U.S. flag

An official website of the United States government

Dot gov

The .gov means it's official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you're on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Rotenone (83-79-4)

DOI: https://doi.org/10.22427/NTP-DATA-DTXSID6021248

Study Results

Chronic Bioassay Level of Evidence

An overview of chronic evidence from Rats studies.
Rats
View
  • Equivocal Evidence, Male, Rats
View
  • No Evidence, Female, Rats
An overview of chronic evidence from Mice studies.
Mice
View
  • No Evidence, Male, Mice
View
  • No Evidence, Female, Mice

Genetic Toxicology

An overview of Genetic Toxicology Mammalian Cell Mutagenicity study conclusions related to Rotenone (83-79-4).
Mammalian Cell Mutagenicity
View
  • Positive
An overview of Genetic Toxicology Mammalian Cell Cytogenetics study conclusions related to Rotenone (83-79-4).
Mammalian Cell Cytogenetics
CA SCE
  • View
    • Weakly Positive
  • View
    • Not a Valid Test
An overview of Genetic Toxicology Bacterial Mutagenicity study conclusions related to Rotenone (83-79-4).
Bacterial Mutagenicity
View
  • Negative

Citation Information

NTP. Rotenone (83-79-4). Chemical Effects in Biological Systems (CEBS). Research Triangle Park, NC (USA): National Toxicology Program (NTP).

Related Links

Publications

TR-320 Toxicology and Carcinogenesis Studies of Rotenone (CASRN 83-79-4) in F344/N Rats and B6C3F1 Mice (Feed Studies)
Tumorogenic Potential of Rotenone and its Specificity for Mammary Tissue, published by National Center for ToxicologicalResearch (NCTR Experiment No. 216). Call NCTR (501-543-7115) for availability of document.
Zeiger E, Anderson B, Haworth S, Lawlor T, Mortelmans K, Speck W. Salmonella mutagenicity tests: III. Results from the testing of 255 chemicals. Environ Mutagen. 1987;9 Suppl 9:1-109.
McGregor, D., Brown, A., Cattanach, P., Edwards, I., McBride, D., Riach, C., and Caspary, W. Responses of the L5178Y tk+/tk- mouse lymphoma cell forward mutation assay: III. 72 coded chemicals. Environ. Molec. Mutagen. Vol. 12 (1988) 85-154
Myhr B.C., McGregor, D., Bowers, L., Riach, C., Brown, A., Edwards, I., McBride, D., Martin, R., and Caspary, W.J. L5178Y mouse lymphoma cell mutation assay results with 41 compounds. Environ. Molec. Mutagen. Vol. 16 (Suppl 18) (1990) 138-167
Anderson, B.E., Zeiger, E., Shelby, M.D., Resnick, M.A., Gulati, D.K., Ivett, J.L., and Loveday, K.S. Chromosome aberration and sister chromatid exchange test results with 42 chemicals. Environ. Molec. Mutagen. Vol. 16 (Suppl 18) (1990) 55-137
Systematic Evaluation of the Application of Zebrafish in Toxicology (SEAZIT): Interlaboratory Study Dose Range Finding (DRF) data DOI: https://doi.org/10.22427/NTP-DATA-002-00102-0001-000-6

Study Data

Protocol

Toxicity and Carcinogenicity Studies

Evaluation of the Chronic Toxicity and Carcinogenicity of Rotenone (83-79-4) in Male F344 Rats Exposed via Intraperitoneal Injection
Individual Animal Data
Evaluation of the Chronic Toxicity and Carcinogenicity of Rotenone (83-79-4) in Female F344 Rats Exposed via Intraperitoneal Injection
Individual Animal Data
Evaluation of the Chronic Toxicity and Carcinogenicity of Rotenone (83-79-4) in Male F344 Rats Exposed via Dosed Feed
Individual Animal Data
Evaluation of the Chronic Toxicity and Carcinogenicity of Rotenone (83-79-4) in Female F344 Rats Exposed via Dosed Feed
Individual Animal Data
Evaluation of the Chronic Toxicity and Carcinogenicity of Rotenone (83-79-4) in Male B6C3F1 Mice Exposed via Dosed Feed
Individual Animal Data
Evaluation of the Chronic Toxicity and Carcinogenicity of Rotenone (83-79-4) in Female B6C3F1 Mice Exposed via Dosed Feed
Individual Animal Data
Protocol

Genetic Toxicology Studies

Genetic Toxicity Evaluation of Rotenone in Salmonella/E.coli Mutagenicity Test or Ames Test. Study 635953
Summary Data

Other NTP Studies

Screen for Developmental Toxicity in Zebrafish- Study 1
Results

NTP Data Collections