U.S. flag

An official website of the United States government

Dot gov

The .gov means it's official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you're on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Evaluation of Androgen Receptor Agonists Dataset

DOI: https://doi.org/10.22427/NTP-DATA-022-00002-0012-000-9

Evaluation of androgen assay results using a curated Hershberger database. Kleinstreuer NC, Browne P, Chang X, Judson R, Casey W, Ceger P, Deisenroth C, Baker N, Markey K, Thomas RS. Published: 25 May 2018. https://doi.org/10.1016/j.reprotox.2018.08.017. Performance data from applying the ToxCast/Tox 21 androgen receptor model, based on 11 high throughput assays, to 39 reference chemicals.

  • Primary Search Criteria
  • Additional Search Criteria
Download
Chemical Name Activity Concentration at Cutoff: NVS_NR_hAR CASRN Source for Clearance In Vitro ToxCast Androgen Receptor Model Call Number of Positive Assays All Agonist Assays Negative (T/F) Agonist Lowest Observed Effect Level (T/F) Androgen Recptor Agonist Activity Group Hershberger: No Observed Effect Level Hershberger: Minimum Lowest Observed Effect Level Hershberger: Median Lowest Observed Effect Level Hershberger: Maximum Lowest Observed Effect Level Pharmacokinetics: Fraction of Unbound Chemical Pharmacokinetics: Renal Clearance Pharmacokinetics: MW Pharmacokinetics: Intrinsic Clearance Source for Fraction of Unbound Chemical Activity Concentration at Cutoff: ATG_AR_TRANS_up Activity Concentration at Cutoff: NVS_NR_cAR Activity Concentration at Cutoff: NVS_NR_rAR Activity Concentration at Cutoff: OT_AR_ARELUC_AG_1440 Activity Concentration at Cutoff: OT_AR_ARSRC1_0480 Activity Concentration at Cutoff: OT_AR_ARSRC1_0960 Activity Concentration at Cutoff: TOX21_AR_BLA_Agonist_ratio Activity Concentration at Cutoff: TOX21_AR_LUC_MDAKB2_Agonist Equivalent Administered Dose: ATG_AR_TRANS_up Equivalent Administered Dose: NVS_NR_hAR Equivalent Administered Dose: NVS_NR_cAR Equivalent Administered Dose: NVS_NR_rAR Equivalent Administered Dose: OT_AR_ARELUC_AG_1440 Equivalent Administered Dose: OT_AR_ARSRC1_0480 Equivalent Administered Dose: OT_AR_ARSRC1_0960 Equivalent Administered Dose: TOX21_AR_BLA_Agonist_ratio Equivalent Administered Dose: TOX21_AR_LUC_MDAKB2_Agonist Equivalent Administered Dose: Median Equivalent Administered Dose: Predicted Maximum at ACC=100 uM ToxCast Agonist Area Under the Curve ToxCast Antagonist Area Under the Curve ToxCast Antagonist Confidence Score ToxCast Assay Confirmation Flag