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Bisphenol A (80-05-7)

DOI: https://doi.org/10.22427/NTP-DATA-DTXSID7020182

Study Results

Chronic Bioassay Level of Evidence

An overview of chronic evidence from Rats studies.
Rats
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  • Equivocal, Male, Rats
View
  • Equivocal, Female, Rats
An overview of chronic evidence from Mice studies.
Mice
View
  • Equivocal, Male, Mice
View
  • Negative, Female, Mice

Genetic Toxicology

An overview of Genetic Toxicology Rodent Cytogenetics study conclusions related to Bisphenol A (80-05-7).
Rodent Cytogenetics
CA SCE
  • View
    • Positive (Nonstandard Protocol)
  • View
    • Negative (Nonstandard Protocol)
An overview of Genetic Toxicology Micronucleus Rats study conclusions related to Bisphenol A (80-05-7).
Micronucleus - Rats
View
  • Male: Negative
An overview of Genetic Toxicology Mammalian Cell Mutagenicity study conclusions related to Bisphenol A (80-05-7).
Mammalian Cell Mutagenicity
View
  • Negative
An overview of Genetic Toxicology Mammalian Cell Cytogenetics study conclusions related to Bisphenol A (80-05-7).
Mammalian Cell Cytogenetics
CA SCE
An overview of Genetic Toxicology In Vivo Alkaline Comet Assay Rats study conclusions related to Bisphenol A (80-05-7).
In Vivo Alkaline Comet Assay - Rats
View
  • Male: Negative
An overview of Genetic Toxicology Drosophila Germ Cell Mutagenicity study conclusions related to Bisphenol A (80-05-7).
Drosophila Germ Cell Mutagenicity
SLRL
An overview of Genetic Toxicology Bacterial Mutagenicity study conclusions related to Bisphenol A (80-05-7).
Bacterial Mutagenicity
View
  • Negative
View
  • Negative
View
  • Negative

Citation Information

NTP. Bisphenol A (80-05-7). Chemical Effects in Biological Systems (CEBS). Research Triangle Park, NC (USA): National Toxicology Program (NTP).

Related Links

Publications

TR-215 Carcinogenesis Bioassay of Bisphenol A (CASRN 80-05-7) in F344 Rats and B6C3F1 Mice (Feed Study)
RR-4 Biological Activity of Bisphenol A (BPA) Structural Analogues and Functional Alternatives
RR-9 Draft NTP Research Report on the CLARITY-BPA Core Study: A Perinatal and Chronic Extended-Dose-Range Study of Bisphenol A in Rats
Haworth, S., Lawlor, T., Mortelmans, K., Speck, W., and Zeiger, E. Salmonella mutagenicity test results for 250 chemicals Environ. Mutagen. Vol. 5 (Suppl 1) (1983) 3-142
Final Report - Teratologic Evaluation of Bisphenol A Administered to CD-1 Mice on Gestational Days 6 through 15
Final Report - Teratologic Evaluation of Bisphenol A Administered to CD® Rats on Gestational Days 6 through 15
Myhr, B. and Caspary, W. Chemical mutagenesis at the TK locus in L5178Y mouse lymphoma cells. I. Results for 31 coded compounds in the National Toxicology Program. Environ. Molec. Mutagen. Vol. 18 (1991) 51-83
Foureman, P., Mason, J.M., Valencia, R., Zimmering, S. Chemical Mutagenesis Testing in Drosophila. X. Results of 70 coded compounds tested for the National Toxicology Program. Environ. Molec. Mutagen. Vol. 23 (1994) 208-227
Ivett, J.L., Brown, B.M., Rodgers, C., Anderson, B.E., Resnick, M.A., Zeiger, E. Chromosomal aberration and sister chromatid exchange tests in Chinese hamster ovary cells in vitro IV: Results for 15 chemicals Environ. Molec. Mutagen. Vol. 14 (1989) 165-187
Binding of Bisphenol A, Bisphenol AF, and Bisphenol S on the Androgen Receptor: Coregulator Recruitment and Stimulation of Potential Interaction Sites Lalith Perera, Yin Li, Laurel A. Coons, Rene Houtman, Rinie van Beuningen, Bonnie Goodwin, Scott S. Auerbach, and Christina T. Teng.
Toxicology in Vitro (2017) DOI: https://doi.org/10.1016/j.tiv.2017.07.020 PMID: 28751236
Evaluation of Prenatal Exposure to Bisphenol Analogues on Development and Long-Term Health of the Mammary Gland in Female Mice Tucker DK, Hayes Bouknight S, Brar SS, Kissling G, Fenton S
Environmental Health Perspectives(2018) DOI: https://doi.org/10.1289/EHP3189 PMID:30102602
DOI: https://doi.org/10.22427/NTP-DATA-021-00004-0001-0000-8
Characterization of Estrogenic and Androgenic Activities for Bisphenol A-like Chemicals (BPs): In Vitro Estrogen and Androgen Receptors Transcriptional Activation, Gene Regulation, and Binding Profiles Katherine E. Pelch, Yin Li, Lalith Perera, Kristina A. Thayer, Kenneth S. Korach
DOI: https://doi.org/10.22427/NTP-DATA-002-00060-0001-0000-9

Study Data

Protocol

Toxicity and Carcinogenicity Studies

Evaluation of the Chronic Toxicity and Carcinogenicity of Bisphenol A (80-05-7) in Male F344 Rats Exposed via Dosed Feed
Individual Animal Data
Evaluation of the Chronic Toxicity and Carcinogenicity of Bisphenol A (80-05-7) in Female F344 Rats Exposed via Dosed Feed
Individual Animal Data
Evaluation of the Chronic Toxicity and Carcinogenicity of Bisphenol A (80-05-7) in Male B6C3F1 Mice Exposed via Dosed Feed
Individual Animal Data
Evaluation of the Chronic Toxicity and Carcinogenicity of Bisphenol A (80-05-7) in Female B6C3F1 Mice Exposed via Dosed Feed
Individual Animal Data
Protocol

Genetic Toxicology Studies

Genetic Toxicity Evaluation of Bisphenol A (80-05-7) in DNA Damage Study G10034B in Sprague-Dawley Rats
Summary and Individual Animal Data
Genetic Toxicity Evaluation of Bisphenol A (80-05-7) in Micronucleus Study A24930 in F344 Rats
Summary and Individual Animal Data
Genetic Toxicity Evaluation of Bisphenol A in Salmonella/E.coli Mutagenicity Test or Ames Test. Study 121422
Summary Data
Genetic Toxicity Evaluation of Bisphenol A in Salmonella/E.coli Mutagenicity Test or Ames Test. Study 441712
Summary Data
Genetic Toxicity Evaluation of Bisphenol A in Salmonella/E.coli Mutagenicity Test or Ames Test. Study 680342
Summary Data

Other NTP Studies

Prenatal Developmental Toxicity Study (TER85051) of Bisphenol A (80-05-7) in Sprague-Dawley Rats Exposed via Gavage
Individual and Summary Data
Prenatal Developmental Toxicity Study (TER85052) of Bisphenol A (80-05-7) in Swiss CD-1 Mice Exposed via Gavage
Individual and Summary Data
Screen for Developmental Toxicity in Zebrafish- Study 1
Results

Other Studies

NTP Data Collections