L-Ascorbic acid (50-81-7)
DOI: https://doi.org/10.22427/NTP-DATA-DTXSID5020106
Study Results
Chronic Bioassay Level of Evidence
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Genetic Toxicology
| Rodent Cytogenetics | |
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| CA | SCE |
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| Micronucleus - Mice |
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| Mammalian Cell Mutagenicity |
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| Mammalian Cell Cytogenetics | |
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| CA | SCE |
| Drosophila Germ Cell Mutagenicity |
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| Bacterial Mutagenicity |
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Publications
TR-247
Carcinogenesis Bioassay of L-Ascorbic Acid (Vitamin C) (CASRN 50-81-7) in F344/N Rats and B6C3F1 Mice (Feed Study)
Zeiger, E., Anderson, B., Haworth, S., Lawlor, T., and Mortelmans, K. Salmonella mutagenicity tests. IV. Results from the testing of 300 chemicals Environ. Molec. Mutagen. Vol. 11 (Suppl 12) (1988) 1-158
Shelby, M.D., Erexson, G.L., Hook, G.J., and Tice, R.R. Evaluation of a three-exposure mouse bone marrow micronucleus protocol: Results with 49 chemicals. Environ. Molec. Mutag. Vol. 21 (1993) 160-179
Myhr, B. and Caspary, W. Chemical mutagenesis at the TK locus in L5178Y mouse lymphoma cells. I. Results for 31 coded compounds in the National Toxicology Program. Environ. Molec. Mutagen. Vol. 18 (1991) 51-83
Foureman, P., Mason, J.M., Valencia, R., Zimmering, S. Chemical Mutagenesis Testing in Drosophila. IX. Results of 50 coded compounds tested for the National Toxicology Program. Environ. Molec. Mutagen. Vol. 23 (1994) 51-63
Gulati, D., Witt, K., Anderson, B., Zeiger, E.,and Shelby, M. Chromosome aberration and sister chromatid exchange test in Chinese hamster ovary cells in vitro III: Results with 27 chemicals Environ. Molec. Mutagen. Vol. 13 (1989) 133-193
Study Data
Toxicity and Carcinogenicity Studies
Evaluation of the Chronic Toxicity and Carcinogenicity of L-Ascorbic Acid (50-81-7) in Male F344 Rats Exposed via Dosed Feed
Evaluation of the Chronic Toxicity and Carcinogenicity of L-Ascorbic Acid (50-81-7) in Female F344 Rats Exposed via Dosed Feed
Evaluation of the Chronic Toxicity and Carcinogenicity of L-Ascorbic Acid (50-81-7) in Male B6C3F1 Mice Exposed via Dosed Feed
Evaluation of the Chronic Toxicity and Carcinogenicity of L-Ascorbic Acid (50-81-7) in Female B6C3F1 Mice Exposed via Dosed Feed
Genetic Toxicology Studies
Genetic Toxicity Evaluation of L-Ascorbic Acid (50-81-7) in Micronucleus Study 521899 in B6C3F1 Mice
Summary and Individual Animal Data
Genetic Toxicity Evaluation of L-Ascorbic Acid in Salmonella/E.coli Mutagenicity Test or Ames Test. Study 065391
Summary Data
- G06 - Ames Summary Data (180 KB)
Genetic Toxicity Evaluation of L-Ascorbic Acid in Salmonella/E.coli Mutagenicity Test or Ames Test. Study 070079
Summary Data
- G06 - Ames Summary Data (99 KB)
Other NTP Studies
Screen for Developmental Toxicity in Zebrafish- Study 1
Results
- Zebrafish 2,3,7,8-Tetrachlorodibenzo-p-dioxin CASRN 1746-01-6 (28 kB)
- Zebrafish 1-Ethyl-3-methylimidazolium diethylphosphate CASRN 848641-69-0 (21 kB)
- Zebrafish 1-Methyl-4-phenylpyridinium iodide CASRN 36913-39-0 (21 kB)
- Zebrafish 2,2',4,4',5,5'-Hexabromodiphenyl ether (BDE-153) CASRN 68631-49-2 (21 kB)
- Zebrafish 2,2',4,4',5-Pentabromodiphenyl ether (BDE-99) CASRN 60348-60-9 (22 kB)
- Zebrafish 2,2',4,4'-Tetrabromodiphenyl ether CASRN 5436-43-1 (28 kB)
- Zebrafish 2-Ethylhexyl diphenyl phosphate (EHDP) CASRN 1241-94-7 (28 kB)
- Zebrafish 2-Ethylhexyl-2,3,4,5-tetrabromobenzoate (TBB) CASRN 183658-27-7 (21 kB)
- Zebrafish 2-Methoxyethanol CASRN 109-86-4 (22 kB)
- Zebrafish 3,3'-Iminodipropionitrile CASRN 111-94-4 (22 kB)
- Zebrafish 3,3’,5,5’-Tetrabromobisphenol A CASRN 79-94-7 (28 kB)
- Zebrafish 4-H-Cyclopenta(d,e,f)phenanthrene CASRN 203-64-5 (28 kB)
- Zebrafish 5-Fluorouracil CASRN 51-21-8 (21 kB)
- Zebrafish 5-nitro-2-furaldehyde semicarbazone CASRN 59-87-0 (23 kB)
- Zebrafish 6-Hydroxydopamine hydrochloride CASRN 28094-15-7 (21 kB)
- Zebrafish 6-Propyl-2-thiouracil CASRN 51-52-5 (21 kB)
- Zebrafish Acenaphthene CASRN 83-32-9 (28 kB)
- Zebrafish Acenaphthylene CASRN 208-96-8 (28 kB)
- Zebrafish Acetaminophen (4-hydroxyacetanilide) CASRN 103-90-2 (22 kB)
- Zebrafish Acetic acid, manganese (2+) salt CASRN 638-38-0 (22 kB)
- Zebrafish Acetylsalicylic acid CASRN 50-78-2 (21 kB)
- Zebrafish Acrylamide CASRN 79-06-1 (22 kB)
- Zebrafish Aldicarb CASRN 116-06-3 (28 kB)
- Zebrafish Amoxicillin CASRN 26787-78-0 (21 kB)
- Zebrafish Anthracene CASRN 120-12-7 (21 kB)
- Zebrafish Auramine O CASRN 2465-27-2 (28 kB)
- Zebrafish Benz(a)anthracene CASRN 56-55-3 (27 kB)
- Zebrafish Benzo(a)pyrene CASRN 50-32-8 (27 kB)
- Zebrafish Benzo(b)fluoranthene CASRN 205-99-2 (28 kB)
- Zebrafish Benzo(e)pyrene CASRN 192-97-2 (28 kB)
- Zebrafish Benzo(k)fluoranthene CASRN 207-08-9 (27 kB)
- Zebrafish Benzog,h,i perylene CASRN 191-24-2 (21 kB)
- Zebrafish Berberine chloride CASRN 633-65-8 (21 kB)
- Zebrafish Bis(2-ethylhexyl) 3,4,5,6- tetrabromophthalate (TBPH) CASRN 26040-51-7 (21 kB)
- Zebrafish Bis(tributyltin)oxide CASRN 56-35-9 (28 kB)
- Zebrafish Bisphenol A CASRN 80-05-7 (27 kB)
- Zebrafish Bisphenol AF CASRN 1478-61-1 (28 kB)
- Zebrafish Bisphenol S CASRN 80-09-1 (21 kB)
- Zebrafish Captan CASRN 133-06-2 (27 kB)
- Zebrafish Carbamic acid, butyl-, 3-iodo-2-propynyl ester CASRN 55406-53-6 (28 kB)
- Zebrafish Carbaryl CASRN 63-25-2 (27 kB)
- Zebrafish Chlorpyrifos (Dursban) CASRN 2921-88-2 (27 kB)
- Zebrafish Chrysene CASRN 218-01-9 (21 kB)
- Zebrafish Colchicine CASRN 64-86-8 (27 kB)
- Zebrafish D-Glucitol CASRN 50-70-4 (21 kB)
- Zebrafish Deltamethrin CASRN 52918-63-5 (45 kB)
- Zebrafish Di(2-ethylhexyl) phthalate CASRN 117-81-7 (22 kB)
- Zebrafish Diazepam CASRN 439-14-5 (28 kB)
- Zebrafish Dibenz a,c anthracene CASRN 215-58-7 (21 kB)
- Zebrafish Dibenz(a,h)anthracene CASRN 53-70-3 (27 kB)
- Zebrafish Dichlorodiphenyltrichloroethane (DDT) CASRN 50-29-3 (28 kB)
- Zebrafish Dieldrin CASRN 60-57-1 (27 kB)
- Zebrafish Diethylstilbestrol CASRN 56-53-1 (28 kB)
- Zebrafish Estradiol CASRN 50-28-2 (28 kB)
- Zebrafish Firemaster 550 CASRN 860302-33-6 (28 kB)
- Zebrafish Fluorene CASRN 86-73-7 (28 kB)
- Zebrafish Heptachlor CASRN 76-44-8 (28 kB)
- Zebrafish Hexachlorophene CASRN 70-30-4 (28 kB)
- Zebrafish Hydroxyurea CASRN 127-07-1 (21 kB)
- Zebrafish Isodecyl diphenyl phosphate CASRN 29761-21-5 (27 kB)
- Zebrafish L-Ascorbic acid CASRN 50-81-7 (21 kB)
- Zebrafish Lead (II) acetate trihydrate CASRN 6080-56-4 (27 kB)
- Zebrafish Lindane CASRN 58-89-9 (27 kB)
- Zebrafish MPEP CASRN 95737-68-1 (29 kB)
- Zebrafish Manganese, tricarbonyl (1,2,3,4,5-.eta.)-1-methyl-2,4-cyclopentadien-1-yl- CASRN 12108-13-3 (21 kB)
- Zebrafish Methyl mercuric (II) chloride CASRN 115-09-3 (46 kB)
- Zebrafish Naphthalene CASRN 91-20-3 (27 kB)
- Zebrafish Parathion CASRN 56-38-2 (28 kB)
- Zebrafish Permethrin CASRN 52645-53-1 (27 kB)
- Zebrafish Phenanthrene CASRN 85-01-8 (28 kB)
- Zebrafish Phenobarbital CASRN 50-06-6 (21 kB)
- Zebrafish Phenobarbital sodium salt CASRN 57-30-7 (27 kB)
- Zebrafish Phenol, isopropylated, phosphate (3 to1) CASRN 68937-41-7 (28 kB)
- Zebrafish Pyrene CASRN 129-00-0 (27 kB)
- Zebrafish Rotenone CASRN 83-79-4 (28 kB)
- Zebrafish Saccharin Sodium Salt hydrate CASRN 82385-42-0 (33 kB)
- Zebrafish Tebuconazole CASRN 107534-96-3 (28 kB)
- Zebrafish Tetraethylthiuram disulfide CASRN 97-77-8 (28 kB)
- Zebrafish Thalidomide CASRN 50-35-1 (27 kB)
- Zebrafish Toluene CASRN 108-88-3 (21 kB)
- Zebrafish Tricresyl phosphate CASRN 1330-78-5 (28 kB)
- Zebrafish Triphenyl phosphate CASRN 115-86-6 (46 kB)
- Zebrafish Tris(2-Chloroethyl) Phosphate CASRN 115-96-8 (21 kB)
- Zebrafish Valinomycin CASRN 2001-95-8 (29 kB)
- Zebrafish Valproic acid sodium salt CASRN 1069-66-5 (27 kB)
- Zebrafish n-Hexane CASRN 110-54-3 (27 kB)
- Zebrafish tert-Butylphenyl diphenyl phosphate CASRN 56803-37-3 (29 kB)
- Zebrafish tris(Chloropropyl) phosphate, TCPP CASRN 13674-84-5 (27 kB)