 85-01-8 (28 kB)
- Zebrafish Phenobarbital CASRN 50-06-6 (21 kB)
- Zebrafish Phenobarbital sodium salt CASRN 57-30-7 (27 kB)
- Zebrafish Phenol, isopropylated, phosphate (3 to1) CASRN 68937-41-7 (28 kB)
- Zebrafish Pyrene CASRN 129-00-0 (27 kB)
- Zebrafish Rotenone CASRN 83-79-4 (28 kB)
- Zebrafish Saccharin Sodium Salt hydrate CASRN 82385-42-0 (33 kB)
- Zebrafish Tebuconazole CASRN 107534-96-3 (28 kB)
- Zebrafish Tetraethylthiuram disulfide CASRN 97-77-8 (28 kB)
- Zebrafish Thalidomide CASRN 50-35-1 (27 kB)
- Zebrafish Toluene CASRN 108-88-3 (21 kB)
- Zebrafish Tricresyl phosphate CASRN 1330-78-5 (28 kB)
- Zebrafish Triphenyl phosphate CASRN 115-86-6 (46 kB)
- Zebrafish Tris(2-Chloroethyl) Phosphate CASRN 115-96-8 (21 kB)
- Zebrafish Valinomycin CASRN 2001-95-8 (29 kB)
- Zebrafish Valproic acid sodium salt CASRN 1069-66-5 (27 kB)
- Zebrafish n-Hexane CASRN 110-54-3 (27 kB)
- Zebrafish tert-Butylphenyl diphenyl phosphate CASRN 56803-37-3 (29 kB)
- Zebrafish tris(Chloropropyl) phosphate, TCPP CASRN 13674-84-5 (27 kB)