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2,3,7,8-Tetrachlorodibenzo-p-dioxin (1746-01-6)

DOI: https://doi.org/10.22427/NTP-DATA-DTXSID2021315

Study Results

Chronic Bioassay Level of Evidence

An overview of chronic evidence from Rats studies.
Rats
View
  • Positive, Male, Rats
View
  • Positive, Female, Rats
View
  • Clear Evidence, Female, Rats
View
  • Clear Evidence, Female, Rats
An overview of chronic evidence from Mice studies.
Mice
View
  • Equivocal, Male, Mice
View
  • Positive, Male, Mice
View
  • Positive, Female, Mice
View
  • Positive, Female, Mice

Genetic Toxicology

An overview of Genetic Toxicology Rodent Cytogenetics study conclusions related to 2,3,7,8-Tetrachlorodibenzo-p-dioxin (1746-01-6).
Rodent Cytogenetics
CA SCE
  • View
    • Not a Valid Test
An overview of Genetic Toxicology Mammalian Cell Mutagenicity study conclusions related to 2,3,7,8-Tetrachlorodibenzo-p-dioxin (1746-01-6).
Mammalian Cell Mutagenicity
View
  • Negative
An overview of Genetic Toxicology Mammalian Cell Cytogenetics study conclusions related to 2,3,7,8-Tetrachlorodibenzo-p-dioxin (1746-01-6).
Mammalian Cell Cytogenetics
CA SCE
An overview of Genetic Toxicology Drosophila Germ Cell Mutagenicity study conclusions related to 2,3,7,8-Tetrachlorodibenzo-p-dioxin (1746-01-6).
Drosophila Germ Cell Mutagenicity
SLRL
An overview of Genetic Toxicology Bacterial Mutagenicity study conclusions related to 2,3,7,8-Tetrachlorodibenzo-p-dioxin (1746-01-6).
Bacterial Mutagenicity
View
  • Negative

Citation Information

NTP. 2,3,7,8-Tetrachlorodibenzo-p-dioxin (1746-01-6). Chemical Effects in Biological Systems (CEBS). Research Triangle Park, NC (USA): National Toxicology Program (NTP).

Related Links

Publications

TR-201 Carcinogenesis Bioassay of 2,3,7,8-Tetrachlorodibenzo-p-dioxin (CASRN 1746-01-6) in Swiss-Webster Mice (Dermal Study)
TR-209 Carcinogenesis Bioassay of 2,3,7,8-Tetrachlorodibenzo-p-dioxin (CASRN 1746-01-6) in Osborne-Mendel Rats and B6C3F1 Mice (Gavage Study)
TR-521 Toxicology and Carcinogenesis Studies of 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) (CASRN 1746-01-6) in Female Harlan Sprague-Dawley Rats (Gavage Studies)
Mortelmans, K., Haworth, S., Speck, W., and Zeiger, E. Mutagenicity testing of Agent Orange components and related chemicals Toxicology and Applied Pharmacology Vol. 75 (1984) 137-146
McGregor, D., Brown, A., Howgate, S., McBride, D., Riach, C., and Caspary, W. Responses of the L5178Y tk+/tk- mouse lymphoma cell forward mutation assay. IV: 27 coded chemicals. Environ. Molec. Mutagen. Vol. 17 (1991) 196-219
Sirenko O, Parham F, Dea S, Sodhi N, Biesmans S, Mora-Castilla S, Ryan K, Behl M, Chandy G, Crittenden C, Vargas-Hurlston S, Guicherit O, Gordon R, Zanella F, Carromeu C. Functional and Mechanistic Neurotoxicity Profiling Using Human iPSC-Derived Neural 3D Cultures. Toxicol Sci. 2019 Jan 1;167(1):58-76. doi: 10.1093/toxsci/kfy218. PMID: 30169818
Quevedo C, Behl M, Ryan K, Paules RS, Alday A, Muriana A, Alzualde A. Detection and Prioritization of Developmentally Neurotoxic and/or Neurotoxic Compounds Using Zebrafish. Toxicol Sci. 2019 Mar 1;168(1):225-240. doi: 10.1093/toxsci/kfy291. PMID: 30521027
Frawley R, DeVito M, Walker NJ, Birnbaum L, White K Jr, Smith M, Maynor T, Recio L, Germolec D. Relative potency for altered humoral immunity induced by polybrominated and polychlorinated dioxins/furans in female B6C3F1/N mice. Toxicol Sci. 2014 Jun;139(2):488-500. doi: 10.1093/toxsci/kfu041. Epub 2014 Apr 8. PMID: 24713691
Zimmering, S., Mason, J.M., Valencia, R., and Woodruff, R.C. Chemical mutagenesis testing in Drosophila. II. Results of 20 coded compounds tested for the National Toxicology Program. Environ. Mutagen. Vol. 7 (1985) 87-100
Galloway, S., Armstrong, M., Reuben, C., Colman, S., Brown, B., Cannon, C., Bloom, A., Nakamura, F., Ahmed, M., Duk, S., Rimpo, J., Margolin, B., Resnick, M., Anderson, B., and Zeiger, E. Chromosome aberration and sister chromatid exchanges in Chinese hamster ovary cells: Evaluations of 108 chemicals. Environ. Molec. Mutagen. Vol. 10 (Suppl 10) (1987) 1-176
Gene Expression Alterations in Immune System Pathways in the Thymus Following Exposure to Immunosuppressive Chemicals Rachel Frawley, Kimber White, Jr., Ronnetta Brown, Deborah Musgrove, Nigel Walker, Dori Germolec
Environmental Health Perspectives (2011) DOI: https://doi.org/10.1289/ehp.1002358 PMID: 21041162
DOI: https://doi.org/10.22427/NTP-DATA-002-00086-0001-0000-6

Study Data

Protocol

Toxicity and Carcinogenicity Studies

3-Month Evaluation of the Toxicity (C20306) of PCN 66/67 Comparison Study (PCNCOMPARISN) in F344/N Rats Exposed via Gavage
TCDD Study Tables
Study Tables
PCN67 Study Tables
PCN66 Study Tables
Individual Animal Data
Evaluation of the Chronic Toxicity and Carcinogenicity (C96007B) of TEF (Dioxin Mixture) (TEFDIOXINMIX) in Harlan Sprague-Dawley Rats Exposed via Gavage. NTP Special Study
Individual Animal Data
Evaluation of the Chronic Toxicity and Carcinogenicity of 2,3,7,8-Tetrachlorodibenzo-p-dioxin (1746-01-6) in Male Osborne-Mendel Rats Exposed via Gavage
Individual Animal Data
Evaluation of the Chronic Toxicity and Carcinogenicity of 2,3,7,8-Tetrachlorodibenzo-p-dioxin (1746-01-6) in Female Osborne-Mendel Rats Exposed via Gavage
Individual Animal Data
Evaluation of the Chronic Toxicity and Carcinogenicity (C96007G) of TEF (TCDD) (1746-01-6) in Sprague-Dawley Rats Exposed via Gavage. NTP Special Study
Pathology Tables
Individual Animal Data
Clinical Chemistry Reports
Evaluation of the Chronic Toxicity and Carcinogenicity of 2,3,7,8-Tetrachlorodibenzo-p-dioxin (1746-01-6) in Male B6C3F1 Mice Exposed via Gavage
Individual Animal Data
Evaluation of the Chronic Toxicity and Carcinogenicity of 2,3,7,8-Tetrachlorodibenzo-p-dioxin (1746-01-6) in Female B6C3F1 Mice Exposed via Gavage
Individual Animal Data
Evaluation of the Chronic Toxicity and Carcinogenicity of 2,3,7,8-Tetrachlorodibenzo-p-dioxin (1746-01-6) in Male Swiss-Webster Mice Exposed via Topical Application
Individual Animal Data
Evaluation of the Chronic Toxicity and Carcinogenicity of 2,3,7,8-Tetrachlorodibenzo-p-dioxin (1746-01-6) in Female Swiss-Webster Mice Exposed via Topical Application
Individual Animal Data
Evaluation of the Chronic Toxicity and Carcinogenicity (C96007B) of TEF (Dioxin Mixture) (TEFDIOXINMIX) in Harlan Sprague-Dawley Rats Exposed via Gavage
Pathology Tables
Individual Animal Data
Evaluation of the Chronic Toxicity and Carcinogenicity (C96007G) of TEF (TCDD) (1746-01-6) in Harlan Sprague-Dawley Rats Exposed via Gavage
Pathology Tables
Individual Animal Data
Protocol

Genetic Toxicology Studies

Genetic Toxicity Evaluation of 2,3,7,8-Tetrachlorodibenzo-p-dioxin in Salmonella/E.coli Mutagenicity Test or Ames Test. Study 904370
Summary Data

Other NTP Studies

Screen for Developmental Toxicity in Zebrafish- Study 1
Results
Toxicokinetic Evaluation (K01807) of 2,3,7,8-Tetrachlorodibenzo-p-dioxin (DTXSID2021315) in Rat
Data
Toxicokinetic Evaluation (S0621) of 2,3,7,8-Tetrachlorodibenzo-p-Dioxin (1746-01-6) in Sprague-Dawley Rats Exposed via Gavage
Data

NTP Data Collections